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Bortezomib과 Dexamthasone으로 치료한 골수외 형질세포종 4예
백종현,이은영,장리라,손창배,신은경,서정아,이지숙,이호섭,이상민,신성훈,김양수 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2
Despite the use of aggressive local and systemic treatment including autologous stem cell transplantation in multiple myeloma, extramedullary recurrences are common and the prognosis of these patients is poor. Many novel drugs such as thalidomide, lenalidomide and bortezomib improve the response of treatment of multiple myeloma, but some reports failed to describe thalidomide has effect in extramedullary plasmacytoma. Recent data report on the successful treatment plasmacytomas with bortezomib in patients with advanced multiple myeloma. We treated 4 relapsed or refractory extramedullary plasmacytomas with bortezomib at our institution. We recognized all these extramedullary plasmacytomas decreased and showed more than partial response. This report lends support to the efficacy of bortezomib in the treatment of plasmacytoma and describes the safe use of bortezomib. Responses may, however, be of short duration. Therefore, despite our limited experience, we propose that bortezomib may be considered a therapeutic option for such patients who have risk of radiation therapy
백기엽,김주학,선정훈,최영일,정경호 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 1996 연구보고서 Vol.1 No.-
기내 생산된 마늘 종구의 휴면타파에 적당한 방법을 모색하고자 저온처리 온도 및 처리 기간별로 맹아율을 조사해본 결과 저온처리기간이 길수록 맹아소요일수가 단축되었고 맹아율도 증가하였다. 저온처리온도를 8℃로 하여 4주 이상 저장하였을 때 85% 이상의 높은 발아율을 나타냈으며 배양종구의 휴면타파를 위해 저온처리가 필수적이었다. 종구의 크기에 따라 맹아율에는 큰 차이를 나타냈으며 가장 큰 종구를 사용한 경우 작은 종구에 비해 2배 이상의 맹아율이 증가되었다. 따라서 기내에서 보다 균일하고 비대된 종구의 생산 방법이 개발되어야 할 것으로 보인다. Sprouting of tissue cultured garlic(Allium sativum L.) microbulbs after planting was hastened and sprouting rate was increased by extending chilling period. Above 85% of sprouting rate was obtained by chilling treatment at 8℃ for more than 4 weeks and it represents that in vitro propagated microbulbs should be stored in low temperature before planting in order to break dormancy. One of the factors for early sprouting and increase of sprouting rate was size of microbulbs; sprouting was doubled by planting large microbulbs compared to small ones. These results indicate that development of proper tissue culture methods for producing uniform and large sized microbulbs is necessary to increase sprouting rate and further growth.
소아의 비사구체성 혈뇨와 연관된 Nutcracker 증후군
박경미,김우선,민재홍,최용,정해일,하일수,백경훈,김정수,김인원 대한신장학회 1998 Kidney Research and Clinical Practice Vol.17 No.5
Purpose: This study was designed to aid the diagnosis and to predict the outcorne by understanding the clinical course of nutcracker syndrome in childhood. Methods: The clinical, laboratory, radiological and cystoscopic data from the medical records of eleven children who were diagnosed as nutcracker syndrome by gross hematuria and pressure gradient criteria($gt;3mrnHg) were studied retrospectively and analyzed. Results: Sex ratio of the cases was 7:4, and the median age of onset was 12.8(3-14.3) years. Six cases showed persistent and 5 cases manifested interrnittent, exercise induced hematuria. Left flank pain(64%), abdominal pain(18%), left varicocele(9%) were associated in some of the children, but hematuria was the only symptom in 36Yo. Left renal vein entrapment was documented in 10 cases by ultrasonography. Out of the 5 cases studied by renal Doppler ultrasonography, 4 and 5 cases showed higher($gt;5) mean left renal vein diameter ratio(Distal/ Aortomesenteric portion) and mean peak velocity ratio respectively. Unilateral bleeding from left ureteral orifice was documented in 7 of the 9 cases at cystoscopy. The mean pressure gradient between proximal left renal vein and inferior vena cava was 4.4±1.6(3-7) mmHg. Hematuria of 25% and 57% of the cases disappeared spontaneously in 3 and 5 years after onset respectively. Proteinuria disappeared in 3 of the 5 initial proteinuric cases. Conclusion: Nutcracker syndrome must be considered in the differential diagnosis of non-glomerular, especially gross hematuria in childhood, and Doppler ultrasonography can aid diagnosis non-invasively. The renal function remained stable, but 4396 of the cases continued to show hematuria still 5 years after onset.
Kim, Kyung Hwan,Chi, Zhenguo,Cho, Min Ju,Jin, Jung-Il,Choi, Dong Hoon,Paek, Sang Hyon Wiley - VCH Verlag GmbH & Co. KGaA 2007 Macromolecular Symposia Vol.249 No.-
<P>First generation thiophene-labeled conjugated dendrimers have been synthesized through the Heck coupling reaction between the 5-vinyl-[2,2′]bithio- phenyl derivative and 1,2,4,5-tetrabromo-benzene as a core. One dendrimer has hexyl groups at the periphery and the other does not have it. They display a considerably better solubility than the linear conjugated oligothiophene. We observe drastic spectral change in a film state of dendrimer due to crystallization and a high extent of intermolecular interaction. Effect of peripheral alkyl groups on the intermolecular interaction and lamella orderness was investigated using two dendrimers.</P>
Sohn, Kee Hoon,Segonzac, Cé,cile,Rallapalli, Ghanasyam,Sarris, Panagiotis F.,Woo, Joo Yong,Williams, Simon J.,Newman, Toby E.,Paek, Kyung Hee,Kobe, Bostjan,Jones, Jonathan D. G. Public Library of Science 2014 PLoS genetics Vol.10 No.10
<▼1><P>Plant nucleotide-binding leucine-rich repeat (NB-LRR) disease resistance (R) proteins recognize specific “avirulent” pathogen effectors and activate immune responses. NB-LRR proteins structurally and functionally resemble mammalian Nod-like receptors (NLRs). How NB-LRR and NLR proteins activate defense is poorly understood. The divergently transcribed Arabidopsis <I>R</I> genes, <I>RPS4</I> (resistance to <I>Pseudomonas syringae</I> 4) and <I>RRS1</I> (resistance to <I>Ralstonia solanacearum</I> 1), function together to confer recognition of <I>Pseudomonas</I> AvrRps4 and <I>Ralstonia</I> PopP2. <I>RRS1</I> is the only known recessive NB-LRR <I>R</I> gene and encodes a WRKY DNA binding domain, prompting suggestions that it acts downstream of RPS4 for transcriptional activation of defense genes. We define here the early RRS1-dependent transcriptional changes upon delivery of PopP2 <I>via Pseudomonas</I> type III secretion. The Arabidopsis <I>slh1</I> (<I>sensitive to low humidity 1</I>) mutant encodes an RRS1 allele (RRS1<SUP>SLH1</SUP>) with a single amino acid (leucine) insertion in the WRKY DNA-binding domain. Its poor growth due to constitutive defense activation is rescued at higher temperature. Transcription profiling data indicate that RRS1<SUP>SLH1</SUP>-mediated defense activation overlaps substantially with AvrRps4- and PopP2-regulated responses. To better understand the genetic basis of RPS4/RRS1-dependent immunity, we performed a genetic screen to identify <I><U>su</U>ppressor of</I><U>s</U>l<U>h</U>1 <I><U>i</U>mmunity</I> (<I>sushi</I>) mutants. We show that many <I>sushi</I> mutants carry mutations in <I>RPS4</I>, suggesting that RPS4 acts downstream or in a complex with RRS1. Interestingly, several mutations were identified in a domain C-terminal to the RPS4 LRR domain. Using an <I>Agrobacterium</I>-mediated transient assay system, we demonstrate that the P-loop motif of RPS4 but not of RRS1<SUP>SLH1</SUP> is required for RRS1<SUP>SLH1</SUP> function. We also recapitulate the dominant suppression of RRS1<SUP>SLH1</SUP> defense activation by wild type RRS1 and show this suppression requires an intact RRS1 P-loop. These analyses of RRS1<SUP>SLH1</SUP> shed new light on mechanisms by which NB-LRR protein pairs activate defense signaling, or are held inactive in the absence of a pathogen effector.</P></▼1><▼2><P><B>Author Summary</B></P><P>How plant NB-LRR resistance proteins and the related mammalian Nod-like receptors (NLRs) activate defense is poorly understood. Plant and animal immune receptors can function in pairs. Two Arabidopsis nuclear immune receptors, RPS4 and RRS1, confer recognition of the unrelated bacterial effectors, AvrRps4 and PopP2, and activate defense. Using delivery of PopP2 into Arabidopsis leaf cells <I>via Pseudomonas</I> type III secretion, we define early transcriptional changes upon RPS4/RRS1-dependent PopP2 recognition. We show an auto-active allele of RRS1, RRS1<SUP>SLH1</SUP>, triggers transcriptional reprogramming of defense genes that are also reprogrammed by AvrRps4 or PopP2 in an RPS4/RRS1-dependent manner. To discover genetic requirements for RRS1<SUP>SLH1</SUP> auto-activation, we conducted a suppressor screen. Many <I>suppressor of</I> slh1 <I>immunity</I> (<I>sushi</I>) mutants that are impaired in RRS1<SUP>SLH1</SUP>-mediated auto-activation carry loss-of-function mutations in RPS4. This suggests that RPS4 functions as a signaling component together with or downstream of RRS1-activated immunity, in contrast to earlier hypotheses, significantly advancing our understanding of how immune receptors activate defense in plants.</P></▼2>
Lee, Young Sook,Paek, Kyung Shin,Kang, Eun Sil,Jang, Han-su,Kim, Hyo Jung,Kang, Young Jin,Kim, Jin-Hoi,Lee, Hoon Taek,Lee, Jae Heun,Chang, Ki Churl,Nishinaka, Toru,Seo, Han Geuk Elsevier 2005 The international journal of biochemistry & cell b Vol.37 No.11
<P><B>Abstract</B></P><P>To elucidate the molecular mechanisms underlying the up-regulation of aldose reductase observed in many cancer cells, we investigated the signal transduction pathways mediating induction of aldose reductase gene expression by 12-<I>O</I>-tetradecanoylphorbol-13-acetate, a potent tumor promoter. A maximum of four-fold induction in aldose reductase mRNA was demonstrated in HeLa cells treated with 12-<I>O</I>-tetradecanoylphorbol-13-acetate. The increased level of aldose reductase transcript was accompanied by the elevated level of enzyme activity, and completely abolished in the presence of actinomycin D. Inhibitors of protein kinase C, bisindolylmaleimide I and calphostin C, as well as inhibitors of tyrosine kinase, genistein and tyrphostin A23, significantly attenuated 12-<I>O</I>-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase mRNA. Blockade of the p38 mitogen-activated protein kinase pathway by SB203580 also suppressed 12-<I>O</I>-tetradecanoylphorbol-13-acetate-induced aldose reductase expression. The promoter activity of aldose reductase gene was significantly augmented in the cells treated with 12-<I>O</I>-tetradecanoylphorbol-13-acetate, but attenuated in the presence of bisindolylmaleimide I, tyrphostin A23 or SB203580. Pyrrolidinedithiocarbamate, a nuclear factor κB inhibitor, dose-dependently suppressed 12-<I>O</I>-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase mRNA. 12-<I>O</I>-tetradecanoylphorbol-13-acetate augmented the DNA binding activity of nuclear factor κB and nuclear factor κB-dependent gene transcription, and these effects were attenuated by bisindolylmaleimide I or tyrphostin A23, but not by SB203580. Taken together, activation of protein kinase C and tyrosine kinase by 12-<I>O</I>-tetradecanoylphorbol-13-acetate elicits increased promoter activity of aldose reductase gene via nuclear factor κB. A p38 mitogen-activated protein kinase pathway, distinct from the tyrosine kinase pathway, may also take part in 12-<I>O</I>-tetradecanoylphorbol-13-acetate-induced increase in aldose reductase gene expression.</P>