3채널 맥파 검출장치의 GUI 개발

윤달환,정찬길,소경순 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

한의학은 개념적이고 주관적인 임상정보를 과학적 데이터화하여 환자를 치료하고자 한의의료장비의 응용에 많은 노력을 하고 있다. 맥파를 검출하기 위해서는 센서에 가해지는 압력, 센서 구동부의 운동 등 여러 가지 파라미터가 있다. 본 논문은 맥진의 정확한 맥상을 검출하기 위하여 3채녈 맥파검출 헤드장치 구동부를 유연하게 동작하도록 시스템을 개발하고, 기존의 양단 스위치 동작에 의한 헤드부의 모터운동을 제거함과 동시에 GUI형태로 맥진시스템을 구성한다. 특히 맥진정보를 받아들이는 寸ㆍ關ㆍ尺 헤드부의 정확한 동작이 맥진시스템의 성능을 향상시키는 역할을 하며, 이는 임상판정의 정확성을 기할 수 있도록 한다. In Oriental medicine, most of the medical examination of a patient depend on subjective explanation of self-patient. The application of an apparatus has an important significance in ensuring the objectivity of clinical information and in promoting the reproductivity and stability through the qualification and quantization. This paper development the pulse diagnostic apparatus of 3-channel type to detect exact pulsatory motion of a pulse wave, which is the type of GUI(graphic user interface) that one have the faculty of smoothing motor and the driving part of non-swich operating the sensor head. This system increase the function of pulse diagnosis and support the clinical decision.

맥진단기 채널의 ISI감소를 위한 적응필터

윤달황,정찬길,소경순 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

본 논문은 맥파검출기의 채널간에 발생하는 상호신호간섭을 감소시키기 위해 Sign 알고리듬을 적용한다. 이 알고리듬은 맥파가 저주파이고 매우 천천히 변하는 환경하에서 기존의 알고리듬과 비교하여 보다 유리한 성능을 가지며, 이를 이용하여 분할등화기를 구현한다. We propose the Sign algorithm and analyze the convergence characteristics of it. To evaluate the performance of proposed Sign algorithm, fractionally spaced equalizer is used. Especially, we present that this method have the advantages for the condition having the low-frequency and slow speed.

진동 센서용 3성분계 압전 박막의 제조 및 그 특성 분석(Ⅱ)

윤화중,서일환,구경완,임무열,이진호 경북대학교 센서기술연구소 1994 연차보고서 Vol.1994 No.-

3성분계 PZT 압전박막의 출발물질로는 Pb acetate, Zr propoxide, Ti propoxide, Ni acetate, Nb ethoxide를 사용하였고, 용매로는 iso metoxy ethanol을 사용하였다. 가수분해를 방지하기 위해 coating 용액에 diethanolamine을 첨가하여 chelate화합물을 형성하였고, coating 전에 H_2O를 첨가하여 M-O-M 구조의 polymer gel이 형성되도록 하여 내구성이 강한 박막을 제작하였다. Coating 용액의 열중량 분석 결과, 건조 온도는 90℃∼120℃, 예비소결 온도는 300℃∼400℃가 적합한 것으로 판단되었다. 박막의 SEM 단면 촬영 결과, 하부기판과 하부전극 사이의 TiN-Ti-TiN buffer층이 박막과 하부 기판과의 반응을 막아주어 막이 잘 형성되었으며, 각 계면에서도 별다른 이상이 발견되지 않았다. X-RD로 박막의 결정성을 조사한 결과 Pt 기판과 Pt/TiN-Ti-TiN/Si 기판 공히 550℃의 소결에서 결정성이 가장 양호하며 600℃ 이상에서는 과소결 되는 것으로 판단된다. D-E Hysterisis 곡선을 관찰한 결과 이 박막은 강유전체임을 확인했으며, 항전계는 28.8 ㎸/㎝, 잔유분극은 18.3 μC/㎠ 이었다. 박막의 I-V 특성 결과는 다음과 같다. ◁표 삽입▷(원본을 참조하세요) 3성분계 PZT 박막의 C-V 특성곡선을 측정한 결과 각 조성비에 대한 비유전율은①(50:40:10)은 406, ②(50:30:20)은 1084, ③(45:35:20)은 723, ④(40:40:20)은 316이었다. In order to make the three compound piezoelectric thin film, the Pb acetate, Zr propoxide, Ti propoxide, Ni acetate, Nb ethoxide are used as starting materials, and iso metoxyethanol was used as a solvent. After DEA (diethanolamine) is added in to the solution, the coating solution and chelate compound are made in order to the phenomenon of hydrosys was prevented. Before coating, H2O was added in to the solution, the polymer gel which is M-O-M structure was formed, and then the strong durable film was made. As a result of the analysis by TGA, dry temperature was between 90℃ and 120℃, presintering temperature was indicated between 300℃ and 400℃. As a result of observing the SEM cross section of the film in the pictures were taken, the reaction of membrane and substrate caused by TiN-Ti-TiN buffer layers, and the abnormality was not detected in the boundary surfaces. As a result of checking of the X-RD film crystallization, the crystallization is best at 550℃ sintering and at 600℃ upper the over sintering is made on the both of Pt substrate and Pt/TiN-Ti-TiN/Si substrate. As a result of observing the D-E hysterisis curve, in the thin film the strong dielectricity was found and coercive field was 28.8 ㎸/㎝, the remanent polariztion was 18.3 μC/㎠. Ⅰ-Ⅴ characteristic chart is as following ◁표 삽입▷(원본을 참조하세요) As a result of measuring the C-V characteristic curve of the three compound piezoelectric thin film, the relative dielectric constant was ①(50:40:10)→406, ②(50:30:20)→1084, ③(45:35:20)→723, ④(40:40:20)→316.

진동 센서용 압전 박막의 제조 및 그 특성 분석

윤화중,서일환,구경환,임무열,이진호 경북대학교 센서기술연구소 1993 연차보고서 Vol.1993 No.-

졸-겔 spin-coating법을 이용하여 PZT 압전 박막을 제작하고 그 물리적 및 전기적 성질을 평가하여 진동 측정용 센서로서의 적용 가능성을 검토하였다. PZT의 원료로는 Pb-acetate, Zr-propoxide 그리고 Ti-propoxide를 사용하였다 SEM 단면사진의 결과 하부전극 금속이 silicate화 하였고, SIMS 분석결과 Si와 하부전극의 금속이 PZT 박막의 상층부까지 확산된 것을 알 수 있었다. X-RD로 박막의 결정성을 조사한 결과 하부전극을 Pt로 한 박막과 buffer 층으로 Ti를 증착한 박막에서 강한 perovskite 상이 나타났다. D-E Hysterisis 곡선을 관찰한 결과 강유전성을 나타내며, 항전계는 33.3 ㎸/㎝, 잔유분극은 1.92 C/℃ 이었다. 박막의 비유전율은 57이었다. 박막의 resistance와 impedance의 반공진 주파수는 612 ㎒이고, 이때의 resistance 값은 14 ㏀이었다. 박막의 진동에 대한 주파수 응답 곡선을 측정 결과 12000 ㎐ 이하 저주파 영역에서는 응답 특성이 떨어지고 12000 ㎐ 이상의 어느 정도 높은 주파수 영역에서 응답 특성이 양호하다는 것을 알 수 있었고, 20000 ㎐ 100 ㏈(V)의 진동에 대해 151.4 ㎶의 응답을 나타내었다. PZT thin film was prepared by Sol-Gel spin-coating method and it's physical and electrical caracteristics were appreciated. Pb acetate, Zr propoxide and Ti propoxide used for the starting material to fabricate PZT coating solution. The cross-sectional SEM micrograph showed that the metals of lower electrode was silicated. The SIMS depth profile indicated that the metal of lower electrode and silicon diffused up to the upper part of PZT thin film. For the X-RD data of PZT thin film, the thin film on Pt substrate and with Ti buffer layer had strong perovskite phase. The PZT thin films measured by Sawyer-Tower circuit showed feroelectric characteristic representating D-E hysterisis curve. The remanent polarization and coercive field of the film was 1.92 C/㎠ and 33.3kV/㎝. Dielectric constant of Film is 57. The resistance and impedance antiresonance frequency was 612 ㎒, and the resistance was 14 ㏀ at that frequency. The frequency response curve of PZT film showed that the PZT film responded sensitively at the high frequency, and response voltage of PZT film was 151.4 ㎶ at 20,000 ㎐ 100 ㏈(V) frequency.

3成分界 壓電薄膜을 이용한 超高主波用 素子의 開發 및 그 特性 分析

尹和重,徐日煥,丘庚完,林武悅,李珍昊 경북대학교 센서기술연구소 1995 연차보고서 Vol.1995 No.-

유기금속을 사용한 졸-겔 스핀 코팅법으로 PZT-PNN 박막을 제조하였으며, diethanolamine을 안정화물질로 사용하였다. PT:PZ:PNN의 코팅 용액의 mol%는 각각 #1 (50:40:10), #2(50:30:20), #3(45:35:20), #4(40:40:20), #5(40:50:10), #6(35:45:20) 그리고 #7(30:50:20)으로 제조하였다 스핀 코팅된 박막의 잔류 유기물을 제거하기 위해 350℃에서 예비소결을 하였고, 박막의 결정화를 위해 450℃ ∼ 700℃에서 소결하였다. 백금 기판과 Pt/TiN/Ti/TiN/Si 기판 위에 박막을 성장하였으며, 500℃의 소결에서도 perovskite 상이 출현하였다. 결정성이 가장 양호한 소결온도는 700℃이었다. Sawyer-Tawer 회로를 이용하여 박막의 P-E 이력곡선을 관찰하였다. 박막의 항전계와 잔류분극은 각각 28.8 ㎸/㎝과 18.3 μC/㎠이었다. 유전상수 K는 128 ∼ 1120의 값을 나타내었고, 상경계(40:40:20 mol%)에서 최대값을 보여주었다. 박막의 진성파괴전압은 27.0 ∼ 60.0 MV/m이었으며, 소결온도가 올라갈수록 파괴전압은 낮아지는 경향을 나타내었다. 결정성과 전기적 특성을 고려하면 550℃의 소결온도에서 박막의 특성이 가장 양호하다고 생각된다. #4 40:40:20 mol%의 박막을 이용하여 초고주파 필터를 제작하였다. ring-dot 분할전극형 필터의 경우 공진주파수는 435.26 ㎒이고 투과손실은 -0.20 ㏈이며, 반공진주파수는 1905.11 ㎒ 투과손실은 -34.30 ㏈이었다. 두께진동을 이용한 필터의 경우 공진주파수는 1035.17 ㎒ 투과손실은 -0.86 ㏈, 반공진주파수는 2310.07 ㎒ 투과손실은 -29.11 ㏈이며, 탄성표면파 필터의 경우 공진주파수는 228.28 ㎒ 투과손실은 -0.62 ㏈, 반공진주파수는 1352.86 ㎒ 투과손실은 -35.68 ㏈이었다. PbTiO_3-PbZrO_3-Pb(Ni_(1/3)Nb_(2/3)O_3)(PZT-PNN) thin films were been prepared from corresponding metal organics partially stabilized with diethanolamine by the sol-gel spin coating method. The each mol rates of PT:PZ:PNN solutions were #1(50:40:10), #2(50:30:20), #3(45:35:20), #4(40:40:20), #5(40:50:10), #6(35:45:20) and #7(30:50:20) respectively. The spin-coated PZT-PNN films were heat-treated at 350℃ for decomposition of residual organics, and were heat-treated at temperature between 450 ℃ and 750 ℃ for crystallization. The substrates, such as Pt and Pt/TiN/Ti/TiN/Si were used for the spin coating of PZT-PNN films. The perovskite phase was observed in the PZT-PNN films which were heat-treated at 500 ℃. The crystallization of the PZT-PNN films was optimized at 700 ℃ of sintering temperature. The P-E hysteresis curve was drawn by Sawyer- Tower circuit with PZT-PNN film. The coercive field and the remanent polarization of PZT-PNN film was 28.8 ㎸/㎝ and 18.3 μC/cm2 respectively. Its dielectric constants were shown between 128 and 1120, and become maximum value in MPB. The break down voltages of PZT-PNN films were shown between 27.0 and 60.0 MV/m. Crystalline and electrical characteristics of thin film indicate that characteristics of film is optimised at 550 ℃ sintering temperature. S.H.F. filter was made of #4 40:40:20 mol% thin film. For the case of ring-dot electrode type filter, resonance frequency and transmission loss were 435.26 ㎒ and -0.20 ㏈, and antiresonance frequency and transmission loss were 1905.11 ㎒ and -34.30 ㏈. For the case of thickness vibration filter, resonance frequency and transmission loss were 1035.17 ㎒ and -0.86 ㏈, and antiresonance frequency and transmission loss were 2310.07 ㎒ and -29.11 ㏈. For the case of SAW filter, resonance frequency and transmission loss were 228.28 ㎒ and -0.62 ㏈, and antiresonance frequency and transmission loss were 1352.86 ㎒ and -35.68 ㏈.

요골동맥을 이용한 관동맥 중재시술의 경험

윤정한,이승환,김장영,이한요,이명옥,김승년,황성오,최경훈 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

요골동맥을 이용한 관동맥 조영술의 유용성

윤정한,이승환,이한요,김장영,김일회,최윤종,이형준,이명옥,김승년,황성오,홍인수,최경훈 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.10

계절성 정동장애에 관한 임상적 연구

이경규,윤도준,장환일 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.1

The purpose of this study was to investigate : (l) whether seasonal affective disorders (SADs) exist among affective disorders in Korea ; (2) if there were SADs in Korea, whether they would be different from other countries' reports describing SAD as having atypical depressive symptoms ; and (3) Is there any difference between winter depression and summer depression as shown in the studies from other countries ; ie. WD shows atypical depressive symptoms and SD shows typical depressive symptoms ? The 76 subjects, having had suffered relapses for at least 2 years in succession, were selected from 375 patients with affective disorder who had been admitted to the Department of Neuropsychiatry of Kyung Hee University Hospital during the 10 years, from 1 January 1980 to 31 December 1989. This study was done by reviewing their records, making a comparison between SAD with depression (n=23) and nonseasonal affective disorder (NSAD) with depression(n=25). Also, another comparison was made between SD(n= 14) and WD(n=9) in SAD. They were analyzed according to sex, age of onset, season of birth, occupation, premorbid personality. family history of psychosis, and atypical depressive symptoms-hypersomnia. hyperphagia. carbohydrate craving, and irritability. The results were as follows : 1) There indeed were patients with SAD in Korea. The prevalence of SAD in this study was 10.9%. 2) Comparison between SAD and NSAD with depression : There was a significantly higher number of patients with NSAD with depression among those with indoor occupations and in families with a history of psychosis compared with patients with SAD with depression (p<0.05). There were no significant difference between them in other factors. 3) Comparison between SD and WD in SAD : There were no significant difference between them in all factors. In conclusion, SAD exists in Korea. But, there are no significant differences in depressive symptoms between SAD and NSAD with depression, or between SD and WD as is the case in the previous studies from other countries.

새로운 isoquinoline 유도체, AQ44의 혈관평활근 수축에 미치는 영향

김보경,김윤선,용준환,장병준,박태규,조성일,장기철,이상목 한국노화학회 1998 한국노화학회지 Vol.8 No.3

레트로바이러스의 표면단백질 : 인슐린의존형 당뇨병의 동물모델인 NOD 쥐의 혈청과 반응하는 새로운 자가항원 A New Autoantigen Reactive with Non Obese Diabetic (NOD) Mice Sera

김경수,김기환,김현만,윤지원,강엽 아주대학교 1997 아주의학 Vol.2 No.2

IDDM (Insulin dependent diabetes mellitus) is believed to be an autoimmune disease and characterized by the immune activation against insulin-producing pancreatic beta cell. The identification and characterization of new autoantigens reactive with an activated immune System would heip to elucidate the pathogenic mechanism of this disease. Several autoantigens are trying to apply for diagnosis and prevention of IDDM. The NOD (non obese diabetic) mice have been the best model for studying the pathogenesis of human IDDM. To identify new autoantigens reactive with activated humoral immunity of NOD mice, the lambda gt11 cDNA library was constructed from NOD-derived pancreatic beta cell (MIN6N8a: mouse insulinoma cell) and screened with prediabetic NOD sera. Mine positive dones were selected from 2x10^(5) phage plaques. The 5'-end sequencing and homology searching showed that six clones from nine clones had over 98% sequence homolgy with the retroviral envelope gene. Full sequendng reveated that the cloned gene was a fragment of ecotropic retrovirus (emv-3) envelope gene. To confirm the immunoreactivity of doned retroviral envelope protein, the cloned gene fragment was expressed in an E.coli expression vector System. Western blotting showed that the recombinant envelope protein fragment also reacted with prediabetic NOD sera.