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Immobilization with Ketamine HCI and Tiletamine-Zolazepam in Cynomolgus Monkeys
Myung-cheol Kim,Sung-hyeok Hong,Soo-jin Lee,Young-suk Kim,Jae-il Lee 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2
with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus MonkeysJae-il Lee, Sung-hyeok Hong, Soo-jin Lee, Young-suk Kim and Myung-cheol Kim*Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, KoreaReceived March 4, 2003 / Accepted July 2, 2003J. Vet. Sci. (2003), 4(2), 187-191JOURNAL OFVeterinaryScience*Corresponding author: Myung-cheol Kim Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea Tel: +82-42-821-6757, Fax: +82-42-822-4216 E-mail: mckim@cnu.ac.kr
Application of CCPM to Construction Project
김영,이영대,김옥수,김성환,박혁,Kim Young,Lee Young-Dae,Kim Ok-Su,Kim Sung-Hwan,Park Hyeok Korean Institute of Construction Engineering and M 2003 건설관리 : 한국건설관리학회 학회지 Vol.4 No.3
The Theory of Constraints (TOC) is an approach and a philosophy that is used to develop specific management techniques. It was first popularized by the novel, The Coal, that applied the principles to operations management. Since 1997 it has found application in two areas within project management The first application is scheduling of a sing1e project to reduce project duration and simplify project control. there is a further application to allocate resources that are shared by concurrent project. It is the objective of this paper to explore the fundamentals of critical chain and to pursue an application of critical chain method to construction project by a case study. 제약이론은 특정한 관리기술을 개발하는데 사용되는 접근방법이며, 철학이다. 운영관리상에 적용되었던 소설 "The Goal"에 의해서 처음으로 널리 보급되었다. 1997이후로 프로젝트관리의 두 가지 영역에서 적용되어 왔으며, 그 첫 번째 적용은 단일프로젝트에 대한 공기단축과 프로젝트 통제관리의 간소화를 위한 공정관리분야이며, 두 번째 적용은 동시에 수행되는 여러 프로젝트에 의해서 공유되는 자원의 효과적 관리이다. 이 논문은 프로젝트 관리에 적용된 제약이론인 애로사슬(Critical chain)의 원리에 대해서 연구하고, 국내의 건설프로젝트에 적용하는 것을 목적으로 한다.
Lee, Hyungsoo,Choi, Jin Hyeok,Jo, Min Chul,Lee, Donghyun,Shin, Sangmin,Jo, Ilguk,Lee, Sang-Kwan,Lee, Sunghak Elsevier 2018 Materials science & engineering. properties, micro Vol.738 No.-
<P><B>Abstract</B></P> <P>Quasi-static and dynamic compressive properties of 7075-T6 Al matrix composites reinforced with SiC<SUB>p</SUB>s (size; 10 µm, 30 µm, and bimodal (10 + 30) μm), <I>i.e</I>., 10S, 30S, and BS composites, respectively, were investigated in relation with fracture mechanisms. SiC<SUB>p</SUB>s were homogeneously distributed without SiC<SUB>p</SUB> agglomeration, pores, or cracks, and their volume fractions were 49.5 vol%, 54.1 vol%, and 56.5 vol% in the 30S, 10S, and BS specimens, respectively. Compressive properties could be explained by a rule of mixtures based on SiC<SUB>p</SUB> volume fraction and by three major fracture phenomena including deformation of Al matrix, cracking of SiC<SUB>p</SUB>s, and interfacial debonding between SiC<SUB>p</SUB> and Al. As the SiC<SUB>p</SUB> size decreased, crack initiation sites changed from SiC<SUB>p</SUB>s themselves to SiC<SUB>p</SUB>/Al interfaces, which mainly affected the compressive strength. In the BS composite, coarse SiC<SUB>p</SUB>s additionally worked for the strengthening by increasing the total reinforcement fraction, and the three fracture phenomena were well homogenized, thereby leading to the highest strain energy density as well as the best combination of strength and strain.</P>
Development of kW Class SOFC Systems for Combined Heat and Power Units at KEPRI
Lee, Tae-Hee,Choi, Jin-Hyeok,Park, Tae-Sung,Yoo, Keun-Bae,Yoo, Young-Sung The Korean Ceramic Society 2008 한국세라믹학회지 Vol.45 No.12
The Korea Electric Power Research Institute (KEPRI) has been developing planar solid oxide fuel cells (SOFCs) and power systems for combined heat and power (CHP) units. The R&D work includes solid oxide fuel cell (SOFC) materials investigation, design and fabrication of single cells and stacks, and kW class SOFC CHP system development. Anode supported cells composed of Ni-YSZ/FL/YSZ/LSCF were enlarged up to $15{\times}15\;cm^2$ and stacks were manufactured using $10{\times}10\;cm^2$ cells and metallic interconnects such as ferritic stainless steel. The first-generation system had a 37-cell stack and an autothermal reformer for use with city gas. The system showed maximum stack power of about $1.3\;kW_{e,DC}$ and was able to recover heat of $0.57{\sim}1.2\;kW_{th}$ depending on loaded current by making hot water. The second-generation system was composed of an improved 48-cell stack and a prereformer (or steam reformer). The thermal management subsystem design including heat exchangers and insulators was also improved. The second-generation system was successfully operated without any external heat source. Under self-sustainable operation conditions, the stack power was about $1.3\;kW_{e,DC}$ with hydrogen and $1.2\;kW_{e,DC}$ with city. The system also recuperated heat of about $1.1\;kW_{th}$ by making hot water. Recently KEPRI manufactured a 2kW class SOFC stack and a system by scaling up the second-generation 1kW system and will develop a 5kW class CHP system by 2010.
A New Cytotoxic Prenylated Chalcone from Sophora flavescens
Lee, Jae-Hyeok,Baek, Nam-In,Kim, Sung-Hoon,Park, Hee-Wook,Yang, Jae-Heon,Lee, Jeong-Joo,Kim, Seong-Jin,Jeong, Seung-Il,Oh, Chan-Ho,Lee, Kyu-Hee,Kim, Dae-Keun 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.4
We have isolated a new prenylated chalcone from the roots of Sophora flavescens (Leguminosae). We determined that structure of this compound is 7,9,2',4'-tetrahydroxy-8-isopentenyl-5-methoxychalcone (1) on the basis of spectroscopic analysis (1D and 2D NMR data). Compound 1 exhibited potent cytotoxicity against human acute promyelocytic (HL6O), mouse lymphocytic (L1210) and human histiocytic (U937) leukemia cells.
( Sung Soo Ahn ),( Byung-woo Yoo ),( Hyeok Chan Kwon ),( Juyoung Yoo ),( Seung Min Jung ),( Jason Jungsik Song ),( Yong-beom Park ),( Sang-won Lee ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.5
Background/Aims: Measures of body composition, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), and skeletal muscle area (SMA), are considered important prognostic factors in chronic diseases. The association of these measures with auto-inflammatory disorders, such as anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), remains unclear. We investigated the clinical significance of VAT, SAT, and SMA in patients with AAV. Methods: Patients with AAV subjected to chest computed tomography (CT), abdominal CT, or positron emission tomography-CT on diagnosis of AAV were evaluated. Quantitative assessment of VAT, SAT, and SMA was performed at the third lumbar vertebral level and computed by summing the pixel attenuation for tissue-specific Hounsfield units in the corresponding region. Associations of VAT, SAT, and SMA with clinical and laboratory data and clinical outcome measures were evaluated. Results: Of the 117 patients, 61 (52.1%) were classified as having microscopic polyangiitis, 28 (23.9%) as granulomatosis with polyangiitis, and 28 (23.9%) as eosinophilic granulomatosis with polyangiitis. VAT significantly correlated with age, weight, body mass index (BMI), and Birmingham Vasculitis Activity Score, whereas SAT correlated with weight, BMI, and creatinine levels. A significant association was found between SMA and age, height, weight, BMI, and the Five-Factor Score. Cox proportional hazards analysis showed that creatinine levels (odds ratio [OR], 1.346; 95% confidence interval [CI], 1.034 to 1.753; p = 0.027) and high VAT (OR, 7.137; 95% CI, 1.343-37.946; p = 0.021) were independently associated with all-cause mortality during follow-up. Conclusions: Evaluation of VAT using CT is useful for estimating disease activity and all-cause mortality in patients with AAV.
Biopharmaceutical Evaluation of a Solid Dispersion System Containing Sibutramine Freebase
Lee, Min-Suk,Chang, Hee-Chul,Kim, Taewan,Park, Jung-Hwa,Lee, Bong-Sang,Kim, Sung-Hee,Kim, Do-Hwan,Kim, Bo-Gyun,Oh, Seong-Tae,Kang, Myung-Joo,Park, Jong-Hyeok,Lee, Jaehwi,Choi, Young-Wook Korean Chemical Society 2008 Bulletin of the Korean Chemical Society Vol.29 No.4
To increase the solubility of sibutramine freebase, the solid dispersion was prepared using a fluid-bed granulator. The solid dispersion containing sibutramine freebase was characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (XRD). After filling the sibutramine solid dispersion in the gelatin hard capsule, we performed in vitro dissolution test, the stability test under accelerated conditions and pharmacokinetic study in beagle dogs. The DSC and XRD data showed that sibutramine solid dispersion would be amorphous state. The dissolution rate of sibutramine solid dispersion was significantly increased about 70% than sibutramine freebase. The stability of sibutramine solid dispersion capsules was equivalent or above to commercial product of sibutramine. In beagle dogs, the sibutramine solid dispersion showed equivalent pharmacokinetic behavior with commercial product of sibutramine hydrochloride. In conclusion, the solid dispersion system provided a possible way to overcome the low solubility of sibutramine freebase, and the sibutramine solid dispersion can be a bioequivalent with the commercial product in humans.
Lee, Kun Seok,Lee, Won Jun,Park, Nam-Gyu,Kim, Sang Ouk,Park, Jong Hyeok Royal Society of Chemistry 2011 Chemical communications Vol.47 No.14
<P>We prepared vertically aligned nitrogen doped carbon nanotubes (CNTs) on a rigid glass substrate or flexible plastic substrate <I>via</I> a ‘growth-detachment-transfer’ process and the vertically aligned N-doped CNT arrays are employed as counter electrodes for novel dye-sensitized solar cells.</P> <P>Graphic Abstract</P><P>Vertically aligned N-doped carbon nanotube arrays are employed as counter electrodes for novel dye-sensitized solar cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c1cc10471c'> </P>