직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성

홍수민 ( Su Min Hong ),김유선 ( You Sun Kim ),문정섭 ( Jung Seop Moon ),김진남 ( Jin Nam Kim ),오명기 ( Myoung Ki Oh ),권선옥 ( Sun Ok Kwon ),정성연 ( Seong Yeon Jeong ),홍성우 ( Seong Woo Hong ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.

冷却水溫 變化에 따른 가솔린 기관 特性에 關한 實驗的 硏究

권기린,홍성수 제주대학교 산업기술연구소 2000 尖端技術硏究所論文集 Vol.11 No.1

The purpose of this study is to prevent the stick, scuffing, scratch between piston and cylinder in advance, to obtain data for duration test in actual engine operation. The temperature gradient in cylinder bore according to coolant temperature were measured in use of 1.5ℓ class gasoline engine. 20 thermocouples were installed at points of 2mm inside from cylinder wall near top ring of piston in cylinder block, which points have suffered major thermal loads and suggested as proper measurement points for engine design by industrial engineers. Under full load and 70℃, 80℃ and 90℃ coolant temperature conditions, the temperature in cylinder block and engine oil increased gradually in according to the increase of coolant temperature, the siamese side temperature of top dead center is 142℃ in peripheral distribution, that is about 20℃ higher than thrust, anti-thrust, and rear side temperature, the fuel consumption in 70℃ coolant temperature is lower than 80℃ and 90℃ coolant temperature, the engine torque in 80℃, 90℃ coolant temperature condition is about 0.5kg.m higher than 70℃ coolant temperature.

한국인 관상동맥의 변화양상에 대한 형태학적 연구

권태정,이상용,이한영,고영창,권기석,조재홍,김태공,김유훈,조갑래,서중석,이원태 內務部 國立科學搜査硏究所 2001 國立 科學 搜査 硏究所 年報 Vol.33 No.-

전위된 상악 견치 및 하악 측절치의 치험례

권해숙,현홍근,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

Tooth transposition is an anomaly of eruption characterized by the interchanged positions of two adjacent teeth, which is divided into complete and incomplete transposition. There are three common approaches for treating transposition: aligning the involved teeth in their transposed positions, moving them to their correct anatomic position in the arch and extracting one of the transposed teeth. Considerations in treatment plans are esthetic, function, risk of jeopardizing the roots and damaging the supporting structures, position of the root apex, developmental stages of teeth and expected compliance. The presented case reports described one maxillary canine-the first premolar transposition and two mandibular lateral incisor-canine transpositions. The former transposed teeth were arranged in their transposed position, and the latter transposed teeth were rearranged into their normal position. 치아전위란 인접한 두 치아의 위치가 서로 바뀐 치아 위치 이상을 말하며, 치관과 치근의 위치에 따라 완전전위와 불완전전위로 나눌 수 있다. 하악보다는 상악에 편측성으로 호발하며, 특히 상악 견치에서 자주 발생한다. 전위는 발견 시기와 전위된 양상에 따라 치료방법이 달라질 수 있다. 본 증례는 상악 견치와 제1소구치 간의 전위가 일어난 10세 7개월의 환아와 하악 측절치와 견치 간의 전위가 일어난 8세 11개월 환아와 8세 9개월 환아의 교정치료에 대한 것으로 양호한 치료 결과를 얻었고, 증례 별로 치료방법의 차이점에 관한 고찰을 하였기에 이를 보고하는 바이다.

옥정호수계에 있어서 화학적 및 생물학적 오염도 지표조사

권태영,강경홍,박기남 전주대학교 자연과학종합연구소 1997 전주대학교 자연과학연구소 학술논문집 Vol.10 No.3

A inveatigation in water system in Okjung lake for the pollution loading and self purification capacity, the nitrate concentration, as a pollution loading index, was 0.2-0.3mM in Sumjin river and Sangchi stream. Imsil stream was mainly pollution source in water system of Okjung lake. Nitrate concentration of Okjung lake was 0.06-0.1mM. This results was mean that the capacity of self-purification of Okjung lake have in reserve.

유치 수복물에 따른 주변 법랑질의 탈회 저항성 : QLF를 이용한 연구

권해숙,현홍근,김영재,김정욱,장기택,김종철,한세현,이상훈 大韓小兒齒科學會 2010 大韓小兒齒科學會誌 Vol.37 No.1

본 연구에서는 유치 수복물의 불소 방출 여부에 따른 주변 법랑질의 탈회 저항성과 재광화 효과를 살펴보고자 하였다. 건전 유전치 48개를 16개씩 임의로 세 군으로 나누어, FiltekTM Z250(1군), F2000(2군), KetacTM N100(3군)을 사용하여 제조사의 지시에 따라 충전하였다. 3일 동안 인공 우식 병소를 유발한 후, 14일 동안 인공 타액에 담가 재광화를 유발하였다. Quantitative light-induced fluorescence(QLF)를 이용하여 실험 단계와 시간에 따른 무기질 소실량(ΔQ)의 변화를 관찰한 결과는 다음과 같다. 1. 탈회가 일어난 인공 우식 병소의 ΔQ 값은 3군, 2군, 1군 순으로 작게 나타났고, 이 중 3군은 1군에 비해 유의한 탈회 저항성을 보였다. 2. 1군, 2군, 3군 모두 재광화 1일 후부터 초기 인공 우식 병소의 ΔQ 값과 비교 시 유의한 차를 보였으며, 관찰 기간 동안 지속적인 증가 양상을 나타내었다. 3. 재광화 속도를 의미하는 Δ(ΔQ)/일 값은 각 군에서 처음 1일 동안 유의성 있게 크게 나타났으며, 그 이후 급속히 감소하였다. 4. 수복 재료에 따른 재광화 정도는 각 군 간에 유의한 차이가 없었다. The objective of this in vitro study was to detect and monitor demineralization and remineralization of primary teeth according to restorative materials using quantitative light-induced fluorescence (QLF). A single bur hole was drilled on the each sound forty eight primary anterior teeth, and the specimens were divided into three groups. The cavity was restored with FiltekTM Z250(Group 1), F2000(Group 2), KetacTM N100(Group 3) following the manufacturer's instructions. The teeth were subjected to the demineralizing buffer for 3 days, and then subjected to a remineralizing buffer for 14 days. The change of mineral loss(ΔQ) according to the stages was evaluated by QLF and the following results were obtained: 1. When demineralization was done, ΔQ was increased as follows. : Group 1 (-110.79 ± 27.77) < Group 2 (-104.84 ± 28.95) < Group 3 (-90.16 ± 21.87) : Resistance to demineralization was statistically significant in Group 3. 2. There was a statistically significant increase in ΔQ of all groups since 1st day of remineralization 3. The rate of remineralization, Δ(ΔQ)/day, showed significant high value in each group on the 1st day then decreased rapidly. 4. There was no statistically significant difference in the degree of remineralization among restorative materials.

급성 ST 분절 상승 심근경색증의 표준진료지침 설계

권선옥,김우식,오명기,나종천,이홍기,조욱현,최석구 인제대학교 2006 仁濟醫學 Vol.27 No.-

The use of critical pathways for a variety of clinical conditions has grown rapidly in recent years, particularly pathways for patients with acute myocardial infarction. We intend to determine the impact of a clinical pathway on ST-elevation myocardial infarction (STEMI) and to evaluate the efficacy and safety of facilitated percutaneous coronary intervention (PCI) compared with primary PCI. Low risk STEMI patients (ST elevation >0.1mV in more than 2 limb leads or ST elevation >0.2mV in contiguous precordial lead, chest pain lasting more than 30 min without response to nitroglycerin) will be included. All patients will be also treated medically according to critical pathway. STEMI is one of the common diseases in emergency medicine and so it is necessary to establish realistic treatment guidelines. The use of critical pathways will improve the quality of care.

냉각수온 변화에 따른 가솔린 기관 특성에 관한 실험적 연구

권기린,홍성수 濟州大學校 産業技術硏究所 2000 산업기술연구소논문집 Vol.11 No.1

The purpose of this study is to prevent the stick, scuffing. scratch between piston and cylinder in advance, to obtain data for duration test in actual engine operation. The temperature gradient in cylinder bore according to coolant temperature were measured in use of 1.5 1 class gasoline engine. 20 thermocouples were installed at points of 2mm inside from cylinder wall near top ring of piston in cylinder block. which points have suffered major thermal loads and suggested as proper measurement points for engine design by industrial engineers. Under full load and 70%. 80% and 90% coolant temperature conditions. the temperature in cylinder block and engine oil increased gradually in according to the increase of coolant temperature, the Siamese side temperature of top dead center is 142% in peripheral distribution. that is about 20% higher than thrust. anti-thrust. and rear side temperature. the fuel consumption in 70% coolant temperature is lower than 80% and 90% coolant temperature, the engine torque in 80%. 90℃ coolant temperature condition is about O.5kg.m higher than 70% coolant temperature.

불소가 첨가된 실리콘 산화막의 다층금속절연 특성에 관한 연구

權大赫,南基泓,吳相光 慶一大學校 1997 論文集 Vol.14 No.2

The characteristics of fluorinated silicon oxide (SiOF) films prepared by plasma enhanced chemical vapor deposition(PECVD) were discussed. The deposition of these films was carried out in the temperature range of 80 - 220℃ in a conventional parallel plate plasma reactor with 〈 ±3% uniformity by flowing 2 sccm of disilane (Si₂H6), 100 sccm of nitrous oxide (N₂O), and 20 sccm of tetrafluoromethane (CF₄). AS the deposition temperature increased from 80 to 220℃, the deposition rate of the films increased from 16.7 to 18.4 nm/min; meanwhile, the etch rate decreased from 2.69 to 1.48 nm/sec. The refractive index was 1.46 regardless of the deposition temperature. The Fourier transform infrared (FTIR) spectra of the films showed decreasing Si-O stretching wave number with increasing full width at half maximum (FWHM) as deposition temperature increased. The high frequency capacitance-voltage (C-V) measurements of the metal-oxide-semiconductor (MOS) capacitors fabricated using the films showed increasing effective oxide charge density and decreasing dielectric constant with increasing deposition temperature. Deposition temperature of 180℃ resulted in films with the smallest dielectric constant of 3.75. These films showed an average breakdown strength of 9.14 MV/cm with 77.5% of the MOS capacitors having breakdown field strength ≥9.5 MV/cm

오존처리에 의한 하수슬러지의 감량화

권재현,류성호,박기영,안규홍,염익태,이용훈 대한상하수도학회 2002 상하수도학회지 Vol.16 No.2

The effects of ozone treatment on the dewaterability of activated sludge wasted from a sewage treatment plant were investigated in this study. Following ozone treatment, sludge was dewatered using a pressure fitter. The sludge filterability evaluated by SRF deteriorated with ozone dosage at relatively low ozone doses due to sludge solubilization and particle size decrease. However, at ozone doses higher than 0.6gO_3/gSS, the SRF of the ozone treated sludge became comparable with the value for the sludge without ozone treatment. It is suggested that the oxidation of the viscous, high molecule organics attached at cell surface reduces the surface charge of sludge particle and promotes flocculation at relatively high ozone doses. Ozone treatment also cause the release of bound water trapped inside cells or flocs, resulting in significant reduction of cake water content after dewatering. In terms of cake volume, more than 70% reduction was obtained at 0.6gO_3/gSS. These observations suggest that ozone treatment has potential to significantly enhance sludge dewaterability and to produce a more compact cake without severe deterioration of its filterability.