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황석순,이헌영,전석구,남계윤,전영준 啓明大學校 醫科大學 1990 계명의대학술지 Vol.9 No.3
Broncholithiasis has been recognized in medicall literature for centuries. Because of the relative infrequency, broncholithiasis has often been neglecteed in the differential deagnosis of bronchial obstruction. In this case, we could remove the broncholith obstructing the right middle lobar bronchus with the fiberoptic bronchoscope in a 37-year old man without any complications and the complete resolution of the pneumonia was followed.
방사선 조사에 의한 phospholipase D 활성화 연구
김영래,김기환,조문준,임규,황병두,박승길 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1
Activation of oleate-dependent phospholipase D (PLD) isozyme by irradiation was reported previously. However, the effects of irradiation on other PLD isotypes (PLD1 and PLD2) have not been studied. There are several kinds of PLD isozymes in a cell. Therefore, it is difficult to study PLD isotype-specific activation in a cell by irradiation. We tested which isotype of PLD responds to irradiation. We used the fibroblasts cell lines overexpressing PLDl or PLD2 by introducing recombinant PLD1 or PLD2 cDNA. Phospholipids in cells were labelled with [(3)^H] myristic acid. Before irradiation, l-butanol was added. After irradiation with doses of 1, 2, and 10 Gray, we measured the formed phosphatidylbutanol containing [(3)^H] myristic acid. The overexpressed PLD isotypes were functional in those cell lines. PLD2 activity was enhanced by irradiation when we compared the PLD activations between control and PLD1 or PLD2 overexpressing cells. However PLD1 was not activated by irradiation. PLD2 isozyme, but not PLD1, was activated by irradiation. One Gray irradiation showed the maximal effect on PLD2 activation. The activation mechanism and physiological significance of PLD2 activation by irradiation remain to be uncovered.
L1210 세포증식에 대한 Glycyrrhizin의 억제작용 기전
殷載淳,徐龍勳,權鎭,柳東和,吳贊鎬,蘇俊魯,全焄,黃甲洙 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-
The purpose of this research was to investigate the mechanism of inhibitory action of Glycyrrhizin(GZ) on the proliferation of mouse leukemia cell-line, L1210 cells. The cytotoxic activity was tested using a colorimetric tertrazolium assay(MTT assay), the apoptosis was tested using flow cytometry. Nitric oxide(NO) production form mouse peritoneal macrophage was tested using a Griess method and the phagocytosis of human polymorphonuclear cells was tested using a lucigenin chemiluminescence. GZ ingibited the proliferation of L1210, BALB/c 3T3 cells and mouse thymocytes at 50 ug/ml/ GZ did not affect nitric oxide production from mouse peritoneal macrophages in vitro, but ingibited nitric oxide production from lipopolysaccharide and y-interferon treated macrophages. Macrophages of GZ-administered mice accelerated NO production. The proliferation of L1210 cells apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. The apoptosis of L1210 cells were induced by co-culture with macrophage of GZ-administered mice. GZ increased the phagocytosis of human polymorphonuclear cells. These results suggest that GZ inhibit the proliferation of L1210 cells not only as a direct cytotoxic agent o tumor cells, but also by the enhancement of NO production and phagocytic activity.
수술 결함과 연관된 의인성 대퇴 전자 하부 골절 - 2예 보고 -
정국진 ( Kook Jin Chung ),전준영 ( June Young Jeon ),나현우 ( Hyun Woo Na ),황지효 ( Ji Hyo Hwang ) 대한골절학회 2015 대한골절학회지 Vol.28 No.4
Iatrogenic fracture is not popular and might be recognized as a malpractice. Surgical error related to iatrogenic fracture which has occurred after an operation can be detected only by a surgeon. Stress riser fracture is another form of iatrogenic fracture also known as a Young’s modulus fracture. As the majority of surgical related stress riser fractures can be preventive, the accurate prevalence is not known. The majority of fractures occurred in the weight bearing bones such as femur and tibia. The subtrochanter area is the most stress concentrated area in the human body, thus it is a common area for occurrence of stress riser iatrogenic fractures. We experienced 2 cases of stress riser iatrogenic fractures, which are related to technical errors, thus we report cases with literature review.
Effect of Cable Length on Welding Quality in Asynchronous Tandem Gas Metal Arc Welding
June Hyung Hwang,Dong-Yoon Kim,Insung Hwang,Young-Min Kim 대한용접접합학회 2023 대한용접·접합학회지 Vol.41 No.2
When the gas metal arc welding (GMAW) process is applied in the shipbuilding and heavy equipment industries, it is important to increase the amount of welding on the weld without defects. Application of the tandem GMAW process can reduce the man-hours increased owing to multipass and increase productivity. In shipbuilding and heavy equipment industry sites, the weldments are long and large; thus, a carriage-type bed is generally used. Accordingly, the overall lengths of the welding cables in the welding system are increased; thus, arc voltage drop occurs owing to the load voltages generated in the welding cables, and a robust bead cannot be obtained owing to spatters caused by short circuits. In this study, the voltage drop caused by the increase in cable lengths was compensated using a developed welding machine. By compensating for the voltage drop, it was possible to obtain a good quality bead by reducing the occurrence of spatter caused by short circuit. As a result of performing one pass welding using the asynchronous tandem GMAW process and the developed welding machine, it was possible to secure sufficient amount of welding required in the field and to obtain a sound bead appearance.
( June Young Lee ),( Jae Sam Hwang ),( Bo Mi Hwang ),( Jin Kyoung Kim ),( Seong Ryul Kim ),( Yang Mee Kim ),( Dong Gun Lee ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.8
Previously, papiliocin was isolated from the swallowtail butterfly Papilio xuthus and its antimicrobial activity was suggested. In this study, the antifungal mechanism of papiliocin against Candida albicans was investigated. Confocal laser scanning microscopy (CLSM) and 1, 6-diphenyl-1, 3, 5-hexatriene (DPH) fluorescence analysis indicated that papiliocin disturbed the fungal plasma membrane. Moreover, the assessment of the release of FITC-dextran (FD) from liposomes further demonstrated that the antifungal mechanism of papiliocin could have originated from the pore-forming action and that the radius of the pores was presumed to be anywhere from 2.3 to 3.3 nm.