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다변량 역추정 모형에서 경험적 베이스 추정량에 관한 연구
이상호,박래현 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2
In the multivariate calibration model, we propose a new Empirical Bayes estimator(EB estimator) which enables us to predict the panameter of interest. The EB estimator is a compromised type between the classical estimator and the inverse estimator, and attains better precision than any other estimator in Brown(1982).
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이상호,박래현 충남대학교 기초과학연구소 1995 忠南科學硏究誌 Vol.22 No.2
In the simple calibration model, Maritz(1970) gave an empirical Bayes estimator of x_0 when y_01, …, y_0k on x_0 are observed. However, his estimator can not be applied in case k 1 which is occurred more often than not. We propose a new empirical Bayes estimator of x_0 which enables us to predict x_0 for all k and is a compromise between the classical estimator and the inverse estimator.
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박래현,이석훈,김응환 충남대학교 1996 忠南科學硏究誌 Vol.23 No.1
In spite of the debate on fuzzy methods that they may provide an altermative to probabilistic and statistical methods, both approaches are going to give way to collaboration in the very practical fields. In this paper we review the area of fuzzy clustering in which the two approaches get along with each other. The current research interest and direction is discussed and a newly developed algorithm that prevents the output from being fuzziness as much as possible is presented with an illustration.
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박상호,온영근,김현정,이태훈,길효욱,김현건,박수진,송해정,한대희,방덕원,신원용,이내희,김성구,권영주 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1
Background : Microvascular angina or syndrom X is heterogenous and encompasses different pathogenetic entities. Several studies suggest that microvascular angina have good prognosis and occurs predominantly in postmenopausal women. Lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and fibrinogen are the independent risk factor of acute coronary syndrome and are the chief underlying cause of atherosclerosis. We investigated clinical characteristics and markers in patients with microvascular angina. Methods : We studies 23 patients diagnosed with microvascular angina and 16 control group with negative treadmill exercise test and no significant coronary angiogram. We investigated clinical characteristics in patients group and evaluated symptom during a follow-up period of 4.2± 2.5 month. Exercise time in treadmill exercise test was compared between patients and control group. We assessed the level of markers, such as lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and ESR in two groups. Results : There is no difference in age between two groups. Patients group had a tendency to increase in female, hypertension, DM, and smoking history, but there was no statistical significance difference. Exercise duration time was significantly decreased in patients with microvascular angina (p<0,05). Serum lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholestrol, Triglyceride, ESR, Fibrinogen and Homocystein value were no significant difference between microvascular angina and control group. Only CRP was significantly high in patients with microvascular angina (p<0.05). Conclusion : There was no statistical significance difference in age, sex, hypertension, DM and smoking history between two groups but patients group had a tendency to increase the prevalence in hypertension, DM and smoking history, female. Also, Symptom improvement and disappearance in follow-up was presented in 11 patients of 19(57.9%). Exercise tolerance was worse in patients group than control group. CRP value was significantly higher in patients group than control group. There was no statistical significance difference in lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, ESR and Fibrinogen between two groups.
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( Nae Yun Heo ),( Young Suk Lim ),( Woochang Lee ),( Minkyung Oh ),( Jiyun An ),( Dan Bi Lee ),( Ju Hyun Shim ),( Kang Mo Kim ),( Han Chu Lee ),( Yung Sang Lee ),( Dong Jin Suh2 ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. Methods: This was a retrospective cohort study of 156 patients with chronic hepatitis C virus (HCV) infection who received combination treatment of PEG-IFN plus RBV. Blood samples from these patients were analyzed to identify the IL28B SNPs at rs12979860, rs12980275, rs8099917, and rs8103142. Association analyses were performed to evaluate the relationships between each IL28B SNP and SVRs. Results: Seventy six patients with HCV genotype 1 and 80 with genotype non-1 were enrolled. The frequencies of rs12979860 CC and CT genotypes were 90.4% and 9.6%, respectively; those of rs12980275 AA and AG genotypes were 87.2% and 12.8%, respectively; those of rs8099917 TT and TG genotypes were 92.3% and 7.7%, respectively; and those of rs8103142 TT and CT genotypes were 90.4% and 9.6%, respectively. Among the patients with HCV genotype 1, the SVR rates were 69.7% and 80.0% for rs12979860 CC and CT, respectively (P=0.71). Among the HCV genotype non-1 patients, SVR rates were 88.0% and 100% for rs12979860 CC and CT (P=1.00), respectively. Conclusions: Genotypes of the IL28B SNP that are known to be favorable were present in most of the Korean patients with chronic hepatitis C in this study. Moreover, the IL28B SNP did not influence the SVR rate in either the HCV genotype 1 or non-1 patients. Therefore, IL28B SNP analysis might be not useful for the initial assessment, prediction of treatment outcomes, or treatment decision-making of Korean chronic hepatitis C patients. (Clin Mol Hepatol 2014;20:177-184)
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Neurite Outgrowth on Nanocomposite Scaffolds Synthesized from PLGA and Carboxylated Carbon Nanotubes
Lee, Hyun Jung,Yoon, Ok Ja,Kim, Do Hee,Jang, Yeong Mi,Kim, Hyun Woo,Lee, Won Bok,Lee, Nae-Eung,Kim, Sung Su WILEY-VCH Verlag 2009 Advanced engineering materials Vol.11 No.12
<P>Carbon nanotubes (CNTs) have been suggested as suitable materials for biomedical applications, especially in the neural area. It is essential not only to investigate the biocompatibility of CNTs with the neural system but also to determine proper methods for applying CNTs to neuronal growth. This work represents the first application of CNTs by electrospun poly(D,L-lactic-co-glycolic acid) (PLGA) scaffolds for a neural system. We synthesized electrospun nanocomposites of PLGA and single-walled carbon nanotubes functionalized by carboxylic acid groups (c-SWNTs), and investigated neurite outgrowth from SH-SY5Y cells on these nanocomposites as compared to that on fibrous PLGA alone. Cells on our PLGA/c-SWNT nanocomposite showed significantly enhanced mitochondrial function and neurite outgrowth compared to cells on PLGA alone. We concluded that c-SWNTs incorporated into fibrous PLGA scaffolds exerted a positive role on the health of neural cells.</P> <B>Graphic Abstract</B> <P>Carbon nanotubes (CNTs) have distinctive characteristics such as high conductivity which could help the promotion of neuronal function. Electrospun nanocomposites of poly(D,L-lactic-co-glycolic acid) (PLGA) and CNTs were synthesized, and neurite outgrowth and mitochondrial function of human neuroblastoma cells were investigated on these nanocomposites and compared with that on fibrous PLGA alone. The results showed that CNTs incorporated into fibrous PLGA scaffolds exerted a positive role on the health of neural cells. <img src='wiley_img_2010/14381656-2009-11-12-ADEM200900144-content.gif' alt='wiley_img_2010/14381656-2009-11-12-ADEM200900144-content'> </P>
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Hyun, Jong-Nae,Hong, Yeon-Kyu,Lim, Sea-Gyu,Kim, Yang-Gil,Kim, Mi-Jung,Lee, Mi-Ja,Lee, Key-Woon The Korean Society of Crop Science 2008 Korean journal of crop science Vol.53 No.4
Barley Yellow Mosaic Virus (BaYMV) caused significant reduction in barley yield and is difficult to control due to alive parasitic soil-borne fungus, Palmyra gamines that transmits the, virus. Previous studies have indicated that a virus-free soil could be infested by using virus-contaminated farming machineneries and implements. For the further confirmation of this finding, different proportions of BaYMV-infested soil were mixed into virus free soil. Three barley varieties (Hordum vulgarae, cv "Olbori", "Baegdong" and "Sacheon 6") were sown in pots treated with different rate of P. graminis-infested soil ranging from 0% to 100% in October 20, 2001. Results showed that BaYMV infection increased as the rate of infested soil increased. Initial symptoms were observed in a pots treated with 10% infested soil in all the 3 varieties of barley. "Olbori" had about 5% infection in 20% infested soil and about 10% infection in 40% or 50% infested soil and about 20% infection in 60% infested soil. In "Baegdong", the trend of BYMV occurrence was similar with "Olbori" but the time of severe infection was earlier than "Olbori". BaYMV infection in "Sacheon 6" was even earlier than "Baegdong" with much more severe symptoms than "Baegdong". The growth rate of barley was affected by about 19-22% when grown in 20% infested soil. As the rate of BaYMV infested soil increased the heading date was delayed but the maturing date was early in "Olbori" and "Sacheon 6". Also, reduction rate of culm length in 3 varieties increased with increase of infested soil content. However, "Olbori" showed the highest reduction. "Sacheon 6", have been characterized with long spike length, however was significantly reduced as the infested soil increased. On the other hand, spike length of "Olbori" was not significantly affected despite of increased of infested soil. The reduction rate of 1000 kernel weight was higher in large kernel size cultivar "Sacheon 6" and "Olbori" than small kernel size "Baegdong" as increase of BaYMV-infested soil content.
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Lee, Hyun Min,Han, Kyung do,Kong, Soo Keun,Nam, Eui Cheol,Park, Shi Nae,Shim, Hyun Joon,Byun, Jae Yong,Park, Hong Ju,Im, Gi Jung,Lee, Il-Woo Lippincott Williams Wilkins 2018 Otology & Neurotology Vol.39 No.6
OBJECTIVES:: Prevalence of tinnitus has been reported to vary according to the target population and definition of tinnitus. To improve the understanding of tinnitus, authors used the nation-wide health claim data to study the tinnitus in the entire population of South Korea. STUDY DESIGN:: Retrospective big data review. SETTING:: Analysis of big data from the National Health Information Database. PATIENTS:: Patients diagnosed with tinnitus according to International Classification of Diseases code 10th edition (ICD-10) and requested to receive National Health Insurance claim at least once from January 2006 to December 2015. INTERVENTION:: None. MAIN OUTCOME MEASURE:: Epidemiologic data, association of tinnitus with the otologic and systemic diseases. RESULTS:: The number of patients who received medical care because of tinnitus was 1.44% (0.78 million per 51 million) in 2015. There was a higher prevalence of tinnitus in women, and the overall prevalence increased with increasing age of patients and peaked at patients in their 70s (4.43%). The prevalence of tinnitus among patients aged 10 to 30 years, showed a tendency to increase during study period. In the regional analysis, highest prevalence was observed in Gwangju (2.02%). In comparison with the control group, the patients with tinnitus showed a higher frequency in otologic and systemic disease. Especially, noise induced hearing loss (adjusted odds ratio [AOR] = 82.1, 95% confidence interval [95% CI] = 74.8–90.2) and sudden sensorineueal hearing loss (AOR = 49.7, 95% CI = 48.4–51.0) showed high frequency in tinnitus patient group. CONCLUSIONS:: The prevalence and incidence of tinnitus in this study for entire nation were lower than previously reported studies. These results have limitation because the study only covered patient using the medical service for tinnitus and missed tinnitus sufferers not seeking medical service. However, this study is meaningful in that it was targeting entire nation, reflected the characteristics of clinically significant tinnitus patient enough to visit medical service
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