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채병진,강병조 대한생물치료정신의학회 2000 생물치료정신의학 Vol.6 No.1
This study was performed to determine if there is an increased risk of diabetes mellitus and/or impaired glucose tolerance and/or glycemic peak delay during clozapine treatment compared with haloperidol treatment. Oral glucose tolerance tests were used for 8 weeks to assess the prevalence of diabetes mellitus, impaired glucose tolerance and glycemic peak delay in 19 patients of the clozapine group compared with 15 patients of the haloperidol group. There were 2 dropouts in the clozapine group and 5 in the haloperidol group. So finally 17 patients in the clozapine group and 10 patients in the haloperidol group participated in this study. In the clozapine group, 6 patients(35%) had impaired glucose tolerance, and 7 patients(41%) had glycemic peak delay. In the haloperidol group, no patient(0%,) had impaired glucose tolerance, and 1 patient(10%) had glycemic peak delay. None of either group developed diabetes mellitus. In conclusion, subjects in the clozapine group had more impaired glucose tolerance and glycemic peak delay than subjects in the haloperidol group. However, this difference did not achieve statistical significance (p=0.056, p=0.079).
Venlafaxine-Induced Mania After Nortriptyline-Induced Hypomania in Unipolar Depression
Beang-Jin Chae(채병진) 대한생물치료정신의학회 2008 생물치료정신의학 Vol.14 No.1
Venlafaxine은 세로토닌 수용체나 아드레날린 수용체 차단을 통해 효과를 나타내는 항우울제이다. 저자는 33세의 우울증을 앓고 있는 여성에서 venlafaxine에 의한 조증을 경험하여 보고하고자 한다. 이 여성은 nortriptyline에 의한 경조증의 과거력과 자살의 가족력이 있었다. Venlafaxine으로 치료한지 51일째부터 조증으로 전환되었고, 이후venlafaxine을 중단한후 25일째부터 조증 증상이 소실되었다. 이 증례는 양극성 성향을 가진 단극성 우울증 환자에서 venlafaxine을 사용시 조증이나 경조증으로는 전환을 일으킬 수도 있음을 시사한다. Venlafaxine is an effective antidepressant medication which acts through the blockage of serotonergic or noradrenergic receptors. I present a case of venlafaxine induced mania in a unipolar depressed 33 year old woman. She had a history of nortriptyline induced hypomania and a family history of suicide. 51 days after beginning venlafaxine, she began developing manic switch. Twenty five days after stopping venlafaxine, manic symptoms disappeared. This case suggests that venlafaxine may be associated with a switch to mania or hypomania in unipolar depressive patient with bipolarity.
강병조,채병진,권도훈,김풍택,김재식 경북대학교 병원 2002 경북대학교병원의학연구소논문집 Vol.6 No.1
In order to out whether or not the general public have understanding of modern and oriental medical practices and if they do what the extent of their understanding is, 640 subjects were chosen over a four-month period in 1998. They were given questionnaires to answer and the key results of the study are as the following: 1.The public were found to prefer modern medicine. 2.About 1/3 were using both modern and oriental medicines. 3.4/5 of the cases believed certain diseases are to get better efficacy from oriental medicine and such diseases are known to be neuraligia, mylgia, stroke, lumdago and gastric disease. 4.3/4 believed that modern medicine is good for treatment while oriental medicine is good as restorative. In summary, this study show that major medical system is modern medicine and oriental medicine is only restorative and complementary.