Association of 20 potential ATP2B1‐interacting genes with blood pressure in Koreans

Kyung‐Won Hong,Hyun‐Seok Jin,Ji‐Eun Lim,Bermseok Oh 한국유전학회 2011 Genes & Genomics Vol.33 No.3

Plasma membrane calcium‐transporting ATPase 1 (ATP2B1)is associated significantly with blood pressure in Caucasians and Asians. ATP2B1 regulates calcium homeostasis and belongs to the P‐type calcium pump family; several studies have identified diverse proteins that bind to ATP2B1. We hypothesized that ATP2B1 regulates blood pressure through ATP2B1‐interacting genes. To this end, 20 potential ATP2B1‐interacting genes were selected, 197 SNPs of which were analyzed for their association of systolic and diastolic blood pressure. These 20 genes were categorized into 2 groups: ATP2B1‐binding genes and ATP2B1‐cleaving calpain family members. Three ATP2B1‐binding genes (CALM1, NOS1, and PDLIM1)were associated with blood pressure, and a SNP in CALM1(rs2401887) generated the strongest association signal (beta=‐3.60±0.92, p=8.9×10^(‐5) for systolic blood pressure and beta=‐1.40±0.62, p=0.02 for diastolic blood pressure). Of the calpain family members, 3 genes (CAPN6, CAPN9, and CAPN10)were associated with blood pressure, and the CAPN10 SNP rs4676348 yielded the strongest association signal (beta=‐0.88±0.27, p=0.001 for systolic blood pressure and beta=‐0.58±0.18, p=0.015 for diastolic blood pressure). Further, the interaction of CALM1 to ATP2B1 was examined using the blood pressure of individuals who carried both variants of CALM1and ATP2B1 genes. Similarly the interaction of CAPN10 to ATP2B1 was also examined. The CALM1 variant (rs2401887)and CAPN10 variants (rs4676348) appear to decrease blood pressure further in addition to the decrease by the variant (rs17249754) of ATP2B1, which suggests that ATP2B1 might regulate blood pressure through the ATP2B1‐interacting genes CALM1 and CAPN10.

진심통(眞心痛)에 관(關)한 문헌적(文獻的) 고찰(考察)

전찬용,조기호,이원철,김영석,배형섭,이경섭,구본홍,Jun, Chan-Yong,Jo, Ki-Ho,Lee, Won-Chol,金永錫, Yong-Seok,Bhae, Hyung-Sup,Lee, Kyung-Sup,Goo, Bon-Hong 대한한방내과학회 1990 大韓韓方內科學會誌 Vol.11 No.1

The true heartache is a condition of severe heartache corresponding to angina pectoris, as recorded from Hwang Jae Nai Kyung. According to the literatural study of true heartache, some results can be acquired, such as follows. 1. The site of the true Heartache, can be divided into two categories, first, its superficial and conscious area is the chest as same as the other heartache. But its inner lesion is the Heart-Meridian as others occupied at the Pericardium-Meridian in stead of the Heart-Meridian. 2. The etiological classification of true heartache, are Cold-evil, Heat-evil, Wind-evil, Blood stasis etc. But its major factor is Cold-evil, more than anything else. 3. The symptomatic signs of true heartache, consist of cyanotic change from hands and feet to phalanges; severe heartache pale complexion with cold breathing and its extreme state can manifestate unceased sweating called as Yang exhaustion.

Studies on Venerupin Shellfish Poison in Korea

Hong, Sa Suk,Kim, Won Joon,Kim, Kyung Hwan,Lee, Yoo Bock 大韓消化器病學會 1975 大韓消化器病學會雜誌 Vol.7 No.2

Effect of Bile Acids on Biliary Excretion of Cholesterol in Rabbits

Hong, Sa Suk,Kim, Kyung Hwan,Kim, Won Joon Yonsei University, College of Medicine 1973 Yonsei medical journal Vol.14 No.-

Manifestations of Sasang Typology according to Common Chronic Diseases in Koreans

Hong, Seung Wan,Suh, Young Sung,Kim, Dae Hyun,Kim, Mi Kyung,Kim, Hye Soon,Park, Kyung Sik,Hwang, Jae Seok,Shin, So Jin,Cho, Chi Heum,Jung, Sung Won,Ha, Il Do,Kwon, Young Kyu Hindawi Limited 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-

<P>Sasang typology is a traditional Korean medical classification scheme that combines medical management with general medicine and can be applied to chronic diseases. We aimed to analyze differences in Sasang Personality Questionnaire (SPQ) and Sasang Digestive Function Inventory (SDFI) results in patients with diabetes mellitus (DM), hypertension, functional dyspepsia, major depressive disorder (MDD), and adenomyosis. In this cross-sectional study, data were collected at a medical college hospital in South Korea. A total of 248 patients were included: 52 with DM, 47 with hypertension, 36 with functional dyspepsia, 26 with MDD, and 87 with adenomyosis. The subjects took both the SPQ and the SDFI. The outcome measures in this study were body mass index (BMI), SPQ score, and SDFI score. The DM and hypertension groups, which were expected to demonstrate many Taeeum-type traits, exhibited high BMI, high SPQ-Behavior and SDFI-Appetite scores, and low SPQ-Emotionality and SDFI-Digestion scores. The functional dyspepsia group showed low BMI and high scores for SPQ-Behavior, SPQ-Emotionality, SDFI-Digestion, and SDFI-Appetite. The MDD group demonstrated high SPQ-Emotionality and SDFI-Digestion scores, low BMI, and low SPQ-Behavior and SDFI-Appetite scores. The adenomyosis group demonstrated high scores for SPQ-Behavior, SDFI-Digestion, and SDFI-Appetite, low BMI, and low SPQ-Emotionality scores. Different characteristics distinguishing Sasang traits according to chronic diseases were ascertained, especially for Taeeum and Soeum types.</P>

Importance of accurate trophic level determination by nitrogen isotope of amino acids for trophic magnification studies: A review

Won, Eun-Ji,Choi, Bohyung,Hong, Seongjin,Khim, Jong Seong,Shin, Kyung-Hoon Elsevier 2018 Environmental pollution Vol.238 No.-

<P><B>Abstract</B></P> <P>During the last several decades, persistent organic pollutants and metals cause great concern for their toxicity in organisms as well as for their bioaccumulation and/or trophic transfer through the food chains in ecosystems. A large number of studies therefore have focused on the trophic levels of organisms to illustrate food web structure, as a critical component in the study of pollutant dynamics and biomagnification. The trends in biomagnification of pollutants in food webs indeed provide fundamental information about the properties and fates of pollutants in ecosystems. The trophic magnification supports the establishment of a reliable trophic structure, which can further aid the understanding of the transport and exposure routes of contaminants in accumulation and risk assessments. Recently, efforts to interpret the food web structure using carbon and nitrogen stable isotope ratios have contributed to better understanding of the fate of pollutants in the ecosystem. However, it is known that this isotope analysis of bulk ones has many weaknesses, particularly for uncertainties on the estimate of trophic levels and therefore of magnification factors for studied organisms, enough to support a regulatory interpretation. In this review, we collate studies that investigated biomagnification characteristics of pollutants in aquatic ecosystems, along with calculated trophic magnification factors. Moreover, we introduce a novel approach, compound-specific stable isotope analysis of nitrogen in amino acids, to establish reliable food web structures and accurate trophic levels for biomagnification studies. This method promises to provide sound results for interpreting the influence of the pollutant in organisms, along with their bioaccumulation and magnification characteristics, as well as that in ecosystem.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bioaccumulation of pollutants is a crucial issue with repercussions in organisms. </LI> <LI> Transfers of pollutants through food chain are important fate of pollutants. </LI> <LI> Trophic magnification factor is considered as one of the great issue on pollutants. </LI> <LI> Compound specific isotope analysis (CSIA) allows presenting sound trophic levels. </LI> <LI> Reliable food web structure deepens a field on biomagnification and pollutants. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

The Protective Effect of Resveratrol on Dimethylnitrosamine-Induced Liver Fibrosis in Rats

Hong, Sang-Won,Jung, Kyung-Hee,Zheng, Hong-Mei,Lee, Hee-Seung,Suh, Jun-Kyu,Park, In-Suh,Lee, Don-Haeng,Hong, Soon-Sun 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4

Oxidative stress in liver injury is a major pathogenetic factor in progress of liver fibrosis. Resveratrol, a representative antioxidant derived from grapes, has been reported to show widespread pharmacological properties. In this study, we investigated the protective effects of resveratrol on dimethylnitrosamine (DMN)-induced liver fibrosis in rats. Rats were treated with resveratrol daily by oral gavage for seven days after a single intraperitoneal injection of DMN (40 mg/kg). Resveratrol remarkably recovered body and liver weight loss due to DMNinduced liver fibrosis. Liver histology showed that resveratrol alleviated the infiltration of inflammatory cells and fibrosis of liver tissue. Resveratrol decreased the level of malondialdehyde and increased the levels of glutathione peroxidase and superoxide dismutase. Also, resveratrol significantly inhibited the mRNA expression of inflammatory mediators including inducible nitric oxide, tumor necrosis factor-alpha and interleukin-1beta. In addition, resveratrol showed not only reduced mRNA expression of fibrosis-related genes such as transforming growth factor beta 1, collagen type I, and alpha-smooth muscle actin, but also a significant decrease of hydroxyproline in rats with DMN-induced liver fibrosis. Our results suggest that resveratrol could be used to treat liver injury and fibrosis and be useful in preventing the development of liver fibrosis and cirrhosis.

Inhibitory Effects of Mulberry Fruit on Intestinal Disaccharidase Activity and Hyperglycemia in Streptozotocin-Induced Diabetic Rats

Hong, Jung-Hee,Kim, Sang-Woon,Choi, Kyung-Ho,Choi, Sang-Won,Rhee, Soon-Jae The Korean Nutrition Society 2004 Nutritional Sciences Vol.7 No.4

The current study examined the effects of freeze-dried mulberry fruit on disaccharidase activity in the small intestine and the lowering of blood glucose in streptozotocin (STZ)-induced diabetic rats. Sprague-Dawley male rats were randomly assigned to one normal and three streptozotocin (STZ)-induced diabetic groups. The diabetic groups were fed a mulberry fruit-free diet (DM-group), 0.3% mulberry fruit diet (DM-F group) or 0.6% mulberry fruit diet (DM-2F group). After they were fed the experimental diets for three weeks, diabetes was induced with an intraperitoneal injection of streptozotocin 50 mg/kg b.w before sacrificing 9 days later using the same experimental treatments. Analyses of anthocyanins, flavonoid and 1-deoxynojirimycin (DNJ) of lyophilized mulberry fruit were carried out and the major anthocyanins were rutin (142.5 mg), isoquercitrin (10.3 mg), quercetin (5.8 mg), morin (1.6 mg) dihydroquercetin (3.83 mg), cy-3-O-glucopyranoside (230.45 mg) and cy-3-O-rutinoside (131.5 mg) on the basis of 100 g dry weight. Total DNJ content was 2.39 mg/g dry weight of lyophilized mulberry fruit. Blood glucose level decreased in the diabetic mts fed the mulberry fruit supplement. The content of the liver glycogen increased in the diabetic mts fed the mulberry fruit supplement. Disaccharidase activity in the proximal part of the intestine, such as that of maltase, sucrase and lactase in the mulberry fruit supplementation groups, were lower than that of the DM group. These results suggest that mulberry fruit possess a suppressive effect on hyperglycemia, possibly by inhibiting the activity of disaccharidase in the small intestine of rats.

A New Black Soybean Cultivar, "Cheongja 3" with Green Cotyledon, Medium-Late Maturity and High Anthocyanin

Hong Tae Yun,Keum Yong Park,Jung Kyung Moon,Yong Ho Kim,Sun Lim Kim,Ja Hwan Ku,Yeong Ho Lee,Yong Hwan Ryu,In Youl Baek,Won Young Han,Hyun Tae Kim,Jun Hyeon Cho,Jong Min KoDoo 한국육종학회 2005 한국육종학회지 Vol.37 No.4

Solid Phase Crystallization Kinetics of Amorphous Silicon at High Temperatures

Won-Eui Hong,Bo-Kyung Kim,Jae-Sang Ro 한국표면공학회 2008 한국표면공학회지 Vol.41 No.2

Solid phase crystallization (SPC) of amorphous silicon is usually conducted at around 600°C since it is used In the application of flat panel display using thermally susceptible glass substrate. In this study we conducted SPC experiments at temperatures higher than 600°C using silicon wafers. Crystallization rate becomes dramatically rapid at higher temperatures since SPC kinetics is controlled by nucleation with high value of activation energy. We report SPC kinetics of high temperatures compared to that of low temperatures.