위암과 식도암이 병발된 다발성 원발성 악성종양 1예

박사영,이나영,이효진,이선영,최진혁,이순남,심강섭,성순희,한운섭 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.3

Multiple primary cancer means that more that two cancers occur independently in an individual. Recently, the incidence of multiple primary cancer has increased with lengthened survival, of cancer patients, development of new diagnostic technique and increased clinical evaluation. We report a patient who had adenocarcinoma of stomach combined with squamous cell carcinoma of esophagus simultaneously.

제7차 중학교 사회과 교과서의 다문화 교육 내용분석

박현호,강운선 大邱大學校 師範大學 附設 敎育硏究所 2009 學校敎育硏究 Vol.5 No.1

이 연구의 목적은 제7차 중학교 사회과 교과서의 일반사회 영역에서 다문화 교육의 반영 정도를 분석하는 것이다. 이를 위하여 다문화 교육에 관한 선행연구를 고찰하고, 그것에 따라 시민권(운동),소수인종, 성(여성), 소수문화, 소수언어, 평등, 집단관계, 이중언어, 다양성, 사회정의, 사회계층, 장애인, 형평성, 총체성 등의 14개 개념 요소를 내용 분석을 위한 분석 기준으로 선정하였으며, 분석을 위한 방법으로 사회연결망 기법을 활용하였다. 분석 대상으로는 제7차 교육과정에서 활용되는 교과서 중에서 일선 학교에서 선택율이 높은 교과서 세 종을 선택하였다. 세 교과서를 대상으로 사회연결망 분석을 실시한 결과는 다음과 같다. 첫째, 선택한 교과서 중에서 한 교과서(A)에서는 다문화 교육 준거 개념 중에서 소수언어, 소수인종, 이중언어, 장애인 개념이 한 번도 출현하지 않았다. 둘째, 분석 대상 중의 다른 교과서(B)의 경우, 다문화교육의 준거 개념 모두 한번 이상 다루어진 것으로 나타났다. 셋째, 두 교과서 모두 정치와 사회문화 영역에서 다문화 교육 준거 개념이 많이 등장한 것으로 나타났다. Multicultural education contents in the middle school social studies textbook focused on 7th curriculum was investigated using social network analysis. We observed if the phase correspondence to the principle of assimilation or the multiculturalism in Banks's four levels of multicultural education. Two kinds of textbooks were introduced for this study. And the analysis result shows that their compatibility for multicultural education was low in the social studies textbook. But there were highly appropriated fields after classifying the contents of the textbook to 4 fields such as politic, economy, social-culture and law. There was a little consideration regarding to the multicultural education in the middle school social studies textbook in 7th curriculum. This study started from a point of view of the principle of assimilation. There was a textbook which was formed network followed by the basic concept for the multicultural education which was guided by Banks's multicultural education definition and objective. So, there was the textbook adequate for multicultural education within the field of the general social studies Multicultural education contents in the middle school social studies textbook focused on 7th curriculum was investigated using social network analysis. We observed if the phase correspondence to the principle of assimilation or the multiculturalism in Banks's four levels of multicultural education. Two kinds of textbooks were introduced for this study. And the analysis result shows that their compatibility for multicultural education was low in the social studies textbook. But there were highly appropriated fields after classifying the contents of the textbook to 4 fields such as politic, economy, social-culture and law. There was a little consideration regarding to the multicultural education in the middle school social studies textbook in 7th curriculum. This study started from a point of view of the principle of assimilation. There was a textbook which was formed network followed by the basic concept for the multicultural education which was guided by Banks's multicultural education definition and objective. So, there was the textbook adequate for multicultural education within the field of the general social studies

외과적 보조의 급속상악확장술 : 치험 5예 REPORT OF 5 CASES

박충열,이용욱,송종운,김영운,박홍주,오희균,유선열,이기현,황현식 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

Five adults (3 cases of bilateral posterior crossbite, 2 cases of unilateral posterior crossbite) with intermaxillary discrepancy of over 5㎜ due to maxillary transverse deficiency were treated by surgically assisted rapid maxillary expansion (SARME). Bilateral maxillary horizontal osteotomies, osteotomies of pterygomaxillary junction and anterior lateral nasal wall, ans anterior palatal osteotomy were performed in 4 cases, and unilateral osteotomies in 1case, followed by palatal expansion with tooth-borne orthopedic applicance. No significant complication was observed. The mean palatal expansion was 7.2㎜ (5.8∼10.0㎜) in the maxillary first molar region. During the mean follow-up period of 4 years (5 months∼8 years 7 months), no recurrence of crossbite was observed in all cases. The SARME seemed to be a simple, stable, and reliable procedure for achieving a permanent increase of over 5㎜ in skeletal maxillary transverse width of adults.

메치실린 내성 포도상구균에 대한 SK-302의 시험관내 및 생체내 효과

박윤선,김수기,신운섭,최선주,정종순,이종수 關東大學校醫科大學醫科學硏究所 1998 關東醫大學術誌 Vol.2 No.1

SK-302 is the active compound purified from culture filtrate of a streptomyces species (streptomyces sp. 302). The in vitro and in vivo antibacterial activities of SK-302 were evaluated against 6 clinically isolated MRSA strains and compared with the activities of vancomycin. SK-302 had node in virto antistaphylocoal activity stronger than that of vancomycin exhibiting MIC's, while vancomycin showed very weak 4 to 8fold lower than that of vancomycin. In SK-302 showed killing activity at the MIC, so SK-302 was superior to vancomycin. Furthermore, in acute systemic infections in mice, the ED_50s of SK-302 against infections by high-resistance MRSA were 30 to 40-feold less than that of vancomycin, therefore SK-302 showed potent in vive therapeutic efficacy against MRSA infection, These results suggest that SK-302 has excellent in virto in and in vivo activities against high-resistance MRSA.

메치실린 내성 황색포도알균의 신속한 검출을 위한 multiplex PCR

박윤선,신운섭 關東大學校 醫科大學 醫科學硏究所 2004 關東醫大學術誌 Vol.8 No.2

Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of nosocomial infections as well as community acquired infections. The rapid identification of MRSA is very important for the appropriate antibiotic therapy, and MRSA must be differentiated from coagulase-negative staphylococci, which may be members of normal microbial flora. However, the conventional phenotypic methods for MRSA detection often lack sensitivity, because of the hetrogeneous expression of methicillin resistance and the dependence of resistance expression on the test conditions. In this study, we developed a multiplex PCR (MPCR) assay for rapid and accurate detection of MRSA. Two pairs of primers were used, which yielded two PCR products. One PCR product is a 310-bp mecA-based PCR fragment specific for methicllin resistance, and the other is a 108-bp S. aureus-specific DNA fragment. The multiplex PCR developed in this study showed excellent specificity and sensitivity for MRSA detection. When three methods for DNA extraction from MRSA were compared, lysostaphin methods and bead beating methods were more efficient than the heating methods. Therefore, the MPCR using two pairs of primers is thought to be a very sensitive and specific tool for rapid detection of MRSA, especially when the DNA of MRSA is extracted by bead beating method.

항이디오타입 종양 백신

신운섭,박윤선 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

Anti-idiotypic antibodies (Ab2) that bind to the antigen-combining sites(paratopes) of anti-tumor antibodies (Ab1) may functionally and structurally mimic the tumor antigen defined by the Ab1. Thus, the anti-idiotypic antibodies resembling the original tumor antigen are called internal images of the tumor antigen and can be used as surrogate antigens for active specific immunotherapy. The advantages of Ab2 vaccines over conventional antigen vaccines are their high specificity, safety, ease of production, and potential to break immune tolerance to tumor antigen. The basic mechanism for immune tolerance breakage by Ab2 vaccines is a kind of cross-reaction between tumor antigen and Ab2 at T cell level. Anti-idiotypic antibodies have been shown to induce antigen-specific humoral and cellular immune reponses in experimental animals and cancer patients. In this paper, we will describe the idiotypic network, the advantages of Ab2 vaccines over conventional antigen vaccines, the mechanism of action of Ab2 vaccines, and the preclinical and clinical trials of active specific immunotherapy with Ab2 vaccines.

다결정 니켈표면과 산소 기체와의 상호 작용

안운선,이순보,부진효,박유용 성균관대학교 기초과학연구소 1986 論文集 Vol.37 No.2

The interaction of the gaseous oxygen molecule with polycrystalline nickel surface has been studied by the XPS through the wide range above the room temperature. For relatively lower oxygen exposure, only an O(1s) peak was observed at 530.2 eV, which is associated with the dissociative adsorption. On the other hand, with increasing oxygen exposures, two peaks was appeared at 529.7eV and 531.3eV. These peaks are attributed to nickel oxide and Ni_2O_3, respectively. The latter oxide is ascribed due to the excess adsorption over the NiO stoichiometry. However at high temperatures above 423K, the dissociative adsorption and oxidation was found to take place simultaneously. As a whole, through these XPS study it is found that the interaction of the oxygen with the polycrystalline nickel surface commences through three steps: the fast dissociative adsorption following slow initiation process, rapid oxidation corresponding to the epitaxial NiO formation, and finally the bulk oxide formation.

악하부에 발생한 결핵성 경부 임파선염

김영운,정숭룡,이승호,이종호,김창룡,박문성,류선열 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.4

Tuberculosis, a chronic infectious granulomatous disease, is preumed to be quite a rare entity. Because of the development of chemotherapy and the improvement of nutritional conditions, incidence of tuberculosis have reduced. For these reasons, tuberculosis may be overlooked in the differential diagnosis whenever dealing with a submandibular swelling. Diagnosis of tuberculous lymphadenitis consists of historical data, physical findings, laboratory tests and histologic examination. The treatment of choice seems to be surgical excision and long term antituberculosis chemotherapy. Surgery provides a rapid tissue diagnosis, because the histological examination of the excisional biopsy is the most reliable diagnostic test. This is the report of a case of tuberculous cervical lymphadenitis on left submandibular area with no evidence of the involvement of lung.

분할골절단술후 고정방법에 따른 전단강도 비교

송종운,박영준,유선열 전남대학교 치의학연구소 2001 구강과학 Vol.13 No.3

Purpose : the purpose of the present study was to compare the shear strength of the three techniques for the fixation of simulated sagittal split ramus osteotomies in terms of their ability resist vertical loads. Materials and Methods : Fifteen bovine ribs of similar size and shape were subjected to uniform osteotomies resembling a sagittal split ramus osteotomy. They were divided into three groups as wire, screw and plate group. The osteotomitized fragments were fixed with 18 gauge stainless steel wire, three bicortical screws, and with a 4-hole miniplate and monocortical screws in the wire, secrw and plate group respectively. The fixed bovine rib specimens were secured in a jig, subjected to vertical loads, and evaluated for mean shear strength at failure and for mean weight resisted by the wire, screw, and miniplate. Results : The mean weight resisted by the wire, screw and miniplate was (1.01±0.40g/㎣), (8.87±3.95g/㎣) and (6.93±2.82g/㎣) respectively. The mean weight resistances in the screw and miniplate group were significantly higher than those of the wire group (p<0.05). But no significant differences existed between the screw and plate group (p>0.05). Conclusion : These results suggest that the both screw and miniplate fixation have higher mean weight resistances than wire fixation and both methods would be much better for rigid internal fixation than wire fixation after sagittal split ramus osteotomy.

Osteotome Sinus Floor Elevation Procedure를 이용한 임프란트 매식

송종운,조용기,박홍주,김영운,오희균,유선열 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Maxillary sinus has an anatomic limitation to bone support available for dental implant. When there is less than 10㎜ of bone remaining between the upper alveolar ridge crest and the maxillary sinus floor, bone augmentation should be considered. In 1994, Summers reported two sinus floor elevation techniques of limmediate implant insertion, using osteotomes, for patients who have at least 5㎜ of bone remaining between the alveolar ridge crest and the maxillary sinus floor. One technique is osteotome sinus floor elevation (OSFE) procedure in which uses osteotomes to elevate the sinus floor. The other is bone-added OSFE (BAOSFE) procedure in which bone graft is added into osteotomy site. Both procedures conserve all of the remaining bone and selectively displace it upward, thereby raising sinus floor. This study was aimed to evaluate the long-term success rate of implants which had been placed by osteotome sinus floor elevation procedure. Between February 1996 and June 1998, 10 implants were placed using OSFE or BAOSFE procedures in 6 patients who had at least 6㎜ of bone remaining between the alveolar ridge crest and the sinus floor. OSFE procedures were performed in patiens, 2∼4㎜ sinus floor elevation was needed, whereas BAOSFE procedures were done in patines, more than 4㎜ sinus floor elevation was needed. During the mean follow-up period of 4 years 4 months (3 years 6 months ∼ 5 years 9 months), no implant was failed and all patients showed good functional results. OSFE and BAOSFE procedures seemed technically easier and less invasive compared to conventional sinus lift procedure. And both procedure have good success rate.