성장기 아동에서 전치부 개교의 치료증례 : A CASE FEPORT

육근영,양규호,최남기,김선미 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.2

전치부 개교는 중심 교합시 수직선상에서 상하악 전치간에 교합이 되지 않는 상태이며, 부정교합의 특성과 원인이 치료계획에 중요한 역할을 한다. 혼합 치열기에 전치부 개교의 치료 목적은 악습관을 조절하고 입 주위 근육의 비정상적인 기능을 제거하며, 악정형 장치를 통해 하악의 수직성장을 수평성장으로 전환하는 것이며, 치료 후의 안정성을 위해 계속적인 관찰이 필요하다. 본 증례에서는 혀내밀기 습관이 동반된 전치부 개교 환아의 치료를 위해 습관을 차단하는 tongue crib과 그 밖에 다양한 가철성 및 고정성 장치를 사용하여 양호한 결과를 얻었기에 보고하는 바이다. Anterior open bite is defined as the lack of contacts between the functional occluding teeth on vertical line at centric occlusion and classified into functional and skeletal anterior open bite based on its causes and characteristics. In mixed dentition, habit control and the elimination of abnormal perioral muscle function and moving the vertical direction development to the sagittal direction of the mandible by the functional appliance is a goal of treatment. This study presents the effective interception of oral habit by the tongue crib and functional-fixed treatment and treatment response of open bite related to tongue thrust habit.

산성 불소가 복합레진 표면에 미치는 영향

양규호,육근영,최남기,김선미 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.2

복합레진 수복은 치아우식 및 치아우식 예방치료를 위한 대표적인 술식으로 소아치과 영역에서 널리 시행되고 있으며 불소도포는 치아우식 예방을 위한 대표적인 술식으로 1년에 2번 정도 실시되고 있다. 하지만 이러한 이점에도 불구하고 Acidulated phosphate fluoride(APF)가 복합 레진의 표면을 거칠게 한다는 부작용에 대한 논란이 있다. 이에 본 연구에서는 불소도포가 복합레진의 표면에 미치는 영향을 평가하기 위해 시판용 레진인 Solitaire 2^(®)(Heraeus Kulzer, Germany), Metafil CX^(®)(Sun medical, Japan), Composan LCM^(®)(Promedica, Germany), Charmseal^(®)(DenKist, Korea)을 이용하여 시편을 제작하고, 불소젤은 Topex^(®)(Sultan Dental Products, Canada)를 각각 1분과 4분동안 도포시킨 후 변화를 관찰하여 다음과 같은 결과를 얻었다. 1. 불소젤을 도포시키지 않은 대조군에서 가장 평활한 표면을 보였으며 1분군, 4분군 순으로 표면 거칠기가 증가하였다. 그리고 Composan LCM^(®)을 제외한 모든 제품에서 유의한 차이를 보였다(p<0.05). 2. 국소도포용 불소젤을 도포한 각 레진 시편의 무게 차이를 비교한 결과 대조군, 1분군, 4분군 간에 유의한 차이는 없었다(p>0.05). 3. 주사전자현미경 관찰시 불소젤을 도포시킨 실험군은 대조군에 비해 거친 표면을 나타내었다. Composite resin restorations are widely used to restore decayed teeth or preventive restoration in children. Children often receive topical fluoride treatments on a semiannual basis. However there is concern that topical acidulated phosphate fluorides (APF) may cause deterioration of composite resins. The aim of this study was to evaluate the surface changes in composite resins due to topical fluoride application. Composite resins(Solitaire 2^(®), Metafil CX^(®), Composan LCM^(®), Charmseal^(®)) in topical fluoride agents were immersed and their surface roughness, weight loss and SEM findings were evaluated. The results were as follows: 1. The 4 minutes-immersion group showed more roughened surface than 1 minute-immersion group and the control group showed the smoothest surface among all the materials, and there was statistically significant difference between the groups except the Composan LCM^(®)(P<0.05). 2. There was no significant difference between the 1 minute-immersion group and 4 minutes-immersion group in weight loss (P>0.05). 3. The experimental group treated with topical fluoride gel showed generally more roughened surface than control group in the SEM findings.

위절제술 환자의 표준진료지침 개발 및 적용 효과

김은희,김철규,이순교,김순덕,이혜옥,권정순,이경미,이민미,심순미,유용만,신종식,강은희,이상일,김병식,오성태,육정환,박수길 한국의료QA학회 2003 한국의료질향상학회지 Vol.10 No.2

Background : Gastric cancer is the most common malignant tumor in Korea. surgical operation is one of the major treatment modalities for gastric cancer patients. Therefore, gastrectomy is one of the most common procedures in General Surgery. There were variation in length of hospital stay and medical treatment for gastrectomy between three surgeons at Asan Medical Center. Clinical pathways have received considerable attention as a tool for recucing the medical practice variation, increasing the efficiency of care process, and improving the quality of care. The aim of this study was to evaluate the effect of a clinical pathway for gastrectomy in gastric cancer patients. Methods : The clinical pathway for gastrectomy was developed and implemented by a multidisciplinary group in Asan Medical Center. A computerized clinical pathway program was developed and revised after a pilot test. A total of 145 patients underwent gastrectomy by three surgeons at Asan Medical Center. We compared the length of hospital stay, patient satisfaction, and unplanned readmission rate between the pre-pathway group(n=67) and the post-pathway group(n=78). We also investigated the degree of satisfaction among the physicians and nurses who were main end-users of the clinical pathway. Results : The clinical pathway was applied to all target patients. The average length of hospital stay was shortened from 12.7days to 10.6days(p<0.01). The degree of patient satisfaction with the care process changed from 90.3% to 89.2% after the implementation of the clinical pathway, but the difference was of satistically significant(p=0.761). Unplanned readmission rate was 2.9% in the pre-pathway group. More than 90% of physicians and nurses answered that the clinical pathway had been a useful tool in their medical practice. Conclusions : The findings of the study demonstrated that implementation of the clinical pathway for gastrectomy produced substantial reduction in the length of hospital stay while improving the quality of patient outcomes. The computerized clinical pathway program can be used as one of the powerful patient management tools for reducing the practice variations and increasing the efficiency of care process in Korea hospital settings.

Efficient lipid extraction from the oleaginous yeast <i>Yarrowia lipolytica</i> using switchable solvents

Yook, Sang Do,Kim, Jiwon,Woo, Han Min,Um, Youngsoon,Lee, Sun-Mi Pergamon 2019 RENEWABLE ENERGY Vol.132 No.-

<P><B>Abstract</B></P> <P>Biodiesel production using oleaginous yeasts, such as <I>Yarrowia lipolytica</I>, has recently attracted strong attention in terms of lipid yield and productivity. However, efficient methods of lipid extraction from oleaginous yeasts are required to further improve the economic feasibility of yeast-based biodiesel production. We investigated the effectiveness of selected switchable hydrophilicity solvents (SHSs), namely, N-ethylbutylamine (EB), N-dipropylamine (DP), and N,N-dimethylcyclohexyl-amine (DMCHA), for lipid extraction from the oleaginous yeast <I>Y. lipolytica</I>. Regardless of using harvested cells or culture broth, DMCHA and EB effectively extracted lipids from <I>Y. lipolytica</I>, resulting in up to 13% higher lipid yields than that obtained by conventional organic solvent extraction using a chloroform/methanol mixture. The lipid extracts obtained by the SHSs showed fatty acid compositions comparable to that obtained with the conventional solvent, thus assuring the quality of biodiesel produced through this method. After switching processes by purging with CO<SUB>2</SUB> and N<SUB>2</SUB>, the lipids and solvents were successfully recovered, demonstrating the practicability of lipid extraction using SHSs. Consequently, this study provides an effective lipid extraction method for <I>Y. lipolytica</I> that could significantly improve energy efficiency and economic feasibility of an oleaginous-yeast-based biodiesel production process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Lipids were extracted from <I>Yarrowia lipolytica</I> by SHSs (DMCHA, EB, and DP). </LI> <LI> DMCHA and EB showed up to 13% higher yields relative to the conventional method. </LI> <LI> Lipids were effectively extracted from both harvested wet cells and culture broth. </LI> <LI> This extraction method would improve energy efficiency and economic feasibility. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Leafy Vegetable Mix Supplementation Improves Lipid Profiles and Antioxidant Status in C57BL/6J Mice Fed a High Fat and High Cholesterol Diet

Mi Yeon Kim,정선희,Min Hee Kim,ChanWok Son,Hong-Sun Yook,석대은,김진희,YongSik Cho,김미리 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.4

Daily consumption of an antioxidant-rich leafy vegetable mix (LVM) was assessed for beneficial effects on plasma lipid profiles, tissue lipid peroxidation, and oxidative DNA damage in C57BL/6J mice fed a high fat and high cholesterol diet (20% fat and 1% cholesterol, wt/wt) for 4 weeks. The LVM contained beet leaf, angelica, red leaf lettuce, dandelion, green cos lettuce, lollo rosso, romaine lettuce (12.5%, respectively), scotch kale, and red kale (6.25%, respectively). The mice (n=16) were randomly divided into either the control (high fat and cholesterol diet without LVM) or the LVM (high fat and cholesterol diet with 8% LVM supplement) groups after a 1-week acclimation. Lipid peroxidation as measured by thiobarbituric acid-reactive substances in the plasma, liver, heart, and kidney was significantly lower. Antioxidants (glutathione and β-carotene) and antioxidant enzyme activities (glutathione peroxidase, glutathione reductase, and superoxide dismutase) were improved in mice fed LVM diet. In the comet assay, tail extent moment, olive tail moment, and tail length were significantly less in the hepatocyte and lymphocyte DNA of the LVM group, indicating the beneficial effect of LVM on the resistance of hepatocytes and lymphocytes DNA to oxidative damage. Findings from the present study suggest that dietary supplementation with LVM may be useful for protecting cells from lipid peroxidation and oxidative DNA damage.

Antioxidant activity of Corni Fructus Nabak Kimchi, Yoghurt Kkakdugi, Onion Jangajji

Mi-Hwa Tae,Kyoung-Hee Kim,Hong-Sun Yook 한국식품영양과학회 2013 한국식품영양과학회 학술대회발표집 Vol.2013 No.11

Antioxidant Activity of Hexane and Dichloromethane Fraction from Kaempferia parviflora Powder

Mi-Hyun Choi,Hong-Sun Yook 한국생활과학회 2017 한국생활과학회 학술대회 Vol.2017 No.12

Differential Expression of $PKD2$-Associated Genes in Autosomal Dominant Polycystic Kidney Disease

Yook, Yeon-Joo,Woo, Yu-Mi,Yang, Moon-Hee,Ko, Je-Yeong,Kim, Bo-Hye,Lee, Eun-Ji,Chang, Eun-Sun,Lee, Min-Joo,Lee, Sun-Young,Park, Jong-Hoon Korea Genome Organization 2012 Genomics & informatics Vol.10 No.1

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by formation of multiple fluid-filled cysts that expand over time and destroy renal architecture. The proteins encoded by the $PKD1$ and $PKD2$ genes, mutations in which account for nearly all cases of ADPKD, may help guard against cystogenesis. Previously developed mouse models of $PKD1$ and $PKD2$ demonstrated an embryonic lethal phenotype and massive cyst formation in the kidney, indicating that $PKD1$ and $PKD2$ probably play important roles during normal renal tubular development. However, their precise role in development and the cellular mechanisms of cyst formation induced by $PKD1$ and $PKD2$ mutations are not fully understood. To address this question, we presently created $Pkd2$ knockout and $PKD2$ transgenic mouse embryo fibroblasts. We used a mouse oligonucleotide microarray to identify messenger RNAs whose expression was altered by the overexpression of the $PKD2$ or knockout of the $Pkd2$. The majority of identified mutations was involved in critical biological processes, such as metabolism, transcription, cell adhesion, cell cycle, and signal transduction. Herein, we confirmed differential expressions of several genes including aquaporin-1, according to different $PKD2$ expression levels in ADPKD mouse models, through microarray analysis. These data may be helpful in $PKD2$-related mechanisms of ADPKD pathogenesis.

Comparison of Antioxidant Activities in Tomato Bagel and Tomato Cookie Added Tomato Powder

Mi Hwa Tae,Kyoung Hee Kim,Hong Sun Yook 한국식품영양과학회 2015 한국식품영양과학회 학술대회발표집 Vol.2015 No.8

동결건조 들깻잎 분말을 첨가한 머핀의 품질특성

윤미향(Mi-Hyang Yoon),김경희(Kyoung-Hee Kim),김나영(Na-Young Kim),변명우(Myung-Woo Byun),육홍선(Hong-Sun Yook) 한국식품영양과학회 2011 한국식품영양과학회지 Vol.40 No.4

기능성 소재로서의 들깻잎 분말의 이용가능성을 알아보기 위해 들깻잎 분말 0, 3, 6 및 9% 첨가한 머핀을 제조하여 품질 특성을 조사하였다. 머핀의 무게는 들깻잎 분말 첨가량이 증가할수록 감소하였고, 굽기손실률 및 높이는 증가하였다. 넓이는 윗넓이, 밑넓이 모두 들깻잎 분말 첨가에 따른 일정한 경향을 보이지 않았다. 머핀의 색도는 첨가량이 증가할수록 L, b값은 감소하였고, a값은 유의차가 나타나지 않았다. 물성 측정결과 경도와 탄력성은 들깻잎 분말 첨가량에 따라 유의차를 나타내지 않았으며, 응집성, 검성, 씹힘성은 들깻잎 분말 첨가에 따른 일정한 경향을 보이지 않았다. 항산화 활성 측정결과는 들깻잎 분말 첨가량이 증가할수록 증가하는 경향을 보였으며, 관능 측정 결과 동결건조 들깻잎분말 3∼6%(w/w)로 첨가할 시 개발가능성이 있는 것으로 나타났다. This study investigated the quality of muffin prepared with various concentrations of freeze dried-perilla leaves (Perilla frutescens var. japonica HARA) powder. Muffin was prepared by addition of 0, 3, 6 and 9% powder to the flour of basic formulation. The weight of muffin decreased with increase in freeze dried-perilla leaves powder concentration, but no constant tendency in the bottom and upper dimensions by its addition was found. The height and baking loss rate of the muffin increased with increase in the powder concentration but with no significant differences. Lightness and yellowness of muffin decreased as the concentration of the powder increased, whereas no significant differences in the redness was found with increased powder concentration. The hardness of muffin increased, and springiness decreased with increase in the powder concentration, although not significant. The cohesiveness, gumminess and chewiness showed no consistent tendency by addition of the powder. The antioxidative activity measured by 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity of muffin increased as the concentration of the powder increased. The muffin contained 0∼6% freeze dried-perilla leaves powder had acceptable sensory properties, such as color, taste, and overall acceptability. Results indicated that optimal concentration of freeze dried-perilla leaves powder into the muffin formula was 3∼6%(w/w).