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      • 나노/마이크로 압입 시험에 의한 플라즈마 세라믹 용사코팅의 특성 평가

        최세영(Se-Young Choi),채영훈(Young-Hun Chae),김석삼(Seock-Sam Kim) 한국트라이볼로지학회 2003 한국트라이볼로지학회 학술대회 Vol.36 No.-

        The most controversial topics in plasma sprayed ceramic coating systems are recently mechanical properties such as bond strength, cohesive strength, toughness and so on. In this research, critical fracture load(Pc) and interface toughness(Ks) of four coatings materials were computed from the applied load, crack length and Young's modulus data which were measured by micro-vickers and nano indentation test. It is reasonable to consider the Pc value as comparison data of bond strength, and the Kc value, considering a trace of indent in the interface, was computed by a modified (E/H)I<SUP>½</SUP> ratio. In the case of the high loads (9.8N and 19.6N) in the Al₂O₃+13%TiO₂ coating, the critical point(Pco) at which the coating was broken was found. Also, used by a XRD phase analysis, we checked a change of coating' s properties, predicting a possible change of the phases in plasma sprayed coating.

      • 複合 韓藥劑 淸籬滋坎湯의 抗癌效果 및 作用機轉 糾明

        Cho, Kyung-Sam,Kim, Si-Young,Park, Jai-Kyung,Choi, Seung-Hoon,Chung, Se-Young,Yoon, Hwi-Joong 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

        Kyung Sam Cho¹Si Young Kim¹, Jai Kyung Park²,Seung Hoon Choi³,Se Young Chung⁴, Hwi Joong Yoon¹¹College of Medicine, ²East-West Medical Research Institute, ³College of Oriental Medicine, ⁴College of Pharmacology, Kyung Hee University,Seoul, Korea. The Anti-cancer Effect of Oriental Medicine Chung-Ri-Ja-Gam-Tang in the Mouse with Metastatic Lung Cancer. Proceedings of International Symposium on East-West Medicine, Seoul. 231-243, 1999.-The oriental medicine Chung-Ri-Ja-Gam-Tang is an herbal medicine which has been used for pulmonary diseases and known as having immune stimulatory effects. It has been known effective in lung cancer. So we studied the effects and the mechanisms of this herbal medicine it the mouse with metastatic lung cancer. The metastatic lung cancer of the mouse was produced with melnoma cell line(B16BL/6).5×10□/mouse tumor cells were injected intravenously to the CDF1 mouse via tail vein. The mice were divided 4 groups. The first group was treated with 50mg/kg extract of Chung-Ri-Ja-Gam-Tang per oral for 10 days after cancer cell injection, second group treated with saline after cancer cell injection, the third group with medicine without cancer cell, and the last group with saline only. After 10 days treatments some of the mice were scarificed and the lung and spleen was removed. The survival duration, weight change, the number of metastatic cancer nodule of the lung, the NK cell activity, the capacity of cytokines(INF-γ,INF-α,IL-2) production and the proliferation activities of mouse lymphocytes were measured. The surival times of the group 1 mice were longer and the weight loss was less than the group 2 significantly. The number of the metastatic nodule of the lung were decresed in the group 1 than the group 2. The production of INF-γ,was increase in group 2 than group 3 and 4, IL-2 production was increased in group 1 than group 2,3,4 significantly. There was no difference in TNF- α production and proliferation activity of lymphocyte in each group. The NK cell activity was significantly increased in group 1 than group 2,3,4. We conclude that the Chung-Ri-Ja-Gam-Tang has the effect of increasing the NK cell activity of the CDF1 mouse with metastatic lung cancer(B16BL/6). And it is suggested that the increased production of the IL-2 is the mechanisms of enhanced NK cell activity.

      • 항암제(Adriamycin, Cyclophosphamide, 5-Fluorouracil)로 유발된 흰쥐의 간독성에 대한 Squalene의 효과

        최영복,김종세,윤중식 조선대학교 기초과학연구소 1998 自然科學硏究 Vol.21 No.1

        The objective of the present study was to investigate the cytotoxicity of Adriamycin〔ADM〕. Cyclophosphamide〔CP〕, 5-Fluorouracil〔5-FU〕 in mouse liver cells (group A, B, c), and the protective effect of squalene to the hepatocytes to which ADM, CP, and 5-Fu-induced cytotoxicity(group A-1, B-1, C-1) was examined by transmission electron microscope. In the group A, The cisternae of rough endolplasmic reticulum(RER) and smooth endoplasmic reticulum(SER) are dilated/disoriented at 24 hours and 48 hours. The inner and outer membrane of mitochondria are detached or destructed, and attached ribosomes of RER are diminished in number. The cisternae of the SER are dilated, and the cristae of mitochondria are disrupted at 72 hours and 96 hours. In the group A-1, the cisternae of the RER and the SER are dilated at 24 hours. The cisternae of the SER are dilated at 48 hours. The cell organelles of hepatocytes are recovered from cytotoxicity at 72 hours. At 96 hours, hepatocytes were simillar to those of normal hepatocytes. In the group B, the cisternae of RER were partially destructed and attached ribosomes were remarkable decreased at 24 hours. A number of the mitochondria were dilated and increased in number, the filamentous materials also detected at 72 hours. In the group B-1, the difference between the normal and the treated groups were not detected at 24 hours, but the few mitochondria were expanded at the 72 hours. In the group C, the nucleus was destroyed at 24 hours and 48 hours group, however, somewhat repaired at 72 hours group. The dilated inner cavity and the irregular lamellae of the RER were observed continually until 72 hours group. The inner cavity of the SER were dilated in all groups. However, the destroyed and the normal membrane were observed simultaneously at 72 hours group. The inner membrane of the mitochondria were almost repaired at 96 hours group. In the group C-1, the nucleus was a little finfluenced by the toxicity of 5-Fu at 24 hours and 48 hours, RER were observed to keep the typical lamella structure of cisternae from 24 to 72 hours group, but inner cavity kept on dilating. In SER, inner cavity were also observed to flatten from 24 to 72 hours group. Mitochondria were always shown normal. All cell organelles were similar to those of normal at 96 hours. Accordingly, it can be said that the treatment of SQ prevents the cytotoxicity of ADM, CP, 5-FU on cell organelles of liver cell and that is concerned with the formation of membrane system of cell organelles.

      • KCI등재
      • KCI등재

        응급의료센터의 단기입원치료실 활용경험

        최승필,박승현,정시경,박규남,김영민,김세경,이운정,이환 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

        Overcrowding of emergency department is a serious and growing problem at St. Mary's Hospital. This has motivated the development of short-stay unit(SSU) as an alternative ward to routine hospital admission and ED discharge. In our hospital a SSU begun to admit patients in January 6, 1997. The SSU received 247 patients from the ED during the eight month interval(January 6, 1997 to August 31, 1997). To examine the utilization of the SSU in ED, we retrospectively analyzed 247 patients admitted in SSU from the ED, and compared the average hours per patient with acute gastroenteritis spent in the ED during the 2-month intervals before(July-August 1996) and after(July-August 1997) the establishment of the SSU. The following results were obtained; 1. The total patients consist of EM 92(37.2%), GS 48(19.4%), IM 24(9.7%), PS 21(8.5%), OS 20(8.1%), OBGY 14(5.7%) and others 28(11.3%) 2. The results of EM patients admitted in SSU from ED 1) Sex ratio of male to female was 1:1.1 and the mean age was 37.3±16years 2) In diagnosis, acute gastroenteritis was 29 cases(31.5%), multiple contusion 14 cases(15.2%), drug intoxication 12 cases(13%), limb laceration 6 cases(6.5%), tendon rupture of hand 6 cases(6.5%), and others 19 cases(20.6). 3) Mean length of stay in ED was 9.18 hours. 4) Among 92 patients to the SSU, 79 patients(85.9%) were discharged, 11 patients(11.9%) formally admitted to hospital and 2 patients(2.2%) transferred to otherhospital. The mean hospital stay time of the patients admitted to SSU was 2.6 days. 3. There was a significant reduction in the average stay time spent in the ED by treat-and-releasing patients with acute gastroenteritis after the establishment of the SSU(from 14.65±9.6 to 7.52±5.4 hr/patient, p<0.001). Conclusively, the establishment of the SSU can shorten the average stay time that treat-and-releasing patients spend in the ED, and reduce the number of admitted patients waiting in the ED.

      • 나트형 불소 4규소운문[NaMg_2.5(Si_4O_10)F_2]의 이온교환(Ⅱ)

        崔世千,宋宗澤,申榮文 단국대학교 대학원 1984 學術論叢 Vol.8 No.-

        Ion exchange of Na­fluor­tetrasilicic Mica (Na­TSM) by univalent cations of Li^+, K^-, and bivalent cations of Mg^2+, Ca^2+, Ba^2+, was studied to investigate the fundamental properties of cation exchangability of it. The absorbed equivalents of the alkali and alkali earth metal ions were smaller than Na^2+ ion equivalents dissolved from the Na­TSM. The difference of their ion exchange capacities was changed by the kind and concentration of the cations and was considered that H^+ ions from the dissociation of water were absorbed in the surface of the Na­TSM. H^+ ion and cation exchange capacities were about 80% of the interlayer Na^+ ion in the Na­TSM, and it was considered in terms of the particle size and the drying condition of the starting material.

      • 고진공내의 1,2-디클로로벤젠 및 m-크실렌 용매하에서 n-프로필아민과 브롬화갈륨과의 상호작용에 관한 연구

        최성용,김세경,강봉수,김영철,안홍주 漢陽大學校 環境科學硏究所 1994 環境科學論文集 Vol.15 No.-

        고진공내의 1, 2-디클로로벤제 및 m-크실렌 용매하에서 n-프로필아민의 용해도를 5, 15, 25℃에서 브롬화갈륨이 존재할 때와 존재하지 않을 때의 두 경우에 대하여 측정하여 보았다. 브롬화갈륨이 존재하지 않을 때 m-크실렌에서 n-프로필아민의 용해도가 1,2-디클로로벤젠에서 보다 크게 나타나는 것은 n-프로필아민과 m-크실렌의 상호작용이 n-프로필아민과 1,2-디틀로로벤젠에서 보다 더 강하다는 것을 알 수 있다. 브롬화갈륨이 계내에 존재할 때에는 용액내에서 n-프로필아민과 브롬화갈륨이 불안정한 complex를 형성한다고 생각되어 이 complex를 여러 경우로 가정하여 계산하여 본 결과 ??·GaBr₃이 1 : 1 complex가 형성됨을 알았으며, 이 complex는 용액내에서 다음 화학평형식에 의해 이루어지다고 보았다. ??·GaBr₃? ??+ 1/2 ?? 또한 이 complex에 대한 엔탈피, 자유에너지 및 엔트로피 변화도 산출 하였다. The solubilities of n-propyl amine in 1, 2-dichlorobenzene and m-xylene in high vacuum have been measured at 5℃, 15℃ and 25℃ in the presence and absence of gallium bromide. When gallium bromide does not exist in the system, the solubilities of n-propyl amine in m-xylene is greater than it is in 1, 2-dichlorobenzene, indicating a stronger interaction on n-propyl amine wiht m-xylene than with 1, 2-dichlorobenzene. In the presence of gallium bromide in the system, it coule be thought that n-propyl amine forms unstable complex with gallium bromide. The complex has been assumed in various ways and it was evaluated that instability constant K value was relatively constant under the assumption of 1 : 1 complex, ??·GaBr₃ The complex would form the following chemical equilibrium equation in the solution. ??·GaBr₃ ? ?? + 1/2 GaBr₃ The change of enthalpy, free entropy for the equilibrium of the complex were also calculated.

      • 해리수직편위의 치료

        최미영,오세오 충북대학교 의과대학 충북대학교 의학연구소 1997 忠北醫大學術誌 Vol.7 No.1

        해리수직편위에서 수술적 치료의 목적은 상방편위된 눈에 의한 미용상의 문제를 해결하기 위함이다. 여러 가지 수술 방법이 보고된 바 있으나, 수술에 의한 합병증이 동반되고 있다. 이에 저자들은 해리수직편위 환자에서 양안성, 편위정도, 그리고 주시형태에 따라서 가림치료 및 수술적 치료를 시행하였다. 가림치료를 통하여 미용문제를 개선할 수 있었으며, 수술적 치료에 있어서 최소한의 상직근 후전술을 통하여 상방편위를 교정할 수 있었기에 문헌고찰과 함께 보고하는 바이다. The cosmetic importance of surgical management of manifest dissociated vertical divergence has been agreed upon, but a number of different operative approaches have been cited in the literature. However these procedures have had significant problems. Therefore we undertook occlusion treatment or superior rectus muscle recession according to bilaterality, amount of deviation, and fixation preferene. A good result in cosmetic problem is achieved when unilateral dissociated vertical divergence and bilateral disease with dominant fixation. Superior rectus musc1e recession of 4-7mm was the satisfactory successful treatment.

      • 졸겔법에 의한 알루미나 박막의 제조 및 특성(Ⅰ) ; 코팅용 알루미나 sol의 합성

        최세영,안준모,이재호,윤태일 연세대학교 산업기술연구소 1993 논문집 Vol.25 No.1

        The properties of alumina sol for single layer Anti-Reflective film by dip-coating were investigated. Transparent alumina sol could be obtained by heating the sol within 2 hours after hydrolysis at room temperature. The particle size of sols decreased with increasing the amount of nitric acid, while the specific surface area and the total pore volume of heat treated gels increased, up to the ratio of 0.1 mol nitric acid per 1 mol alkoxide. Excess addition of nitric acid above 0.1 mol resulted in decrement of the specific surface area and the total pore volume, and broadness of the pore size distribution. The average pore diameter and the total pore volume of heat-treated gel at 400℃ with composition of 1 alkoxide·100 water·0.1 nitric acid in ratio were ?? and 0.315 cc/g, respectively.

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