원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

高度産業社會에서의 都市와 農村의 連繫性 强化方案

黃明水,李顯鍾 단국대학교 산업연구소 1980 산업연구 Vol.2 No.-

급성 골수성 백혈병 환자에서 관해 유도 항암 화학요법 후 발생한 베르니케 뇌증

황진원,정재현,서광원,최병진,송영진,김종윤,이은지,임홍규,이상민 인제대학교 2009 仁濟醫學 Vol.30 No.-

Wernicke's encephalopathy is characterized by the triad of ocular symptoms, ataxia, and mental confusion and neuropsychiatric condition generally caused by acute thiamine deficiency. Although it is common in the severe alcoholics, several other causes also have been identified, such as total parenteral nutrition (TPN) use, hyperemesis gravidarum, anorexia nervosa, hemodialysis, uremia, and acquired immunodeficiency syndrome(AIDS). Chemotherapy in patient with malignanacy and long term total parenteral nutrition following bone marrow transplantation are related with Wernicke's encephalopathy. A 48-year-old woman had been treated with Daunorubicin and Cytarabine for remission induction chemotherapy of acute myeloblastic leukemia and intravenous hyperalimentation due to persistent hematochezia and ileus caused by infiltration of leukemic cell in terminal ileum. She suddenly complained of diplopia, tremor, and mental confusion at 32th day after chemotherapy and generalized tonic-clonic seizure at 34th day after chemotherapy. The diagnosis of Wernicke's encephalopathy was made with clinical presentations and brain MRI. Brain MR T2-weighted & Flair image revealed a high signal intensity lesions bilaterally at the medial thalamus and peri-acueductal grey matter of the midbrain. The patient was successfully treated with vitamin B1. We presented a case of acute Wernicke's encephalopathy developed after remission induction chemotherapy followed by intravenous hyperalirnentation in a patient with acute myeloblastic leukemia.

ANA 선별 검사가 음성이면 ENA 자가항체 검사는 안해도 되는가? : IIFA에 의한 ANA선별 검사 결과와 LIA에 의한 Ro60과 Ro52 자가항체 검사 결과의 연관성 분석

황현용,김종국 고신대학교의과대학 2007 고신대학교 의과대학 학술지 Vol.22 No.2

Background: Differently from a theory, the test results of anti-extractable nuclear antigen antibody (ENA Ab) are sometimes positive when those of antinuclear antibody are negative in the same patient. We performed the association analysis between the result of ANA and that of R060 and Ro52 ENA Abs which are prevalently identified in the laboratory practice. Methods: From January 2006 to June 2007, a total of 133 patients’ test results of ANA by indirect immunofluorescence assay (IIFA) and 13 ENA Abs by line immunoassay (LIA) were analyzed. The patients were divided into 3 groups depending on the results of Ro antibodies: 1) Ro60 (+)-Ro52 (+), 2) Ro60 (+)-Ro52 (-), 3) Ro60 (-)-Ro52 (+). The associations between the results of IIFA and those of LIA in between the groups were analyzed. The associations between the results of IIFA and those of LIA and the prevalence of ENA Abs were analyzed in the ENA (+) group. The prevalence of ENA Abs in the IIFA (-)-LIA (+) group was analyzed. The distributions of ENA Abs identified in the same patient were analyzed in LIA (+), IIFA (+)-LIA (+), and IIFA (-)-LIA (+) groups. Results: There were no statistical differences between the results of ANA and those of ENA Abs in between the groups, but significant difference was suspected between the Ro60 (+)-Ro52 (+) and the Ro60 (-)-Ro52 (+) groups (p=0.052). The prevalence of Ro60 a d Ro52 were high among 13 ENA Abs identified (18.8% and 24% respectively). Statistically significant association between the results of ANAs and those of Ro60 was observed (p=0.005). The prevalence of Ro52 was highest in the IIFA (-)-LIA (+) group (28.6%). The numbers of ENA Abs identified in the same patient decreased in the IIFA (-)-LIA (+) group. Conclusion: When the autoimmune diseases associated with Ro52 autoantibody are suspected, an ENA profile test should be performed regardless of the ANA results.

상시계측자료의 관리를 위한 테이터베이스의 원형 설계

황진하,박종희,조대현 충북대학교 건설기술연구소 2003 建設技術論文集 Vol.22 No.2

Prototype design of the database for ambient measurement data management is presented in this paper. To express the associated data generated during the whole process of ambient measurement efficiently, requirement/task analysis for database management system are peformed. And then to define and organize objects and schema for data model, conceptual and logical design are performed, which convert data model into logical schema. This prototype database is constructed by using via the object-relational data modelling approach.

이산화탄소수소화 및 MTO반응을 이용한 탄화수소 직접합성에 관한 연구

황종현,서은철,정석진 경희대학교 자연과학종합연구원 1999 자연과학논문집 Vol.5 No.-

지구온난화 현상의 주 원인 물질로 알려진 이산화탄소를 저감 또는 재활용하는 방안으로 촉매화학적 전환방법이 가장 경제적 타당성이 있는 기술로 평가되고 있다. 따라서 본 연구에서는 이산화탄소의 수소화 반응을 통한 methanol합성과 methanol로부터 olefin을 생성시키는 MTO공정의 연계를 통하여 CO_(2)로부터 olefin을 직접제조하고자 하였다. 메탄을 합성용 촉매로 주로 사용되고 있는 구리계 촉매를 대상으로 촉매 제조변수에 따른 메탄을 합성반응의 활성특성에 대한 연구를 수행하였으며, MTO반응에 있어서 최적 촉매계의 선정 및 공정변수에 따른 전환반응의 활성양상을 검토하였다. 또한 메탄올합성반응과 MTO공정의 연계효과와 hybrid 촉매 상에서 1-bed와 2-bed의 활성결과를 상호 비교하였다. The catalytic fixation of CO_(2) has attracted much attention as one of the most promising methods to mitigate global warming effect. Therefore, we wanted to produce directly hydrocarbons by connection CO_(2) hydrogenation with methanol to olefin(MTO) reaction. With copper based catalyst used for hydrogenation of CO_(2), we studied on the activity of methanol synthesis reaction by preparation method and tried to select optimal catalyst system and the activity aspect by process variation is consulted for the MTO reaction. In addition, direct synthesis of hydrocarbons from CO_(2) hydrogenation and MTO rxn. over hybrid catalyst consists of methanol synthesis catalyst(CuO/ZnO/Al2O3) and zeolite(ZSM-5) were investigated.

폐도자기로부터 제조된 재활용 소지의 소결특성

황규홍,한현근,김상우,이종국 조선대학교 생산기술연구소 2007 生産技術硏究 Vol.29 No.1

As increasing the porcelain as a home ware, the amount of waste porcelain is increased in factory or at home every year. It is very important to recycle the waste porcelain from environmental and economic point if views. Recycling of porcelain body to batch composition can be reduced the manufacturing cost of porcelain by production of raw materials and dropping of sintering temperature about 150~200℃. In this study, we prepared porcelain ceramics by mixing recycled waste ceramic raw materials and normal ceramic raw materials. The waste ceramic raw materials were recycled by crushing and ball milling waste porcelain bodies. The recycled ceramic raw materials after milling have a mean particle size about 22-40 ㎛ with irregular shape and narrow particle size distribution. Shrinkage and sintered density of compacts from recycled ceramic batch composition increased with increasing sintering temperatures, however the sintered density was independent on the amount of the recycled ceramic raw materials. The batch composition containing 30% of recycled ceramic raw materials showed the highest sintered density. Sintered density was decreased over the temperature of 1200℃ due to the creation of cracks on surface and in bulk. It may be concluded that sintering temperature can be reduced in the processing of porcelain body by adding of recycled ceramic raw matehals to normal batch composition.

Ethyoene Oxide 폭로 근로자의 말초 임파구 자매염색분체 교환에 관한 연구

황천현,박종태,장성훈,김대성,이원진,김청식,김영환 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.4

Operators of hospital sterilizers who use ethylene oxide(EtO) were studied to determine the exposure of EtO level and the frequency of sister chromatid exchanges(SCEs) from June 12 to July 20, 1997. To evaluate SCEs in the peripheral blood cells, we selected 22 workers at the central supply room of 4 university hospitals and 22 unexposed workers at the same hospitals according to match sex, age, and smoking habit and also did questionnaires. The mean air concentrations(8-hr TWA) of EtO at 4 university hospitals were less than 1 ppm. The SCE frequencies in exposed workers to EtO and controls were normally distributed. The SCE frequencies in exposed workers to EtO and controls were 6.42±0.63, 5.86±0.69, respectively and their differences were statistically significant(p=0.0093). But there were no statistically significant differences in smoking, alcohol intake, coffee drinking. Especially smokers who exposed to EtO were increased SCE statistically significant than the exposed group who did not smoke.

좌심실비후 환자에서 베타차단제의 급중단이 임상증상 및 좌심기능에 미치는 영향

황종현,김영태,배용학,임현주,조용근,채성철,전재은,박의현 慶北大學校 醫科大學 1997 慶北醫大誌 Vol.38 No.1

목적 : 베타 차단제와 칼슘 길항제의 장기투여로 안정상태에 있는 비후형 심근증이나 고혈압성좌심실비후 환자에서 이들 약제를 갑자기 중단하였을 때 혈역학, 심기능 및 임상상에 미치는 영향을 알아보기 위하여 본 연구를 시행하였다. 대상 및 방법 : 경북대학교 병원 순환기내과에서 통원치료중인 비후형 심근중 환자 5명과 심한좌심실비후를 동반한 고혈압 환자 6명(남자 6명, 여자 5명)을 대상으로 장기투여 중이던 베타 차단제와 칼슘 길항제를 최소 5일 중단한 후 임상증상, 혈압 및 심박수의 변동, 그리고 투약중지 전후에 도플러 심초음파도를 기록하여 좌심실내경, 벽두께, 좌심실근량, 구혈율 및 승모판혈류속도곡선의 변화를 관찰하였다. 결과 : 1) 약물치료 중단 후, 베타차단제의 경우 9명 중 6명에서, 그리고 칼슘길항제 및 디소피라미드를 복용하던 각 1명, 도합 7명의 환자에서 심계항진, 호흡곤란의 악화, 흉통이 관찰되었고, 심계항진을 호소한 1예에서는 심방세동이 재발되었다. 2) 혈압, 심박수, 확장말기 및 수축말기 좌심실내경, 심실중격 및 심실후벽 두께, 좌심실근량 및 구혈을 모두는 치료약물 중단 전후에 다소 변화하였으나 유의하지 않았다. 3) E파 최고속도와 E파 시간속도적분은 약물투여 중단 전후에 유의한 변화는 없었으나, A파 최고속도와 A파 시간속도적분은 중단 후에 각각 유의하게 증가하였으며(both P<0.01), E/A 최고속도비와 E/A 시간속도적분비는 각각 유의하게 감소하였다(both P<0.01). 한편, E파 감속시간, 등용이완시간 그리고 A-Ar 간격[A파의 최고점에서 A reversal(Ar)파의 최저점간의 시간] 모두는 중단 후 유의한 변화가 없었다. 1 결론 : 비후형 심근증 이나 고혈압성 좌심실비후 환자에서 장기투여중이던 베타 차단제와 칼슘길항제를 일시적으로 중단하였을 때 임상중상의 악화와 더불어 확장기 기능의 변화를 초래하였다. 따라서 약물치료로 비록 임상적으로 안정상태에 있더라도 치료를 갑자기 중단할 때는 주의해야 할 것으로 생각된다. Objectives : This study was done to evaluate the changes in clinical findings, hemodynamics and cardiac function after abrupt withdrawal of longterm beta-blockers and/or calcium channel blockers in hemodynamically stable patients with hypertrophic cardiomyopathy and left ventricular(LV) hypertrophy associated with hypertension. Methods : Eleven patients with hypertrophic cardiomyopathy(n=5) and LV hypertrophy associated with hypertension(n=6) were studied. Symptom assessment, blood pressure, electrocardiography and echocardiography including pulsed Doppler examination were obtained before and at least 5 days after abrupt cessation of beta-blockers and calcium antagonists. Results : 1) Deterioration in symptoms(i.e. palpitation, aggravation of dyspnea and chest pain) was observed in seven patients after abrupt withdrawal. 2) There were no significant changes in blood pressure, heart rate, end-systolic and end-diastolic LV dimensions, interventricular septal thickness, LV posterior wall thickness, LV mass, and ejection fraction before and after drug withdrawal. 3) Doppler time intervals and E wave peak-velocity and time velocity integral(TVI) were not significantly changed before and after drug withdrawal. But A wave peak-velocity and TVI after abrupt withdrawal were significantly increased(both p<0.01), and E/A peak-velocity ratio and TVI ratio were significantly decreased(both p<0.01). Conclusions : These findings suggest that temporary omission of beta blockers and calcium channel blockers develops deterioration in symptoms and LV diastolic dysfunction in hypertrophic cardiomyopathy and LV hypertrophy associated with hypertension. Physicians should avoid abrupt withdrawal of longterm beta blockers in LV hypertrophy.

두가지 혈류 유발방법에 의한 새로운 심폐소생술(이중 혈류 유발 심폐소생술)장치의 개발

황성오,김현,조준휘,오범진,임종천,최경훈,윤정한,이승환,김영식,이강현,이윤선 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: There have been many efforts to augment blood flow during cardiopulmonary resuscitation. These efforts have focused on maximizing the effect of cardiac pump or thoracic pump alone. However, considering that the heart is the biggest blood reservoir and increase of intrathoracic pressure can generate blood flow, simultaneous exploitation of both mechanisms may have synergistic effect. We hypothesized that simultaneous chest constriction in addition to sternal compression by standard CPR may have additive hemodynamic effects by preventing deformation of the chest and increase of intrathoracic pressure. Methods and results: we built a new mechanical device to perform compression and thoracic constriction simultaneously. The device consists of two main elements. Piston in the center is to depress the sternum. Strap is to constrict the thorax circumferentially. Strap is attached to both sides of the piston. When the piston is pushed down, it depresses the sternum and pulls on the thoracic strap. To determine strap width to produce optimal hemodynamic effect, we measured hemodynamic parameters with variable widths of strap in two dogs after induction of ventricular fibrillation. Result of the experiment showed that 10cm wide strap was determined to be most effective. We also determined optimal depth of compression to produce maximal hemodynamic effect with animal experiments using two dogs. Animal experiments showed that the highest aortic pressure could be generated when the stemum was depressed to 5 cm. Cardiopulmonary resusciation using a new device could generate higher systolic aortic pressure, coronary perfusion pressure and end-tidal carbon dioxide tension in comparison with standard cardiopulmonary resuscitation in a pilot animal study using two dogs. Conclusion: New cardiopulmonary resuscitation method using a mechanical device designed by us could perform sternal compression and simultaneous thoracic constriction, and generate better hemodynamic effects than standard cardiopulmonary resuscitation in pilot animal experiments.