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Nguyen Thu Hien,Nguyen Duc Quan,Kim Lien Nguyen Thi,Thi Thanh Ngan Nguyen,Nguyen Thi Phuong Mai,Tran Ngoc Dung,Nguyen Huy Hoang 한국유전학회 2023 Genes & Genomics Vol.45 No.4
Background Androgens and androgen receptor (AR) are critical regulators of the masculinization process in male sexual development. The absence of a functioning AR results in the development of the androgen insensitivity syndrome (AIS), a rare disorder of sexual development (DSD) characterized by the external genitalia feminization, gynecomastia, and impaired spermatogenesis. Objective To determine the AR gene mutations associated with male DSD in four unrelated Vietnamese patients. Methods To detect the disease-causing mutations, whole exome sequencing (WES) was performed on four patients diagnosed with AIS. Sanger sequencing was then used for validation of the identified mutations. Finally, 12 web-based tools, three-dimensional protein modeling software, and the guidelines issued by the American College of Medical Genetics and Genomics were used to assess the potential pathogenicity of these mutations. Results Four distinct novel mutations, namely c.1834T > A (p.Cys612Ser), c.2122 C > G (p.Leu708Val), c.2630T > G (p.Phe877Cys), and c.2641 C > A (p.Leu881Met) in the AR gene, were identified in four AIS patients using WES. The in silico analysis results revealed that the Cys612, Leu708, Phe877, and Leu881 sites are important for an appropriate response to androgens of the AR, and mutation at these sites can have adverse effects on the AR functions, androgen–AR interaction, and AR signaling pathway. Conclusions WES and in silico analyses strongly suggested that four novel AR mutations are pathogenic and have led to the development of AIS in the four Vietnamese patients under consideration.
NGO, Chi Thanh,NGUYEN, Thi Ngoc Mai,NGUYEN, Duy Dat,LE, Hoang Ba Huyen,LE, Van Cuong,LE, Thi Binh Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9
The study aims to investigate factors affecting enterprise's satisfaction and loyalty toward the Social Security's online public services, looking at the case of Thanh Hoa province, Vietnam. This study employs samples with 216 enterprises that use online public system of Thanh Hoa province's Social Security. The research model is closely linked to the SERVQUAL model developed by Parasuraman, Zeithaml and Berry (1988). We propose 23 scales that constitute the quality of service, three scales that constitute Customer Satisfaction and three components that constitute Customer Loyalty. This study use the tool of Exploratory Factor Analysis (EFA), Cronbach's Alpha test, Confirm Factor Analysis (CFA) and Structural Equation Modeling (SEM) in order to address the question of satisfaction and loyalty. The result shows that the factor with the most impact is Reliability, next is Capacity of staffs, Tangibles, Attitude of staffs, and the least impacting factor is Empathy; moreover, the results also show that Satisfaction has a strong impact on Customer Loyalty. The findings of this study suggest that Thanh Hoa province's Social Security should: (i) strengthen the reliability of online service system; (ii) build capacity for staffs; (iii) develop the responsiveness of electronic transactions systems; and (iv) improve the empathy of staffs.
Spectrum of Lysosomal Storage Disease Targeted for Newborn Screening in Vietnam
Dung, Vu Chi,Ngoc, Can Thi Bich,Khanh, Nguyen Ngoc,Mai, Do Thi Thanh,Thao, Bui Phuong,Mai, Tran Thi Chi,Ha, Nguyen Thu,Huong, Nguyen Thi Mai,Nam, Nguyen Hoang,Hai, Le Thanh,Tomatsu, Shunji,Yoo, Han-Wo Association for Research of MPS and Rare Diseases 2017 Journal of mucopolysaccharidosis and rare disease Vol.3 No.1
Nguyen Thanh-Nho,Thai Huynh-Thuc,Le-Thi Anh-Dao,Do Minh-Huy,Le-Thi Huynh-Mai,Le Quang-Huy,Nguyen-Thi Kim-Sinh,Nguyen Cong-Hau 한국분석과학회 2023 분석과학 Vol.36 No.5
Aluminium (Al) is one of the major elements in rocks and its concentration can be varied, depending on different rock types as well as sources. The present study aimed to propose an analytical method based on the UV-Vis as a cheap, simple, and common instrument equipped in most laboratories for Al quantification in rocks after the microwave assisted acid digestion. The aluminone and 8-hydroxyquinoline were investigated for the colorimetric assay. The results show that the 8-hydroxyquinoline reagent was more favorable in terms of the minimized affects of the potential interferences present in the digested solutions, i.e., Fe3+, Si4+ and F–. The calibration curve was constructed from 0.10 mg/L to 3.00 mg/L with the goodness of linearity (R2 = 0.9996). The limits of detection and quantification (LOD and LOQ) were estimated, i.e., 0.029 mg/L and 0.087 mg/L, respectively. The 8-hydroxyquinoline was applied to real rock samples, demonstrating favorable precision (RSD = 0.34 %-1.8 %) and no remarkable differences were found compared to the inductively coupled plasma-mass spectrometry (ICP-MS) as a reference measurement approach.
Determinants Influencing Management Competency of Small and Medium Enterprise Directors in Vietnam
Thi Mai Huong DOAN,Minh Thuy DO,Thanh Lan MAI,Vu Phuong Anh DO,Thi Loan NGUYEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.12
Currently, small and medium-sized enterprises (SMEs) are accounting for about 98% of the total number of enterprises in Vietnam. Each year, SMEs create over one million new jobs, utilize up to 51% of the labor force in the society, and contribute more than 40% of GDP to the country. The study aims to analyze factors affecting the management competency of directors in small and medium enterprises in Vietnam. To achieve these research objectives, quantitative and qualitative methods were used concurrently. 300 questionnaires were sent out, but only 276 were collected and used for the quantitative analysis through SPSS 20.0 software. Cronbach’s Alpha, EFA, and regression were used to further confirm the research findings. The research findings show that all four proposed factors have impacts on the management competency of SME directors, among which enterprise features and specific policies for entrepreneur development in the locality have the strongest impacts, followed by personal features and business environment. The findings of this study suggest that managers need to focus on factors affecting the management competency of directors. This paper also provides new insight into the management competency of directors. Based on the findings, some recommendations are given for SMEs to improve management competency.
Advanced Magnetic Materials Produced by Using Rapid Quenching Technology
Nguyen Hoang Nghi,Nguyen Van Dung,Trinh Thi Thanh Nga,Bui Thi Khanh Nhung,Mai Thanh Tung,Nguyen Huu Tinh,Hoang Nhat Hieu,Bui Xuan Chien,Nguyen Thi Hong Tam 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.6
Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view. Amorphous alloys produced by using a rapid quenching technique are considered to be a precursor for producing nanosized and multiphase structures by precipitation (the top-down method). By using this technique, several new magnetic materials with different magnetic properties based on different physical mechanisms have been manufactured and investigated. Three new magnetic materials, a nanocrystalline soft magnetic material, a soft-hard permanent magnet and a Me-3d granular alloy with a GMR effect, what were prepared under local conditions, are presented and discussed in the experimental point of view.
Vo Thi Tuyet Mai,Nguyen Anh Triet,Le Thi Phuong Ngoc,Nguyen Thanh Long 경남대학교 기초과학연구소 2020 Nonlinear Functional Analysis and Applications Vol.25 No.4
In this paper, we consider the initial boundary value problem for a nonlin-ear Kirchho-Carrier-Love equation. At rst, by combining the linearization method, the Faedo-Galerkin method and the weak compactness method, we prove the local existence anduniqueness of a weak solution. Next, by constructing Lyapunov functional, we establish a blow-up result for solutions with a negative initial energy and give a sucient condition to obtain the exponential decay of weak solutions.
Phan Thi Anh Dao,Nguyen Xuan Hai,Nguyen Trung Nhan,Tran Le Quan,Nguyen Thi Thanh Mai 한국생약학회 2012 Natural Product Sciences Vol.18 No.1
Among 90 Vietnamese medicinal plant extracts investigated for their antioxidant activity by DPPH assay at various concentrations from 10 - 100 ?g/mL, 67 showed an inhibition rate over 50% at 100 ?g/mL; 47 had greater than 50% inhibition at 50 ?g/mL; 17 showed over 50% inhibition at 25 ?g/mL. 8 extracts which exhibited strong inhibitory activity more than 50% inhibition at 10 ?g/mL were further tested for lipid peroxidation inhibition by TBA assay. They displayed activity with IC50 values from 30.6 to 158.9 ?g/mL. Until now, this is the first report on antioxidant activity of the female flower of Borassus flabellifer, and the stem of Combretum latifolium, Embelia ribes, Spatholobus parviflorus, and Tetrastigma erubescens. Fractionations of the EtOAc extract prepared from S. parviflorus led to the isolation of protocatechuic acid (1), ferulic acid (2), epicatechin (3), and gallic acid (4). These compounds showed significant DPPH inhibitory activity with IC50 values from 6.5 to 23.6 ?M.
Phuc Nguyen Thien,Giang Nguyen Thi Huong,An Vu Nguyen Thien Truong,Nam Nguyen Thanh Hoai,Anh Ly Duc,Nguyen Huynh Cam,An Hoang,Phong Mai Thanh,Hieu Nguyen Huu 한국탄소학회 2023 Carbon Letters Vol.33 No.2
In this study, graphene oxide (GO) was synthesized by the improved Hummers’ method. The degree of oxidation from graphite (Gi) to GO was determined through interlayer spacing calculated from X–ray diffraction. Besides, the effect of KMnO4:Gi ratios (X1), H2SO4 volume (X2), oxidation temperature (X3), oxidation time of stage 1 (X4), and oxidation time of stage 2 (X5) was screened by the Plackett–Burman model. The simultaneous impact of three factors that influenced the degree of oxidation (X1, X2, and X3) was studied by the Box–Behnken experimental model of response surface methodology to achieve suitable conditions for the GO synthesis process. The characterization of GO product was investigated via the modern analytical methods: X-ray diffraction, Raman spectroscopy, Fourier transform infrared spectroscopy, UV–Vis spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, and atomic force microscopy. In addition, the study was also carried out on a pilot scale for orientation in industrial application with the yield of 14 g/batch.
LE, Thai Thanh Dat,HO, Thi Thanh Ngan,LE, Nguyen Truc Quyen,HUYNH, Thi Khanh Tuyen,NGUYEN, Minh Tri,LUU, Thi Mai Anh,HOANG, Thi Phuong Thao,NGUYEN, Trong Luan Korea Distribution Science Association 2022 The Journal of Asian Finance, Economics and Busine Vol.9 No.6
The purpose of the study is to analyze the significant impacts of expectations, performance, complaints, and fairness that affect consumer satisfaction. The methodology involves reviewing and referencing relevant literature carefully, then proposing a model for customer satisfaction. This study is empirically based on a survey with 50 respondents who work in the field of import and export in the region stretching from the north to the south of Vietnam. The sampling method used in this study is the in-depth interview method. The results show that: (1) expectation has a specific impact on customer satisfaction, (2) performance has a positive impact on customer satisfaction, and (3) complaint which is an intermediary factor between expectation, performance, and fairness has an impact on satisfaction, (4) fairness has a positive effect on satisfaction, in addition, fairness is an extremely important feature when customers choose an import-export service. Research implies that increasing expectations, performance, and fairness results in an improved customer experience and satisfaction when they use the service. It is suggested that the complaint factor continue to be studied and looked into because it still has some effect on satisfaction and is an intermediate variable that changes how the other factors relate to each other.