비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

자가방수액이 가토 결막조직에 미치는 영향

신경학,고명규,최준규 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.2

It has been well known that the failure of the trabeculectomy is associated with the migration and proliferation of the fibroblast at the fistula site, which may be influenced by the aqueous humor. It is not clear whether the aqueous humor nas growth factor or inhibitory factor. This experiment was designed to elucidate the effect of the aqueous humor on the conjunctiva in rabbit. The aqueous humor was injected into the subconjunctival area in the rabbit, twice weekly upto for 1 minth. In addition, the autologous conjunctival tissue was implanted into the anterior chamber of the fellow eye, which was observed for three months. The conjuntiva, which was treated by the aqueous humor in situ and in anterior chamber, was examined with electron microscopy. The conjunctiva, treated with autologous aqueous humor, showed the infiltration of the inflammatory cells and fivrin in the substantia propria. These findings may be affected by the disruption of the blood-aqueous barrier or chemoattractant activity of the aqueous humor. The conjunctiva, implanted into the anterior chamber, disappeared with fragmentation or was shrinked in appearance. The conjunctival epithelial cells showed the degeneration with widened intercellular space, slightly protruded villous projection into intercellular space and separation of desmosome between adjacent cells. The substantia propria was well preserved with both the endothelial and pericyte cell uninterruptedly lined with basement membrane. The widened intercellular space and slightly projected villous projection may be influenced by the growth activity in the aqueous humor. However, the inhibitory activity in the aqueous humor may contributetothe degeneration in teh superficial epithelium and no further growth of the conjuntival tissue. These fundings may be summed up by the growth activity of the plasmoid aqueous by disruption of blood-aqueous barrier following surgical manipulation and by inhibitory activity in stabilized aqueous humor. The influence of aqueous homor on the cytologic or histologic pattern will depend on the biochemical components of the aqueous humor.

수지(手指)에 발생한 Glomus Tumor - 치험 2례 보고 -

신경현,김준영,윤치순,최창욱,김학현 순천향의과대학 1978 Journal of Soonchunhyang Medical Science Vol.1 No.1

Glomus tbmor of the hand has been well documented lesion that usually presents as painful dermal nodule in the finger. Glomus tumor may be difficult in diagnostic and therapeutic problems because of relatively rare and not easily experienced cases. Normal glomus body presents in the skin and subcutis of the extremity, but the normal body is not more than 1 mm3) in size. Most evidence indicates that the main function of the normal glomus body is to aid in regulation of the skin circulation. The glomus tumor is thought to be an abnormal proliferation of the glomus body and accompained by the classic triad of symptoms : pain, tenderness and temperature sensitivity. This paper reports two cases of glomus tumor occurring in the nail bed and finger pulp. One case was found 30 years later & another case 15 years after the onset in spite of srvere pain, tenderness and lancinating pain when exposed to the cold tempera ture but the excision of the tumor resulted in complete recovery.

18S-srRNA 분석에 의한 Acantbamoeba 한국 분리주들의 분류 검토

신호준,지영진,조명수,김형일,박연희,임경일 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.2

Acanthamoeba spp. spread in soil, ponds, air and swimming pool, cause a granulomatous amoebic meningitis and amoebic keratitis in human and experimental animals. Their classification had depended upon morphological characteristics and physiological conditions such as thermophilic status and generation times. However, because amoeba species showed the morphological and physiological diversity in isolates, many attempts have been made on identification of Acanthamoeba spp. Restriction fragments length polymorphism (RFLP) analysis of IBS-small subunit ribosomal RNA (srRNA) was an useful tool for classification among morphologically and genetically closely-related species. In this study, 18S-srDNAs of amoebae were amplified by PCR with primer encoding 18S-srRNA gene and digested with restriction endonudeases, and RFLP analysis was applied on classification of Acanthamoeba Korean isolates (YM-4, YM-5 and YM-7), comparing with reference amoebae, A. culbertsoni, A. polyphaga and A. royreba. Trophozoites of six Acanthamoeba spp. had typical acanthopoda, but did not show any morphological differences. Cyst of Acanthamoeba sp. YM-7 was similar to that of A. polyphaga which was designated as group Ⅱ Acanthamoeba. Morphologically other amoebae belonged to group Ⅲ Acanthamoeba. Digestion of 18S-srDNA with six enzymes, Dde Ⅰ, Hae Ⅲ, Hind Ⅲ, EcoR Ⅰ, Rsa Ⅰ and Sph Ⅰ, resulted in various DNA fragments. Using the method of Nei and U (1979) for RFLP analysis, genetic divergence was not observed between A culbertsoni and Acanthamoeba sp. YM-4. Between A. culbertsoni and Acanthamoeba sp. YM-5, genetic distance was 0.070, 0.364 between Acanthamoeba sp. YM-4 and A. polyphaga, and 0.277 between Acanthamoeba sp. YM-7 and A. polyphaga. In comparison with A. culbertsoni and A. polyphaga, Acanthamoeba sp. YM-7 showed genetic distance of 0.330 and 0.154, respectively. Thus, Acanthamoeba sp. YM-7 is a similar species to A. polyphaga. Acanthamoeba sp. YM-5 is a different species from A. polyphaga, but closely-related to A. culbertsoni. Acanthamoeba sp. YM-4 can be classified as a subspecies or a strain of A. culbertsoni.

퇴행성 요추 질환의 후방 수술시 발생한 경막 손상

신병준,이재철,조영일,최원기,허일,김경제,김연일 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

가토 악골에 매식된 Apatite-Wollastonite Glass Ceramic의 생체반응에 관한 실험적 연구

任昌俊,金慶勖,申承澈,金豪建,申建澈 단국대학교 1992 論文集 Vol.26 No.-

The authors implanted the Apatite Wollastonite Glass Ceramic(AWGC) powders in the rabbit maxillae to evaluate the possibility of clinical use as an artificial bone substitute material. Firstly we made AWGC and analized powder X-ray diffraction pattern of glass after crystalization. Secondly we made animal experiment with New Zealand white rabbits. The rabbits were sacrificed at the day of opstoperative 2 weeks and 4 weeks after implantation. We took the radiography of the maxillae block specimens, each of which includes the AWGC, at the day of sacrifice. And the block specimens were routinely prepared for the SEM and EDX study. We observed the attitudes at the border between the bone and the material with the SEM, and we searched the components such as Ca or P by use of EDX and compared the periodic changing data. The obtained results are as follows : 1. On SEM findings, silica band-like zone was found between the bone and the implanted materials at 2-week specimen, and this zone was found diffusely mingled between the bone and the implanted meterials at the 4-week specimen. 2. On intraoral X-ray findings, the border line was definitely found between the bone and the the material just after implantation of AWGC, but the border line became difused and fusion was occasionally found at the border area. 3. There was a little change in the natural bone components at the border area, and Ca or P was drawn out from Awgc at the border area. 4. Si of AWGC was increased as the time being, and AWGC was dissolved with leakage of Ca and P. So it is suggested that the intermediate zone of Calcium Phosphate Apatite was formed at the border area by Ca and P from AWGC dissolution, and it makes AWGC further tightly bonded to the bone.

Zn-Fe 합금 도금강판의 점용접성에 관한 연구

민준기,신재경,안효영,서수정,서창제 成均館大學校 科學技術硏究所 1992 論文集 Vol.43 No.1

Spot welding is widely used in automobile assembly lines. Electroplating of Zn-Fe on steel sheets is increasingly used in assembly lines, because of its good spot weldability, formability and corrosion resistance. In this study, to evaluate spot weldability, tensile shear strength and cross tensile strength of steel sheets electroplated with Zn and Fe up to 0.7mm thickness were investigated, and these mechanical properties were compared with those of steel sheets electroplated with Zn only. The thickness of electroplated steel sheets was measured with SEM. The following conclusions were obtained. (1) In spot welding, the weldability lobe was getting wider and directed toward low currency direction, in steel sheets electroplated with Zn-Fe compared with those electroplated with Zn only. (2) Electrode force and welding time obviously affected the ultimate welding strength, and the range representing constant ultimate welding strength was observed. (3) When Zn-Fe were electroplated on steel sheets, the ductility ratio was increased in optimal welding condition, indicating that good weldability was obtained. (4) Around 8.5KA where optimal strength existed, by spot welding, the amount of the electroplated layer was observed to be reduced by approximately 15% in thickness.

대학병원 정신과 외래 환자의 약물순응도

권준수,신성웅,정영미,박경호 大韓神經精神醫學會 1997 신경정신의학 Vol.36 No.3

Objective : In view of the facts that education about diseases and realization of the need form drugs can improve compliance of the patients, we assessed the knowledge about drugs and medication compliance in psychiatric outpatients. In addition, we investigated factors that influence patients compliance to develop a model of medication compliance. Methods : One-hundred twelve male and eighty female psychiatric outpatient were asked about drug information using questionnaires. We developed a model that predicts medication compliance using chi square tests and multiple regression analysis. Results : More than a half of the patients knew at least one of the names and the effects of the drugs they had taken, but many of them didn't know the side effects of drugs. About eighty percent of the patients showed good compliance. Knowledge of side effects, belief in the benefits of drugs, and level of education could predict medication compliance reliably. Conclusions : Because education level could not be managed by physician, we could enhance compliance through education about drug side effects and benefits of medications.

창공91의 비행시험을 통한 속도 및 고도 보정에 관한 연구

黃明信,李晶模,李璟埈 한국항공대학교 1992 論文集 Vol.30 No.-

본 연구는 창공91 항공기의 비행시험을 수행하기 위하여 기본이되는 항공기의 고도계와 속도계를 보정하는 방법에 대해 기술하였으며, 실제 비행시험을 통한 결과를 이용하여 항공기의 계기를 보정하는 방법을 나타내었다. 속도계와 고도계를 보정하기 위하여 수행되는 비행시험에는 여러가지 방법이 있지만, 본 연구에서는 일반적으로 경항공기를 제작하여 판매하는 항공기 제작사에서 운용되는 방법인 tower flyby 방법과 system to system방법을 사용하였다. 이 방법은 pitot head에 오차가 없음을 가정한 방법이다. 비행시험을 통해 실제 측정된 자료들은 항공기 계기 보정에 적절함을 알 수 있었다. A study on the airspeed and altimeter calibration of Chang-Gong 91 was conducted by the flight test. Airspeed calibration are conducted using the altimeter method(tower flyby). This method assumes that all the airspeed position error is caused by the static system and that there is no error in the pitot head. For that reason, this method is used mainly in the small aircraft manufacture company. We have been also conducted the ‘system to system’ method using the swivel head airspeed booms. Flight test data is corrected for instrument error and position error, and the resulting data was satisfied.

Plasmid DNA의 세포전이에 대한 PEI 분자량의 영향

이경만,김인숙,이용복,신상철,오인준 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

Polyethylenimine (PEI) has been used as cationic polymers for efficient gene transfer without the need for endosomolytic agents. Various kinds of PEIs with different molecular weight were tested in order to investigate the effects of the molecular weight of PEI on the transfection efficiency and cell cytotoxicity. The [3-galactosidase expression (pCMV-13-gal) plasmid was used as a model DNA. Complex formation between PEI and pDNA was assessed by 1% agarose gel electrophoresis method. Particle size and zeta-potential of complexes were determined by electrophoretic light scattering spectrometer. In vino transfection efficiency was assayed by measuring (3-galactosidase activity. Cell cytotoxicity was deter-mined by MTT assay. Particle sizes of the complexes became smaller on increasing molecular weights of PEI and N/P ratios. Surface potential of complexes was increased as the molecular weight of PEI increased. Transfection efficiency of pCMV-[3-gal on the HEK 293 cells was greatest with PEI 25 K system but having the lowest cell viability. PEI with high molecular weight showed higher transfection efficiency and cell viability than PEI with low molecular weight.