새로운 연노출의 효과지표로서의 혈장 δ-aminolevulinic acid 측정의 유용성

이금원,황보영,김용배,리갑수,이성수,장봉기,함정오,안규동,이병국 순천향대학교 산업의학연구소 2001 순천향산업의학 Vol.7 No.1

To evaluate the usefulness of the measurement of plasma δ - aminolevulinic acid (ALAP) as a new effect indicator of lead exposure, the association of ALAP with blood lead, DMSA chelatable lead and bone lead with a special emphasis of genetic interaction of ALAD polymorphism was studied with 419 lead exposed workers and 85 non-lead exposed workers. Lead workers were recruited from storage battery industries, secondary smelting industries and other lead using industries and non-lead workers selected from electronic refrigerator manufacturing industry. Blood lead, DMSA chelatable lead and bone lead were chosen for parameters of lead exposure. Plasma and urinary ALA were selected for the effect parameter of lead intoxication. Information for age, smoking, drinking habit and body mass index were also obtained. Job duration for lead workers was also collected. The overall prevalence of the variant allele, ALAD type 1-2 or 2-2(ALAD2) in lead exposed workers was 10.0% (42 out of 419 lead workers) which was not differed from control workers (9.4% : 8 out of 85). The means blood lead and DMSA chelatable lead of lead workers with ALAD 1(ALAD type 1-1) were lower than those of lead workers with ALAD2, but the differences were not statistically significant. On the other hand, the mean of tibia lead of lead workers with ALADI was higher than that of lead workers with ALAD2, but the difference was not statistically significant. DMSA chelatable lead showed highest correlation with log transformed plasma ALA(LALAP)(r=0.682) and blood lead and tibia lead had r=0.650, r=0,402 correlation coefficient with LALAP respectively On the other hand. log transformed urinary ALA(LALAU) had lower correlation coefficient with all three parameters of lead exposure than LALAP. The equation of robustic simple linear regression of blood lead on LALAP was LALAP=2.0439+0.0165PbB in ALADI lead workers and LALAP=2.031+0.0121PbB in ALAD2 lead workers. ALAD genotype in the multiple regression analysis of blood lead with LALAP after adjusting for possible confounders(sex, ago, BMI, smoking and drinking status and job duration) showed significant main effect on LALAP resulting lower LALAP in ALAD2 lead workers than ALADI lead workers. On the other hand, effect modification of ALAD genotype was observed in the multiple regression analysis of tibia lead with LALAP after adjusting for possible confounders, but there was no significant effect of ALAD genotype in the multiple regression analysis of DMSA chelatable lead with LALAP after covariate adjustment. With above results, plasma ALA was found to be a useful effect parameter of lead exposure compared with urinary ALA. It was also observed that ALAD polymorphism made significant effect on the association of blood and tibia lead with ALAP. Thc lower plasma ALA in ALAD2 lead workers suggested supportive effect of ALAD2 in lead exposure.

뇌사환자의 갑상선 기능, 전신대사 및 중증도에 관한 연구

이영주,정금희,왕희정,문봉기,한연희,이영석 아주대학교 의과학연구소 1999 아주의학 Vol.4 No.1

Background and Objectives : Brain death may lead to hormonal depletion, metabolic derangement and multiple organ dysfunction. We have carried out present study to examine the effects of brain death on the thyroid function, metabolic indices, and the severity scoring systems. Methods : 13 adults patients admitted for organ donation or brain death evaluation were examined after brain death was confirmed. Thyroid hormones measured were .thyroid stimulating hormone (TSH), triiodothyronine (T3), thyroxine (T4), and free thyroxine (FT4). The metabolic indices measured were arterial ketone body ratio (AKBR), lactic acid (LA), and base defiat (BD). as for reference to the severity scoring systems, APACHE Ⅲ and multiple organ failure score (MOFS) were assessed on the day of brain death confirmation. Arterial blood was drawn for all measurements. Results : As for the thyroid function, there were significant decreases in T3 (40.48±20.96 ng/dL) and T4 (3.47±2.15 ㎍/dL), but no significant change in FT4 (0.75±0.31 ng/dL) and TSH (1.12±1.37 uIU/mL) compared to the normal range. Significant decreases in AKBR (0.39±0.31) and BD (-9.46±5.83 m㏖/L), and significant increase in LA (2.57±2.46 m㏖/L) In metabolic indices, were shown, as for severity scoring systems, APACHE Ⅲ score (101.54±19.41) and MOF score (9.11±2.57) indicated a high mortality. There were significant correlation between thyroid hormones (r=0.565 -0.781) but no correlation among other indices. Also, significant inverse correlations were shown between base deficit and lactic acid (r=-0.660), APACHE Ⅲ score (r=-0.726) and MOF score (r=-0.604). The highest correlation was observed between APACHE Ⅲ score and MOF score (r=0.851). Conclusions : As for the thyroid function, significant decrease in T3 and T4, and almost normal range of FT4 and TSH imply the euthyroid sick syndrome. Abnormal finding of the metabolic parameters indicates an inhibition of the aerobic metabolic rate of the body as a whole. And the severity scoring parameters are compatible with high mortality.

幼稚園 敎育課程 運營을 위한 프로그램 硏究 : 梨花프로그램 開發硏究

李相琴,李恩和,李其淑 이화여자대학교 한국문화연구원 1980 韓國文化硏究院 論叢 Vol.36 No.-

Early Childhood Education in Korea has been in need of improvements to meet the changing needs of the government and its children. The lack of a adequate educate educational program development and basic research prohibits Korean preschool education from advancing form an underdeveloped state. Efforts to determine what changes are made and how they are implemented into the existing system of early childhood education should be made. The purpose of the present study is to develop and assess the effects of the early childhood education program administered by the Ewha Experimental Kindergarten. The program consists of two component sub-programs: 1) a mother involvement program designed to involve mothers in the actual classroom activities as teacher aides 2) a child program, consisting of 11-unit learning experiences. In conceptualizing the program, four basic factors were considered; The DARCEE(Demonstration and Research Center for Early Education) program, Kansas program, the Ewha kindergarten program, the analysis of elementary textbooks. The entire program emphasizes principles based upon "Whole child" not only the development of the child's cognitive abilities but also of personality characteristics. The theories of the curriculum development and the importance of mother involvement in the classroom to obtain the guidelines of the overall organization and implementation of the program have been applied. Experimental design of the study was the pretest-posttest control group design. The duration of the study was 10 months form March 1979 to December 1979. The mother education program began in May and they participated in the classroom as teacher aides from June to November 1979. The subjects of this study were 60 children, ages 5 to 6, living in Seoul area. More specifically stated, 30 children comprised the experimental group and 30 children the control group. The instrument used for the present study were: 1) The Kodae-Binet Intelligence Tests 2) The School Readiness Test 3) The Unit Test(DARCEE program) 4) Observations 5) Interviews The t-test and covariance analysis were applied to analyzing data collected from the pretests and posttests. The results of the analysis can be summarized as follows: 1. The result of pre-and-post test showed that intelligence increments of the experimental group were more than that of the control group. The result of covariance analysis of the gains was sustained at 5% level of significance. 2. Through the experimental treatment, a significant improvement(p<.05) of school readiness abilities was discovered among the experimental group. 3. The result of DARCEE unit test showed a significant improvement (p <.05) of the basic concepts, language developments and visual skills in the experimental group. On the other hand, the results suggest that the program needed to be enriched in the aspects of auditory and motor coordination skills. 4. Through the observational records, it was found that most of the pre-planned activities were performed in the classroom and the spontaneous needs of children also took into account in the program planning as the uniqueness characteristics of preschool education. 5. Mothers involved in classroom activities as teacher aides showed positive attitudes toward the program. They reported an improved sense of competence and self-esteem regarding parent skills, her understanding of her child's development and the strong liaison role for home-school communication. In short, This study, in spite of some limitations in research methodology, had a great significance in finding out clear empirical evidence that the Ewha Experimental Preschool Program, in a systematic way, was effective in improving the development of young children in the early years. The present study must be by repeated follow-up studies to identify the long-term effects of the program and the possibility of application to public kindergarten. It is also suggested that comprehensive studies to deal with the physical, social and emotional development and a more active parent involvement program are needed.

반응성 스펏터링법으로 제조한 Ta₂O₅ 막의 특성

금동렬,박욱동,김기완,이우일 경북대학교 센서기술연구소 1991 센서技術學術大會論文集 Vol.2 No.1

Tantalum pentoxide(Ta₂O₅) thin films on p-type (100) silicon wafer were fabricated by RF reactive sputtering. Physical properties and structure of the specimens were examined by XRD and AES. From the C-V analysis, the dielectric constant of Ta₂O₅ films was 10-12 in oxygen mixing ratio of 10 %. The ratio of Ta:O was 1:2 and 1:2.49 by AES and RBS examination, respectively. The heat treatment at 700℃ in O₂ ambient led to induce crystallization. When the heat treatment temperature was increased to 1000℃, the dielectric constant was 20.5 in O₂ambient and 23 in N₂ ambient, respectively. This crystal structure was pseudo hexagonal of δ-Ta₂O₅ . The flat band voltage shift(ΔV_(FB)) of the specimens and the leakage current density were decreased with the mixng ratio of oxygen. The maximum breakdown field was 2.4 MV/cm in oxygen mixing ratio of 10 %. These Ta₂O₅ films will be applicable to hydrogen ion sensitive film and gate oxide material of memory device.

Porphyromonas gingivalis 분쇄액으로 유도된 파골세포의 분화에 미치는 Taurine과 Alendronate의 효과

금기연,박주현,유윤정,이정현,이승종 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.4

크롬을 처리한 마우스비장세포에서 초기에 발현되는 유전자분석

고재기,백기룡,김우형,정금분,우기민,이상한 순천향대학교 의학연구소 2006 Journal of Soonchunhyang Medical Science Vol.12 No.1

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65세 이상 노인 급성 심근경색증 환자의 사망에 영향을 미치는 인자들

정봉기,양금열,손준혁,주시내,남홍우,전용덕,이홍순 대한노인병학회 2001 대한노인병학회지 Vol.5 No.2

식이섬유제품의 위장관 기능조절 기능성 평가

Jung, Ki-Haw,Koo, Ja-Young,Kim, Sun-Ja,Seung, Keum-Ran,Lee, Eun-Kyung 덕성여자대학교 약학연구소 2005 藥學論文誌 Vol.16 No.1

This study was undertaken as a literature survey to reevaluate the functionality of the health functional foods for gastrointestinal tract, in particular, dietary fibers. This study intend to furnish data which can be applied to assessment of permitted dose and description of notice, investigating literatures about functionality related to control of gastrointestinal function and establishment of intake for these dietary fibers.

일부 농촌 지역의 취학전 어린이 시력에 관한 연구

송기철,이현,이효,안금순 대한보건협회 2003 대한보건연구 Vol.29 No.2

We performed ophthalmic examinations for 569 children in cheong yang(3-6 years of age), during May, 2002. 78 children were shown to have either visual acuity of less than 0.5 or anisometropia of over 2 lines. Detailed ophthalmic examinations were conducted on those 78 children. The 69 children(l2.1%) had ametropic eyes, 14(2.5%) amblyopia, and 3(0.5%) strabismus. Among the types of ametropia, Myopic astigmatism 21(30.4%) was the most common type. Astigmatism was combined with all other types in 56(81.2%) children. Among the types of amblyopia, visual deprivation amblyopia was 8(57.1%) and anisometropic amblyopia was 6(42.9%). In cases of strabismus, exotropia was 3. The early detection and adequate care of eye problems for preschool children are important to prevent the permanent visual disability. It is necessary to make institutional devices for preschool vision screening and participation rate for this screening will be more increased by efforts of constitutional support and parental cooperation.

법량질 표면의 탈회 및 재광화 후 EPMA (electron probe micro-analysis)를 이용한 칼슘, 인, 불소 변화의 정량적 분석

홍경식,허복,이찬영,금기연 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.5

The aim of this in vitro study was to analyze the composition of human tooth enamel in terms of there components, Ca, P, and F after demineralization and remineralization in acid buffer solution. A total of 8 human premolars without any defects and cracks were selected and buccal and lingual sides of the teeth were cleaned with an ultrasonic device and pumice without fluoride. 5×5mm windows were opened, and other areas were completely covered with 3-coats of nail varnish to prevent from being in contact with demineralized and remineralized solutions. After demineralization process, each tooth was sectioned into two slices, highly polished one of them withγ-alumina, and then analyzed the composition of the demineralized tooth with EPMA(electron probe micro-analyzer) . The ocher slices were put into the remineralized solution for 10 days, polished, and analyzed in the same manner. These data were statistically analyzed with one sample t-test(p<0.05) . The results were as follows. 1. Normal tooth enamel consists of 49.76% Ca, 39.80% P, and 0.28% F. 2. After demineralization, percentage of Ca and P ratio were decreased by about 5.57 and 5.07% respectively. Percentage of F ratio was also decreased by about 0.01%, which was not statistically significant. 3. After remineralization, percentage of Ca, P increased about by 4.47 and 4.35% respectively. Percentage of F decreased by about 0.01%, which was not statistically significant. In conclusion, remineralized solution used in our study has the potential to induce the uptake the Ca and P into the pore sites of the demineralized enamel. But, in the oral cavity, there were rapid temperature change, organic matrix that inhibits the movement of the ions, and limitation of continuous contact with this remineralized solution. Therefore, further in vivo study is necessary.