자궁내 태아사망의 임상적 고찰

이권해,이정재,조현철,이석민,이임순,이해혁,김권대,이순곤,남계현 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

Objective: This study was designed to evaluate diagnosis and complication, prognosis during clinical study of cases of intrauterine fetal death. Methods and materials: This is a clinical study of 56 cases of the intrauterine fetal death among 8064 deliveries at Seoul Sunchunhyang university hospital during 5 years from January, 1994 to December, 1998. Results: The incidence was 0.7%. The age distribution of mothers was 18 - 44 years and was highest in the 25 - 29 years range(46.4%). The parity was the most highest in the nulliparous group(51.8%). The most common gestational weeks was 20 - 28 weeks gestational period(46.4%), and most common presentation was cephalic(73.5%). The most common weights of the intrauterine fetal death was from 5,00gm to 1,000g(48.2%). The mode of the most common delivery was the induction of delivery(57.2%). The etiologic factors were: unknown(42.9%), preeclampsia(17.9%), chorioamnionitis(14.3%), congenital anomaly(12.5%), abruptio placenta(7.1%), cord complication(3.6%), placenta previa, death of one for twin. There were 2 cases of maternal complication(DIC, Uterine atony). Conclusion : Intrauterine fetal death should be diagnosised early and treated properly to reduce risk of the maternal complication.

조산의 예측 지표로서의 fetal fibronectin의 유용성

정집광,이해혁,이정재,이석민,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: The purpose of this study was to evaluate clinical efficacy of fetal fibronectin as a marker to predictor of preterm labor. Materials & Methods: The study group consisted of sixty-eight healthy pregnant women, at gestational age between 24 and 36 weeks, who visited our department with vaginal discharge from April, 1995 to December, 1997. For comparison, we divided all of the pregnant women into two groups by the result of ROM-Check^®, positive groups(N=21) and negative groups(N=47). When preterm labor appeared, 50mg of ritodrine hydrochloride(Yutopar^®) mixed I liter of 5% dextrose solution was administered slowly intravenously. Results: 1) The gestational age at delivery and the interval time from admission to delivery in the positive groups were significantly shorter than those of the negative groups(p<0.05). 2) The positive groups had significantly lower birth weight and Apgar scores than the negative groups(p<0.05). 3) Among the negative groups, in case of tocolytics administration, the interval time from admission to delivery significantly delayed more than that time in case of no tocolytics administration(p<0.05). Conclusions: The detection of the fetal fibronectin in vaginal discharge had a useful method as a predictor of preterm labor. Tocolytics was more effective in the negative groups than in the positive groups.

자궁선근증의 고찰

조환성,이해혁,정성윤,김성욱,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: This study was designed to estimate the frequency and risk factor for edenomyosis Methods: The clinical records of 623 women undergoing hysterectomy were retrieved in the Department of Obstetrics and Gynecology, Soonchunhyang University Hospital, during 5 years, from Jan. 1995 to Dec. 1999. Results: The following result were obtained. 1. Adenomyosis was found in 247 of 623 patients(39.6%) 2. The highest incidence was 40-49 years of age group, an incidence of 46.6% and mean age was 44.7 years. 3. Adenomyosis was more frequently observed in parous women than non-parous women, such as 93.1% and 6.9%, respectively. 4. Dysmenorrhea, metrorrhagia, pelvic pain and vaginal bleeding were common symptom of adenomyosis, an incidence of 28.7%, 19.0%, 18.2% and 16.2%, respectively. 5. Myoma was the most combined disease in adenomyosis, showing the incidence of 54.7%. 6. Grossly, the size of uterus was enlarged more than 10 weeks gestational size in adenomyosis, an incidence of 61.9%. 7. Preoperative diagnostic accuracy of adenomyosis was 6.9%. Conclusion: The results show that deeply understanding of the common symptoms and epidemiology of adenomyosis improve the preoperative diagnostic accuracy.

아음속풍동의 제작과 난류경계층 구조의 변화에 관한 연구

李南榮,朴桂香,柳相信 한국항공대학교 1991 論文集 Vol.29 No.-

본 연구에서는 풍동의 활용성과 경제성, 장비설치 및 취급의 용이성등을 고려하여 요구풍속을 결정한 후 확산부, 정체실, 수축부, 시험부등을 설계하고, 제작된 풍동에 대한 성능검사를 실시하였다. 정체부와 시험부 수축비는 9이고 시험부의 단면은 406mm×406mm 이며 길이는 1,200mm 이다. 시험부에서 얻을 수 있는 최대속도는 송풍기 회전수 1,500rpm 일때 36m/sec이다. 송풍기 동력은 19kW 이며 송풍기 형태는 원심형 임펠러를 선택하였다. 시험부의 성능을 검사하기 위해 열선유속계를 사용하여 시험부 출구 단면에서의 속도분포와 난류강도를 조사하였다. 시험부의 속도는 5m/sec 에서 30m/sec 까지의 범위에서 난류강도는 0.5%이고 벽면경계층 두께를 고려하면 유효 단면적은 약 85%이다. 제작된 풍동에 에머리 페이퍼(emery paper) 또는 트리핑 와이어(tripping wire)를 부착한 매끈한 평판과 축대칭 3차원 물체를 장치하여 경계층 속의 흐름이 난류가 되도록 하였고 발생된 난류 경계층의 특성을 분석 하였다. In the present experimental study, the range of wind speed at the test section was determined by considering the availability, economy, installation and handling of the wind tunnel, and diffuser section, settling chamber, contraction section and test section of the wind tunnel were designed and manufactured to satisfy the prescribed wind speed range. Performance of the manufactured wind tunnel was tested according to the normal testing procedure. Contraction ratio of the test section to the settling chamber is 9 and the cross section of the test section is 406mm×406mm and the test section is 1200mm long. The maximum air speed at the test section is 36m/sec for the motor speed of 1500 rpm. A centrifugal type fan is used and the maximum power required is 19kw. The hot-wire anemometer system was employed to test the performance of the wind tunnel by measuring the velocity distribution and turbulent intensity at the exit of the test section. Measured values of turbulent intensity were less than 0.5% for the range of wind speed from 5m/sec to 30m/sec. The available cross sectional area of the test section was about 85%. Flat plate and axisymmetric three dimensional body were used as models to identify the boundary layer characteristics. The boundary layers were triggered by emery paper and/or tripping wire. The characteristics of the generated turbulent boundary layers were analyzed.

풍력발전의 설비이용율 특성연구

이계주,이은학,김유남 한라대학교 2009 論文集 Vol.12 No.-

The scheme described checking the change transition for annual average plant factor month and season respectively as standard with measuring power exchange on Korea Power Exchange (KPX) from 2003 to 2006 and analysis of characteristic of output of wind power on a huge Wind Power Plant Complex which is selected for evaluating capacity of wind pover The result of the change transition for annual average plant factor will carry out good place construction plan and Long-term Electric Power Development Plan It can find that Wind Energy will be very useful when comparison between the value of data for long-term operating of wind power and the value of data for real wind

40세 이하 관상동맥 질환자에서 장기적 임상 관찰

이승욱,정명호,박종철,박형욱,조상희,김원,김계훈,이상현,강경태,조장현,김남호,김건형,안영근,조정관,박종춘,강정채 全南大醫大 2001 전남의대학술지 Vol.37 No.2

골반 내 농양 1예

조인숙,이해혁,김태희,이권해,남계현,이임순,김정식,박성진 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Pelvic inflammatory disease (PID) is a disease that affects young, sexually active, reproductive age women. Most pathogens are Chlamydia trachomatis and Neisseria Gonorrheae transmitted sexually. One of serious acute complication of PID is tubo-ovarian abscess (TOA) that involves the fallopian tube, ovary and adjacent structures (eg, bowel, pelvic peritoneum). The microbiology of TOAs is polymicrobial with anaerobic organisms and causal organisms of PID. Common anaerobic organisms are Peptostretococcus spp, Bacteriodes spp, Prevotella spp, Escherichia coli and aerobic streptococci. Treatment is necessary to admission for intravenous broad-spectrum antibiotics and surgery is often reserved for patients with suspected rupture or patients who fail to respond to antibiotics. So, we reported this case found pelvic abscess due to ruptured tube-ovarian abscess.

비정질 Se_90Sb_10 박막의 결정화에 관한 연구

金太晩,李啓南 慶熙大學校 1989 論文集 Vol.18 No.-

The change of the dc conductivity during the isothermal annealing of Se_90Sb_10 film with time was studied at 60, 70 and 80℃. The change of the conductivity as a function of time was used as the characteristic quantity of amorphous-crystal transition. The Avrami equation which is represented with the change of log conductivity was applied to expain the process of crystallization of samples, and values of different parameters for the crystallization were evaluated. X-ray diffraction records of samples were used to study the same process. Evaluated values of Avrami exponent of samples were close to 2 or 1, which correspond to the one dimensional growing process. Rate constants k were 2.67 × 10 exp (-4), 1.02 × 10 exp (-3) and 2.22 × 10 exp (-3) for samples annealed at 60, 70 and 80℃, respectively. The activation energy of the crystallization, E, was 2.47 kcal/mole. And then dependence of the radius R of the spherulite crystalline domain on the time, and of the time rate of crystallization, ν, on R were understood.

원발성 난소 소세포암 2례

조인숙,남계현,김태희,김정식,이해혁,이권해,권계원 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Two cases of primary small cell carcinoma of the ovary occurred. One was a case of 43-year-old woman associated with hypercalcemia and the other was a case of 40-year-old woman with pulmonary type. Ovarian small cell carcinoma of the hypercalcemic type have clinicopathological, immunohistochemical, ultrastructural, and flow cytometric features that from differ from those of small cell carcinomas of the pulmonary type. It is important for therapeutic reasons to distinguish these two types of ovarian tumors from each other and from a variety of malignant small cell tumors that ovary primarily or secondarily. So, we reported these cases with a brief review of the concerned literatures.

Paclitaxel 및 Apo-2L/TRAIL이 자궁경부암 세포주 아포토시스에 미치는 영향

김주영,남계현,김태희,이권해,이해혁,배동한 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Objective: TRAIL(also called Apo-2L) is a member of the tumor necrosis factor(TNF) family of cytokines which induces apoptosis cell death in a variety of tumor cell lines. It mediates its apoptotic effects through one of two receptors, DR4 and DR5, which are members of the TNF receptor family, and whose cytoplasmic regions contain death domains. TNF and Fas ligand induces apoptosis in tumor cells; however, their severe toxicity toward normal tissues hampers their application to cancer therapy. We examed if paclitaxed and/or Apo-2LTRAIL induces apoptosis of cervical cancer HeLa, SiHa, ME-180, and CaSki cells. Mehods : We have demonstrated that paclitaxel and Apo-2L/TRAIL induces apoptosis of cervical cancer HeLa, SiHa, CaSki and ME-180 cell lines in a dose-dependent manner. HeLa, SiHa, ME-180 and CaSki were obtained from American Type Culture Colection. Recombinant Human TRAIL(Chmicon). DR4 and DR5 were purchased from Santa Cruz. Paclitaxel, MTT assay Kit, Acridine orange and Ethium bormide were purchased from Sigma. HeLa and SiHa were grown in DMEM. ME-180 and CaSki were grown in RPMI. Tripan blue stain and MTT assay were done for cytotoxicity. Annexin V-FITC and PI(propidium iodide) flowcytometry for apoptosis assay. DR4 and DR% were expressed by Western Blot. Fluorescent Microscopy used Acridine orange(AO) and Ethium bromide(EB). Results : Importantly, concurrent treatment of cervical cancer cells with paclitaxed and Apo-2L/TRAIL induces significantly more apoptosis than Apo-2L/TRAIL alone. Conclusion : We need further studies which reveals possible therapeutic potential in the women with cervical cancer by suing Apo-2L/TRAIL.