Enalapril 에 의한 기침 발생율

노승익(Seung Ik Roh),김명선(Myeong Seon Kim),김은실(Eun Sil Kim),서두선(Du Seon Seo),정내인(Nae In Jeong),이명숙(Myeong Suk Lee),한승수(Seung Soo Han),김광희(Kwang Hoi Kim),김윤권(Yoon Kweon Kim) 대한내과학회 1994 대한내과학회지 Vol.47 No.1

N/A Background: Enalapril is an angiotensin-converting enzyme inhibitor that has been widely used in treating hypertension, congestive heart failure, DM and various renal diseases. Cough has been recognized as a side effect of angiotensin-converting enzyme inhibitors. Therefore we studied the incidence and the chracteritics of Enalapril induced cough in Korea. Method: The sixty eight patients with Enalapril who visited out-patients department of internal medicine, Han-Il General Hospital during the period from april 1992 to october 1992 were included in this study. In all patients careful history taking and review of chart was done. Patients with respiratory disease were excluded. The criteria of angiotensin converting enzyme inhibitor induced cough was that cough developed after administration of Enalapril and improved after discontinuing drug and readministration of drug induce resume of symptom. Resnlts: Subjects include 34 males, 34 females and their average age was 53.3 years, Diseases of theirs were hypertension (57 cases}, congestive heart failure (5 eases), various renal disease (28 cases) and 9 patients of them were smokers. Average drug dosage was 11.7 mg a day and average administration duration was 182 days. Of the 68 patients, 23 patients (33.8%) had chronic cough due to enalapril, which had 12 male and 11 female patients. The cough disappearing time after withdrawal of the angiotensin-converting enzyme inhibitors was average 7.8 days. In 16 patients (two thirds of them), cough disappeared within 4 days after drug withdrawal. 9 patients had to stop taking drug because of severe cough. Generally the characters of cough induced by angiotensin-converting enzyme inhibitors were dry, persistent, tickling and tended to develope especially at night, Conclusion: Cough is not uncommon side effect in angiotensin-converting enzyme inhibitor users. There fore clinician should consider angiotensin-converting enzyme inhibitor induced cough initially when cough developed after angiotensin-converting enzyme inhibitor administration.

수막종의 Flow Cytometry 및 Nucleolar Organizer Regions(NORs)에 관한 비교연구

韓東錫,蔡暘錫,金仁仙,白承龍 고려대학교 의과대학 1990 고려대 의대 잡지 Vol.27 No.1

The flow cytometric DNA analysis and the Ag-NORs staining method have been reported to reflect the cellular activities and the proliferative rates of the normal and the neoplastic cells. Currently, these methods have attracted many interests from clinical fields in evaluating the patient regarding on the prognosis and the responsiveness to therapy of human tumors. The author analyzed thirty eight meningiomas(meningothelial 5, transitional 7, fibrous 5, psammomatous 2, atypical 11, hemangiopericytic 6 and hemangoblastic 2 cases) using flow cytometry and Ag-NORs staining in the paraffin embedded tissues. The results are summarized as follows : 1. In flow cytometric study, twenty eight cases were diploid and the remaining 10 cases were aneuploid. The latter included meningothelial 3, atypical 3, hemangiopericytic 2 and hemangioblastic 2 cases. 2. In Ag-NORs study, the mean mumber of Ag-NORs had a significant difference between classical types(1.46±O.21) and atypical meningiomas(1.88±0.36) including hemangiopericytic one(1.74±0.38) (P<0.05). 3. The cytometric S phase, G_(0)/G₁ phase and proliferation index and the mean number of Ag-NORs had a significant difference between classical diploid and atypical diploid meningiomas(P<0.005). 4. There was no significant relationship between cytometric S phase and the mean number of Ag-NORs in classical meningiomas.

눈의 통증으로 발현된 급성 외측연수경색증

석승한,손일홍 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2

Spontaneous facial pain is diagnostic and is a cardinal feature of the lateral medullary infarction. Especially, pain is most often affected in or aroud eye. This symptom usually come on with the onset of lateral medullary infarction and is sometimes first symptom noted. This may be related to ipsilateral dysfunction of sensory neuron in the nucleus of the spinal tract of the trigeminal nerve and important to early detection and management of acute brainstem ischemia. However, this pain has usually recieved little emphasis in clinica1 situation. Therefore, we report three patients with lateral medullaty infarction, one complete, two partial involvement who were complained with severe eye pain as first presenting symptom, confirmed with MRI. Since patient with sudden onset of eye or facial pain may has acut brainstem lesions, it is very important that their presence should be diligently sought with high index of suspicion, especially in elderly patient with risk factors for stroke.

한국과 호주의 스쿼시 경향과 향후 추세에 관한 비교 연구

한성유,황영성,박재성,허정석 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.1

This research is based on squash professionals opinion, precedent literature as well as other books and internet-researched information. In hopes that squash will not only become a more life-time sport, but a profession collegiate sport as well, and help change the publics recognition as an elite sport, and become an opportunity for professional literature and researches will recognize squash as a learning field: and in doing so, provide a compilation of strategic plans based on those of Australia to set a basic foundation. As a result of this research: 1. Financial independence must be acquired through more company sponsorship and T.V. broadcasting of squash games. 2. Municipal and provincial branch must become more autonomous through horizontal relationship. 3. A thorough reeducation course is needed to increase the quantity, but the quality of present Korean coaches and players. 4. Regulations and laws regarding the establishment of squash facilities must be drafted to avoid users from being exposed to danger through thoughtless governmental approval. If regulations and laws suitable for Korea conditions are created based on those of more advanced nations, then squash in Korea will continue on its path to further development.

Pt/MCM-41을 이용한 NO제거활성에 관한 연구

한상현,양재승,정석진 경희대학교 산학협력기술연구원 1999 산학협력기술연구논문집 Vol.5 No.-

In this study, in order to make up its drawbacks in the MCM-41 catalytic system, platinum metals was doped in MCM-41. To confirmed MCM-41 structure investigations of XRD,N2 Adsorption-Desorption Isotherm, and B.E.T.surface areas were examined. Additionally NO-TPD and Simulated Flue Gases Mixing & Acitivity Test were peformed.According to Specific character of platinum metal, NO reduction activity was favored in low temperature range less than 300℃ and More Activity was obtained when platinum was doped over aluminum substituted MCM-41 than silica type MCM-41. Injected of 10 vol% water vapor on Pt/Al-MCM-41catalyst, negligible effect of NO reduction was found. when compared with the activity performance of Pt-ZSM-5, still Pt/Al-MCM-41 has relatively higher resistant to water vapor and sulfut contents in flue-gases.

Cone 상태의 resonance 에너지 : A Complex Rotation Approach

한승석 명지대학교 자연과학연구소 2004 자연과학논문집 Vol.23 No.-

Complex scaling has been developed and applied to problems of resonances in atomic and molecular physics and in chemistry. Using the complex scaling in the square integrable (L^(2)) basis calculation we approach cone state problem to get resonances. Resonances in conical intersections have bound state characters embedded in continuum. Complex scaling이

濟州道內 組織培養室의 實態및 改善方案에 關한 硏究

金承炫,李宗錫,韓炅哲 濟州大學校 亞熱帶農業硏究所 1988 亞熱帶農業硏究 Vol.5 No.-

濟州道內에 施設된 組織培養室의 現況과 實態를 調査하고 이들 培養室의 構造와 設備, 環境制御, 幼苗 馴化 施設 및 方法의 改善 方向에 關한 結果를 要約하면 다음과 같다. 組織培養室의 構造는 運營者의 實情에 따라 매우 多樣하였으나 效率性을 考慮할 때 必須的으로 準備室과 無菌室 및 培養室의 3部分으로 區分되어 있어야 한다. 이에 따른 組織培養室의 基本 形態를 크기별로 區分해 볼 때 2人用인 境遇 48.6㎡(15坪型), 3∼4人用에 81.0㎡(25坪型), 그리고 5人 以上인 境遇에는 129.6㎡(40坪型)이 適合한 것으로 思料된다. 培養室의 空間을 效果的으로 活用하기 爲하여 比較的 넓은 培養室의 境遇 4∼5段式 移動 旋盤臺가 바람직하며 螢光燈에서 發生하는 熱을 줄이기 爲하여 旋盤의 높이는 60∼75㎝ 그리고 넓이는 90∼120㎝로 하는 것이 바람직하다. 旋盤의 材料로는 有空합판이나 철망을 使用하는 것이 培養室의 空氣循環을 圓滑하게 하는 데 效果的이다. 道內 大部分의 組織培養室은 比較的 充分한 培養 機資材들을 갖추고 있었으나 蒸溜를 하지 않은 水道물이나 地下水는 培地製調用으로 適合치 못하기 때문에 蒸溜水를 使用하는 것이 바람직한 것으로 思料된다. 培養室內의 光線條件과 溫度는 매우 重要한 環境要因 等이기 때문에 正確하게 調節되어야 한다. 그러나 大部分의 培養室들은 1,000lux 以下의 낮은 光度條件으로서 充分치 못하므로 螢光燈을 利用하여 1,000 以上∼3,000lux 以下의 光度를 12∼16時間의 光週期로 照射해 주는 것이 좋다. 溫度는 에어컨을 利用하여 比較的 잘 調節이 되고 있으나 旋盤의 下段部와 上段部 그리고 培養用器 內外의 溫度差는 전혀 考慮되고 있지 않다. 培養室의 濕度와 空氣의 循環은 거의 無視되고 있으며 正確한 溫度調節을 하기 爲해서는 70% 程度의 濕度를 維持해 주어야 하고 培養室內 溫度差를 줄이기 爲해서는 下向式 空氣循環 方法을 摸索하는 것이 바람직하다. 組織培養에 依하여 增殖되는 作物의 種類는 주로 東,西洋 蘭類와 그리고 파인애플로 制限되어 있어서 앞으로 作物의 種類를 多樣化하고 品種의 改善을 爲한 高度의 培養技術이 開發되어야 한다. 培養된 植物體의 馴化施設로는 비닐하우스가 一般的으로 利用되고 있으나 그 方法이 適合치 못하므로 生存率을 높이기 爲해서는 光과 溫度 및 濕度를 容易하게 調節할 수 있도록 하기 爲하여 培養室의 環境調節裝置와 類似한 馴化施設을 갖추는 것이 바람직하다. The results from the survey of commercial tissue culture labs distributed in Cheju-do, Korea, and their improvements on lab organization, facility, equipment, environmental control, hardening facility and produres, etc. are summarized as follows. The lab organization varies, depending upon a situation that a lab operator faces when a lab is constructed. However, no matter what situations are faced, three distinct lab areas, media preparation, transfer, and culture growing rooms, must be established for long term efficiency. Three basic models are suggested for lab sizes: 48.6㎡(15 pyung) for less than 2 technicians, 81.0㎡(25 pyung) for 3 to 4 technicians and 129.6㎡ for more than 5 technicians. To use more spaces of the culture growing room, the movable shelf frames with 4-5 stacked shelves are recommended to be used in a relatively large tissue culture lab. 60-75 cm in height and 90-120 cm in width as an adequate shelf size are also recommended to reduce overheat from lamps and ballasts, and to precisely control the temperature of the culture growing room. As a material of the shelf board, perforated plywood or wire mesh is better for air circulation. Most labs in Cheju-do were equipped with relatively enough equipments for plant micropropagation except a water purification system. A water distiller or other distillatory apparatus is strongly suggested to be purchased for a successful tissue culture program. Tap, subterranean, or even demineralized water is not good quality for tissue culture media. Light and temperature as environmental factors should be precisely controlled. Humidity and air movement might not be ignored. Most labs in Cheju-do do not provide optimal light intensities to the cultures, less than 1,000 lux being inadequate. Intensities between 1,000 and 3,000 lux are recommended to be supplied for the cultures with photoperiods of 12 to 16 hours. Fluorescent lamps are most widely used for plant tissue cultures because they provide a high output of photosynthetically active and photomorphogenetic radiations. Temperatures are relatively well controlled in many tissue culture labs in Cheju-do by using air conditions. However, lab operators do not realize temperature gradients from bottom to top shelves, and inside and outside of culture vessels, which sometimes cause a critical danger to the cultures Humidity and aeration have been almost ignored in Cheju-do. However, 70% relative humidity is better to be maintained for the precise temperature control. A downward pattern of air movement is recommended preferable to reduce the temperature gradients of the culture growing room. Crops propagated by tissue culture were very limited to mainly orchids, banana, and pineapple. For successful tissue culture programs in the future, plant species must be diversified or highly advanced culture techniques should be developed for plant improvement. Greenhouse as a hardening facility is most widely used in Cheju-do and hardening procedures should be also improved to enhance a survival ratio when transplanting the cultures to potting media. A special hardening room similar to the culture growing room is recommended to be constructed in order that light, temperature, and constant humidity can be easily controlled.

약물치료에 가역적 회복을 보인 갈색세포종에 동반된 확장성 심근증 1례

홍숙경,최현,이승철,천경일,김영철,한재룡,김미숙,정경태,박순창 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.2

스포츠 센터 평생 회원들의 체련장 이용 실태에 관한 연구

이한경,유호길,김미정,김석일,남승현 龍仁大學校 1998 용인대학교 논문집 Vol.15 No.-

The purpose of this study is to analyze privileged mass' use of the sport for all facilities. The subject was members of five in hotel, who answered a questionnaire. The main results of this study are as follows : 1. It was found that comsumers of fitness center were at 40-50 age, and the mean of using period is longer than 3 years. 2. The membership card motivated members to improve, their health and in the older members losed self-health condition. 3. The members were used lower at facilities less. The mean of using frequency is one per four days. 4. It was found that sauna room was the most utilized facilities in fitness center. 5. It was fecund that training room was utilized less, because of lack of time. 6. The participant of training room not showed lower facility use at higher age. 7. The participator of trainning room did showed satisfaction for instructor and facilities. As started above, the turn of recognition which answers the purpose is needed for a privileged mass' use of facilities for sports for all, and a positive motivation of the managements of commercial sports center must be prepared indispensably. Also, a consideration for a resasonable and step by step remedy for all age groups is deeply demanded.

고콜레스테롤 혈증 환자에서 Cerivastatin(LIPOBAY, 의과학연구소)의 임상효과 및 안전성에 관한 연구

박성훈,김미연,정수진,이영숙,박창한,변은경,전성희 梨花女子大學校 醫科大學 醫科學硏究所 2001 EMJ (Ewha medical journal) Vol.24 No.3

목적 : Cerivastatin(LIPOBAY)은 최근에 개발되어 사용되기 시작한 HMG-CoA 환원효소 억제제로서 저용량으로 탁월한 콜레스테롤 강하효과를 보이는 약물이다. 저자들은 Cerivatatin(LIPOBAY)의 혈중 콜레스테롤 강하효과를 평가하고 약물의 안전성을 평가하기 위하여 본 연구를 시행하였다. 방법 : 고콜레스테롤혈증 환자 37명(남자 13명, 여자 24명)을 대상으로 하였다. 대상환자는 2주간의 저콜레스테롤 식이 후에도 혈청 콜레스테롤이 240㎎/㎗이상이거나, 관상동맥질환이 있는 환자는 혈청콜레스테롤이 220㎎/㎗이상인 경우 cerivastatin 0.4㎎을 8주간 복용하도록 하였다. 임상적 관찰과 검사실 검사(간기능검사, 일반혈액검사, 혈청지질검사)는 투약개시 후 4주 및 8주 후에 시행하였다. 결과 : Cerivastatin 0.4㎎을 4주간 투여한 후 측정한 LDL 콜레스테롤, 총콜레스테롤, triglyceride, 및 HDL 콜레스테롤은 각각 38%, 28.8%, 11.6% 및 7.8% 감소하였다. 총콜레스테롤/HDL 콜레스테롤 비 및 LDL/HDL비는 각각 20.8% 및 31.1% 감소하였다. 투약 8주후에 측정한 검사소견은 4주후에 비해 유의한 변화를 보이지 않았다. 한명의 환자(2.7%)에서 간기능 검사상 AST, 및 ALT의 지속적인 상승으로 투약을 중지하였다. 결론 : Cerivastatin 0.4㎎/day는 혈청콜레스테롤을 효과적으로 감소시켰으며 심각한 부작용은 볼 수 없었다. 따라서 적극적으로 LDL콜레스테롤을 낮출 필요가 있는 고콜레스테롤혈증 환자에서 cerivastatin은 효과적이고 안전한 약물이라고 생각된다. Objectives : Cerivastain(LIPOBAY) is recently developed HMG-CoA reductase inhibitor which is effective in lowering serum cholesterol levels at microgram does. We evaluated the clinical efficacy and safety of cerivastatin(LIPOBAY) in patients with hypercholesterolemia. Method : Thirty-seven patients(male : 13, female : 24) with hypercholesteolemia defined as baseline serum total cholesterol ≥240㎎/㎗, or ≥220㎎/㎗ in patients with known coronary artery disease were included for this study. After 2 weeks of low cholesterol diet, if the serum total choesterol level meet the criteria, cerivastain 0.4㎎/day was prescribed for 8 weeks. Clinical follow-up and laboratory tests were performed 4 weeks and 8 weeks after medication. Results : After 4 weeks of cerivastain 0.4㎎/day treatment, low density lipoprotein(LDL) cholesterol decreased 38% and total cholesterol decreased 28.8% from baseline. Triglyceride decreased 11.6%, and high density lipoprotein(HDL) cholesterol decreased 7.8% from baseline. Total cholesterol/HDL ratio decreased 20.8% and LDL/HDL ratio decreased 31.1% from baseline. After 8 weeks of treatment, no further significant changes were noted compared with the values at 4 weeks. Cervastatin was discontinued in one patient(2.7%) due to continuous liver enzyme elevation. Conclusion : Cerivastatin 0.4㎎/day is effective in lowering serum cholesterol levels without significant adverse reactions. Cerivastatin is effective and safe for patients with hypercholesterolemia who needs aggressive LDL cholesterol lowering.