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Correlations between abnormalities of morphological details and DNA fragmentation in human sperm
Nguyen, Hiep Tuyet Thi,Dang, Hong Nhan Thi,Nguyen, Thai Thanh Thi,Nguyen, Trung Van,Dang, Thuan Cong,Nguyen, Quoc Huy Vu,Le, Minh Tam The Korean Society for Reproductive Medicine 2022 Clinical and Experimental Reproductive Medicine Vol.49 No.1
Objective: As the associations of sperm DNA fragmentation with morphology have not been examined in detail, this study aimed to investigate the relationship between abnormalities of morphological details and DNA integrity in human sperm. Methods: In this cross-sectional study, men from infertile couples were enrolled at Hue Center for Reproductive Endocrinology and Infertility, Vietnam. Conventional semen parameters, including morphological details, were analyzed following the World Health Organization 2010 criteria. Sperm DNA fragmentation was evaluated using a sperm chromatin dispersion assay. The relationships and correlations between semen parameters, sperm morphology, and the type of halosperm and the DNA fragmentation index (DFI) were analyzed. Results: Among 130 men in infertile couples, statistically significant differences were not found in the sperm halo type between the normal and abnormal sperm morphology groups. The percentage of round-head spermatozoa was higher in the DFI >15% group (16.98%±12.50%) than in the DFI ≤15% group (13.13% ±8.82%), higher values for amorphous heads were found in the DFI >15% group, and lower values for tapered heads were observed in the DFI ≤15% group; however, these differences were not statistically significant. Small-halo sperm and the DFI were positively correlated with round-head sperm (r=0.243, p=0.005 and r=0.197, p=0.025, respectively). Conclusion: The rate of general sperm morphological abnormalities in semen analysis was not related to sperm DNA integrity. However, round sperm heads were closely associated with sperm DNA fragmentation.
A New Dimeric Lignan from the Stems of Willughbeia edulis
Nguyen, Hai Xuan,Do, Truong Nhat Van,Le, Tho Huu,Dang, Phu Hoang,Nguyen, Mai Thanh Thi,Nguyen, Nhan Trung The Korean Society of Pharmacognosy 2022 Natural Product Sciences Vol.28 No.2
As part of our continued study on the chemical constituents of Willughbeia edulis stems, a new dimeric lignan named edulignan (1) was isolated from its EtOAc-soluble extract. Based on NMR spectroscopic interpretation, the planar structure of 1 has been suggested to have two 2-substituted 4-chromanone subunits with different stereochemical configurations. In addition, the MS/MS analysis of the products obtained by acid-catalyzed hydrolysis of 1 was supportive of its structure. Unfornatually, the new compound 1 did not show 𝛼-glucosidase inhibitory activity with an IC<sub>50</sub> value > 250 𝜇M.
Minh Tam Le,Hiep Tuyet Thi Nguyen,Trung Van Nguyen,Thai Thanh Thi Nguyen,Hong Nhan Thi Dang,Thuan Cong Dang,Quoc Huy Vu Nguyen The Korean Society for Reproductive Medicine 2023 Clinical and Experimental Reproductive Medicine Vol.50 No.2
Objective: This study aimed to compare the efficacy of physiological intracytoplasmic sperm injection (PICSI) and intracytoplasmic sperm injection (ICSI) in terms of the fertilization rate and embryo quality using sibling oocyte cycles. Methods: This prospective, cross-sectional study collected data from 76 couples who underwent their first cycle at the Hue Center for Reproductive Endocrinology and Infertility, Vietnam, between May 2019 and November 2021. The inclusion criteria were cycles with at least eight oocytes and a sperm concentration of 5×10<sup>6</sup>/mL. Sperm parameters, sperm DNA fragmentation (SDF), fertilization, and the quality of cleavage-stage embryos on day 2 and blastocysts on day 5 were examined. Results: From 76 ICSI cycles, 1,196 metaphase II (MII) oocytes were retrieved, half of which were randomly allocated to either the PICSI (n=592) or ICSI (n=604) treatment group. The results showed no significant difference between the two groups in terms of fertilization (72.80% vs. 75.33%, p=0.32), day 2 cleavage rate (95.13% vs. 96.04%, p=0.51), blastulation rate (52.68% vs. 57.89%), and high-quality blastocyst rate (26.10% vs. 31.13%, p=0.13). However, in cases where SDF was low, 59 cycles consisting of 913 MII oocytes produced a considerably higher blastulation rate with PICSI than with ICSI (50.49% vs. 35.65%, p=0.00). There were no significant differences between the pregnancy outcomes of the PICSI and ICSI embryo groups following embryo transfer. Conclusion: Using variable sperm quality provided no benefit for PICSI versus ICSI in terms of embryo outcomes. When SDF is low, PICSI appears to be able to produce more blastocysts.
The Impact of Human Resource Management Activities on the Compatibility and Work Results
NGUYEN, Duc Trung,HA, Van Dung,DANG, Truong Thanh Nhan Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9
This research focuses on determining the impact of human resource management activities on the compatibility and work results of employees of Ho Chi Minh Stock Exchange (HOSE) listed companies. The paper includes five parts: introduction, literature review, research methodology, research results, and conclusion and policy implications. The data are collected from the survey of 350 listed companies in HOSE, in which 315 survey notes filled with sufficient information are used for analysis. The paper employs both qualitative method and quantitative method. Group discussion of 10 experts is for qualitative research. Quantitative method performs analysis of Statistics, Cronbach's Alpha, EFA analysis, CFA analysis and SEM model. The results of the research clearly indicate that human resource management (HRM) activities are measured through improving the ability, improving the motivation and improving the opportunity. While compatibility is measured through suitability, connection and sacrifice; whereby HRM activities of ability improvement have a positive effect on the job suitability and connection; HRM activities of motivation improvement have a positive effect on the job suitability, connection and sacrifice; and HRM activities of opportunity improvement have a positive effect on the job suitability, sacrifice and connection; Finally, the job suitability, sacrifice and connection positively affect the work results of employees.
Phan Thi Anh Dao,Nguyen Xuan Hai,Nguyen Trung Nhan,Tran Le Quan,Nguyen Thi Thanh Mai 한국생약학회 2012 Natural Product Sciences Vol.18 No.1
Among 90 Vietnamese medicinal plant extracts investigated for their antioxidant activity by DPPH assay at various concentrations from 10 - 100 ?g/mL, 67 showed an inhibition rate over 50% at 100 ?g/mL; 47 had greater than 50% inhibition at 50 ?g/mL; 17 showed over 50% inhibition at 25 ?g/mL. 8 extracts which exhibited strong inhibitory activity more than 50% inhibition at 10 ?g/mL were further tested for lipid peroxidation inhibition by TBA assay. They displayed activity with IC50 values from 30.6 to 158.9 ?g/mL. Until now, this is the first report on antioxidant activity of the female flower of Borassus flabellifer, and the stem of Combretum latifolium, Embelia ribes, Spatholobus parviflorus, and Tetrastigma erubescens. Fractionations of the EtOAc extract prepared from S. parviflorus led to the isolation of protocatechuic acid (1), ferulic acid (2), epicatechin (3), and gallic acid (4). These compounds showed significant DPPH inhibitory activity with IC50 values from 6.5 to 23.6 ?M.
ĐÁNH GIÁ KHẢ NĂNG LÀM LÀNH VẾT BỎNG TRÊN CHUỘT CỦA HYDROGEL TỪ AgNP-CHITOSAN-CURCUMIN
Hoang Ngoc Anh Nhan,Nguyen Ba Trung,Giang Thi Kim Lien,Truong Thi My Phuong,Ho Kha Vinh Nhan,Pham Xuan Anh 한국베트남학회 2023 베트남연구 Vol.21 No.1
Skin burn is one of the major causes of morbidity and mortality in burn patients due to its susceptibility to infection. The disruption of the epidermal barrier, combined with the denaturation of proteins and lipids, provides a fertile environment that is rich in bacterial nutrients for microbial growth, making it significantly prone to infection. This study aimed to formulate a thermoresponsive hydrogel containing silver nanoparticles (300 ppm), oligo chitosan 2%, and curcumin (0.1%) in the polymer pluronic F127 matrix with a final concentration of 13% to effectively promote the healing of skin wounds. The prepared thermoresponsive hydrogel was investigated for its physical and chemical stability, gelation temperature, and chemical composition. In addition to in vitro antibacterial activity against Staphylococcus aureus found in burn infections, in vivo burn healing and antibacterial activities were also investigated and compared with those of a commercial product using burn-induced infected wounds in mice. The formulation showed antibacterial activity with effective values for wound healing properties, as shown in vivo and by histopathological studies. This study also demonstrates that the thermoresponsive hydrogel was successful as an antibacterial and burned wound-healing transdermal drug delivery system.
Cholinesterase Inhibitory Activities of Alkaloids from Corydalis Tuber
Tran Manh Hung,Phuong Thien Thuong,Nguyen Trung Nhan,Nguyen Thi Thanh Mai,Tran Le Quan,최재수,우미희,민병선,배기환 한국생약학회 2011 Natural Product Sciences Vol.17 No.2
Several isoquinoline alkaloids (1 - 18), which have basic chemical structures as protoberberine and aporphine skeletones, were evaluated for their inhibitory activities on AChE and BuChE. Among them, compounds 3, 4, 6, 8 and 12 showed the potent AchE activity with the IC50 values ranging from 10.2 ? 0.5 mM to 24.5 ? 1.6 mM, meanwhile, compound 14 - 17 exhibited strong inhibitory activity with IC50 values from 2.1 ? 0.2 to 5.5 ? 0.3 mM. Compounds 14 - 17 exhibited selective inhibition for AChE compared with BuChE. The isoquinoline alkaloid possesses aromatic methylenedioxy groups and quaternary nitrogen atoms are crucial for the anti-cholinesterase inhibitory activity.