심혈관계 질환으로 관상질환 집중치료실에 입원한 환자들의 혜후 측정을 위한 APACHEⅢ점수 체계의 임상적 유용성

이공섭,이창선,최현주,홍종서,강지향,김도형,이민영,오인균,김병엽,김상억,김학찬,한승혜,이재용,지영우,안경주 대한순환기학회 2000 Korean Circulation Journal Vol.30 No.8

四物湯이 Rat 體溫變化에 미치는 影響

朱榮丞,安文生 又石大學校 1989 論文集 Vol.11 No.-

The effects of the extract of SAMULTANG was investigated on the changes of body temperature in rats. The treatment of SAMULTANG ext.(i.p.) was significantly decreased in the rat body temperature. Body temperature decrease in chloropromazine-treated rats was inhibited by the SAMULTANG ext. The increased body temperature in morphine-treated rats was inhibited by the treatment of SAMULTANG exit. And the treatment of SAMULTANG exit was accelated to the decrease of reserpine-serotonine treated rats. On the other hands, SAMULTANG ext had no effect of changes of body temporature in sodium-phenobarbital, histamine and aspirin-treated rats.

N-cadherin이 배양 계배 근아세포에서 발현되는 유전자에 미치는 영향

안병태,김영주 가톨릭대학교 자연과학연구소 2003 자연과학논문집 Vol.24 No.-

근아세포는 여러 단계의 근육형성 프로그램을 거쳐 다핵의 근관세포를 형성하며, 근특이 단백질의 합성 및 축적이 일어난다. 근특이 단백질이 합성은 유전자 조절 단백질인 Myo D, myogenin, Myf-5 그리고 MRF-4 등에 의해 조절되며, 이들 단백질이 동형접합체나 이형접합체를 형성함에 따라 DNA와 결합하여, 전사를 조절한다. 근아세포가 응집을 하기 위해서는 cell adhesion molecule이 필요하며, 이 과정에서 칼슘 의존적인 cell-cell adhesion molecule로서 생쥐와 닭의 뇌세포에서 발현되는 N-cadherin이 관여한다. N-cadherin은 골격근 세포나 그 밖의 많은 세포에서도 태아시기에 일시적으로 발현되며, 분화초기에 근아세포에서 발현되어 근세포간의 집합등에 관여한다. 본 연구는 N-cadherin이 근육에서 일시적으로 발현되는 것에 초점을 맞추고, anti-N-cadherin antibody(NCAD2)를 사용하여 N-cadherin을 억제함으로써 발생하는 근육분화의 형태적, 생화학적 변화를 분석하였다. 근아세포 성장에 NCAD2를 처리함에 따라 형태적 분화양상의 차이를 관찰하였고, 융합의 정도가 감소되어 나타났다. 이러한 분화에 작용하는 기작을 보기 위하여 7.5k의 cDNA chip을 사용하여 실험을 수행하였다. 이 실험을 통하여 NCAD2를 처리하였을 때 근세포 분화동안 발현되는 여러 유전자의 발현이 변화하는 것을 관찰하였다. 근세포분화과정에 관여하는 것으로 알려져 있는 Wnt 경로, TGF-beta 경로, ubiquitin경로가 작용하는 것으로 추정할 수 있었다. 이 중에서 근분화에 관여하는 유전자만을 선별하였고, 또한 calponin, integrin, ADAM15, ARNT-like 1 등이 세포-세포, 세포-기질간의 상호 관계에 관련된 유전자의 발현이 증폭됨을 알 수 있었다. 또한 NCAD2를 처리했을 때, 근세포 분화동안 발현되는 MyoD이 발현이 단백질 수준에서 억제됨을 관찰하였다. 이러한 결과들을 종합하여 세포 상호작용을 중재하는 N-cadherin이 근세포 분화에 요구되는 여러가지의 경로에 중요한 역할을 하는 것을 알 수 있었다.

장거리 달리기 선수에서 횡문근융해와 생화학적 지표의 변화에 대한 연구

안선호,최석채,김태현,나용호,송주흥,이영진,조지현,최석준 대한신장학회 2000 대한신장학회잡지 Vol.19 No.5

아우슈비츠와 전능 하나님 : 부조리에 대한 프리모 레비와 엘리 위젤의 양극적 사유

안주영 이화여자대학교여성신학연구소 2014 여성신학논집 Vol.10 No.-

God's omnipotence has been one of the most controversial issues in theology, especially after Auschwitz. In this article, first of all, I confront Auschwitz and the absurd through Claude Lanzmann's documentary film, Shoah. Then I compare these two Holocaust's icons, Elie Wiesel and Primo Levi, in relation to their opposite responses to the Event. Levi, whose reflection on Auschwitz bears the likeness to Albert Camus', refused to connect God and the absurd. In spite of the devastating absurdity of Auschwitz, I doubt about the validity of their atheism which the existentialists had finally concluded. I assert that they were disenchanted not with God, but with the image of an omnipotent god onto which humans had projected their contaminated desires. Wiesel, on the other hand, struggled to create meaning from the overwhelming Event. This is exactly what we find from Qoheleth, the so-called “ancient existentialist” or “ancient Elie Wiesel.” Observing the world and honestly confronting its absurd. they both refused to disconnect God from the absurd. They give us a new horizon of “the impossible possibility” to reconcile God and Auschwitz.

아파트 거주 주부의 주거에 관한 가치관 연구 : 서울과 원주시를 중심으로

주영애,안혜숙,김인옥 尙志大學校 1998 論文集 Vol.19 No.-

This study was designed to know the housing values effect on the dwelling locational change. The major purpose of this study was to identify the influences on housing values, the theoretical foundations of housing values, and the understanding of ranking in housing values between groups. For the purpose of this study questionnaires were administrated 286 housewives living in apartment house in Seoul and Wonju. X2-test, t-test, F-test, Duncan's Multiple Range Test were applied for the analysis of data. The major findings are as follows: 1. Genaral housing concept of the respondents was significant difference in P<.o5. 2. The plan of move into a new house was not siginigicant difference. 3. The first housing values ranked economy--> familycentrism--> convenience--> health, safety--> education--> housing environment--> social authority--> location--> aesthetics. 4. Among the variables, age, job, space per Apt. houseownership, income, children, family, city were significant difference.

생쥐 위장관의 Interstitial cells of Cajal(ICC)에 대한 면역조직화학적 연구

김영철,차경훈,신무경,임건한,김주영,안병수,김장만,양경철,박도영,오재욱,장인엽 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : Interstitial cells of Cajal(ICC) are the pacemakers in gastrointestinal tract that modulates gastrointestinal motiliey and these cells also transmit neural input from enteric nerves to smooth muscles. Recent work on tissues from patients with motility disorders that suggest that loss or defect in ICC could be related to pathophysiology in human and animal models. Immunolabelling of ICC in intestinal wall is recently developed by using specific marker, anti-c-kit antibody. Immunohistochemistry was done for ICC network in attempt to provide a morphological basis for the mechanism regulating gastrointestinal motility Methods : Cryosection was done, and whole-mount preparations of mouse stomach, gastrointestinal tract were immunolabelled using the anti-c-Kit. Immunolabelled ICC networks were observed under a confocal laser scanning microscopy. Results : According to three dimensional reconstruction study, we found that the c-Kit-positive celluar networks were widely distributed in the gastrointestinal muscle (1) circular muscle layer(IC-IM), (2) myenteric plexus(IC-MY), (3) deep muscular plexus(IC-DMP) in ileum, (4) submucosal plexus(IC-SMP) and longitudinal muscle layer(IC-LM) in colon. Conclusion : The characteristic profiles of ICC celluar networks provide a morphological basis upon the mechanism regulating gastrointestinal motility. Additional studies for the enteric nerves-ICC interaction are need to evaluate the detailed roles of Icc in gastrointestinal tract.

微分方程式의 攝動이 있는 安定性에 관한 硏究

오영선,황정주,안정향 대구대학교 부설 과학교육연구소 1994 과학교육 Vol.7 No.-

Squalene Adjuvant를 이용한 단백질 항원의 세포성 면역반응 유도

도현주,김성열,안종성,하영주,이승찬,오재택,장명호,정홍석,문홍모,박해준 大韓免疫學會 1996 大韓免疫學會誌 Vol.18 No.3

To investigate the role of adjuvant for cytotoxic T lymphocytes (CTL) induction, squalene-based adjuvant was studied its capability eliciting to the induction of cellular immunity as well as humoral immunity to exogeneous proteins. Ovalbumin (OVA) was used as model proteins. It was demonstrated that antigen formulation consisted of metabolizable oil squalene mixed with Tween 80 and pluronic L121 (S/TJ121) could induced the antigen specific CTL responses and antibodies irrespective of immunization routes in mice. We also demonstrated that this antigen formulation was a inducer of CD8+, major histocompatibility complex(MHC) class I-restricted, and antigen-specific C;1'Ls. These data suggest that the squalene-based emulsion system is a potent adjuvant inducing cellular immunity as well as humoral immunity.

방사선 치료를 받는 암 환자들의 사회적 지지와 삶의 질과의 관계

정주희,류소연,윤혜은,남택근,오윤경,안현옥,박계남,이영선 朝鮮大學校 附設 醫學硏究所 2002 The Medical Journal of Chosun University Vol.27 No.2

Objective : This study was performed to investigate the relationship between social support and quality of life among cancer patients receiving radiation therapy. Matehals and Methods : The data were collected from 98 patients, who were receiving radiation therapy at two university hospitals located in GwangUJu, used by structured questionnaire. For statistical analyses of the association between quality of life and various characteristics, data were analyzed using t-test, ANOVA, Pearson 's correlation, and multiple regression analysis. Results: 1. There were 56(57.1%) males and 42(42.9%) females. Age ranged from 21 to 82 years. The primary sites of cancer were gastrointestinal tract (24.5%), lung (23.5%), breast (21.4%), and head and neck (11.2%) in order. 2. The mean scores of social, family, and medical support were 4.30 0.58, 4.49 0.78, 4.11 0.65, respectively. The score of quality of life was 5.83 1.63 (range: 1.95 ~ 9.05). 3. An analysis of the association between several factors of patients and quality of life showed that the statistically significant factors were age, the presence of distant metastasis, family support, medical support and social support. 4. As a result of the multiple regression analysis, only social support was significant (β=0.932, P=0.02) with quality of life, but age and presence of distant metastasis were not significant. Conclusion : This suggests that quality of life in cancer patients could be improved by strengthening the social support which consists of family and medical support. Further study would be necessary to evaluate separately several aspects of quality of life among cancer patients.