대구시 도심의 접근특성과 가로이용특성에 관한 연구

최영은,하재명 대한건축학회 2003 대한건축학회논문집 Vol.19 No.5

The purpose of this study is to examine the access characteristics of people visiting at the urban street and district. In this study, the access characteristics were classified into three factors, a access method, a visiting aim and a visitor's character. The case study areas were selected the nine streets and districts which crowded with stores dealing with similar goods in Daegu CBD. The results of the case study has been summarized as follows; Firstly, in the individual districts dealing with a specific goods, the access characteristics appeared differently. Secondary, the visitors' visiting aim in the case study areas affected the selection of a access method. Thirdly, the street behavior according to a operational situation appeared differently. And in the interview with visitors, the subjects answered that the urgent problems in the case areas are the traffic confusion and the shortage parking space.

대구시 建築審議制度 變遷에 관한 硏究

최판길,박영홍,하재명 대한건축학회 2004 대한건축학회논문집 Vol.20 No.5

This study focuses on the change of the architectural design-review system that is pointed of committee members, object and criteria of the review in Daegu. Members of the committee were seen to grow up each year. It related with the addition of review-objects and the separation of two committee that intended to proceed the review equitably. The review-objects were more and more easily adjusted in design review. Because it was an intention of the activating construction and administrational changes from city government to its sub-government. The review-criteria were also gradually simplified and changed to be based on the law and regulations. This paper draws four complements through the change of the review system : First, the major and vocation of the committee are needed to control. It is equally needed in each parts of committee members, and it is needed to participate experts in new parts. Second, the review-objects are needed to strengthen the city regulations that present object is over 21 stories and the area is 100,000 square meters. So the important commercial building of the roadside will be included in the review-object. Third, the more objective review-criteria is needed. Because most of the architects want to know the design criteria which the committee consider continuously. Fourth, an addition of the sustainable criteria is needed. These changes are more helpful set of a progressive review system and they will improve the architectural design and its environment.

고위험 유방암환자에서 CPB(Cyclophosphamide, Cisplatin, BCNU) 고용량 화학요법과 자가조혈모세포이식술 : A Phase II Multi-Center Trial

최정혜,안명주,조은경,신동복,이재훈,이문희,김철수 대한조혈모세포이식학회 2001 대한조혈모세포이식학회지 Vol.6 No.2

배경: 림프절 전이가 많은 고위험군 유방암환자에서 CPB(cyclophosphamide, cisplatin, BCNU)를 이용한 고용량화학요법 및 자가조혈모세포이식술이 무병생존율에 미치는 영향과 안전성을 규명하기 위하여 연구를 시행하였다. 방법: 1998년 2000년 까지 한양대학병원, 가천의대병원과 인하대학병원에서 4개 이상 림프절을 침범한 유방암으로 근치적 절제술 시행 후 고용량 화학요법과 자가조혈모세포이식을 시행 받은 13명의 환자를 대상으로 하였고 대조군은 4개 이상 림프절을 침범한 유방암으로 보조화학요법을 받은 환자들 중 39명을 무작위로 선택하여 비교분석하였다. 고용량 화학요법은 제-6일에 BCNU 450 mg/m², 제-5일부터 3일까지 cyclophosphamide 2.0 g/m²와 cisplatin 55 mg/m²를 각각 투여하였다. 결과: 채집된 단핵구수의 중앙값은 8.5 x 10^(8)/kg (범위 2.44-17.90)이었고 CD34양성세포수의 중앙값은 11.0 x 10^(6)/kg (범위 0.8-78.35)이었다. 모든 환자가 이식 후 중앙치 10.0일(범위 8-15)에 말초혈액 과립구가 500 /mm³에 도달하였고 중앙치 9.0일(범위 0-18)에 혈소판이 20,000 /mm³에 도달하였다. 고용량 화학요법을 시행 받은 환자군의 추적기간의 중앙값은 24.6 개월 (범위 15.5-40.5)이었으며 총 13명의 환자 중 1명이 뇌전이로 인하여 사망하였으며 3명(23.1%)에서 재발이 관찰되었다. 대조군은 재발율이 25.6%이었고 무병생존율은 고용량 화학요법을 시행 받은 군(70.5%)과 대조군(78.8%) 사이에서 통계학적으로 의미 있는 차이를 나타내지 않았다 (P=0.744). 고용량 화학요법을 시행 받은 환자 중 10명 76.9%에서 발열이 관찰되었고 WHO 기준 3도 및 4도의 부작용은 혈액학적 부작용이 6예, 소화기적 부작용이 6예에서 관찰되었다. 결론: 고위험군 유방암 환자에서 CPB를 이용한 고용량화학요법 및 자가조혈모세포이식술은 안전하게 적용할 수 있는 치료의 한 방법이나 고용량 화학요법의 효과에 대해서는 앞으로 발표될 대규모 3상 연구의 결과를 주시해야 할 것으로 생각된다. Background: Despite the improvement of prognosis by multimodality therapy for the treatment of breast cancer, primary breast cancer patients with multiple involved axillary lymph node still have a high risk of recurrence. Methods: Between January 1998 and May 2000, we treated 13 women with histologically proven stage II or III breast cancer with 4 or more axillary lymph nodes at the time of primary mastectomy with high-dose chemotherapy and autologous stem cell transplantation. Results: The median age was 45 years (range: 32-57) and the median number of involved lymph node was 13 (range: 6-31). Ten patients were premenopausal state and 40 percent were positive hormone receptor. Seven patients received radiation therapy. Patients were treated with high-dose CPB (cyclophosphamide 2 g/m² D-5--3, cisplatin 55 mg/m² D-5--3, BCNU 450 mg/m² D-6) with autologous peripheral blood stem cell transplantation after 2-4 cycles of adjuvant chemotherapy (CAF, CEF or AC). We compared those patients with age and other clinical factors-matched 39 patients who received conventional adjuvant chemotherapy. The median follow-up for surviving patients who received high-dose chemotherapy was 25.6 months. The relapse rate and 2-year relapse-free survival was 23.1%, 25.6% and 70.5%, 78.8% for high-dose and conventional dose chemotherapy, respectively, but there was no significant difference between two groups (P>0.05). Conclusion: Further follow-up and additional studies are required to resolve the role of high-dose chemotherapy with autologous stem cell transplantation in high-risk breast cancer.

담도 및 췌장 악성종양에서의 CAl9-9의 진단적 가치에 대한 평가

명승재,최승목,김은옥,최호순,이성구,김명환,민영일,류진숙 大韓消化器病學會 1995 大韓消化器病學會誌 Vol.27 No.3

N₂분위기에서 Solder 접합부의 젖음성 및 결함특성에 관한 연구

최명기,황선효,이창배,정재필,서창제 大田産業大學校 2001 한밭대학교 논문집 Vol.18 No.-

본 실험을 통하여 대기와 N_2분위기에서의 젖음력과 솔더 접합부의 결함특성에 대하여 연구 검토하였다. 모든 시편 조건에서 질소분위기에서의 젖음성이 대기 중에서 젖음성 보다 좋아졌다. 또한 N_2유량이 증가함으로서 젖음 시간은 짧아지고, 젖음력은 증가하였다. N_2분위기에서 브리지(Bridge)발생률이 25∼76%정도로 현저히 감소하였다. N_2분위기에서는 젖음력의 향상으로 솔더 접합부가 안정되었으며 결함 발생률도 현저하게 감소되는 것을 확인할 수 있었다. This study was prepared to find out wettability and properties of defects on solder joints in N_2 conditions. The wettability of solder joints in N_2 condition was better than that in atmosphere condition, and when the flow rate of N_2 was increased, it is found that the wetting time got a little bit short and the wetting force got stronger as time passed. Also the rate of bridge defects was specially decreased in N_2 conditions, showing the decreasing ratio of 25∼76%. The solder joints were stabilized and the rate of defects was decreased by cause to increasement of wetting force in N_2 conditions.

6주간의 淸暑益氣湯 經口投與가 에너지대사 및 호르몬 변화에 미치는 영향

최용어,강명신,유종만,이규성,오재근,조준용 韓國體育大學校附屬 體育科學硏究所 1994 韓國體育大學校附屬 體育科學硏究所論文集 Vol.13 No.1

The purpose of this study was to investigate the effects of chung-seo-ik-gi -tang administration on the metabolic responses and hormones in 18 healthy-male elite boxes. All subjects were divided randomly with two groups, Chung-sea-ik-gi-tang Group(N=18) and placebo group(N=18) and perfored with 70% of HR max using bycicle ergometer unfil exhaustion. During the submaximal exercise, heart rate was maesured every two min. The blood samples were collected from antecubital vein by 10ml syranges(6ml/each) before immediately after exhaustion, recover-10 min, recover-20 min and recover-30 min. The samples were to analyzed for the level of glucose, lactate, TG, TC, HDL-C, insulin and catecholamine. The results of various blood parameters were summarized as follow; l. Energy substrates (plasma glucose, TG, TC, HDL-C) changes in group C were significantly different from group P. Plasma glucose in group C was significantly lowered at recover-10 min compared to group P (P<0.05). and also TG, TC and HDL-C in group C were significantly increased after 3 weeks compared to group P (P<0.05) whereas. Lactate accumulation in group C was significantly decreased after 3 weeks compared to group P (P<0.05). 2. Plasma insulin level was not showed significant difference between two groups. But insulin depression tendency after 3, 6 weeks in group C was allevated compared to group P. Increasing rate of norepinephrine in group C at Post-exhaustion after 3weeks lowered compared to group P. Norepinephrine in group C at rest periods after 3 weeks showed significant difference compared to group C. The results indicated that Chung-seo-ik-gi-tang had the effects of ergogenic aids on fatigue resistance and recovery from exhaustive exercise at the level of 70% HR max.

TFD 소자의 전기적 특성에 관한 상위전극의 영향

최희동,이명재,고동완,곽성관,김동식,정관수 慶熙大學校 레이저 工學硏究所 2002 레이저공학 Vol.13 No.-

In this work, we examined the electrical and mechanical characteristics of TFD devices for various top electrode materials by measuring barrier height and performing ASE depth profile. It was found that the shift of current-voltage(Ⅰ-Ⅴ) characteristics of TFD device depends on the top electrode material. The main reason of the asymmetry in Ⅰ-Ⅴ curve was the differences in barrier height of top and bottom electrodes, and chemical composition at the interface region between top electrode and insulator layer also was important reason. The barrier heights(φ_B) evaluated from temperature dependence of the Ⅰ-Ⅴ relation are 0.7795(Al) 1.0287(Ti) and 1.2928(Ta) eV.

재조합 균주 Bacillus subtilis LKS88에 의한 Streptomyces albus KSM-35 Amylase의 생산조건

최원진,유도진,이재우,소명환,김영배 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.4

Streptomyces albus KSM-35의 amylase의 유전자를 Bacillus subtilis LKS88에서 발현시킨 균주를 사용하여 amylase의 생산에 미치는 몇가지 요인들을 조사하였다. 본 실험에 사용한 탄소원들중에서 sodium citrate와 왕겨의 효소 생산량이 가장 높았고, 이들을 1:1의 비율로 혼합하여 첨가하였을 때 효소의 생산량은 대조군으로 사용한 가용성 전분에 비하여 20배 이상 증가하였다. 질소원으로 대두박을 사용하였을 경우 yeast extract의 첨가량을 줄이면서 효소의 생산량을 증가시켰다. 배양을 위한 초기 pH를 60으로 조절하고 SDS를 0.01%첨가하였을 때 대조구조보다 높은 효소 생산량을 나타내었다. Bacillus subtilis LKS88 (pASA240)을 sodium citrate와 왕겨 각각 1.5%, K_2HPO_4 0.66%, yeast extract 0.3%, 대두박 0.7%, SDS 0.01% 및 초기 pH를 6.0으로 조절한 배지에서 37℃에서 배양시 최대 효소 활성은 배양 후 36시간에서 나타났으며 이때 효소 활성은 56.6 U/ml이었다. The effects of culture conditions on the production of amylase expressed by Bacillus subtilis LKS88 with a cloned gene from Streptomyces albus KSM-35 were investigated The production of amylase was increased significantly by using sodium citrate and rice hull as a carbon source. In addition, the use of a mixture of sodium citrate and rice hull(1:1) resulted in increase of enzyme production by 20-fold when compared to that of soluble starch. The soybean meal as the nitrogen source could be partially replaced with yeast extract without changing the enzyme production yield. The amylase production was also increased by adjusting initial pH to 6.0 or by adding 0.01% SDS. Maximum amylase production was observed in the medium containing 1.5% sodium citrate, 1.5% rice hull, 0.7% soybean meal, 0.3% yeast extract, 0.66% K_2HPO_4, 0.05% MgSO_4·7H_2O, 0.08% CaCl_2·2H_2O, 0.01% SDS with initial pH of 6.0. The maximum yield of amylase reached 56.6 U/ml when B. subtilis LKS88(pASA 240) was cultured at 37℃ for 36 hr.

무선 ATM에서의 효율적인 자원할당 알고리즘

최명렬,조태경,권재우 漢陽大學校 工學技術硏究所 2000 工學技術論文集 Vol.9 No.1

본 논문에서는 셀을 섹터로 구분하고 이동국이 어느 섹터에 위치하는가를 추정하여 핸드오버할 확률이 가장 높은 최인접셀을 정하므로써 효율적인 대역폭 할당을 할 수 있는 핸드오버 알고리즘을 제안하였고, 서비스 트래픽을 실시간과 비실시간으로 구분하므로써 무선 멀티미디어 환경에 알맞은 대역폭 할당을 가능하게 했다. 또한 이에 적합한 무선 MAC프로토콜을 제안하여 구현하고자 하는 무선 ATM환경을 보다 구체적이며 실제적으로 나타냈다. 본 논문에서 제안한 알고리즘은 기존의 핸드오버 알고리즘과 SMPL로 비교 시뮬레이션하여 성능을 검증해 보았다. We propose the handover algorithm considering the position of mobile terminal and determining the most adjacent cell with the highest probability of handover. The proposed algorithm can make a effective bandwidth allocation and may be applicable to the condition of wireless multimedia. In addition, the proposed algorithm is considered efficient wireless MAC protocol. The simulation results of the proposed algorithm show better performance in both blocking probability and handover probability than conventional one.

유방암의 뇌하수체 전이에 의한 양안 시력소실 1 예

최낙원,안명주,김재민,박동우,박용욱 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Pituitary gland metastasis is a rare clinical diagnosis, usually made in the setting of known primary systemic cancer with widespread metastasis to other organs. But visual loss as a presenting symptom of metastasis to the pituitary gland is unusal. We report here a case of 45-year-old woman who had been diagnosed as having metastatic breast cancer involving bone and liver 2 years ago, and received high dose chemotherapy with peripheral blood stem cell transplantation, developed sudden bilateral complete visual loss. At initial presentation, the patient had no light perception and no pupillary response to light in both eyes, but without evidence of panhypopituitarism, or diabetes insipidus. Brain MRI showed a large enhanced mass invasion to the cavernous sinus and extension to the suprasella portion without dura or base-of-skull metastasis. Pathologic examination showed metastatic breast cancer. Despite the transsphenoidal decompression surgery of metastatic tumor, the visual loss was not improved.