A facile in-situ activation of protonated histidine-derived porous carbon for electrochemical capacitive energy storage

Tran, Thanh-Nhan,Jung Kim, Hwa,Samdani, Jitendra S.,Hwang, Jun Yeon,Ku, Bon-Cheol,Kwan Lee, Jae,Yu, Jong-Sung Elsevier 2019 Journal of industrial and engineering chemistry Vol.73 No.-

<P><B>Abstract</B></P> <P>A unique and effective synthesis approach to tune the structural and electrochemical properties of carbon materials (CMs) is demonstrated by template-free one-step pyrolysis of protonated histidine (His) containing each of different inorganic acids (HAs) such as HI, HBr, HCl, HNO<SUB>3</SUB>, H<SUB>2</SUB>SO<SUB>4</SUB>, and H<SUB>3</SUB>PO<SUB>4</SUB>. In particular, the (H<SUB>3</SUB>PO<SUB>4</SUB>)His-CM possesses high specific surface area, high capacitance, superior energy density and power density along with excellent cycle life. Such excellent electrochemical performance of (H<SUB>3</SUB>PO<SUB>4</SUB>)His-CM is attributed to the tunable structural properties of the precursor, where H<SUB>3</SUB>PO<SUB>4</SUB> plays dual roles of in-situ activation and additional P doping in the carbon skeleton.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Structural and electrochemical properties of carbon materials (CMs) is tuned by protonating histidine using different inorganic acids (HAs). </LI> <LI> The effects of each HA on the structural properties of respective (HA)His-CM and on its electrochemical behaviors are investigated. </LI> <LI> (H<SUB>3</SUB>PO<SUB>4</SUB>)His-CM possesses high specific surface area, high capacitance, superior energy density and power density along with excellent cycle life. </LI> <LI> H<SUB>3</SUB>PO<SUB>4</SUB> plays dual roles of in-situ activation and additional P doping in the carbon skeleton. </LI> <LI> A strategy of acid treatment of histidine and in-situ activation is unique and favorable for scalable production of novel carbon materials. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>Unique synthesis method of protonating histidine with different inorganic acids is proposed as a novel efficient way to control the structural and surface properties of resulting carbon materials and eventually their electrochemical performance.</P> <P>[DISPLAY OMISSION]</P>

A facile in-situ activation of protonated histidine-derived porous carbon for electrochemical capacitive energy storage

Thanh-Nhan Tran,김화정,Jitendra S. Samdani,황준연,구본철,이재관,유종성 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.73 No.-

A unique and effective synthesis approach to tune the structural and electrochemical properties of carbonmaterials (CMs) is demonstrated by template-free one-step pyrolysis of protonated histidine (His)containing each of different inorganic acids (HAs) such as HI, HBr, HCl, HNO3, H2SO4, and H3PO4. Inparticular, the (H3PO4)His-CM possesses high specific surface area, high capacitance, superior energydensity and power density along with excellent cycle life. Such excellent electrochemical performance of(H3PO4)His-CM is attributed to the tunable structural properties of the precursor, where H3PO4 plays dualroles of in-situ activation and additional P doping in the carbon skeleton.

Effects of Injection Molding Parameters and their Interactions on Mechanical Properties of PMMA/PC Blend

Hoang, Van Thanh,Luu, Duc Binh,Toan Do, Le Hung,Tran, Ngoc Hai,Nguyen, Pham The Nhan,Tran, Minh Sang,Tran, Minh Thong Materials Research Society of Korea 2020 한국재료학회지 Vol.30 No.12

A combination of Polycarbonate (PC) material and Polymethylmethacrylate (PMMA), fabricated using an injection molding machine, has been investigated to determine its advantages, as studied in Ref. 1). This paper aims to investigate the optimization of PMMA/PC blend for both tensile yield strength and impact strength. Furthermore, interaction effects of process conditions on mechanical properties including tensile yield strength and impact strength of PMMA/PC blend by injection molding process are interpreted in this study. Tensile and impact specimens are designed following ASTM, type V, and are fabricated by injection molding process. The processing conditions such as melt temperature, mold temperature, packing pressure, and cooling time are applied; each factor has three levels. As a result, in comparison with optimization of separated responses, mechanical properties of PMMA/PC are found to decrease when optimizing both tensile and impact strengths simultaneously. The melt temperature is found to be the most significant interaction parameter with the mold temperature and packing pressure. In addition, there is more interaction between the mold temperature and cooling time. This investigation provides a useful understanding of the control of injection molding processing of polymer blends in optical application.

Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A

Huong Thi Thanh Tran,김희남,이일권,Thanh-Nhan Nguyen Pham,안재숙,김여경,이제중,박경수,국훈,김형준 대한의학회 2013 Journal of Korean medical science Vol.28 No.2

SUV39H1 is a histone 3 lysine 9 (H3K9)-specific methyltransferase that is important for heterochromatin formation and the regulation of gene expression. Chaetocin specifically inhibits SUV39H1, resulted in H3K9 methylation reduction as well as reactivation of silenced genes in cancer cells. Histone deacetylase (HDAC) inhibitors inhibit deacetylases and accumulate high levels of acetylation lead to cell cycle arrest and apoptosis. In this study, we demonstrated that treatment with chaetocin enhanced apoptosis in human leukemia HL60, KG1, Kasumi, K562, and THP1 cells. In addition, chaetocin induced the expression of cyclin-dependent kinase inhibitor 2B (p15), E-cadherin (CDH1) and frizzled family receptor 9 (FZD9) through depletion of SUV39H1 and reduced H3K9 methylation in their promoters. Co-treatment with chaetocin and HDAC inhibitor trichostatin A (TSA)dramatically increased apoptosis and produced greater activation of genes. Furthermore,this combined treatment significantly increased loss of SUV39H1 and reduced histone H3K9 trimethylation responses accompanied by increased acetylation. Importantly, cotreatment with chaetocin and TSA produced potent antileukemic effects in leukemia cells derived from patients. These in vitro findings suggest that combination therapy with SUV39H1 and HDAC inhibitors may be of potential value in the treatment of leukemia.

Lenalidomide Synergistically Enhances the Effect of Dendritic Cell Vaccination in a Model of Murine Multiple Myeloma

Nguyen-Pham, Thanh-Nhan,Jung, Sung-Hoon,Vo, Manh-Cuong,Thanh-Tran, Huong-Thi,Lee, Youn-Kyung,Lee, Hyun-Ju,Choi, Nu-Ri,Hoang, My-Dung,Kim, Hyeoung-Joon,Lee, Je-Jung Lippincott-Raven 2015 Journal of immunotherapy Vol.38 No.8

We investigated the efficacy of lenalidomide (LEN) in combination with dendritic cell (DC) vaccination in the MOPC-315 murine myeloma model. After tumor growth, LEN was injected intraperitoneally for 4 consecutive days in combination with DC vaccination. The combination of LEN and vaccination efficiently inhibited tumor growth compared with the single agents alone. A cytotoxic assay revealed that the anticancer effects of DC vaccination plus LEN involved not only generation of antigen-specific cytotoxic T lymphocytes but also NK cells. Vaccinated mice had reduced numbers of suppressor cells, including both myeloid-derived suppressor cells and regulatory T cells, in the spleen. The proportions of CD4 and CD8 T cells increased in the spleen, and a Th1 cytokine (interferon-&ggr;) rather than a Th2 cytokine (interleukin-10) was synthesized in response to tumor antigens. LEN enhanced the innate immune response by modulating NK cell numbers and function. In addition, LEN reduced the production levels of angiogenesis-inducing factors in tumor-bearing mice. Together, these results suggest that a combination of LEN and DC vaccination may synergistically enhance anticancer immunity in the murine myeloma model, by inhibiting immunosuppressor cells and stimulating effector cells, as well as effectively polarizing the Th1/Th2 balance in favor of a Th1-specific immune response.

China-ASEAN Trade Relations: A Study of Determinants and Potentials

TRAN, Hiep Xuan,HOANG, Nhan Thanh Thi,NGUYEN, Anh Thuy,TRUONG, Hoan Quang,DONG, Chung Van Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9

The purpose of this study is to investigate the development and determinants of China-ASEAN trade relations over the period of 2000-2018. Employing both the qualitative and quantitative approaches, the results show that the trade relations between China and the Association of South East Asian Nations (ASEAN) have remarkably developed and rapidly grown over times, with a significantly important concentration on the segments of high technological and medium technological products. We also find that China's economic scale is crucially impacting on the China-ASEAN trade relations under both the aggregate and sub-sector level. It is interesting to notice that there is no evidence to support accession to the World Trade Organization (WTO) and officially forming of ASEAN-China Free Trade Agreement (ACFTA) to enhance trade relation between both sides. The findings also quantitatively indicate that there is much significant potential for the expansion of mutual trade between China and some members of ASEAN such as Brunei, Laos and Malaysia, while less potential is predicted for other members of ASEAN. It is strongly suggested that China and ASEAN should find a new proactive approach and make more efforts in improving the mutual political trusts to enhance trading activities in the coming years.

Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber

Tran Manh Hung,Phuong Thien Thuong,Nguyen Trung Nhan,Nguyen Thi Thanh Mai,Tran Le Quan,최재수,우미희,민병선,배기환 한국생약학회 2011 Natural Product Sciences Vol.17 No.2

Several isoquinoline alkaloids (1 - 18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the IC50 values ranging from 10.2 ? 0.5 mM to 24.5 ? 1.6 mM, meanwhile, compound 14 - 17 exhibited strong inhibitory activity with IC50 values from 2.1 ? 0.2 to 5.5 ? 0.3 mM. Compounds 14 - 17 exhibited selective inhibition for AChE compared with BuChE. The isoquinoline alkaloid possesses aromatic methylenedioxy groups and quaternary nitrogen atoms are crucial for the anti-cholinesterase inhibitory activity.

Synthesis of Water-Dispersible Single-Layer CoAl-Carbonate Layered Double Hydroxide

Li, Haiping,Tran, Thanh-Nhan,Lee, Byong-Jun,Zhang, Chunfei,Park, Jong-Deok,Kang, Tong-Hyun,Yu, Jong-Sung American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.24

<P>Despite extensive study on single-layer layered double hydroxides (SL-LDHs) with NO3- counterions, SL-LDHs with CO32- counterions (CO32- SL-LDHs) have never been prepared before. Herein, a CoAl-CO32- SL-LDH which stays stable in water and powdery state is first synthesized using ethylene glycol as a reaction medium. The SL-LDH, with thickness of similar to 0.85 nm, is composed of one Co(Al)O-6 layer sandwiched between two CO32- layers. The SL-LDH powder shows high specific surface area (similar to 289 m(2)/g) and excellent electrocatalytic oxygen evolution efficiency. This work provides the first simple way to prepare CO32- SL-LDHs and will open an avenue for synthesizing other SL-LDHs.</P>

Oral cavity: An open horizon for nanopharmaceuticals

Nguyen Oanh Oanh Thi,Tran Khue Dan,Ha Nhan Thi,Doan Sang Minh,Dinh Thi Thanh Hai,Tran Tuan Hiep 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.4

Background Oral administration is the primary route employed for drug delivery. In addition to the gastrointestinal tract, the oral cavity has been drawing considerable attention owing to its physiological properties and advances in drug carrier development. Notably, nanotechnology has made immense contributions to enhancing drug bioavailability, stability, and efficacy, both in research and clinical settings. Area covered The present review comprises lessons from physiological characteristics to fundamental material science knowledge, summarizing the pros and cons of nanotechnology applications in therapeutic drug delivery. The oral cavity presents inherent challenges, including oral cancer, dental caries, oral infection, or oral inflammation, that necessitate local solutions. Simultaneously, the vascular system under the tongue and in the buccal region offers a portal for systemic drug absorption. Expert opinion Among available delivery systems, nanoparticle-based drug delivery, with the oral cavity as the action or absorption site, can be developed as a principal dosage formulation. Although convenience and fast onset might be advantageous, additional studies are warranted for preclinical characterization, especially in animal models, and for determining manufacturing competence, prior to human trials to meet standards in clinical settings.

Eco-friendly Aqueous Binder-Based LiNi 0.4 Mn 1.6 O 4 Cathode Enabling Stable Cycling Performance of High Voltage Lithium-Ion Batteries with Biomass-Derived Silica

Ngoc Thi Bao Nguyen,Hoang Van Nguyen,Nhan Thanh Tran,Phat Tan Vu,Phung My Loan Le,Man Van Tran 대한금속·재료학회 2023 ELECTRONIC MATERIALS LETTERS Vol.19 No.3

High voltage cathode materials LiNi x Mn 2−x O 4 (x = 0.4; 0.5) have been attracting greater attention in developing high energydensity Li-ion battery technology for electrical vehicles and large-scale applications. The main challenge of high voltagecathodes is severe electrolyte decomposition leading to short cell cycle life. In addition, LiNi 0.4 Mn 1.6 O 4 cathode materialprocessed with polyvinylidene fl uoride (PVdF) binder generally suff ers an oxidation decomposition as well as cathodedelamination from current collectors during cycling. Herein, we suggest using sodium carboxymethyl cellulose (CMC),lithium polyacrylic acid (LiPAA) as water-soluble binders for replacing conventional PVdF in cathode processing to demonstratethe eff ectiveness on long-cycling of half-cell Li || LiNi 0.4 Mn 1.6 O 4 , full-cell SiO 2 -graphite || LiNi 0.4 Mn 1.6 O 4 and SiO 2|| LiNi 0.4 Mn 1.6 O 4 . In half-cell, the cells with water-soluble binders-based cathode exhibited a higher discharge capacity thanthe one using PVdF binder (CMC—126.0 mAh/g; LiPAA—125.7 mAh/g; PVdF—117 mAh/g at C/5, respectively). CMCand LiPAA also improve retention capacity up to 90% after 500 cycles at C/3. Interestingly, LiPAA based electrode exhibitsan excellent rate-capability with discharge capacity of 80 mAh/g at 8C. The stability of electrodes was also investigated byelectrode chemical impedance spectroscopy (EIS) and Scanning electron microscope (SEM). In full-cell, CMC and LiPAAbased cells showed eff ectiveness in decreasing transition metal dissolution and preventing the cathode degradation duringlong-cycling through its excellent capacity retention in 200 cycles at C/3.