RISS 학술연구정보서비스

검색
다국어 입력

http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.

변환된 중국어를 복사하여 사용하시면 됩니다.

예시)
  • 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
  • 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
닫기
    인기검색어 순위 펼치기

    RISS 인기검색어

      검색결과 좁혀 보기

      선택해제
      • 좁혀본 항목 보기순서

        • 원문유무
        • 음성지원유무
        • 원문제공처
          펼치기
        • 등재정보
        • 학술지명
          펼치기
        • 주제분류
          펼치기
        • 발행연도
          펼치기
        • 작성언어
        • 저자
          펼치기

      오늘 본 자료

      • 오늘 본 자료가 없습니다.
      더보기
      • 무료
      • 기관 내 무료
      • 유료
      • KCI우수등재
      • KCI등재

        Poor prognostic significance of Mycobacterium tuberculosis infection during bortezomib-containing chemotherapy in patients with multiple myeloma

        안재숙,류성윤,양덕환,정성훈,강승지,김미영,이승신,김여경,김형준,이제중 대한혈액학회 2013 Blood Research Vol.48 No.1

        Background Bortezomib administration leads to a transient decrease in CD4+ T cells, increasing the susceptibility to opportunistic infections. The activation and proliferation of CD4+ T cells are particularly important in the host’s defense against tuberculosis infection. The aim of this study was to determine the incidence and clinical significance of tuberculosis infection in patients with multiple myeloma (MM) treated with a bortezomib-containing regimen. Methods We retrospectively investigated the incidence of Mycobacterium tuberculosis in 115 patients with MM who were given a bortezomib-containing regimen and studied the disease prognosis. Results All patients received chemotherapy prior to bortezomib administration, and the median duration from diagnosis to bortezomib administration was 12.4 months (range, 0.2‒230). We diagnosed tuberculosis in 8 patients (8/115, 7%): 7 patients had a pulmonary granulomatous lesion prior to chemotherapy and 1 developed reactivation of tuberculosis, but none of them died of uncontrolled tuberculosis infection. In 50% of patients with tuberculosis, bortezomib-containing therapy was interrupted. This resulted in significantly lower response rates to the bortezomib-containing therapy (P<0.05) and significantly shorter overall survival times amongst tuberculosis vs. non-tuberculosis patients (P=0.017). Conclusion Tuberculosis infection was not uncommon among the patients with MM who were treated with bortezomib-containing therapy, and tuberculosis infection in these patients resulted in an interruption of bortezomib administration, which significantly affected patient outcomes. Therefore, early diagnosis and treatment of tuberculosis infection are critical to avoid worsening outcomes in such patients.

      • KCI우수등재

        서해암 방조제 공사 기간중 유실토량 측정시험

        안재숙 한국농공학회 1972 한국농공학회논문집 Vol.14 No.1

        The studies were carried out to find the cause and the quantitative evaluation of sea dike materials loss which is occured during the period of construction works for the tideland reclamation projects on the west coast of Korea. Major subjects to studies were to establish the typical relationships between the tidal flow and the movement of dike materials, the tidal-flow and the erosion, the dike materials and the ratio of material movement(losses), construction methods and the ratio of materials movement (losses). Based on the above subjects, the studies were made for the purpose of obtain the following informations; (1) Collecting and evaluaing the data of dike material losses due to foundation settlement, from designed existing dikes on the west coast. (2) By the field investigation at A-San Sea Dike, Pyong Taek Project, the Comparison would be made by the relationships between the tide velocity and the movement of dike foundation under the natural conditions and the period of construction so that find out the relationship between the dike materials of foundation situation and settlements. With regard to the dike construction works, it is so difficult to calculate the exact quantity of material losses due to the foundation settlements. The major factors that affect the settlement losses of the dike materials are: (1) Topographical variation (2) Swepting the sectional area of dike by the tide velocity. (3) Dumping riprap to the outerside of dike during the period of construction works. (4) Sectional area losses by the cause of occurence of the new tide channels. (5) material losses by the heavy storms. (6) Consolidation settlement by the foundation weakness. (7) Material losses by the earth materials by tide flow. Most hi호 material losses were occured by the Consolidation settlement due to the foundation weakness, the maximum tide velocities due to decrease the cross sectional area of the gaps and erosion of foundation due to the range of tide, Inner and outerside of dike, or dike material loses due to the tide flow. Final conclusion would be obtained by the continuous measurement of consolidation settlement at the stage of final clusure of the dike. (It is scheduled to close on the end of 1972) However, intermediate conclusion can be introduced as follows: (1) The estimation of material(losses) during the period of construction works for the existing sea-dikes up to date were only empirical. The material losses at the general closure for design was estimated at 10% of the riprap, 20% of the earth materials, and 20% of the riprap, 40% of the earth materials at the final closure of the dike. The final closure estimated double quantity to the general closure, but it is still doubt. (2) The ratio of consolidation settlements was found smaller than the calculated quantity. It can be foreseen that settlement speeds is higher thom the calculated speeds. (3) The movement of dike foundation under the natural conditions were not so depends on the geological conditions of the foundation. (4) When the tide velocities was estimated 100 at the normal tide, it was estimated 125 at the high tide and 55 at the low tide. The tide velocities at the low tide shows apparently lower than the high tide and the higher velocities at the deep water depth.

      • KCI등재후보
      • KCI우수등재
      • KCI우수등재
      • KCI등재

        산지개간공법(山地開墾工法)

        안재숙,신상혁,신호철,Ahn, J.S.,Shin, S.H.,Shin, H.C. 한국토양비료학회 1979 한국토양비료학회지 Vol.11 No.4

        우리나라의 산지개간(山地開墾)은 부족(不足)한 토지자원(土地資源)의 확보(確保)를 위하여 필요(必要)하다. 산지(山地)를 농지(農地)로 조성(造成)하는 개간공법(開墾工法)은 종래에는 주(主)로 인력(人力)과 축력(畜力)에 의(依)하여 시공(施工)되어 왔다. 그러나 근간(近間)에는 노동력의 부족(不足)과 노임의 상승(上昇)에 따라 기계화(機械化) 시공(施工)이 공정관리(工程管理)와 경제적으로 유리(有利)하게 되었으며 앞으로 이런 현상(現象)은 더욱 증대될 것이다. 산지개간(山地開墾) 공법(工法)의 유형(類型)으로서는 원지형(原地形) 공법(工法), 개량원지형(改良原地形) 공법(工法), 계단형(階段形) 공법(工法), 사면형(斜面形) 공법(工法)이 있다. 앞으로 산지개간(山地開墾) 공법(工法)의 채택 방향(方向)은 경사(傾斜) 및 토지이용(土地利用) 조건에 따라 다소(多少) 다르겠으나 보통전(普通田)의 경우(境遇)는 가급적(可及的) 구획을 대형화(大型化)하고 경사(傾斜)를 완화(緩化)하여 기계화(機械化) 영농이 가능(可能)한 개량원지형(改良原地形) 공법(工法)이 바람직하다. 목야지(牧野地)를 위한 개간(開墾)의 경우(境遇)는 요철(凹凸)을 정형(整形)하는 개량원지형(改良原地形) 공법(工法)이 유리(有利)하며 수원지(樹園地) 조성(造成)의 경우는 등고선(等高線)에 따라 계단(階段)을 축조(築造)하고 경작도(耕作道)를 배치(配置)하는 사면형(斜面形) 공법(工法)으로 조성(造成)하는 것이 바람직할 것이다. The neccessity of hillside land reclamation for food production in Korea is no matter of question. Accordingly, the Government has launched some large scale hillside land reclamation projects. From the past experiences followings are pointed out as to the rational hillside land reclamation engineering methodologies. 1. It is observed that due to the shortages in labor and high wage, the machanization in hillside land reclamation will be an urgent subject. 2. There are several engineering methods for the reclamation of hillside lands; contour terracing, improved contour terracing, bench terracing and sloping bench terracing. 3. Selection of suitable methods will demand the considerations on the topography, particularly degree of slope, and the land use after reclamation. For ordinary crops cultivation, slope should be low and contour terracing is to be recommended, to enable the introduction of machines. In case of grass land development, after smoothing the land surface, improved contour terracing might be selected. And for the orchard development, sloping bench terracing with the construction of roads between the terrace will be suitable.

      연관 검색어 추천

      이 검색어로 많이 본 자료

      활용도 높은 자료

      해외이동버튼