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정진일,김기영,최윤희,최원영,고종철,오명규,홍하철,이승엽,이명철 한국국제농업개발학회 2004 韓國國際農業開發學會誌 Vol.16 No.4
평야지재배 적응 조생종 벼 품종의 선발 및 품종 육성의 기초 자료로 활용코자 극조생종(1품종)과 조생종(10품종) 및 준조생(3품종)등 총 14품종을 산간지(운봉)와 평야지(익산)에 지역별 표준재배법으로 공시한 결과, 1. 극조생종 및 조생종들은 감온성이 커 산간지에서 출수가 빠르나, 준조생종에 속하는 상미벼, 영덕34호, 히또메보레 등은 감광성이 감온성보다 커, 평야지재배에서 4일정도 빨리 출수하였다. 2. 수량성은 대부분의 품종들이 산간지재배에 비해 평야지 재배에서 높았고 대체로 출수가 빠른 품종일수록 지역간의 수량차가 크게 나타났으며, 출수가 다소 늦은 준조생종들은 산간지와 평야지의 재배에서 수량차가 크지 않아 산간지 뿐만 아니라 평야지에서도 적응성이 높았다. 3. 단백질함량은 숙기가 다소 늦은 품종일수록 낮은 경향을 보였고 산간지보다는 평야지에서 낮았으며, 품종간에는 오대벼, 운봉30호, 영덕34호, 신석조생, 상미벼 등이 함유량이 낮았다. 4. 식미치는 산간지재배가 평야지에 비해 보다 높게 나타났고, 출수가 늦을수록 높았으며, 지역간 차가 크게 나타난 품종은 극조생종인 키라라397이었고, 출수가 늦은 상미벼와 히또메보레는 차가 적었다. 5. 산온도와 수량과의 상관은 산간지에서만 영향이 있을 뿐 평야에서는 영향이 적고 일사량과 일조시수가 수량에 보다 상관성이 높았으며, 식미치는 적산온도와는 부의상관, 생육 일수와는 정상관을 보였다. This experiment was carried out to clarify the difference of rice yield and the quality of rice in southern plan area and in alpine area. Yield and quality of fourteen early varieties were investigated under the different transplanting dates and planting densities in southern plan area(Iksan) and in alpine area(Unbong). In the alpine area, extremely early variety and early varieties headed early compared to the plain area, but medium early varieties headed about 4 days late unlike the alpine area. The yield difference of most early varieties including Kilara 397 of extremely early flowering variety were greater in plain area than in alpine. The different of yield between plain and alpine area was less in varieties with Sinseogjosaeng, Odaebyeo, Akidagomachi, and Yeungdeuk34. The rate of protein was lower in plain area than alpine and more lately flowering than early, but palatability of milled rice was higher at the alpine area and more lately flowering varieties. Correlation coefficients between yield and meterological data during maturity, yield shower the significant correlation with integrated solar radiation and sunshine hours at cultured in southern plan area, but it showed only cumulative temperature in alpine area. Palatability of miller rice was positive correlation at growth duration but negative correlation at cumulative temperature.
( Seung Hyeun Lee ),( Sue In Choi ),( Won Jai Jung ),( Eun Joo Lee ),( Kyung Hoon Min ),( Gyu Young Hur ),( Seung Heon Lee ),( Sung Yong Lee ),( Je Hyeong Kim ),( Sang Yeub Lee ),( Chol Shin ),( Jae J 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Reactive oxygen species modulator 1 (Romo1) is key mediator of intracellular reactive oxygen species production. Increased expression of Romo1 has been reported in human malignancies and was associated with poor survival in lung cancer patients who undergo surgery. We investigated whether Romo1 expression is associated with clinical outcomes of patients who were treated with platinum-based chemotherapy for advanced non-small cell lung cancer (NSCLC). Methods: Romo1 expression in tumor tissues was examined by immunohistochemistry and evaluated by a semiquantitative histologic score (H score). We performed survival analyses and evaluated the association between Romo1 expression and clinical parameters. Results: A total of 81 tumor specimens were available for Romo1 evaluation. At the cutoff value of H score 200, multivariate analysis showed that high Romo1 expression was significantly associated with short progression-free survival (hazard ratio [HR] = 4.40, 95% confidence interval [CI]: 2.54 -7.62), and with short overall survival (HR = 3.00, 95% CI: 2.88-5.02). Romo1 expression was not associated with any clinical parameter including age, gender, smoking status, stage, differentiation, or tumor histology. Conclusion: Increased Romo1 expression was associated with poor response and short overall survival in advanced NSCLC patients treated with platinum-based chemotherapy. Romo1 overexpression could be a potential adverse prognostic marker in this setting.
Lee, Seung Hyeun,Kim, Sung-Woo,Lee, Sehyun,Kim, EunSub,Kim, Duck-Joong,Park, Sohyun,Lee, Eun Joo,Lee, Sang Yeub,Lee, Ji Sung,Lim, Chae Seung,Kim, Won-Ki,In, Kwang Ho Elsevier 2014 Chest Vol.146 No.5
<P>NBS LabChip G2-3 is a novel, ultrafast, chip-type portable real-time polymerase chain reaction (PCR) system. We evaluated the clinical usefulness of this system in detecting pulmonary TB and assessed its diagnostic performance compared with a conventional tube-type PCR system.</P>
( Seung Hyeun Lee ),( Sue In Choi ),( Won Jai Jung ),( Eun Joo Lee ),( Kyung Hoon Min ),( Gyu Young Hur ),( Seung Heon Lee ),( Sung Yong Lee ),( Je Hyeong Kim ),( Sang Yeub Lee ),( Chol Shin ),( Jae J 대한결핵 및 호흡기학회 2015 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.120 No.-
Background: Reactive oxygen species modulator 1 (Romo1) is a novel protein that plays an important role in intracellular reactive oxygen species generation. Recently, serum and tissue Romo1 was suggested as a diagnostic and prognostic marker, respectively, for non-small cell lung cancer. We evaluated the clinical usefulness of pleural fluid Romo1 measurement for the diagnosis of malignant effusion in lung cancer patients. Methods: Romo1 level was measured in pleural fluid using enzyme-linked immunosorbent assay in four groups: lung cancer-associated malignant effusion (n =56; 26 adenocarcinomas, 26 squamous cell carcinomas and 4 small cell lung cancers), tuberculous pleurisy (n = 31), parapneumonic effusion (n =30) and transudate (n = 30). The discriminative power for lung cancer-associated malignant effusion was determined using receiver operating characteristic curve analysis. Results: Median Romo1 level in lung cancer-associated malignant effusion was 99.1 ng/mL which is significantly higher compared with other groups (all p < 0.001). The optimal cutoff value of Romo1 for lung cancer-associated malignant effusion was 67.0 ng/mL with a sensitivity of 73.9% and specificity of 84.1%, with an area under the curve of 0.814 (95% confidence interval : 0.730 - 0.866, p = 0.0001). Conclusion: Romo1 discriminated lung cancer-associated malignant effusion from non-malignant effusions with considerable sensitivity and specificity. Pleural fluid Romo1 could be a potential diagnostic marker for lung cancer-associated malignant effusion.
( In Yeub Hwang ),( Seung Hwan Lee ),( Yoo Seong Choi ),( Si Jae Park ),( Jeong Geol Na ),( In Seop Chang ),( Choongik Kim ),( Hyun Cheol Kim ),( Yong Hwan Kim ),( Jin Won Lee ),( Eun Yeol Lee ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.12
Methane is considered as a next-generation carbon feedstock owing to the vast reserves of natural and shale gas. Methane can be converted to methanol by various methods, which in turn can be used as a starting chemical for the production of value-added chemicals using existing chemical conversion processes. Methane monooxygenase is the key enzyme that catalyzes the addition of oxygen to methane. Methanotrophic bacteria can transform methane to methanol by inhibiting methanol dehydrogenase. In this paper, we review the recent progress made on the biocatalytic conversion of methane to methanol as a key step for methane-based refinery systems and discuss future prospects for this technology.
Clinical Results of Drug-Coated Balloon Treatment in a Large-Scale Multicenter Korean Registry Study
Sang Yeub Lee,Yun-Kyeong Cho,Sang-Wook Kim,Young-Joon Hong,Bon-Kwon Koo,Jang-Whan Bae,Seung-Hwan Lee,Tae Hyun Yang,Hun Sik Park,Si Wan Choi,Do-Sun Lim,Soo-Joong Kim,Young Hoon Jeong,Hyun-Jong Lee,Kwan 대한심장학회 2022 Korean Circulation Journal Vol.52 No.6
Background and Objectives: The aim of this study was to demonstrate the efficacy and safety of treatment with drug-coated balloon (DCB) in a large real-world population. Methods: Patients treated with DCBs were included in a multicenter observational registry that enrolled patients from 18 hospitals in Korea between January 2009 and December 2017. The primary outcome was target lesion failure (TLF) defined as a composite of cardiovascular death, target vessel myocardial infarction, and clinically indicated target lesion revascularization at 12 months. Results: The study included 2,509 patients with 2,666 DCB-treated coronary artery lesions (1,688 [63.3%] with in-stent restenosis [ISR] lesions vs. 978 [36.7%] with de novo lesions). The mean age with standard deviation was 65.7±11.3 years; 65.7% of the patients were men. At 12 months, the primary outcome, TLF, occurred in 179 (6.7%), 151 (8.9%), 28 (2.9%) patients among the total, ISR, and de novo lesion populations, respectively. A history of hypertension, diabetes, acute coronary syndrome, previous coronary artery bypass graft, reduced left ventricular ejection fraction, B2C lesion and ISR lesion were independent predictors of 12 months TLF in the overall study population. Conclusions: This large multicenter DCB registry study revealed the favorable clinical outcome of DCB treatment in real-world practice in patient with ISR lesion as well as small de novo coronary lesion.
만성 폐쇄성 폐질환 환자에서 Tiotropium 1일 1회, 1회 18㎍ 요법과 Ipratropium 1일 4회, 1회 40㎍ 요법의 치료효과 및 안전성 비교
김승준 ( Seung Joon Kim ),김명숙 ( Myung Sook Kim ),이상학 ( Sang Haak Lee ),김영균 ( Young Kyoon Kim ),문화식 ( Hwa Sik Moon ),박성학 ( Sung Hak Park ),이상엽 ( Sang Yeub Lee ),인광호 ( Kwang Ho In ),이창률 ( Chang Youl Lee ) 대한결핵 및 호흡기학회 2005 Tuberculosis and Respiratory Diseases Vol.58 No.5
( Yongcheol Kim ),( Jun-won Lee ),( Sang Yeub Lee ),( Jang-whan Bae ),( Sang Jun Lee ),( Myung Ho Jeong ),( Seung-hwan Lee ),( Youngkeun Ahn ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.0
Background/Aims: Recently, distal radial approach (DRA), called as snuffbox approach, has gained the interest of interventional cardiologists, but there is a lack of data about the feasibility of DRA as an alternative route for primary percutaneous coronary intervention (PCI). Methods: A total of 138 patients presenting with ST-elevation myocardial infarction (STEMI) in whom primary PCI via the DRA was attempted at three hospitals from October 2017 to September 2019 were analyzed. Results: The success rate of snuffbox puncture in the setting of STEMI was 92.8% (128/138). Successful primary PCI via the DRA was achieved in all 128 patients. The snuffbox puncture time, defined as the time interval from local anesthesia induction to successful sheath cannulation, was 2.7 ± 1.6 minutes, and snuffbox puncture was performed within 5 minutes in 95.3% of patients. Moreover, the percentage of the puncture time in the door-to-balloon time was 3.3%. The left DRA was selected in 103 patients (80.5%), and primary PCI via the DRA was performed using a 6-Fr guiding catheter in 125 patients (97.7%). There was no major bleeding; however, there were four cases (3.1%) of access-site complications, including three cases of local hematoma (≤ 5 cm diameter) and one case of local numbness, which improved 3 months later. Conclusions: In the setting of STEMI, the DRA could be a feasible alternative access route for primary PCI.