Impact of Interferon-Based Treatment on Quality of Life and Work Related Productivity from the Korean Cohort in the MOSAIC Study

( Sang Hoon Ahn ),( Won Hyeok Choe ),( Yoon Jun Kim ),( Jeong Heo ),( Dorota Latarska-smuga ),( Jiho Kang ),( Seung Woon Paik ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Chronic Hepatitis C Virus (HCV) infection increases the risk for progressive liver disease, hepatocellular carcinoma and negatively impacts the patient’s quality of life. HCV treatment is evolving with direct acting antivirals but IFN based therapy has been the standard of care for many years and remains available in some countries. The MOSAIC study aims to characterize patients with chronic HCV infection and assess the impact of IFN-containing treatment on health-related quality of life, work related productivity and health care utilization. Methods: MOSAIC is an international prospective multicenter observational study that has been conducted in 20 countries. Consecutive patients with chronic HCV infection were enrolled and those who initiated an IFN based regimen were prospectively followed for 48 weeks. We report results from the Korean cohort Results: 100 patients were enrolled: 86 were treatment naïve and 14 were treatment experienced. 33 patients initiated an IFN based regimen: 6 patients started IFN + RBV, 26 patients started Peg-IFN + RBV, none started Peg-IFN + RBV + DAA and 1 patient received other treatment. Among the treated cohort, demographic and disease characteristics were the following: the mean age was 54.5 years; 14 patients were male. 14 had minimal or no fibrosis, 2 portal fibrosis, 3 bridging fibrosis and 6 patients suffered from cirrhosis. HCV Genotype distribution was as follows: genotype 1: 11; genotype 2: 19 and genotype 3: 3. Table 1 describes the results at baseline and changes over 4, 12 and 48 weeks and end-of-treatment (EOT) for the quality of life and work productivity outcome measures (EQ-5D-5L, HCV-PRO and WPAI). Conclusions: Results from the Korean cohort of the MOSAIC study show a moderate trend for deterioration of health-related quality of life and work productivity associated with IFN based treatment for patients with chronic HCV infection during treatment period. Acknowledgements: The design, study conduct, analysis, and financial support of MOSAIC study were provided by AbbVie. AbbVie participated in the interpretation of data, review, and approval of the content of the abstract. All authors had access to all relevant data and participated in writing, review, and approval of this abstract. Medical writing support was provided by Olivier Van de Steen of Medeor-consulting, funded by AbbVie. Disclosures: Sang Hoon Ahn: served as an advisor and lecturer for Bristol-Myers Squibb, Gilead Sciences, F.Hoffmann-La Roche, Merck, AbbVie, and has received unrestricted grants from Bristol-Myers Squibb, Gilead Sciences, and F. Hoffmann-La Roche for investigator- initiated trials Won Hyeok Choe: Nothing to disclosure Yoon Jun Kim: Nothing to disclosure Jeong Heo: received a grant from GSK; Research support from BMS, and Roche; Advisor for Abbvie, BMS, Gilead Sciences, Pharma Essentia, SillaJen, and Johnson & Johnson. Dorota Latarska-Smuga, Jiho Kang: are employees of AbbVie, Inc. and may hold stock or stock options. Seung Woon Paik: received grant and research support from AbbVie, BMS, Gilead, GSK, Merck, Novartis, and Roche

Session 9 Distribution Science(Student-Myongii University)-VIII : Graduate School of Distribution

Ahn,Sung-Woo,Kim,Dae-yun,Kim,Mi-Song,Kim,Han-Sung,Jung,Je-Woo,Song,Ha-Su,Eom,Heung-Jun 한국유통과학회 2008 한국유통과학회 학술대회 논문집 Vol.2008 No.-

제주 성상 S/S MTr #1 행원 풍력단지 전압해석

김상준(Sang-Jun Kim),조민호(Min-Ho Cho),윤기갑(Gi-Gab Yoon),장상옥(Sang-Ok Jang),안정식(Jeong-Shik Ahn) 대한전기학회 2003 대한전기학회 학술대회 논문집 Vol.2003 No.11

제 3 대구치 발치시 환자의 호흡 패턴이 스트레스 변화 양상에 미치는 영향

이상명,김형욱,박양호,김진철,박준우,이성준,안재목,Rhee, Sang-Myung,Kim, Hyung-Wook,Park, Yang-Ho,Kim, Jin-Cheol,Park, Jun-Woo,Rhee, Sung-Jun,Nyamdorj, Selenge,Ahn, Jae-Mok 대한구강악안면외과학회 2007 대한구강악안면외과학회지 Vol.33 No.5

Purpose: Heart rate variability(HRV) is the clinical consequence of various influences of the autonomic nervous system(ANS) on heart beat. HRV can estimate the potential physiologic rhythm from the interval between consecutive beats(RR interval or HRV data). It is known as RSA which represents respiration-related HR rhythmic oscillation. Previous studies demonstrated a specific breathing pattern(0.1Hz, 6breaths/min) to improve a physiological body condition related to the stress. In this paper, the level of stress would be evaluated in terms of three phases of the dental treatment, combined with 6breaths/min. Methods: These phases include before, during and after tooth extraction or anesthesia or something.36 patients' stresses were assessed using HRV stress analyzer in each phase in Kangdong Sacred Heart Hospital, and Chuncheon Sacred Heart Hospital, Hallym University Medical Center from Jun. to Sept. of 2007. HRV 5-min data collected were analyzed in time-domain and frequency-domain to evaluate the activity of autonomic nervous system(ANS) which represents the level of stress. Results: All HRV parameters including HF(high frequency), LF(low frequency) and LF/HF ratio showned a significant change affecting the ANS balance. There was a 6.4% difference between R(LF/HF)s on general breathing pattern for balance of Autonomic nervous system, but on controlled breathing pattern, 0.1Hz, was made narrow till 1.4%. The activity of ANS has increased by 1.4% on general breathing pattern, and by 2.9% on controlled breathing pattern, 0.1Hz. Conclusion: After analysis of preoperative stress changes and effect of breathing pattern of 0.1 Hz on the stress in 36 patients who have undergone third molar extraction, following was concluded. In the preoperative stage, the sympathetic change was the greatest?after the?anesthetic injection, and stress was relieved by controlling the breathing pattern to a frequency of 0.1Hz.

Prediction of Hepatocelluar Carcinoma Using Decision Tree Classification in Treatment Naive Patients for Chronic Hepatitis B

( Sang Bong Ahn ),( Jae Yoon Jeong ),( Dae Won Jun ),( Eileen L. Yoon ),( Sung Eun Kim ),( Jae-jun Shim ),( Yong Kyun Cho ),( Soung Won Jeong ),( Hyoung Su Kim ),( Jun Choi ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: This study aimed to develop prediction model for the development of hepatocellular carcinoma (HCC) in treatment-naive patients receiving entecavir or tenofovir for chronic hepatitis B (CHB). Methods: We enrolled 3184 patients treated with chronic hepatitis B. We analyzed 1350 patients who were treated with entecavir or tenofovir as initial treatment, those with initial clinical records, and those without cancer within one year after treatment. HCC prediction decision tree was constructed through logistic regression using 90 variables including demographic, laboratory data, and cirrhosis. We also analysis with support vector machine (SVM) analysis and random forest analysis. Results: Eighty-four patients were diagnosed with hepatocellular carcinoma. Age (OR=12.3, P=0.001), family history of HBV (OR=7.2, P=0.006), cirrhosis (OR=35.1, P=0.001), diuretics use (OR=4.1, P=0.04), WBC count (OR=4.1, P=0.04), hemoglobin (OR=4.6, P=0.03), admission history (OR=6.2, P=0.01), and ascites (OR=10.7, P=0.001) were the significant predictors of hepatocellular carcinoma development. Cirrhosis, family history of HBV, serum albumin, serum alkaline phosphatase, smoking history, platelet count, and WBC count were selected to set up a decision tree as the prediction model. Decision tree algorithm showed high HCC prediction [96% (95% CI, 93.0-98.0)]. Decision tree algorithm show better area under the curve (AUC) than other analysis. Conclusions: Proposed decision tree algorithm produces high accuracy for prediction of hepatocellular carcinoma in chronic hepatitis B patients.

A case of metastatic squamous cell carcinoma progressed after chronic occupational radiation exposure

( Sung Jin Park ),( Yoon Jae Kim ),( Jun Hyuk Cho ),( Dai Hyun Kim ),( Hyo Hyun Ahn ),( Soo Hong Seo ) 대한피부과학회 2022 대한피부과학회 학술발표대회집 Vol.73 No.2

Mutation Prediction of HA Sequence for AI Preparedness

Ahn Sung-jin,Heo Seo-jun,Kim Yeong-seo 국제과학영재학회 2020 APEC Youth Scientist Journal Vol.10 No.1

South Korea is experiencing intermittent avian flu outbreaks, and the situation is becoming worse because the majority of response efforts are concerned with post-emergence treatment instead of prevention. In this situation, the accuracy of the vaccine should be increased and a method of predicting the mutation of the virus is needed. The aim of this study was therefore to predict the mutation of H5N1 virus HA sequence among domestic poultry. Through analyzing the migratory routes of birds, it was found that the same birds that were infected with H5N1 in Korea were also present in China and Japan and shared breeding grounds. We then used BLAST to obtain molecular evidence that confirms that the AI in China and Japan spreads to Korea with mutations. The HA sequences from previous outbreaks were analyzed for their mutations, and this historical data was used to train a predictive model. Analysis revealed that if the Ka/Ks ratio was over 1, the mutation was preserved. If the Ka/Ks ratio was less than 1, the peaks of the Ka/Ks profiles showed diverse, various mutations. And if the Ka / Ks was significantly low, the mutation did not occur. As a result, based on the Ka/Ks ratios of the AI HA sequences from China and Japan, it was possible to predict which parts of the HA sequence in Korea will be mutated. This will help with vaccine development.

Chronic administration of phosphodiesterase 5 inhibitor improves erectile and endothelial function in a rat model of diabetes

AHN, GOOK JUN,YU, JAE YOUNG,CHOI, SEUL MIN,KANG, KYUNG KOO,AHN, BYOUNG OK,KWON, JONG WON,KANG, SUNG KEUN,LEE, BYEONG CHUN,HWANG, WOO SUK Blackwell Science Ltd 2005 International journal of andrology Vol.28 No.5

<P>Summary</P><P>This study was conducted to determine if the long-term administration of the phosphodiesterase type 5 (PDE 5) inhibitor, DA-8159, to diabetic rats can ameliorate the development of erectile dysfunction (ED) and endothelial dysfunction. After inducing diabetes with streptozotocin, DA-8159 was orally administered at a dose of 3 mg/kg or 10 mg/kg for 8 weeks. To examine the effect on erectile response, electrostimulation of the cavernous nerve with the parameters of 3 V, 5 ms, 5 Hz or 10 Hz, was performed to measure the intracavernous pressure (ICP) and mean arterial pressure (MAP). Thoracic aorta relaxation <I>in vitro</I> was evaluated by adding acetycholine (Ach) cumulatively to the bathing medium. In addition, the plasma endothelin-1 (ET-1) levels were measured in order to investigate the effect of DA-8159 on endothelial dysfunction. The area under the curve (AUC) from the ICP/MAP ratio in the 10 Hz stimulation showed a significantly increased AUC after the 10 mg/kg treatment compared with the diabetic group (8891 ± 619 vs. 6316 ± 1016, respectively, <I>p</I> < 0.05). At the 5 Hz frequency, DA-8159 10 mg/kg also induced a significant increase in the AUC compared with the diabetic control. The maximum ICP/MAP ratio (%) of the 10 mg/kg treatment group was significantly higher in both the 10 Hz and 5 Hz frequency groups (<I>p</I> < 0.05). A treatment of 3 mg/kg tended to increase the AUC and peak ICP/MAP but was not statistically significant. The Ach EC<SUB>50</SUB> value of the diabetic group was significantly higher than in the normal control (120.50 ± 22.90 n<SMALL>M</SMALL> vs. 86.80 ± 9.30 n<SMALL>M</SMALL>, respectively), and 10 mg/kg treatment group showed a significantly lower EC<SUB>50</SUB> value (88.38 ± 19.7 n<SMALL>M</SMALL>). The ET-1 level was lower in groups treated with DA-8159, 3 mg/kg and 10 mg/kg treatment induced a statistical difference compared with the diabetic control (1.15 ± 0.34 fmol/mL vs. 2.51 ± 0.55 fmol/mL, respectively, <I>p</I> < 0.05). These results demonstrate that chronic administration of DA-8159 could attenuate the development of the ED in diabetes and its effect is associated with an improvement in the endothelial function.</P>

Study on the mechanisms of seizure-like events suppression effect by electrical stimulation using a microelectrode array

Ahn, Sora,Jo, Sumin,Jun, Sang Beom,Lee, Hyang Woon,Lee, Seungjun Lippincott Williams & Wilkins 2017 NeuroReport Vol.28 No.9

<P>In this paper, we studied the mechanisms underlying the suppression of seizure-like events (SLEs) by electrical stimulation. We conducted an in-vitro experiment using entorhinal cortex combined hippocampal slices and two convulsant drugs, bicuculline and 4-aminopyridine, to induce spontaneous SLEs. We used a microelectrode array to observe network dynamics over the entire hippocampal area simultaneously, including regions far from the stimulation site. We stimulated the entorhinal cortex region, which has been determined to be a focus of SLEs by Granger causality analysis of multichannel time series data, by an external electrode. In bicuculline application, electrical stimulation showed a marked suppression effect, even though the sizes of the effective region differed. In 4-aminopyridine application, however, stimulation under the same conditions did not suppress the activities in similar to 80% of SLEs. The suppression effect was more remarkable in the areas surrounding the stimulation site in both cases. Our experimental results could support the neuronal depolarization blockade mechanism by accumulation of extracellular potassium ions, which is one of the most convincing mechanisms to understand seizure suppression phenomena because of electrical stimulation. Computer simulation using a neuronal network model also confirmed the mechanism. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.</P>

A study on the optimal thickness of corn flakes produced by using the pressurized steam chamber

( Jun-sang Ahn ),( Jong-suh Shin ),( Min-ji Kim ),( Gi-hwal Son ),( Deok-yun Gil ),( Eung-gi Kwon ),( Byung-ki Park ) 한국축산학회(구 한국동물자원과학회) 2020 한국축산학회지 Vol.62 No.4

This study was conducted to evaluate the effect of the thickness of corn flakes produced by pressurized steam chamber (PSC) on rumen fermentation characteristics and nutrient degradability in Hanwoo and Holstein cows. Corn flakes were treated by PSC, in three groups based on corn flake thickness: < 2.5 mm (T1), 2.5-3.0 mm (T2), and > 3.0 mm (T3). Corn flake thickness significantly influenced pH (p < 0.01) and propionate concentration (p < 0.05) and slightly but not significantly influenced acetate, butyrate, and total-volatile fatty acids (T-VFA) concentrations. The dry matter (DM) degradability increased significantly with a reduction in corn flake thickness (p < 0.01), being significantly greater in T1 and T2 than T3 groups (p < 0.01) and similar between T1 and T2 groups throughout whole incubation time. Also, starch degradability was the lowest in T3 groups than others (p < 0.01). Thus, the present results showed that considering the production efficiency and economic feasibility, the optimal thickness of corn flakes produced in a PSC is recommended to be 2.5-3.0 mm.