A-431 세포주의 방사선 및 항암제의 감수성에 관한 실험적 연구

고광준,최은숙,홍성우 大韓口腔顎顔面 放射線學會 1999 Imaging Science in Dentistry Vol.29 No.1

Objectives: The purpose of this study was to aid in the prediction of tumor cell tolerance to radiotherapy and/or chemotherapy. Material and Methods: Human epidermoid carcinoma A-431 cell lines were irradiated by 2, 4, 6, 8, 10Gy at a dose rate of 210cGy/min using Co Irradiator ALDORADO 8 and then were exposed to bleomycin or cisplatin at concentration of 2㎍/ml for 1 hour. The viable cells were determined for each radiation dose and/or each drug at the 4th day and cell surviving curves were obtained using semiautomated MTT assay. Results: The surviving fraction after irradiation of 2Gy was 0.99, and there was not significant difference of surviving fraction in comparison with the control group on A-431 cell line(P>0.05). But there were significant differences of surviving fractions at doses of 4, 6, 8, 10Gy in comparison with the control group(P<0.05). The cytotoxicity of bleomycin or cisplatin was significantly different in comparison with the control group on A-431 cell line (P<0.05). And the cytotoxicity of cisplatin was greater than that of bleomycin on A 431 cell line (P<0.05). There were significant differences of surviving fractions after irradiation of 2, 4, 6, 8, 10Gy with bleomycin or cisplatin in comparison with each group of irradiation only on A-431 cell line(P0.05). There were significant differences of surviving fractions between the groups of irradiation with bleomycin and cisplatin at doses of 2, 4Gy(P<0.05), but there were not significant differences of surviving fractions at doses of 6, 8, 10Gy on A-431 cell line(P>0.05).(J Korean Oral Maxillofac Radiol 1999:29:325-337)

마라톤 웹사이트의 서비스품질이 고객만족 및 구매후 행동에 미치는 영향

고성온,유근직 江原大學校附設體育科學硏究所 2004 江原大學校附設體育科學硏究所論文集 Vol.- No.27

The purpose of this study was to examing the influence of service quality in marathon web site on customer satisfaction and post-purchase behavior. The subjects of this study were 331 people who had visited a marathon web site. The web site's service quality is consisted of four dimensions as follows; Information, Convenience, flow experience, Communication factors. To analyze the collected data for this study, SPSS 10.0 program and AMOS 4.0 were used for descriptive statistics, factor analysis and structural equation modeling(SEM). The results of this study were as follows. The first, three factors n service quality(Information, Convenience, flow experience) affected the customer satisfaction with statistic significance. Especially, level of providing Information affected customer satisfaction directly. The second, customer satisfaction affected word of mouth(WOM) and reentering in web site related to marathjon with statistic significance. In conclusion, web site for marathon in future needs to improve the information service, helpful and interesting contents, and convenient procedures for facilitating people's interest in marathjon.

일개 지방자치단체의 건강진전도 평가

고광욱,김윤지,송성은,김정민 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.1

Background: Healthy and sustainable community is essential component of development. But there has been no systematic reporting about healthy municipality in specific city, although economic development results in considerable progress. Method: According to the Ontario progress monitoring tool partial monitoring has been done. Survey to the stakeholder including public officers were done and analyzed. Result: Economic area were most lowly reported area. By specific item, direction of improvement were induced in each area including social environment and human health area. Green space, waste treatment, traffic problem, small health service benefit were major agenda among the stockholders. Conclusion: According to the Ontario progress reporting, we got good picture about healthiness of one municipality and concrete direction of improvement.

경찰공무원의 건강체력 실태

노성규,손호중,고성은,엄경일,권호준 江原大學校附設體育科學硏究所 2003 江原大學校附設體育科學硏究所論文集 Vol.- No.26

The purpose of this study is to suggest basic data to make out the program about the health and promotion of physical fitness. So, we measured the status of the present police officers physical fitness through measuring their height, weight, %body fat, and healthy physical fitness and through comparing it with popular physical fitness survey data in an age. The conclusion that compared and analyzed the measuring result of the height, weight, and the element of healthy physical fitness of 143 police officers in G province is following First, Their height, weight, board jumping and VO2max is seemed to be high as compared with the standard. Second, %Body fat is closely similar with the standard. Third, The flexibility and sit-up is seemed to standard below By this time, it is true that the study of the superiority players evaluation of physical fitness is developing in our country. But, the study of the physical fitness evaluation about non-player, that is general person has been neglected in korea. So, it is not very enough the study and developing program for the improving the general person's physical fitness. Therefore, It should make the spacial study of the various physical fitness of korean in an occupation, a sex and age. And then, the special exercise program that can satisfy the various needs of today 'men is needed. Also, it should make the vertical study for the improvement of physical strength in vocational classification. Also, the government and office should invest institutional effort to help the police officer' health and welfare. Police officers also have to learn themselves the efficient and continuous exercise habit to be happy with health in considering their own physical condition. And then, the prescription of the exercise program about the result must come with.

육안적 혈뇨로 내원한 환자에서 발견된 방광 유전분증 : 증례보고

김은진;성 현;홍수민;정성연;박경식;손형래;박일권;구호석;고행일 인제대학교 백병원 2011 仁濟醫學 Vol.32 No.-

Amyloidosis is a disease resulting in deposition of amyloid in the body. The disease can be either primary or secondary. The amyloidosis of urinary bladder is more usually affected by primary amyloidosis and also very rare. The patient with primary amyloidosis of the bladder usually presents with gross hematuria. The amyloidosis resembles bladder cancer in cystoscopy. It can be confirmed by biopsy. The treatment consists of medication (e.g., steroid, antitumor agent, cholchicine, DMSO) and/or transurethral resection. The standard treatment is mephalan and prednisolone. A 49-year-old man complained of recently developed gross hematuria without abdominal pain. We examined urinary bladder cystoscope for gross hematuria. It revealed small bulging mass on trigone are a of bladder. Therefore we did bladder biopsy. Finally, it revealed bladder amyloidosis. The patient was improved by medication (mephalan 2mg and prednisolone 1 mg/kg po daily). We report an unusual case of amyloidosis involving bladder.

직업적 노출에 의한 스티븐스-존슨 증후군에서 트리클로로에틸렌의 노출수준 : 3예의 사례와 문헌고찰을 중심으로

이선웅,김은아,김대성,고동희,강성규,김병규,김민기 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.2

배경: TCE는 심각한 전산적 피부염과 관련 있는 것으로 몇몇 사례들을 통해서 보고되어 왔으나,기존의 사례 보고들에서 노출평가가 수행된 사례는 드물었고 추정되는 노출량 역시 매우 다양하였다. 본 연구에서는 TCE 노출에 의한 것으로 판단되는 스티븐스-존슨 증후군 3예를 확인하고 각 사례들에 대한 작업재연을 통해 노출수준을 추정하였으며,이를 통해 TCE의 직업적 노출수준과 스티븐스-존슨 증후군을 포함하는 전신적 박탈성 피부염 발생의 관계를 이해하고자 하였다. 증례: 사례 1은 24세 필리핀인 여자로 TCE를 이용한 탈지작업을 시작한 35일 후 발진을 포함한 피부증상이 발생하였고 증상이 진행되면서 간기능 이상이 발견되었다. 환자는 스티븐스 존슨 증후군과 독성간염으로 진단되었고 증상발생 39일 간부전으로 사망하였다. 증상발생 전 약물 복용력은 없었고 바이러스 감염 등의 비직업적 원인은 찾을 수 없었으며,작업재연을 통한 TCE의 개인 노출수준 은 TWA 21.9 ppm과 32.3 ppm이었다. 사례 2는 47세 한국인 남자로 TCE를 이용한 탈지 작업을 시작한 20일 후 발진을 포함한 피부증상이 발생하였고 증상이 진행되면서 간기능 이상이 발견되었다. 환자는 중독성 표피괴사증 또는 스티븐스 -존슨 증후군, 전격성간염 및 동반된 패혈증으로 진단되었고 증상발생 42일 간부전 및 패혈증으로 사망하였다. 증상발생 전 약물복용력은 없었고 바이러스 감염 등의 비직업적 원인은 찾을 수 없었으며,작업재연을 통한 TCE의 개인 노출수준은 TWA 30.1 ppm이었으며 세척조 주위의 지역시료는 TWA 116.5 ppm∼229. 7 ppm 이었다. 사례 3은 22세 베트남인 여자로 TCE를 이용한 탐지작업을 시작한 30일 후 발전을 포함한 피부증상이 발생하였고 증상이 진행되면서 간기능 이상이 발견되었다. 환자는 스티븐스-존슨 증후군 및 동반된 독성간염으로 진단되었고 증상발생 37일 증세 호전되어 퇴원하였다. 증상발생전 약물복용력은 없었고 바이러스 감염 등의 비직업적 원인은 찾을 수 없었으며,작업재연을 통한 TCE의 개인 노출수준은 TWA 107.2 ppm이었다. 고찰: TCE에 노출된 일부의 사람들에서 노출 후 2주에서 5주 사이에 심각한 급성 간염이 동반되는 스티븐스­존슨 증후군이 발생할 수 있음을 확인 하였고,이번의 연구결과와 기존의 연구를 종합 할 때 TCE에 대한 감수성이 있는 사람의 상당수는 노출기준 이상의 고 노출에 노 출 후 스티븐스- 존슨 증후군이 발생함을 확인할 수 있었다. 따라서. TCE에 대한 고 노출을 막기 위해 TCE 세척작업에 대한 작업환경 확인과 개선이 우선적으로 필요하며,동시에 노출 후 증상발생기간의 일관성과 노출기준 이하의 저 노출에서의 감작 가능성을 배제할 수 없음을 고려하여,작업시작 후 1개월경의 특수건강검진 역시 고려되어야 할 것으로 판단된다. Back ground: Trichloroethylene (TCE) has been reported to be related to severe generalized exfoliative dermatitis frequently accompanied by toxic hepatitis. The measurements of environmental exposure were limited in the previous case reports and the reported exposure values were also diverse. We reviewed three cases of Stevens-Johnson syndrome associated with TCE. The work environment was measured by the Korea Occupational Safety and Health Agency (KOSHA) after the cases occurred. From the study results, we intended to clarify the relationship between TCE exposure level and Stevens-Johnson syndrome. Case report: Case 1. A 24-year-o1d Filipino female worker developed a skin rash 35 days after starting to use TCE for degreasing. The skin rash developed into a bullous eruption and the liver function findings were abnormal. She was diagnosed with Stevens-Johnson syndrome and toxic hepatitis. She died of hepatic failure 39 days after the onset of the first symptom. She had no previous history of taking medicine or viral infection. The work environment measured 22.0 to 32.3 ppm (Personal exposure level) with TWA. Case 2. A 47-year-o1d Korean male worker developed a skin rash, 20 days after starting to use TCE for degreasing. The skin rash developed into a bullous eruption and the liver function findings were abnormal. He was diagnosed with Stevens-Johnson syndrome, toxic hepatitis and sepsis. He died of hepatic failure and sepsis 42 days after the onset ofthe first symptom. He had no previous history of taking medicine or viral infection. The work environment measured 30.1 ppm (Personal exposure level) and 116.5∼229.7 ppm (area exposure level close to the degreasing rnachine) with TWA. Case 3. A 22-year-old Vietnamese female worker developed a skin rash 30 days after starting to use TCE for degreasing. The skin rash developed into a bullous eruption and the liver function findings were abnormal. She was diagnosed with Stevens-Johnson syndrome and toxic hepatitis. Her symptoms improved and she was discharged 37 days after the onset of the first symptom. She had no previous history of taking medicine or viral infection. The work environment measured 107.2 ppm (Personal exposure level) with TWA. Discussion: These three case reports and the previously reported cases indicated that the majority of people susceptible to TCE develops Stevens-Johnson syndrome after high-level TCE exposure (above the TWA occupational exposure limit of 50 ppm). Therefore, work environmental survey and improvements to the TCE degreasing process are essential to prevent high exposure. Furthermore, considering the consistency of the latency period in symptoms and the possibility of sensitization in low-level exposure, we recommend that the first specific health examination also should be conducted 1 month after workers have commenced working.

정상 성인에서 운동이 혈중 Cortisol과 포도당 및 전해질 농도에 미치는 효과

정진상,정순열,안태순,고성은 최신의학사 1993 最新醫學 Vol.36 No.7

혈액투석 환자에서 대퇴신경범증으로 발현된 장골근 및 요근 농양 1예

이준상,강동구,신상열,윤재호,조영일,고성은,유영범,전혜정,진춘조,송종오 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

인문사회 : 한국 기업의 직장체육 참여 실태 분석: 2004년 상장기업을 중심으로

고은하 ( Eun Ha Koh ),박영옥 ( Young Ok Park ),한태룡 ( Tae Ryong Han ),성봉주 ( Bong Joo Seong ),성창훈 ( Chang Hoon Seong ) 한국스포츠정책과학원(구 한국스포츠개발원) 2008 체육과학연구 Vol.19 No.3

본 연구는 우리나라 상장 기업의 직장체육 실태를 분석함으로써 직장체육 실시의 필요성을 역설하고 향후 직장체육 활성화 정책 수립을 위한 기초 자료를 제공하는 데 그 목적이 있다. 이를 위해 2004년 기준 상장기업 280개를 대상으로 현재 실시하고 있는 프로그램 유형, 실시 빈도 및 기간, 구비 시설 종류, 지도자 및 전담부서 유무, 직장체육에 대한 인식 등의 항목을 조사하였다. 그 결과 조사 기업의 77.9%가 체육 행사를 실시하고 40.4%가 개인 체육활동을 위한 기회를 제공하는 것으로 나타났으나, 단체 체육활동을 실시하는 기업은 상대적으로 적었으며(20.0%), 체육활동의 내용도 15분 미만의 아침체조, 근무시간 이외에 지도자가 없는 체육시설 이용 등으로 소극적인 것으로 나타났다. 그럼에도 불구하고 응답자의 다수(77.1%)가 직장체육이 직장인의 건강증진과 산업재해 예방, 생산성 향상에 도움이 된다고 생각하고 있어 직장인들이 체육활동을 원하고 있음이 드러났다. 이러한 연구 결과는 향후 직장체육 모형 개발과 관련 정책의 제언 측면에서 논의하였다. This study aims to show the significance of worksite sport and physical activities and to provide basic data for government sport policy by analyzing current trend of worksite sport and physical activities among Korean companies. The subjects of the survey were 280 companies listed on Korea Stock Exchange in the year of 2004 and the questionnaire was composed of sport and physical activities program type, frequency, duration and intensity of participation, instructor and facilities, recognition among employers/employees. The results show that 77.9% of the companies have sport events and 40.4% of them provide opportunities for individual exercise, while the number of companies have group program is relatively small(20.0%). The content of group program was rather passive concentrating on morning gymnastics less than 15 minutes while individual exercise is allowed in facilities without instructors after work-hours. Nevertheless, a large number of respondents(77.1%) think that worksite sport and physical activities has positive influence in enhancing employees` health and corporate productivity at the same time showing their needs for sport and physical activities. These results are expected to provide basic data in designing successful corporate sport model and suggesting related sport policy.

대학교양체육 서비스품질과 학생만족, 운동지속의사, 여가만족의 관계

고성은(Seong Eun Koh) 한국사회체육학회 2007 한국사회체육학회지 Vol.0 No.29