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Oral cavity: An open horizon for nanopharmaceuticals
Nguyen Oanh Oanh Thi,Tran Khue Dan,Ha Nhan Thi,Doan Sang Minh,Dinh Thi Thanh Hai,Tran Tuan Hiep 한국약제학회 2021 Journal of Pharmaceutical Investigation Vol.51 No.4
Background Oral administration is the primary route employed for drug delivery. In addition to the gastrointestinal tract, the oral cavity has been drawing considerable attention owing to its physiological properties and advances in drug carrier development. Notably, nanotechnology has made immense contributions to enhancing drug bioavailability, stability, and efficacy, both in research and clinical settings. Area covered The present review comprises lessons from physiological characteristics to fundamental material science knowledge, summarizing the pros and cons of nanotechnology applications in therapeutic drug delivery. The oral cavity presents inherent challenges, including oral cancer, dental caries, oral infection, or oral inflammation, that necessitate local solutions. Simultaneously, the vascular system under the tongue and in the buccal region offers a portal for systemic drug absorption. Expert opinion Among available delivery systems, nanoparticle-based drug delivery, with the oral cavity as the action or absorption site, can be developed as a principal dosage formulation. Although convenience and fast onset might be advantageous, additional studies are warranted for preclinical characterization, especially in animal models, and for determining manufacturing competence, prior to human trials to meet standards in clinical settings.
Thi Thu Huong NGUYEN,Kieu Oanh NGUYEN,Tuan Khanh CAO,Viet Anh LE 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.8
The environment friendly lifestyle and the green product trend have motivated corporates to develop and adopt sustainable business practices. However, an increasing number of corporations have engaged in greenwashing practices to create the appearance of environmental responsibility. By employing the theory of reasoned action, the paper investigated a model linking corporate greenwashing and consumers’ green purchase intentions with the mediating role of green trust and green word-of-mouth about green electronic devices in Vietnam. Using an online survey via Email, Zalo, and Wechat, data was obtained from 308 Vietnamese consumers who have been purchasing green electronic devices. Based on the responses of the participants from the questionnaires conducted, data analysis was conducted by using SEM in AMOS version 23. This investigation shows that corporate greenwashing negatively affects consumers’ green trust, green word-of-mouth, and their green buying intentions. Additionally, the paper verifies that green trust and green word-of-mouth mediate the relationships between greenwashing and consumers’ green purchase intentions. These results reinforce the extant understanding of greenwashing and its consequences. Finally, the study not only stimulates future research but serves as a reference for business managers, scholars, and students who are interested on the topic of environmental sustainability, new product development, and green brands.
About the Mistakes of Sino Language – In the Case of Quoc Su Di Bien in Hong Kong
Nguyen Thi Oanh 경성대학교 한국한자연구소 2016 한자연구 Vol.0 No.14
Quoc su di bien is a historical book written in Sino language which recorded the events taking place under Nguyen dynasty, from the reign of Gia Long King to the reign of Thieu Tri, and was compiled by Phan Thuc Truc around the 4th to 5th years of Tu Duc title (1851-1852). The work at present has two variants: one of them is the handwritten version code A.1045/1-2 stored in the Institute of Sino – Nom Studies and the other was printed from microfilm, code A.1045/1-2 of the Old French School of the Far East, which was edited by researchers in the Institute of New Asian Studies, Chinese University of Hong Kong and whose Sino language version was produced by Tran Kinh Hoa and printed in 1965 in Hong Kong. When reproducing, Mr. Tran Kinh Hoa tried his best to restore the special Nom and Sino characters of Vietnam and all the unclear cases were marked O for further inspection. However, due to use of scanned materials, there remained a lot of mistakes. The work provided a deep analysis on the mistakes and errors of the version QSDB printed in Hong Kong in order to show that Vietnamese, like some other people influenced by Chinese culture such as Japan and Korea, had created their own Sino character system different from China’s. For proper explanation about the unique Sino character system of each country, the researchers should facilitate themselves with the sound knowledge of national culture, history, language and psychology of such country. Therefore, we may avoid the mistakes due to insufficient knowledge.
Invited Mini Review : Phosphoinositide turnover in Toll-like receptor signaling and trafficking
( Oanh Thi Tu Le ),( Tu Thi Ngoc Nguyen ),( Sang Yoon Lee ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.7
Lipid components in biological membranes are essential for maintaining cellular function. Phosphoinositides, the phosphorylated derivatives of phosphatidylinositol (PI), regulate many critical cell processes involving membrane signaling, trafficking, and reorganization. Multiple metabolic pathways including phosphoinositide kinases and phosphatases and phospholipases tightly control spatio-temporal concentration of membrane phosphoinositides. Metabolizing enzymes responsible for PI 4,5-bisphosphate (PI(4,5)P2) production or degradation play a regulatory role in Toll-like receptor (TLR) signaling and trafficking. These enzymes include PI 4-phosphate 5-kinase, phosphatase and tensin homolog, PI 3-kinase, and phospholipase C. PI(4,5)P2 mediates the interaction with target cytosolic proteins to induce their membrane translocation, regulate vesicular trafficking, and serve as a precursor for other signaling lipids. TLR activation is important for the innate immune response and is implicated in diverse pathophysiological disorders. TLR signaling is controlled by specific interactions with distinct signaling and sorting adaptors. Importantly, TLR signaling machinery is differentially formed depending on a specific membrane compartment during signaling cascades. Although detailed mechanisms remain to be fully clarified, phosphoinositide metabolism is promising for a better understanding of such spatio-temporal regulation of TLR signaling and trafficking. [BMB Reports 2014; 47(7): 361-368]
Factors Affecting the Intention to Use Digital Banking in Vietnam
NGUYEN, Oanh Thi Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.3
The study aims to evaluate the factors affecting the intention to use digital banking in Vietnam. Multivariate data analysis techniques (Cronbach's Alpha test, Confirmatory Factor Analysis, Structure equation model) are used for the survey data collected from 201 customers who have access to digital banking. The analysis results show that: (1) attitude towards the service, perceived usefulness has a positive impacts on the intention to use; (2) convenience does not affect the intention to use digital banking services; (3) perceived usefulness factor has a positive effect on the attitude towards the service; (4) The perceived risk has a negative impact on attitude towards the service; (5) trust has no effect on the attitude towards the service; (6) ease of use has a positive impact on perceived usefulness; (7) trust has a positive effect on perceived risk. From the results of this study, perceived usefulness has a positive effect on attitude and intention to use the service. Therefore, it is necessary to enhance the sense of the usefulness of customers through media advertising and consulting so that customers fully understand the benefits brought about by using digital banking services. Perceived risk has a negative impact on attitude towards the service.