강박증 환자에서 신경 심리 검사를 통한 전두엽 기능에 관한 연구

안경흡,김명선,김연수,박은희,박선희,신민섭,류인균,권준수 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 강박증 환자에서 비언어적 기억의 장애, 실행능력(executive function)의 장애, 시공간능력의 장애등의 신경 인지 기능의 장애 및 뇌 영상 연구에서 전두엽-기저핵 신경로의 기능장애가 있다는 결과들이 보고되어 왔다. 저자들은 전두엽의 기능을 반영하는 것으로 알려진 신경 심리 검사를 통하여 강박증 환자의 전두엽의 기능적 변화의 유무 및 기타 인지기능에 미치는 영향에 대해서 평가하고자 하였다. 방 법 : 서울대학교병원 강박증 클리닉에 내원한 32명의 강박증 환자군과 28명의 정상 대조군을 대상으로 강박증상의 중증도에 대한 평가와 함께 한국판 단축형 지능검사(Short-form of K-WAIS)와 주로 전두엽 기능을 평가하는데 민감한 것으로 알려진 신경 인지 기능 검사군(위스콘신 카드 분류 검사, Rey-Os-terrieth Complex Figure test, Controlled Oral Word Association test, 선로 잇기 검사, Luria-Nebraska 신경심리 바테리 중 언어학습능력검사)을 시행하였다. 이 검사들의 결과를 연령과 교육연수를 통제한 후에 ANCOVA로 분석하였다. 결 과 ; 강방증 환자군은 범주적 언어 유창성 점수(ANCOVA, F=15.07, df=58, p<0.001), Rey-Os-terrieth Complex Figure test의 즉각 회상 점수(ANCOVA, F=6.33, df=57, p<0.015), Rey-Os-terrieth Complex Figure test의 지연 화상 점수(ANCOVA, F=5.33, df=57, p<0.022)가 정상 대조군에 비하여 유의하게 저하되어 있었다. 결 론 : 이 결과는 강박증 환자들이 전두엽의 특징적인 기능으로 알려진 실행기능보다는 비언어적 기억능력의 장애 및 언어능력의 장애를 가지고 있음을 시사한다. Objective : Non-verbal memory deficits, impairments in executive function and deficits in visuospartial functions have been repeatedly reported in subjects with obsessive-compulsive disorder(OCD). The present study aimed to evaluate the frontal lobe function using neuropsychological test in subjects with OCD and normal control. Methods : A battery of neuropsychological test(Wisconsin Card Sorting test, Rey-Osterrieth Complex Figure test, Controlled Oral Word Association test, Trail Making test, Verbal Learning test) reflecting frontal lobe function was administrated to 32 OCD patients and 28 healthy comparison subjects. Result : There were no significant differences in age, years of education, or estimated IQ between the groups. Scores in category fluency, immediate recall and delayed recall of Rey-Osterrieth Complex Figure test in OCD subjects were significantly lower than those of healthy comparison subjects(ANCOVA, F=15.07, df=58, p<0.001 ;ANCOVA, F=6.33, df=57, p<0.015 ; ANCOVA, F=5.33, df=57, p<0.022, respectively). Conclusion : OCD patients had selective deficits in task involving non-verbal memory and categorical word fluency relative to healthy comparisons.

Enhancement of Proton Conductivity at Low Humidity of Proton Conducting Membranes with Triazole moieties in the Side Chains

Min-Kyoon Ahn,Su-Bin Lee,Cheong-Min Min,Yong-Guen Yu,Joseph Jang,Jae-Suk Lee 한국고분자학회 2016 한국고분자학회 학술대회 연구논문 초록집 Vol.41 No.2

Facile preparation of blend proton exchange membranes with highly sulfonated poly(arylene ether) and poly(arylene ether sulfone) bearing dense triazoles

Ahn, Min-Kyoon,Lee, Bongho,Jang, Joseph,Min, Cheong-Min,Lee, Su-Bin,Pak, Chanho,Lee, Jae-Suk Elsevier 2018 Journal of membrane science Vol.560 No.-

<P><B>Abstract</B></P> <P>A novel series of blended polymer electrolyte membranes (PEMs) from crosslinked sulfonated poly(arylene ether) (cSPAE100) and triazole-containing poly(arylene ether sulfone) (PAES-DTM) were prepared for fuel cell applications. cSPAE100 with a high degree of sulfonation was synthesized via aromatic condensation. PAES-DTM densely functionalized with di-triazole moieties was blended with cSPAE100. The blend ratios of the fabricated PEMs varied from 2 wt% to 10 wt%, and the blend PEMs (cSPAE-DTMs) displayed sufficiently high ion exchange capacities (IEC = 2.07–1.86 mequiv/g). Introducing the triazole moieties, the proton conductivities of cSPAE-DTM2 and cSPAE-DTM5 increased at high relative humidity (95% RH), whereas their IEC values decreased. Furthermore, evaluation of the cell performance at 80 °C revealed that the performance of the cSPAE-DTMs was superior to that of the pristine membrane under 50% RH. For practical application in fuel cells, the thermal, chemical and mechanical properties of all membranes were investigated.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Preparation of proton exchange membranes by acid-base polymer blend. </LI> <LI> Polymer with dense triazoles in the side chains for a high triazole content. </LI> <LI> Improved proton conductivities of blend membranes with reduced ion exchange capacity. </LI> <LI> Increased fuel cell performances of blend membranes under reduced humidity condition. </LI> <LI> Maintaining thermal and mechanical stabilities of blend membranes. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Can We Skip Intraoperative Evaluation of Sentinel Lymph Nodes? Nomogram Predicting Involvement of Three or More Axillary Lymph Nodes before Breast Cancer Surgery

Ahn, Soo Kyung,Kim, Min Kyoon,Kim, Jongjin,Lee, Eunshin,Yoo, Tae-Kyung,Lee, Han-Byoel,Kang, Young Joon,Kim, Jisun,Moon, Hyeong-Gon,Chang, Jung Min,Cho, Nariya,Moon, Woo Kyung,Park, In Ae,Noh, Dong-You 대한암학회 2017 Cancer Research and Treatment Vol.49 No.4

<P><B>Purpose</B></P><P>The American College of Surgeons Oncology Group Z0011 trial reported that complete dissection of axillary lymph nodes (ALNs) may not be warranted in women with clinical T1-T2 tumors and one or two involved ALNs who were undergoing lumpectomy plus radiation followed by systemic therapy. The present study was conducted to identify preoperative imaging predictors of ≥ 3 ALNs.</P><P><B>Materials and Methods</B></P><P>The training set consisted of 1,917 patients with clinical T1-T2 and node negative invasive breast cancer. Factors associated with ≥ 3 involved ALNs were evaluated by logistic regression analysis. The validation set consisted of 378 independent patients. The nomogram was applied prospectively to 512 patients who met the Z0011 criteria.</P><P><B>Results</B></P><P>Of the 1,917 patients, 204 (10.6%) had ≥ 3 positive nodes. Multivariate analysis showed that involvement of ≥ 3 nodes was significantly associated with ultrasonographic and chest computed tomography findings of suspicious ALNs (p < 0.001 each). These two imaging criteria, plus patient age, were used to develop a nomogram calculating the probability of involvement of ≥ 3 ALNs. The areas under the receiver operating characteristic curve of the nomogram were 0.852 (95% confidence interval [CI], 0.820 to 0.883) for the training set and 0.896 (95% CI, 0.836 to 0.957) for the validation set. Prospective application of the nomogram showed that 60 of 512 patients (11.7%) had scores above the cut-off. Application of the nomogram reduced operation time and cost, with a very low re-operation rate (1.6%).</P><P><B>Conclusion</B></P><P>Patients likely to have ≥ 3 positive ALNs could be identified by preoperative imaging. The nomogram was helpful in selective intraoperative examination of sentinel lymph nodes.</P>

Effects of Non-ionic Surfactant Supplementation on Ruminal Fermentation, Nutrient Digestibility and Performance of Beef Steers Fed High-roughage Diets

Ahn, Gyu-chul,Kim, Jeong-hoon,Park, Eun-kyu,Oh, Young-Kyoon,Lee, Gang-yeon,Lee, Jung-il,Kim, Chong-min,Park, Keun-kyu Asian Australasian Association of Animal Productio 2009 Animal Bioscience Vol.22 No.7

Three experiments were conducted to determine the effects of non-ionic surfactant (NIS) supplementation on ruminal fermentation, nutrient digestibility and performance of beef steers fed high-roughage diets. The objective of experiment 1 was to investigate the effects of NIS supplementation on in vitro ruminal fermentation of cultures administered with corn and barley as grain substrate and rice straw and timothy hay as roughage substrate. The in vivo ruminal fermentation, nitrogen balance and digestibility of nutrients were also examined with steers fed a high-roughage diet in experiment 2. The aim of experiment 3 was to determine the responses to NIS of growing steers fed a high-roughage diet. In experiment 1, ammonia nitrogen concentration for NIS supplementation was higher (p<0.05) than for the control with all substrates. However, concentrations of total volatile fatty acid (VFA), acetate, butyrate and valerate of the incubated roughage substrates, rice straw and timothy hay, were higher (p<0.05) for NIS supplementation than for the control whereas VFA concentrations in the cultures of corn and barley were unaffected. These results indicated that effects of NIS on ruminal fermentation are diet dependent, specifically on roughage sources. In experiment 2, ruminal pH of steers supplemented with NIS was lower (p<0.05) than the control. Ruminal concentrations of ammonia nitrogen, acetate, total VFA and urinary concentrations of purine derivatives were increased (p<0.05) by NIS supplementation. In experiment 3, supplementation of NIS increased (p<0.05) intakes of total feed and corn silage, average daily gain, and feed efficiency of growing steers although they varied depending on supplementation level. Due to the roughage-specific feature of NIS effects, NIS appears to enhance ruminal fermentation of fibrous parts of feeds and, consequently, performance of steers fed a high-roughage diet.

광반응 결사슬기로서 4-스티릴피리딘유도체를 가지는 용해성 폴리이미드의 합성과 광배향

김민우(Min Woo Kim),안득균(Deuk Kyoon Ahn),이동호(Dong Ho Lee),박이순(Lee Soon Park),서관호(Kwan Ho Seo),하기룡(Ki Ryong Ha),김우식(Woo Sik Kim) 한국고분자학회 2004 폴리머 Vol.28 No.4

Nomogram for Predicting Breast Conservation after Neoadjuvant Chemotherapy

Kim, Min Kyoon,Han, Wonshik,Moon, Hyeong-Gon,Ahn, Soo Kyung,Kim, Jisun,Lee, Jun Woo,Kim, Ju-Yeon,Kim, Taeryung,Lee, Kyung-Hun,Kim, Tae-Yong,Han, Sae-Won,Im, Seock-Ah,Kim, Tae-You,Park, In Ae,Noh, Dong Korean Cancer Association 2015 Cancer Research and Treatment Vol.47 No.2

<P><B>Purpose</B></P><P>The ability to accurately predict the likelihood of achieving breast conservation surgery (BCS) after neoadjuvant chemotherapy (NCT) is important in deciding whether NCT or surgery should be the first-line treatment in patients with operable breast cancers.</P><P><B>Materials and Methods</B></P><P>We reviewed the data of 513 women, who had stage II or III breast cancer and received NCT and surgery from a single institution. The ability of various clinicopathologic factors to predict the achievement of BCS and tumor size reduction to ≤ 3 cm was assessed. Nomograms were built and validated in an independent cohort.</P><P><B>Results</B></P><P>BCS was performed in 50.1% of patients, with 42.2% of tumors reduced to ≤ 3 cm after NCT. A multivariate logistic regression analysis showed that smaller initial tumor size, longer distance between the lesion and the nipple, absence of suspicious calcifications on mammography, and a single tumor were associated with BCS rather than mastectomy (p < 0.05). Negative estrogen receptor, smaller initial tumor size, higher Ki-67 level, and absence of <I>in situ</I> component were associated with residual tumor size ≤ 3 cm (p < 0.05). Two nomograms were developed using these factors. The areas under the receiver operating characteristic curves for nomograms predicting BCS and residual tumor ≤ 3 cm were 0.800 and 0.777, respectively. The calibration plots showed good agreement between the predicted and actual probabilities.</P><P><B>Conclusion</B></P><P>We have established a model with novel factors that predicts BCS and residual tumor size after NCT. This model can help in making treatment decisions for patients who are candidates for NCT.</P>

울산항 위험물 환적부두 지정을 위한 폭발 위험성 평가에 관한 연구

강민균(Min-Kyoon Kang),이윤석(Yun-Sok Lee),안영중(Young-Joong Ahn) 한국항해항만학회 2021 한국항해항만학회지 Vol.45 No.3

울산항 부두에 이중 접안하여 환적작업 중이던 케미컬 탱커선 폭발로 주변 선박화재 등 울산항 내에서 큰 피해가 발생하였다. 유사 사고의 재발을 방지하기 위한 후속 조치로 ‘항만 내 위험물 안전관리 종합대책’이 수립되었으며 사고 발생 시에 폭발 위험성과 항내 주요시설에 대한 영향 등을 고려한 위험물 환적부두의 지정이 요구된다. 본 연구는 폭발 위험성 기반의 환적부두 제시를 위하여 울산항 주요 환적화물 대상의 Fire & Explosion Index 평가를 실시하였다. 스티렌모노머와 벤젠의 Fire & Explosion Index 평가결과 심각한 폭발 위험성을 확인하였고, 평가결과를 기준으로 노출반경을 산출 하였다. 노출반경 결과를 기반으로 주요 부두별 위험범위를 산정하였으며, 항만시설, 주변 위험시설 및 거주시설을 고려한 환적가능 부두 후보지로 12개 부두를 제시하였다. 본 연구는 위험반경만을 고려하였기 때문에 향후 실질적인 위험물 환적 부두의 지정 시에는 해상교통안전성, 부두 및 계류시설, 안전설비 및 비상대응을 위한 접근성 등을 종합적으로 고려하여 결정하여야 할 것이다. The explosion of a chemical tanker ship during cargo transshipment via double-banking at Ulsan Port, resulted in major damage including fires involving nearby ships. As a follow-up measure to prevent the recurrence of similar accidents, the Safety Management of Dangerous Goods in Port was established, and the designation of a transshipment pier for dangerous goods is required given the risk of explosion and the impact on major facilities in the port. This study evaluated the Fire & Explosion Index of major transshipment cargoes in Ulsan Port to design a transshipment pier based on the Explosion Risk Assessment. Based on the results of Fire & Explosion Index evaluation of styrene monomer and benzene, severe explosion risk was confirmed, and the exposure radius was calculated. Based on the results of the exposure radius, the risk range for each major pier was calculated, and 12 terminals were proposed as transshipment pier candidates considering port facilities, surrounding dangerous facilities, and residential aspects. Since the results of the study suggest transshipment piers based on the risk radius alone, maritime traffic safety, pier and mooring facilities, safety facilities and accessibility for emergency response should be considered comprehensively to designate actual transshipment piers.

A Case of Intrapericardial Extralobar Pulmonary Sequestration -First case in Korea

Chul Min Ahn,Hyung Jung Kim,Hyun Keun Cho,Sung Kyu Kim,Won Young Lee,Sang Jin Kim,Hae Kyoon Kim,Doo Yun Lee,Ki Bum Lee 대한내과학회 1991 The Korean Journal of Internal Medicine Vol.6 No.2

Rapidly Progressive Pericardial Effusion and Cardiac Tamponade in a Term Infant with an Umbilical Venous Catheter: A Case Report

Park Min-Jung,Ahn Ja-Hye,Lee Hyun Ju,박현경,Hwang Jae-Kyoon,Kim Chang-Ryul,나재윤 대한신생아학회 2022 Neonatal medicine Vol.29 No.4

Pericardial effusion (PCE) in neonates has various clinical presentations depending on the amount and speed of fluid accumulation and can cause cardiac tamponade (CT). We report a case of rapidly accumulating PCE and near-fatal CT with an umbilical venous catheter successfully resolved by emergent echo-guided pericardiocentesis in a term infant who had been hospitalized with meconium aspiration syndrome and persistent pulmonary hypertension. This case report suggests that if a patient with an intracardiac umbilical catheter shows sudden cardiopulmonary instability, the possibility of PCE and CT should be considered. Furthermore, if necessary, emergency drainage of the PCE and removal of the umbilical catheter should be immediately performed.