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Lim, Soo,Choi, Sung Hee,Kim, Kyoung Min,Choi, Sang Il,Chun, Eun Ju,Kim, Min Joo,Park, Kyong Soo,Jang, Hak Chul,Sattar, Naveed American Diabetes Association 2014 Diabetes care Vol.37 No.9
<P><B>OBJECTIVE</B></P><P>To investigate the association of the rate of weight gain (Rate<SUB>max_wt</SUB>) between the age of 20 years and the age of maximum lifetime weight gain with indicators of subclinical coronary artery disease (CAD) at the time of diagnosis of type 2 diabetes (T2D).</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>We studied 1,724 consecutive Korean subjects aged ≥30 years with recently diagnosed (within 3 months) T2D and one or more cardiovascular risk factors to investigate the association of Rate<SUB>max_wt</SUB> with subclinical CAD. We used 64-slice cardiac computed tomography angiography to evaluate the degree of coronary artery stenosis, multivessel involvement, plaque characteristics, and coronary artery calcium score (CACS). Body weight at age 20 years (Wt<SUB>20y</SUB>) was obtained from participant records. Participants recalled their maximum weight (Wt<SUB>max</SUB>) before T2D diagnosis and age at maximum weight (Age<SUB>max_wt</SUB>). The Rate<SUB>max_wt</SUB> was calculated as (Wt<SUB>max</SUB> – Wt<SUB>20y</SUB>) / (Age<SUB>max_wt</SUB> – 20 years).</P><P><B>RESULTS</B></P><P>The prevalence of coronary artery stenosis (≥50%), multivessel involvement (two or more vessels), plaque characteristics, and CACS ≥100 were 11.4%, 6.6%, 19.7%, and 12.8%, respectively. Mean Wt<SUB>20y</SUB> and Wt<SUB>max</SUB> were 60.1 ± 10.5 and 73.0 ± 11.5 kg, respectively. Mean Age<SUB>max_wt</SUB> was 41.3 ± 10.7 years, and Rate<SUB>max_wt</SUB> was 0.59 ± 0.56 kg/year. After adjusting for cardiovascular risk factors, including current BMI, the highest quarter of prior weight gain was significantly associated with coronary artery stenosis, multivessel involvement, and plaque characteristics, particularly mixed and noncalcified plaque.</P><P><B>CONCLUSIONS</B></P><P>The findings suggest that a greater rate of prior weight gain may accelerate the development of subclinical vascular complications in patients with newly diagnosed T2D.</P>
Fast Device Discovery for Remote Device Management in Lighting Control Networks
( Sang Il Choi ),( Sang Hun Lee ),( Seok Joo Koh ),( Sang Kyu Lim ),( In Su Kim ),( Tae Gyu Kang ) 한국정보처리학회 2015 Journal of information processing systems Vol.11 No.1
The Remote Device Management (RDM) protocol is used to manage the devices in the lighting control networks. RDM provides bi-directional communications between a controller and many lighting devices over the DMX512-A network. In RDM, using a simple binary search scheme, which is based on the 48-bit unique ID (UID) of each device, discovers the lighting devices. However, the existing binary search scheme tends to require a large delay in the device discovery process. In this paper, we propose a novel partition-based discovery scheme for fast device discovery in RDM. In the proposed scheme, all devices are divided into several partitions as per the device UID, and the controller performs device discovery for each partition by configuring a response timer that each device will use. From numerical simulations, we can see that there is an optimal number of partitions to minimize the device discovery time for a given number of devices in the proposed scheme, and also that the proposed partition-based scheme can reduce the device discovery time, as compared to the existing binary search scheme.
( Joo Hyun Lim ),( Seung Ho Choi ),( Changhyun Lee ),( Ji Yeon Seo ),( Hae Yeon Kang ),( Jong In Yang ),( Su Jin Chung ),( Joo Sung Kim ) 대한장연구학회 2016 Intestinal Research Vol.14 No.4
Background/Aims: A percutaneous gastrostomy can be placed either endoscopically (percutaneous endoscopic gastrostomy, PEG) or radiologically (radiologically-inserted gastrostomy, RIG). However, there is no consistent evidence of the safety and efficacy of PEG compared to RIG. Recently, 30-day mortality has become considered as the most important surrogate index for evaluating the safety and efficacy of percutaneous gastrostomy. The aim of this meta-analysis was to compare the 30- day mortality rates between PEG and RIG. Methods: Major electronic databases (MEDLINE, Embase, Scopus, and Cochrane library) were queried for comparative studies on the two insertion techniques of gastrostomy among adults with swallowing disturbance. The primary outcome was the 30-day mortality rate after gastrostomy insertion. Forest and funnel plots were generated for outcomes using STATA version 14.0. Results: Fifteen studies (n=2,183) met the inclusion criteria. PEG was associated with a lower risk of 30-day mortality after tube placement compared with RIG (odds ratio, 0.60; 95% confidence interval [CI], 0.38-0.94; P =0.026). The pooled prevalence of 30-day mortality of PEG was 5.5% (95% CI, 4.0%-6.9%) and that of RIG was 10.5% (95% CI, 6.8%-14.3%). No publication bias was noted. Conclusions: The present meta-analysis demonstrated that PEG is associated with a lower probability of 30-day mortality compared to RIG, suggesting that PEG should be considered as the first choice for long-term enteral tube feeding. Further prospective randomized studies are needed to evaluate and compare the safety of these two different methods of gastrostomy. (Intest Res 2016;14:333-342)
Aortocaval Fistula by Luetic Abdominal Aortic Aneurysm : Report of a case
Lim, Sang Hyun,Lee, Cheol Joo,Roh,Hwan-Kyu,Kim, Dae Jun,Han, Jung Sun,Shin, Joon Han,Kim, Han Soo 아주대학교 1996 아주의학 Vol.1 No.2
A 53-year-old male patient was operated on because of a spontaneous abdominal aortic aneurysm with aortocaval fistula. The fistula was successfully closed and bifurcated woven Dacron graft was used to replace the aneurysm. The patient had with characteristic signs and symptoms of aortic aneurysm with arteriovenous fistula. Proper diagnosis and prompt surgical repair of aortocaval fistula saved the patient. The use of rapid infusion system provided stable hemodynamics during the operation.
Lim, Sang‐,Kyun,Lee, Jung‐,Joon,Jang, Suk‐,Goo,Lee, Seok‐,In,Lee, Kwang‐,Hee,Choi, Hyoung Jin,Chin, In‐,Joo Wiley Subscription Services, Inc., A Wiley Company 2011 Polymer engineering and science Vol.51 No.7
<P><B>Abstract</B></P><P>Poly(butylene succinate) (PBS)/organoclay nanocomposites were prepared by both solution blending and melt mixing methods. In addition, nanocomposites of PBS/organoclay were also prepared by a two‐step process where the solution blended mixture is subsequently compounded in the melt state using a torque rheometer (SOAM method). We then investigated thermal and mechanical properties of the PBS/organoclay nanocomposite at first and determined an optimum organoclay content for the preparation of nanocomposite foams. All PBS/organoclay nanocomposite foams are found to possess closed spherical‐shaped cells without any rupture when examined by an optical microscopy. The blowing ratio also increased with the increase in the blowing temperature and time, with the maximum blowing ratio of 19. Furthermore, the addition of a small amount of organoclay is found to allow the cell size to follow Gaussian distribution. POLYM. ENG. SCI., 2011. © 2011 Society of Plastics Engineers</P>
( Joo Hun Park ),( Tae Rim Shin ),( Seung Soo Sheen ),( Joon Beom Seo ),( Kwang Ha Yoo ),( Ji Hyun Lee ),( Tae Hyung Kim ),( Seong Yong Lim ),( Ho Il Yoon ),( Jae Seung Lee ),( Yeon Mok Oh ),( Sang Do 대한결핵 및 호흡기학회 2014 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.118 No.-
Background: The progression of emphysema and airflow limitation in chronic obstructive pulmonary disease (COPD) leads to static hyperinflation. However, few studies have been conducted so far regarding the prognostic value of static hyperinflation marked by residual volume (RV)/ total lung capacity (TLC). Therefore we attempted to find the independent factors related to static hyperinflation and to test the hypothesis that static hyperinflation is associated with the prognosis of COPD. Methods: We analyzed 380 COPD patients of our Korean Obstructive Lung Disease (KOLD) cohort who were recruited from 16 hospitals in Korea from June 2005 to April 2012. Hyperinflated COPD was defined as 40% or more of RV/ TLC. Results: Patients with hyperinflated COPD was older and male dominant, and had worse pulmonary function (represented by lower FEV1, FEV1/FVC, and FVC), higher emphysema index, and severer air-trapping, compared to non-hyperinflated COPD group (p<0.05). Multiple logistic regression analysis demonstrated that age (OR = 1.071), FEV1 (OR = 0.923), FEV1/FVC (OR = 0.948), and emphysema index (OR = 1.036) were independently associated with severe static hyperinflation ( RV/TLC =40%) (p<0.05). According to the severity of static hyperinflation, mean survival period was shorter (RV/TLC = 60% : 77.7 ± 4.6 months, 40 = RV/TLC <60 : 94.3 ± 1.9 months, RV/TLC < 40 % : 95.1 ± 1.8 months, p<0.05) and acute exacerbation was more frequent (p<0.05). Conclusions: Old age, emphysema index, FEV1, and FEV1/FVC were independent factors associated with hyperinflated COPD. The survival period was shorter according to the severity of static hyperinflation. This study was supported by a grant from the Korea Healthcare Technology R&D Project, Ministry for health and welfare (A102065).
Joo, Hyung Joon,Kim, Honsoul,Park, Sang-Wook,Cho, Hyun-Jai,Kim, Hyo-Soo,Lim, Do-Sun,Chung, Hyung-Min,Kim, Injune,Han, Yong-Mahn,Koh, Gou Young American Society of Hematology 2011 Blood Vol.118 No.8
<B>Abstract</B><P>Angiopoietin-1 (Ang1) plays a crucial role in vascular and hematopoietic development, mainly through its cognate receptor Tie2. However, little is known about the precise role of Ang1 in embryonic stem cell (ESC) differentiation. In the present study, we used COMP-Ang1 (a soluble and potent variant of Ang1) to explore the effect of Ang1 on endothelial and hematopoietic differentiation of mouse ESCs in an OP9 coculture system and found that Ang1 promoted endothelial cell (EC) differentiation from Flk-1+ mesodermal precursors. This effect mainly occurred through Tie2 signaling and was altered in the presence of soluble Tie2-Fc. We accounted for this Ang1-induced expansion of ECs as enhanced proliferation and survival. Ang1 also had an effect on CD41+ cells, transient precursors that can differentiate into both endothelial and hematopoietic lineages. Intriguingly, Ang1 induced the preferential differentiation of CD41+ cells toward ECs instead of hematopoietic cells. This EC expansion promoted by Ang1 was also recapitulated in induced pluripotent stem cells (iPSCs) and human ESCs. We successfully achieved in vivo neovascularization in mice by transplantation of ECs obtained from Ang1-stimulated ESCs. We conclude that Ang1/Tie2 signaling has a pivotal role in ESC-EC differentiation and that this effect can be exploited to expand EC populations.</P>