Tianeptine,SSRIs,Moclobemide가 성기능에 미치는 영향

권도훈,강병조 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1

In this study, the author prospectively analyzed the effects of SSRIs, RIMA(moclobemide) and SSRE (tianeptine) on sexual function using a questionnaire. Among patients who visited the outpatient department of Kyungpook University Hospital from November 1998 to May 2000, the author included patients who met DSM-IV diagnostic criteria for depressive disorder. Sexual function and satisfaction was evaluated using a series of questions asked of each patient every 2 weeks for 8 weeks. Among 24 patients who completed the full 8 weeks of treatment, 8 received tianeptine(men 3, women 5), 7 received moclobemide(men 3, women 4), and 9 receded SSRIs(men 6, women 3). Of 8 tianeptine group, 7 reported total improvement in sexual function and satisfaction comparable to premorbid condition within 4 weeks of treatment, and another woman who had net experienced substantial improvement till 8 weeks had good tolerance in sexual function and reported some improvement in lubrication. Of 7 moclobemide group, 5 reported no significant differences in their sexual function associated with medication. In SSRI group, all patients complained of delayed ejaculation and anorgasmia associated with medication within 4 weeks of treatment, and among them 2 reported decreased libido and difficulty in erection (lubrication) in addition. But at 8 weeks, except for 1 female patient who couldn't tolerate general sexual dysfunction(especially anorgasmia) and was switched over to another antidepressant, 5 male patients reported no significant differences in their sexual function. The result of this study demonstrated that sexual dysfunction associated with SSRIs might be adapted in most cases when taken continuously and moclobemide had no significant association with sexual dysfunction. Tianeptine, in most depressive patients, recovered general sexual function including libido, erection (lubrication), ejaculation and orgasm to premorbid condition and might be a desirable drug of choice and an altermative in patients who complain of sexual dysfunction.

자의퇴원의 결정요인에 대한 환자-대조군 연구 : 입원 및 재원 적절성을 중심으로

김도환,박훈기,이정권,이도희 大韓家庭醫學會 2000 Korean Journal of Family Medicine Vol.21 No.11

Psychosis, Intermittent Hyponatremia, and Polydipsia에 의해 혼수에 빠진 만성정신분열병 1례

정성훈,권도훈 대한생물치료정신의학회 1997 생물치료정신의학 Vol.3 No.2

PIP 증후군은 임상에서 흔히 볼 수 있는 심인성 다음중에 SIADH가 서로 상호보완적으로 작용하여 발생하는 질환으로 볼 수 있으나, 다음증과 PIP 증후군이 구분없이 사용될 만큼 아직까지 개념이 명백하지 않는 질환으로 많은 경우에서 내과적 질환으로 생각하고 간과되는 경향이 있다. 향후 다음증과 PIP 증후군에 대한 진단기준, 발생기전, 치료에 대해 체계적인 연가 필요할 것으로 생각되며 현재로서는 보다 많은 임상의들이 이 질환에 대해 주의를 해서 조기에 발견하여 PIP 증후군의 심각한 합병증들을 방지하도록 노력할 필요가 있다. Molindone, risperidone, clozapine과 같은 항정신병약물과 naloxone은 정신병적 증상호전과 함께 PIP 증후군 증상완화에 도움이 되리라 생각된다. Psychosis, Intermittent hyponatremia, and Polydipsia(PIP syndrome) is a serious problem in many patients with chronic psychiatric illness. It may have lot of complications. These complications, if not recognized, are likely to contribute to worsening of psychosis despite appropriate pharmacological treatment while severly limiting the patient's ability to actively participate in behavioral interventions. A 48 year old chronic schizophrenic patient developed PIP syndrome with coma state induced by two antipsychotics. Potential pathophysiological mechanisms and treatment considerations are discussed.

한국에서 메스암페타민 남용 또는 의존 환자의 인격장애에 관한 연구

김소영,권성민,조성남,권도훈,강병조,김형태 대한생물치료정신의학회 2003 생물치료정신의학 Vol.9 No.2

연구 목적 : 메스암페타민 남용 또는 의존이 없는 군과 있는 군 사이의 인격장애의 유병율을 알아보고, 메스암페타민 남용 또는 의존군에서 동반 인격장애가 그들의 전반적 기능 및 일반적 특성에 어떠한 영향을 미치는지 알아보고자 하였다. 방 법 : 대상은 정상대조군에서 메스암페타민 남용 또는 의존이 없는 50명과 정신병원에 입원한 메스암페타민 남용 또는 의존환자 50명이었다. 메스암페타민 남용과 전반적 기능에 대한 평가는 DSM-Ⅳ에 의거하였고, 인격장애를 평가하기 위해 대상군 모두에서 PDQ-4+를 시행하였다. 결 과 : 정상대조군은 34%에서 적어도 1개 이상의 인격장애를 나타내었으며, 한 사람 당 평균 3.94개였다. 메스암페타민 남용 또는 의존군은 64%에서 적어도 1개 이상의 인격장애를 보였으며, 한 환자 당 평균 4.72개였다. 메스암페타민 남용 또는 의존군에서 동반 인격장애의 유무는 시작 연령, 사용 용량, 그리고 입원 또는 구치 횟수와는 관련성이 없는 것으로 나타났으나, 3개 이상의 동반 인격장애를 가질 경우, 그렇지 않은 군에 비해 전반적 기능이 떨어졌다. 결 론 : 본 연구 결과, 우리나라에서도 일반인에 비해 물질사용장애 환자에서 인격장애를 동반할 가능성이 높으며, 물질사용장애 환자 중에서도 인격장애를 동반한 군이 그렇지 않은 군에 비해 전반적으로 기능이 떨어진다는 결론이 가능하게 되었다. Objectives : The purpose of this study was to examine the prevalence of personality disorders between normal control group and hospitalized methamphetamine abuse or dependent patients and, among the latter, the influence of comorbid personality disorder on their global assesment function and general characteristics. Methods : Subjects were 50 non-methamphetamine abuse or dependent persons in the general population group and 50 methamphetamine abuse or dependent patients admitted to the psychiatric hospital. Methamphetamine abuse or dependence and the global assesment function were diagnosed according to DSM-Ⅳ, and the presence of personality disorder was assessed with the PDQ-4+. Results : In the normal control group, 34% of subjects had at least one personality disorder and the average number of personality disorder was 3.94 per person. In the methamphetamine abuse or dependent group, 64% of the patients had at least one personality disorder and the average number .of personality disorder was 4.72 per patient. The presence of comorbid personality disorder were not associated with onset age, use dosage and the number of admission or arrest among the methamphetamine abuse or dependent group. But, when methamphetamine abuse or dependent patients had more than three personality disorders, the global assessment function was impaired. Conclusion : In our study, substance use disorder patients had the higher possibility of comorbid personality disorder in Korea, and among substance use disorder patients, those with comorbid personality disorders were associated with the greater global impairment.

메스암페타민 사용 환자의 정신과적 증상에 영향을 미치는 요인

이춘우,권성민,조성남,권도훈,임효덕,이성국 대한생물치료정신의학회 2004 생물치료정신의학 Vol.10 No.1

목 적 : 본 연구는 메스암페타민 남용 또는 의존 환자의 사회인구학적 특성과 이에 따른 동반된 정신장애를 알아보고, 메스암페타민 사용이 정신과적 증상에 미치는 영향을 알아보기 위함이다. 방 법 : 2002년 7월부터 2003년 7월까지 국립부곡병원 약물중독진료소에 입원한 환자 중 DSM-Ⅳ 진단 기준에 의하여 메스암페타민 남용 또는 의존으로 진단된 44명의 남자 환자를 대상으로 사회인구학적 변인과 물질 의존의 병력, SCL-90-R, BPRS, HRSD, YMRS, Impulsive scale 등을 측정하였다. 결 과 : 메스암페타민 사용 환자들의 93.2%가 우울하였으며, 59.1%는 치료가 필요한 정도의 우울증을 가지고 있었다. 20대 연령층에서는 대인예민성, 적대감 및 공포증에서 유의하게 높았고, 중졸 이하의 교육 수준에서는 대인예민성, 충동성에서 유의하게 높았으며, 무직인 경우는 강박증, 불만, 적대감 및 조중 척도에서 유의하게 높았다. 처음 사용한 연령은 사용 횟수, 유병 기간과 유의한 상관 관계를 보였으나, 수감 횟수와는 낮은 상관 관계를 보였다. 사용 횟수와 적대감, 공포증, 편집증은 서로 유의한 정상관을 보였다. 우울증 척도와 정신병 척도 및 충동성 척도는 서로 유의한 정상관을 보였다. 100회 미만보다 500회 이상 사용했을 경우에 불안, 적대감, 공포증 및 편집증에서 유의하게 높았다. 결 론 : 메스암페타민 남용 또는 의존 환자에서 우울증 유병률이 매우 높게 나타났고, 20대 연령층과 중졸 이하의 교육 수준 그리고 무직인 경우 정신과적 증상이 많이 동반되었으며, 사용 횟수에 따라 불안, 적대감, 공포증, 편집증에서 유의한 차이를 보였다. 그러므로 모든 메스암페타민 사용자에 대해 적절한 정신과적 평가가 필요할 것으로 생각한다. Objectives : The purpose of this study was to examine the sociodemographic characteristics and the comorbid psychiatric disorders and the effect of methamphetamine use on psychiatric symptoms in methamphetamine abuse or dependent patients. Methods : The study subjects were 44 hospitalized male patients who met the DSM-Ⅳ criteria for methamphetamine abuse or dependence. The study included items assessing the sociodemographic profiles, history of substance use, and psychiatric symptomatology. Psychiatric assessments were based on SCL-90-R, BPRS, HRSD, YMRS and Impulsive scale. Results : In methamphetamine use patients, 93.2% were depressed and 59% had moderate to severe depression There were significant differences in interpersonal- sensitivity, hostility and phobia in the 3rd decade age group, interpersonal-sensitivity and impulsive scale in .under the middle school education group, and obsession-compulsion, anxiety, hostility and. YMRS in no-job group, respectively compared to the other groups. Age of the first use was correlated with the frequency of use, and also with the duration of illness, but not with the number of incarceration. There were positive correlations among HRSD, BPRS and impulsive scale. In the above 500 times used group there were significant differences in anxiety, hostility, phobia and paranoia compared to the below 100 times used group. Conclusion : In methamphetamine abuse or dependent patients, the incidence rate of comorbid depression was 93.2%. In the 3rd decade age group, under the middle school education group and no-job group showed higher diverse psychiatric symptoms compared to the other groups. Frequency of use was positively correlated with the symptoms such as anxiety, hostility, phobia and paranoia. We suggest that relevant psychiatric evaluations are needed for all methamphetamine users.

양방과 한방에 대한 인식 조사

강병조,채병진,권도훈,김풍택,김재식 대한생물치료정신의학회 1999 생물치료정신의학 Vol.5 No.2

In order to find out whether or not the general public have understanding of modern and oriental medical practices and if they do what the extent of their understanding is, 640 subjects were chosen over a four-month period in 1998. They were given questionnaires to answer and the key results of the study are as the following:1. The public were found to prefer modern medicine to oriental medicine.2. About 1/3 were using both modern and oriental medicines.3. 4/5 of the cases believed certain diseases are to get better efficacy from oriental medicine and such diseases are known to be neuraligia, myalgia, stroke, lumbago and gastric disease.4. 3/4 believed that modern medicine is good for treatment while oriental medicine is good as restorative.In summary, this study show that major medical system is modern medicine and oriental medicine is only for restorative and complementary.

양방과 한방에 대한 인식 조사

강병조,채병진,권도훈,김풍택,김재식 경북대학교 병원 2002 경북대학교병원의학연구소논문집 Vol.6 No.1

In order to out whether or not the general public have understanding of modern and oriental medical practices and if they do what the extent of their understanding is, 640 subjects were chosen over a four-month period in 1998. They were given questionnaires to answer and the key results of the study are as the following: 1.The public were found to prefer modern medicine. 2.About 1/3 were using both modern and oriental medicines. 3.4/5 of the cases believed certain diseases are to get better efficacy from oriental medicine and such diseases are known to be neuraligia, mylgia, stroke, lumdago and gastric disease. 4.3/4 believed that modern medicine is good for treatment while oriental medicine is good as restorative. In summary, this study show that major medical system is modern medicine and oriental medicine is only restorative and complementary.

Antiadhesive effect and safety of oxidized regenerated cellulose after thyroidectomy

Kyoung Sik Park,Kyu Eun Lee,Do Hoon Ku,Su-Jin Kim,Won Seo Park2,Hoon Yub Kim3,,Mi Ra Kwon1,Yeo-Kyu Youn1 대한외과학회 2013 Annals of Surgical Treatment and Research(ASRT) Vol.84 No.6

Purpose: To evaluate the antiadhesive effects and safety of an oxidized regenerated cellulose (Interceed) after thyroidectomy. Methods: Seventy-six thyroidectomized patients were prospectively randomized into two groups with regard to the use of Interceed. We evaluated each group for their adhesive symptoms using four subjective and four objective items at the 2nd week, 3rd and 6th month after thyroidectomy. All patients were examined for vocal cord motility by indirect laryngoscope at each period. Results: Total adhesion scores at each postoperative follow-up period decreased with time, but were not significantly different in each group. The median score for swallowing discomfort for liquid was significantly lower in the Interceed group than in the control group 2 weeks after surgery. In addition, the severity of skin adhesion to the trachea was reduced in the Interceed group compared with the control group 6 months after surgery. During the study, there were no adverse effects or significant differences in postoperative complications between the groups. Conclusion: Interceed appeared to be safe and effective in improving neck discomfort at early postoperative periods and preventing skin adhesion to the trachea 6 months after thyroidectomy.

Synthesis and Evaluation of Multifunctional Fluorescent Inhibitors with Synergistic Interaction of Prostate-Specific Membrane Antigen and Hypoxia for Prostate Cancer

Kwon, Young-Do,Oh, Jung-Mi,La, Minh Thanh,Chung, Hea-Jong,Lee, Sun Joo,Chun, Sungkun,Lee, Sun-Hwa,Jeong, Byung-Hoon,Kim, Hee-Kwon American Chemical Society 2019 Bioconjugate chemistry Vol.30 No.1

<P>Prostate cancer is one of the most common cancers in the world. It is widely known that prostate-specific membrane antigen (PSMA) is highly expressed in prostate cancer, and hypoxia is a common characteristic of many solid tumors, including prostate cancer. In this study, we designed multifunctional fluorescent inhibitors to target PSMA and tumor hypoxia in order to increase the tumor uptake of inhibitors. Novel PSMA inhibitors were prepared using lysine as the backbone to connect three different functional groups: the glutamate-urea-lysine (GUL) structure for inhibiting PSMA, 2-nitroimidazole for the hypoxia-sensitive moiety, and a near-infrared fluorophore (sulfo-Cyanine 5.5). According to the <I>in vitro</I> PSMA binding assay, novel fluorescent inhibitors were demonstrated to have nanomolar binding affinities. Multifunctional inhibitor <B>2</B> with one 2-nitroimidazole had a similar inhibitory activity to inhibitor <B>1</B> that did not contain the hypoxia targeting moiety, but multifunctional inhibitor <B>3</B> with two 2-nitroimidazoles showed lower inhibitory activity than inhibitor <B>1</B> due to the bulky structure of the hypoxia-sensitive group. However, <I>in vivo</I> optical imaging and <I>ex vivo</I> biodistribution studies indicated that both multifunctional inhibitors <B>2</B> and <B>3</B> had higher accumulation in tumors than inhibitor <B>1</B> due to a synergistic combination of PSMA and hypoxia targeting moieties. These observations suggest that this novel multifunctional strategy might be a promising approach to improve the diagnosis and therapy of prostate cancer.</P> [FIG OMISSION]</BR>

A Case of Dural Ectasia with Low Back Pain and Sciatica Treated with Integrative Korean Medical Treatment

Kwon, Oh-Hoon,Kim, Sang-Gyun,Park, Ju-Hun,Yoo, Dong-Hwi,Choi, Ki-Hoon,Choi, Ki-Won,Ha, Do-Hyung,Cho, Hyun-Woo Korean AcupunctureMoxibustion Medicine Society 2019 Korean Journal of Acupuncture Vol.36 No.3

Dural ectasia is defined as ballooning or expansion of the dural sac surrounding the spinal cord. This report describes a rare case of low back pain and sciatica, suspected as being dural ectasia. The patient was hospitalized for 45 days, and underwent integrative Korean medical treatment, including pharmacopuncture, acupuncture, herbal medicine, Chuna therapy, cupping therapy, and physiotherapy. The effect of the treatment was evaluated using the numerical rating scale, Oswestry disability index, European quality of life 5 dimensions, and subjective symptoms. After inpatient treatment, the pain the patient experienced was significantly reduced and the evaluation indices improved. This case report suggested that integrative Korean medical treatment could be an effective therapeutic choice for low back pain and sciatica, with dural ectasia. Further clinical studies are needed to support this observation.