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체외수정시술시 Acid Tyrode 용액을 이용한 배아 보조부화술의 임상적 유용성
최영민,이진용,문신용,김정구,김석현,오선경,지병철,서창석,김희선,류범용,김미하,이기주 대한산부인과학회 1999 Obstetrics & Gynecology Science Vol.42 No.5
목적: 체외수정시술시 배아이식 후 부화 과정의 실패에 의하여 임신이 이루어지지 않는 것으로 추정되는 불임환자를 대상으로 acid Tyrode 용액을 이용한 보조부화술의 임상적 안정성 및 유용성을 규명하고자 하였다. 연구방법: 1997년 1월부터 12월까지 체외수정시술을 시행받은 환자 중 과거력상 3회 이상 임신성립에 실패한 환자[Group Ⅰ; 56명, 66주기], 연령이 37세 이상인 환자[Group Ⅱ; 32명, 38주기], 기초 혈중 FSH 농도가 15mIU/ml 이상인 환자[Group Ⅲ; 12명, 14주기]를 대상으로 acid Tyrode 용액을 이용한 배아의 보조부화술을 시행하였다. 보조부화술은 미세조작기를 이용하여 체외배양 3일째 아침에 6-8-세포기 배아를 대상으로 acid Tyrode 용액을 방출하여 8-세포기 배아의 할구 크기로 구멍을 뚫어주는 방법으로 실시하였다. 결과: 전체 대상 환자의 연령은 36.0±3.5세 이었고, 채취된 난자의 수는 8.6±5.7개, 자궁내로 이식된 배아의 수는 4.5±2.0개, 임상적 임신율은 시술주기당 13.3%[10/75], 시술환자당 15.4%[10/65] 이었다. 3군을 비교하였을 때 채취된 난자의 수, 이식된 배아의 수, 임상적 임신율은 각각 통계학적으로 유의한 차이가 없었다. 결론: 체외수정시술시 acid Tyrode 용액을 이용한 배아의 보조부화술은 기존의 투명대 부분 절개술을 이용한 보조부화술과 비교하여 유사한 임신율을 얻을 수 있어 임상적 안전성 및 효용성이 증명되었으며, 특히 과거력상 3회 이상 체외수정시술에 실패한 환자, 37세 이상인 환자, 기초 혈중 FSH 농도가 15 mIU/ml 이상인 환자 등에서 임신율을 증진시킬 수 있는 유용한 시술 방법이라고 사료된다. Objective : To investigate the clinical efficacy of assisted hatching[AH] using acid Tyrode`s solution in vitro fertilization and embryo transfer[IVF-ET] patients who had previous repeated failure cycles ≥ 3[Group I ; 66 cycles in 56 patients], age of ≥ 37 years[Group II ; 38 cycles in 32 patients], or basal serum FSH level ≥ 15 mIU/ml[Group III ; 14 cycles in 12 patients]. Materials and Methods : From January to December, 1997, a total of 75 IVF-ET cycles in 65 patients was enrolled in this descriptive study. In preimplantation embryos, AH was performed with the application of acid Tyrode`s solution on zona pellucida to create an opening just before ET. Results : The number of oocytes retrieved after controlled ovarian hyperstimulation[COH] was 8.5±5.3[mean±SD] in Group I, 7.9±6.2 in Group II, and 6.8±4.7 in Group III. The number of embryos transferred after AH was 4.6±2.0, 3.9±1.9, and 3.6±1.9, respectively, and the mean cumulative embryo score[CES] was 88.7±49.2, 80.3±45.0, and 78.9±59.6, respectively. There were no significant differences in the numbers of oocytes retrieved and embryos transferred, and CES among three groups. The clinical pregnancy rates per cycle and per patient were not different significantly among three groups : 13.6%[9/66] and 16.1%[9/56] in Group I, 13.2% [5/38] and 15.6%[5/32] in Group II, and 14.3%[2/14] and 16.7%[2/12] in Group III. Conclusion : AH of human preimplantation embryos using acid Tyrode`s solution might be promising in the improvement of pregnancy rates for IVF-ET patients, especially with the previous history of repeated failure, old age, or high basal serum FSH level. Further prospective and randomized study is necessary to determine if the micromanipulation procedure of AH would be beneficial to IVF-ET patients.
김성,박현,황인수,윤길중,최진백,이동민 대한산부인과학회 1997 Obstetrics & Gynecology Science Vol.40 No.7
Acute fatty liver of pregnancy is a rare, clinically distinct cause of jaundice occuring during the third trimester of pregnancy, with maternal death as the usual outcome and first described in 1,940 by Sheehan, which may be characterized by nausea, vomiting, epigastric pain, jaundice and confirmed by liver biopsy. We have experienced a case of acute fatty liver at 38 weeks of gestation in 30 year-old primigravida woman and reproted with a brief review of related literatures.
Mclnodoe 수술후 인공질에 발생한 Condyloma Acumnata 1 례
김원희,장진석,김경리,강기주 대한산부인과학회 1994 Obstetrics & Gynecology Science Vol.37 No.3
저자들은 본원에서 선천성 무질증으로 McInode씨 수술후 추적관찰중 인공질부에 발생한 condyloma acuminata를 경험하였기에 이에 문헌고찰과 함께 보고하는 바이다. Mayer-Rokitansky-Kuster-Hauser syndrome is an unusual Mullerian duct anomaly and commonly associated with developmental anomalies of other organs such as urinary tract and skeleton. McIndoe operation is the method of choice in making the artificial vagina in most of the cases. We experienced a case of condyloma acuminata on the well taken artificial vagina. This is to report this case with a brief review of the literatures.
이지제(GJ Lee),구병삼(BS Koo),박원순(WS Park),김의진(YJ Kim) 대한산부인과학회 1966 Obstetrics & Gynecology Science Vol.9 No.5
11 cases of face presentation among 3,398 parturients during the period from 1955 to 1965 at Soo Do Medical College Hospital were reviewed. It`s incidence was revealed in 1 to 309 deliveries or 0.32% of all deliveries. And a review of face presentation is made briefly
Antiinflammatory and antioxidative effects of Agrimonia pilosa Ledeb
심성용,Kim GJ,Ko SG 경희대학교 융합한의과학연구소 2007 Oriental Pharmacy and Experimental Medicine Vol.7 No.3
Agrimonia pilosa Ledeb. has long been used for a useful natural agent ameliorating inflammation related symptoms in the folk medicine recipe. This study was performed to investigate effects of Agrimonia pilosa Ledeb.(AP) on the expression of inflammation related genes such as the inducible nitric oxide synthase (iNOS) in macrophage cell line, RAW 264.7 cells. The AP (whole plants) was extracted with 80% ethanol and sequentially partitioned with solvents in order to increase polarity. Among the various solvent extracts of AP, the n-butanol (BuOH) fraction showed the most powerful inhibitory ability against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW 264.7 cells without affecting cell viability. Reverse transcriptase-polymerase chain reaction and Western blot analysis revealed that the BuOH fraction provided a primary inhibitor of the iNOS protein and mRNA expression in LPS-induced RAW 264.7 cells. The DPPH and OH radical scavenging activities of the several fractions of 80% ethanol extracts of AP significantly increased by EtOAC and BuOH fractions. Thus, the present study suggests that the response of a component of the BuOH fraction to NO generation via iNOS expression provide an important clue to elucidate anti-inflammatory mechanism of AP.
유금준(GJ Yoo),강경주(KJ Kang),김중근(JG Kim),곽태로(TR Gwag) 대한산부인과학회 1987 Obstetrics & Gynecology Science Vol.30 No.6
저자들은 개인병원에서 소파수술후 지속적인 성기출혈을 주소로하여 내원한 47세의 경산부에서 희귀한 자궁경관임신을 경험하여 자궁전적출술을 시행하였고 병리조직학적 검사에서 확진되었기에 문헌적 고찰과 함께 보고하는 바이다 A case of cervial pregnancy which is recently experienced in our department is presented with a brief review of related literatures