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인지장애 선별을 위한 K-ACE 표준화 연구: 신뢰도, 타당도, 규준치 개발
석승한,신강현,전진수 대한신경과학회 2009 대한신경과학회지 Vol.27 No.4
Background: Addenbrooke’s Cognitive Examination-Revised (ACE-R) is a brief but sensitive and specific test for screening cognitive impairment. The clinical need for brief, inexpensive, and sensitive cognitive screening tools is well acknowledged. The aims of this study were to develop a Korean version of the ACE-R (K-ACE) and to obtain normative data for community-dwelling, apparently healthy adults. Methods: The ACE-R was translated and modified to produce the K-ACE. Some items that were considered less familiar to Koreans were replaced with “Korean-friendly” items. Back-translation was performed. The K-ACE was administered to 422 of 480 subjects who were recruited from stroke- and dementia-free adults living in Ansan-si, Gyeonggi-do, by systematic random sampling. The Korean version of the Short Blessed Test (SBT-K) was also completed by 85 of the subjects. We examined the internal consistency, reliability, and validity of the K-ACE. The influences of age, sex, and education level on K-ACE score were also evaluated. Results: The internal consistency of the K-ACE was high (Cronbach’s alpha=0.854), and the test–retest and interrater reliability were also very good (coefficient=0.929 and 0.984, respectively). The validity of the K-ACE was high through correlations between K-ACE and K-MMSE (r=0.939, p<0.01) and SBT-K (r=-0.871, p<0.01). Male, younger, and highly educated subjects had higher K-ACE scores on univariate analysis. Age and education level, but not sex, were significantly correlated with the score on stepwise multiple regression analysis. Therefore, normative data relative to age and education level were obtained. Conclusions: The K-ACE was found to be a brief, reliable, and valid screening test battery for cognitive dysfunction. We were able to determine the norms for the K-ACE for community-dwelling, middle-aged and elderly people. Background: Addenbrooke’s Cognitive Examination-Revised (ACE-R) is a brief but sensitive and specific test for screening cognitive impairment. The clinical need for brief, inexpensive, and sensitive cognitive screening tools is well acknowledged. The aims of this study were to develop a Korean version of the ACE-R (K-ACE) and to obtain normative data for community-dwelling, apparently healthy adults. Methods: The ACE-R was translated and modified to produce the K-ACE. Some items that were considered less familiar to Koreans were replaced with “Korean-friendly” items. Back-translation was performed. The K-ACE was administered to 422 of 480 subjects who were recruited from stroke- and dementia-free adults living in Ansan-si, Gyeonggi-do, by systematic random sampling. The Korean version of the Short Blessed Test (SBT-K) was also completed by 85 of the subjects. We examined the internal consistency, reliability, and validity of the K-ACE. The influences of age, sex, and education level on K-ACE score were also evaluated. Results: The internal consistency of the K-ACE was high (Cronbach’s alpha=0.854), and the test–retest and interrater reliability were also very good (coefficient=0.929 and 0.984, respectively). The validity of the K-ACE was high through correlations between K-ACE and K-MMSE (r=0.939, p<0.01) and SBT-K (r=-0.871, p<0.01). Male, younger, and highly educated subjects had higher K-ACE scores on univariate analysis. Age and education level, but not sex, were significantly correlated with the score on stepwise multiple regression analysis. Therefore, normative data relative to age and education level were obtained. Conclusions: The K-ACE was found to be a brief, reliable, and valid screening test battery for cognitive dysfunction. We were able to determine the norms for the K-ACE for community-dwelling, middle-aged and elderly people.
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활성산소종으로 손상된 혈관내피세포에 대한 Vitamin E의 항산화 효과
석승한,Suk, Seung-Han 대한동의생리학회 2006 동의생리병리학회지 Vol.20 No.6
In order to examine the injury of vascular endothelial cells related with oxidative stress of reactive oxygen species(ROS), mophological changes of vascular endothelial cells were observed by light microscope after bovine pulmonary vascular endothelial cell line (BPVEC) was treated with 15 uM of hydrogen peroxide. In addition, the effect of vitamin E against ROS-induced oxidative stress was examined by light microscope. In this study, the cell number of BPVEC treated with ROS has significantly decreased than that of control, and the loss of cytoplasmic processes and cell swelling were observed in BPVEC treated with ROS. Whereas, cell number of BPVEC treated with vitamin E has significantly increased than that of BPVEC treated with ROS and also, cytoplasmic processes of BPVEC treated with vitamin E were preserved as control. These findings suggested that not only did ROS induce damage of BPVES by decrease of cell number, loss of cytoplasmic processes and cell swelling, but vitamin E also has protective effect against ROS-induced oxidative stress in cultures of BPVEC.
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석승한 한국보건사회연구원 2013 보건복지포럼 Vol.202 No.-
어느덧 출범 3년째를 맞이하는 의료기관평가인증제는 새롭게 출발한 정부의 화두인`안전`이라는 이슈에서 의료서비스의 질을 제고함으로써`환자안전과 의료시스템의 안전`을 책임져야 할 중요한 보건의료분야의 정책적 임무를 재인식해야할 시점에 있다. 그러나 현재 우리나라의 인증제는 인증기준의 내용과 수준, 조사방법 및 조사위원들의 수준에 따른 개인차의 문제들이 제기되고 있고 상급종합병원을 제외한 급성기 병원들의 인증제 참여가 저조할 뿐 아니라 참여를 독려할 수 있는 확실한 방안마련에 어려움을 겪고 있는 것이 현실이다. 따라서 저자는 현재 우리나라 인증제의 현황과 문제점을 살펴보고 이를 통해 인증제도의 활성화 방안을 기술하려 한다.
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석승한,손일홍 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.2
Spontaneous facial pain is diagnostic and is a cardinal feature of the lateral medullary infarction. Especially, pain is most often affected in or aroud eye. This symptom usually come on with the onset of lateral medullary infarction and is sometimes first symptom noted. This may be related to ipsilateral dysfunction of sensory neuron in the nucleus of the spinal tract of the trigeminal nerve and important to early detection and management of acute brainstem ischemia. However, this pain has usually recieved little emphasis in clinica1 situation. Therefore, we report three patients with lateral medullaty infarction, one complete, two partial involvement who were complained with severe eye pain as first presenting symptom, confirmed with MRI. Since patient with sudden onset of eye or facial pain may has acut brainstem lesions, it is very important that their presence should be diligently sought with high index of suspicion, especially in elderly patient with risk factors for stroke.
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