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이상호,박래현 충남대학교 기초과학연구소 1995 忠南科學硏究誌 Vol.22 No.2
In the simple calibration model, Maritz(1970) gave an empirical Bayes estimator of x_0 when y_01, …, y_0k on x_0 are observed. However, his estimator can not be applied in case k 1 which is occurred more often than not. We propose a new empirical Bayes estimator of x_0 which enables us to predict x_0 for all k and is a compromise between the classical estimator and the inverse estimator.
다변량 역추정 모형에서 경험적 베이스 추정량에 관한 연구
이상호,박래현 충남대학교 기초과학연구소 1996 忠南科學硏究誌 Vol.23 No.2
In the multivariate calibration model, we propose a new Empirical Bayes estimator(EB estimator) which enables us to predict the panameter of interest. The EB estimator is a compromised type between the classical estimator and the inverse estimator, and attains better precision than any other estimator in Brown(1982).
박래현,이석훈,김응환 충남대학교 1996 忠南科學硏究誌 Vol.23 No.1
In spite of the debate on fuzzy methods that they may provide an altermative to probabilistic and statistical methods, both approaches are going to give way to collaboration in the very practical fields. In this paper we review the area of fuzzy clustering in which the two approaches get along with each other. The current research interest and direction is discussed and a newly developed algorithm that prevents the output from being fuzziness as much as possible is presented with an illustration.
박상호,온영근,김현정,이태훈,길효욱,김현건,박수진,송해정,한대희,방덕원,신원용,이내희,김성구,권영주 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1
Background : Microvascular angina or syndrom X is heterogenous and encompasses different pathogenetic entities. Several studies suggest that microvascular angina have good prognosis and occurs predominantly in postmenopausal women. Lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and fibrinogen are the independent risk factor of acute coronary syndrome and are the chief underlying cause of atherosclerosis. We investigated clinical characteristics and markers in patients with microvascular angina. Methods : We studies 23 patients diagnosed with microvascular angina and 16 control group with negative treadmill exercise test and no significant coronary angiogram. We investigated clinical characteristics in patients group and evaluated symptom during a follow-up period of 4.2± 2.5 month. Exercise time in treadmill exercise test was compared between patients and control group. We assessed the level of markers, such as lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, CRP and ESR in two groups. Results : There is no difference in age between two groups. Patients group had a tendency to increase in female, hypertension, DM, and smoking history, but there was no statistical significance difference. Exercise duration time was significantly decreased in patients with microvascular angina (p<0,05). Serum lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholestrol, Triglyceride, ESR, Fibrinogen and Homocystein value were no significant difference between microvascular angina and control group. Only CRP was significantly high in patients with microvascular angina (p<0.05). Conclusion : There was no statistical significance difference in age, sex, hypertension, DM and smoking history between two groups but patients group had a tendency to increase the prevalence in hypertension, DM and smoking history, female. Also, Symptom improvement and disappearance in follow-up was presented in 11 patients of 19(57.9%). Exercise tolerance was worse in patients group than control group. CRP value was significantly higher in patients group than control group. There was no statistical significance difference in lipoprotein (a), total cholesterol, LDL-cholesterol, HDL-cholesterol, triglyceride, homocystein, ESR and Fibrinogen between two groups.
Amine-modified single-walled carbon nanotubes protect neurons from injury in a rat stroke model
Lee, Hyun Jung,Park, Jiae,Yoon, Ok Ja,Kim, Hyun Woo,Lee, Do Yeon,Kim, Do Hee,Lee, Won Bok,Lee, Nae-Eung,Bonventre, Joseph V.,Kim, Sung Su Springer Science and Business Media LLC 2011 Nature nanotechnology Vol.6 No.2
<P>Stroke results in the disruption of tissue architecture and is the third leading cause of death in the United States. Transplanting scaffolds containing stem cells into the injured areas of the brain has been proposed as a treatment strategy, and carbon nanotubes show promise in this regard, with positive outcomes when used as scaffolds in neural cells and brain tissues. Here, we show that pretreating rats with amine-modified single-walled carbon nanotubes can protect neurons and enhance the recovery of behavioural functions in rats with induced stroke. Treated rats showed less tissue damage than controls and took longer to fall from a rotating rod, suggesting better motor functions after injury. Low levels of apoptotic, angiogenic and inflammation markers indicated that amine-modified single-walled carbon nanotubes protected the brains of treated rats from ischaemic injury.</P>
‘노년공학(GT)의 기능성 게임 개발론’ 교과개발을 위한 학제간 수요 연구
이내현(Lee, Nae-Hyun),김경식(Kim, Kyung-Sik),장희동(Chang, Hee-Dong),박성준(Park, Seong-Jun),박창훈(Park, Chang-Hoon),강현구(Kang, Hyun-Koo),박현식(Park, Hyun-Sik),성은현(Sung, Eun-Hyun),김동주(Kim, Dong-Joo) 한국게임학회 2011 한국게임학회 논문지 Vol.11 No.2
노년시대를 대비하는 기능성 게임의 교과목을 개발하기 위하여 인문대학과 공과대학의 관련학과 학생들을 대상으로 연구진의 교과 항목들에 대해 중요성과 필요성에 대한 설문을 조사하였다. 양 대학의 학생들의 인지에 대한 공통점과 차이점을 분석하여 이를 토대로 융합 학제간 신 교과목을 개발하였다. 노인용 기능성 게임의 인식을 학생들에게 확산시키고자 본 교과목을 양대학의 교과과정에 포함시켜 시행하였다. For the development of a curriculum of the serious game for the elderly in preparation of senior society, we have surveyed students of both college of humanity and college of engineering for their perception of importance and necessity on the subjects prepared by this team. We analyzed their common points and different points, and developed a new interdeciplinary curriculum for students in both college. The curriculum has been opened in the last semester successfully.
후천성면역결핍증후군 환자에게 급성 호산구성 폐렴 양상을 보인 폐포자충 폐렴
이보라 ( Bo Ra Lee ),김현국 ( Hyun Kook Kim ),박이내 ( I Nae Park ),최상봉 ( Sang Bong Choi ),정훈 ( Hoon Jung ),이현경 ( Hyun Kyung Lee ),이성순 ( Sung Soon Lee ),이영민 ( Young Min Lee ),이혁표 ( Hyuk Pyo Lee ),최수전 ( Soo Jeo 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.2
A 73-year-old man was admitted with a sudden onset of dyspnea. He had never smoked. The chest radiograph and computed tomography revealed bilateral ground glass opacity and an enlarging perihilar consolidation with lymphadenopathies. There was a higher percentage of eosinophils (72%) in the bronchoalveolar lavage fluid (BALF) than normal. The patient was diagnosed with acute eosinophilic pneumonia and managed with steroid. Pneumocystis pneumonia (PCP) was diagnosed by an examination of the BALF, and the patient was treated with trimethoprim-sulphamethoxazole. The patient tested positive to the HIV antibody and the peripheral blood CD-4 positive lymphocyte count was only 33/μL. The percentage of eosinophils in the BALF can increase in some cases of PCP that is complicated with AIDS. Only a few cases of eosinophilic pneumonia associated with PCP pneumonia have been reported in patients with AIDS but there are no case reports in Korea. This case highlights the need to consider PCP when the percentage of eosinophils in the BALF is elevated.
( Nae Hyun Lee ),( Tae Jong Song ),( Kyoung Ho Ryu ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-
Objective: Intraperitoneal isotonic saline instillation (SI) and pulmonary recruitment maneuver (RM) were indicated to alleviate post-laparoscopic shoulder pain (PLSP) effectively. The aim of this study was to compare the effects of the single strategy using SI alone and the combined strategy using SI and RM on PLSP reduction. Methods: Subjects undergoing elective gynecologic laparoscopy were randomly allocated to a control group (no intervention, n=48) and two intervention groups (single strategy of SI alone, n=48; combined strategy of SI and RM, n=48). In the control group, carbon dioxide was removed only via passive evacuation through the port sites at the completion of the laparoscopic procedure. In the saline instillation group, 20-mL/kg of body weight SI was performed. In the combined strategy group, RM using five pulmonary inflations was performed, in addition to SI. The PLSP scores, which were the primary outcome, were recorded using a visual analog scale postoperatively. Results: The PLSP scores 24 and 48 hours after surgery were significantly lower in the two intervention groups than in the control group (P = 0.014 and P = 0.001, respectively), while no significant differences were observed between the two intervention groups. Conclusions: The single strategy using SI alone is as effective as the combined strategy of SI and RM for removing residual carbon dioxide and consequently preventing PLSP. Therefore, considering the potential risks of pulmonary or hemodynamic complications associated with RM, the single strategy using SI alone might be a better choice than the combined strategy. Conclusion: In conclusion, the combined strategy using SI and RM was not superior to the single strategy using SI alone in terms of PLSP reduction. Furthermore, the single strategy using SI alone is simple and safe; thus, it can be employed to avoid the potential risks of pulmonary or hemodynamic complications associated with RM.