과민성 장증후군 환자에서 베타 아드레날린 수용체 기능의 활성도와 불안 수준

강은호,이풍렬,이준행,김현서,이종철,유범희 大韓神經精神醫學會 2004 신경정신의학 Vol.43 No.1

내시경적 조직검사로 진단된 위 분선충증 1 예

이석호,이화영,이규택,강인구,최규완,백승운,이종균,이준혁,고광철,이종철,오영륜,현재근,이풍렬,김재준,채종일 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.2

Strongyloidiasis is a parasitic disease caused by Strongyloides stercoralis which exists in two forms : the free living and parasitic forms. It exists in warm, moist climate in areas where there is frequent fecal contamination of the soil. After cutaneous invasion by the filariform larvae, petechial hemorrage, pruritus, papular rashes, edema, and urticaria occur. Infection commonly occurs in the proximal intestine of the gastrointestinal (G-I) tract but may extend from the stomach to the anus. Once the worm is established in the small intestine, the physical findings may include epigastric tenderness to palpation. The mucosal biopsy is an inefficient way of making the diagnosis because the worm is found in the biopsy specimen in only 2% of patients. Gastric strongyloidiasis is rare. We experienced a case of gastric strongyloidiasis diagnosed by the endoscopic biopsy and serologic test for parasite specific IgG antibody by micro-ELISA.

한국인에서 네 번째 발병된 장카필라리아증 1예

이석호,이상구,류광현,고광철,이규택,김재준,최규완,이남용,백승운,이종균,이준혁,이종철,심상군,이풍렬,조승렬 대한소화기학회 1999 대한소화기학회지 Vol.34 No.4

Intestinal capillariasis is caused by Capillaria philippinensis. Among them, only 4 species have been found in humans: Capillaria hepatica, C. aerophila (Eucoleus aerophilus), C. plica and C. philippinensis. Reports of human infections with C. hepatica, C. aerophila and C. plica are rare, but reports of C. philippinensis infections are increasing and spreading geographically. Human infestation by C. philippinensis is a rare parasitic disease. We experienced a case of intestinal capillariasis which was misdiagnosed for intestinal tuberculosis or Crohn's disease at first but correctly diagnosed later by detection of numerous eggs of C. philippinensis on the stool examination. The eggs were found in stool only after ingestion of prednisolone for treatment of misdiagnosed Crohn's disease. The 42 year-old patient had a journey to Saipan island in Pacific ocean 6 months ago and ate sliced raw eels. Abdominal pain, watery diarrhea were subsided after therapy of albendazole.

Protective effect of yeoldahanso-tang on radiation-induced oral mucositis in mice

Lee, Jong Hyun,Lim, Sung-Lyul,Lee, Seok-Geun,Ryu, Seung-Hee,Lee, Sang-wook,Kim, Kwanil,Jung, Jinhong,Kong, Moonkyoo,Lee, Jung-woo,Lee, Junhee,Eun, Young-Gyu,Ahn, Kwang Seok Kyung Hee Oriental Medicine Research Center, Kyung 2016 Oriental Pharmacy and Experimental Medicine Vol.16 No.1

Radiation-induced oral mucositis is probably the most common toxicity for head and neck cancer patients. This adverse effect potentially leads to various lesions such as erythema, ulcerations, pain, opportunistic infections, and weight loss. Although there are many experimental studies and clinical trials related to novel therapies for radiation-induced oral mucositis, we here evaluate the protective effect of orally administrated Yeoldahanso-tang (YDHS) on radiation-induced oral mucosal damage in a mouse model. YDHS is a traditional Korean herbal formula, containing 7 herbs: Pueraria thunbergiana Benth., Angelica tenuissima Nakai, Platycodon grandiflorum (Jacq.) A. DC., Raphanus sativus var., Angelica dahurica Benth. et Hooker f., Cimicifuga heracleifolia Kom., and Scutellaria baicalensis Georgi. Oral mucosal damage was induced by irradiation (17 Gy) throughout the head and neck area in male BALB/c mice. YDHS (400 or 800 mg/kg/day for consecutive 12 days) was administered orally, and the protective effect was determined by histological evaluation of the oral mucosa. We found that irradiation highly increased COX-2 expression in salivary glands and its expression was suppressed by YDHS. Histologically, the irradiated mice exhibited the epithelial thickness from the basement membrane to the stratum granulosum significantly decreased as compared to the vehicle group. YDHS-treated mice showed significantly recovered epithelial cell layer thickness compared to irradiated group. Similarly, YDHS-treated group also showed the expression of Ki-67, cell proliferation maker, in the basal layer compared to the irradiated group in both dorsal and ventral surface. From these results, we suggest that YDHS is a promising candidate for preventing or treating radiation-induced oral mucositis during radiation therapy.

소화성 궤양 출혈에서 열탐침 지혈법 후 재출혈의 위험인자

김영호,이석호,이상구,손희정,이규택,최규완,백승운,이종균,이준혁,고광철,이종철,김재준,류광현,이풍렬 대한소화기내시경학회 2000 Clinical Endoscopy Vol.20 No.6

Background/Aims: The precise rebleeding rate and risk factors of rebleeding after heat probe thermocoagulation in peptic ulcer patients with bleeding are not clear and still need to be evaluated. If we could identify the pre-dictors for rebleeding, the mortality rate might be loweted with early retreatment or surgery in these high risk group. Methods: The 94 patients in whom heat probe was applied were enrolled and the 18 patients with bleeding tendencies. Initial hemostasis was defined as hemostasis persisting for 24 hours post-treatment and permanent hemostasis as absence of bleeding for 7 days after therapy. Rebleedig was defined as oozing or spurting hemorrhage in the ulcer base and/or unstable vital signs and continuting tarry or bloody stool or hematemesis after therapy. Results: In 35 patients with active bleeding sign, initial hemostasis was obtained in 30 (85.7%) patients. After having achieved initial hemostasis, 9 (30.0%) patients rebled. In 41 ulcer patients with non-bleeding visible vessel, 40 cases (97.6%) achieved successful pre-vention of rebleeding. No evident complication was observed. With univariate analysis, bleeding ulcer patients with spurting and oozing hemorrhage had a higher re-bleeding rate than those with non-bleeding visible vessel. Conclusions: The heat probe thermocoagulaton is relative safe and effective procedure to protect bleeding in pectic ulcer patients with non-bleeding visible vessel, but insufficient to hemostasis in bleeding peptic ulcer patients with spurting or oozing in ulcer base. Spurting and oozing hemorrhage are the only risk factors of rebleeding after initial hemostasis with heat probe thermocoagulation in peptic ulcer patients with bleeding.

간암 환자의 술전 검사로서 CTAP와 CTHA 의 유용성

이석호,이규택,김재준,강인구,김승훈,백승운,도영수,이종균,이준혁,고광철,이풍렬,최규완,오성윤,이종철 대한간학회 1997 Clinical and Molecular Hepatology(대한간학회지) Vol.3 No.4

Background / Aims : Combined computed tomography during arterial portography(CTAP) and computed tomography during hepatic arteriography(CTHA) are more sensitive methods compared to conventional spiral CT in detection small hepatocellular carcinoma. However, there are few data available on the influence of combined CTAP and CTHA on decision making for treatment of hepatocellular carcinoma. We aimed to evaluate the usefulness of CTAP and CTHA as a preoperative study of hepatocellular carcinoma for surgical treatment. Methods : Eighty -two patients with histologically proven hepatocellular carcinoma who were considered to be surgical candidates on spiral CT and angigraphy were included. CTAP and CTHA were performed as the routine protocol. The findings of CTAP and CTHA were analyzed and compared to conventional spiral CT and angiography. Results : 1)105 nodules were found on spiral CT plus angiography , whereas, 138 nodules found on combined CTAP and CTHA : 33 additional nodules were found in 23 cases(28%). 2) The treatment plan changed from surgery to nonsurgical treatment in 10(12%) cases : 9 cases(10%) with bilobar involvement, and 1 case(1%) with more than three nodules. 3) The larger the tumor nodules on the spiral CT, the more additional tumor nodules were found on CTAP and CTHA : combined CTAP and CTHA were able to find more nodules in 21% of tumor ≤3cm, 27% of tumor with 3- 10cm, and 71% of tumor > 10 am on spiral CT (p=0.03). Conclusion : Compared to spiral CT plus angiography, CTAP and CTHA may be useful in avoiding unnecessary operation of hepatocellular carcinoma, especially in large tumors.

간암의 술전 검사로서 CT AP , CT HA 및 Lipiodol CT 의 유용성

이석호,이규택,김재준,김승훈,백승운,이종균,이준혁,고광철,이풍렬,이종철,최규완,도영수 대한소화기학회 1999 대한소화기학회지 Vol.32 No.6

Background/Aims: Computed tomography during arterial portography (CTAP), computed tomo-graphy during hepatic arteriography (CTHA) and Lipiodol CT are highly sensitive methods to detec intrahepatic tumor. Their sensitivity and accuracy are over 90% and 85%, respectively. We evaluated the usefulness of CTAP, CTHA and Lipiodol CT as a preoperative examination. Methods: For eighty two patients with hepatocellular carcinoma which were considered as the resectable on spiral CT and angiogram, CTAP and CTHA were performed. The additional nodules on CTAP and CTHA were confirmed by Lipiodol CT. Results: CTAP and CTHA could find additional nodules in 28% of the patients. The treatment plan was changed from surgical to nonsurgical method in 12% of the patients The larger tumor nodules were on the spiral CT, the more additional tumor nodules were found on CTAP and CTHA (p=0.03). The probability of finding additional nodules on CTAP and CTHA is no related with the counts of tumor nodules on the spiral CT (p=0.84). CTAP and CTHA could find additional nodules in 6 cases of 27 cases who underwent Lipiodol CT. The treatment plan was changed to nonsurgical treatment in 3 cases by the results of CTAP and CTHA. Conculusions: We concluded that CTAP, CTHA and Lipiodol CT are useful in avoiding unnecessory operation.

혈액투석 중인 만성 신부전 환자에서 TT Virus의 감염률과 임상적 의의

이용욱,허우성,도재혁,백승운,최문석,김소정,이준행,고광철,이풍렬,이종철,최규완,박상종,이준혁,김재준,오하영,임윤정 대한소화기학회 2001 대한소화기학회지 Vol.37 No.1

Background/Aims: TT virus (TTV) is a unenveloped, single-stranded and circular DNA virus isolated from the serum of a patient with posttransfusion hepatitis of unknown etiology. We evaluated the prevalence, risk factors, and clinical significance of TTV in patients with chronic renal failure(CCRF) undergoing maintenance hemodialysis (HD). Methods: We examined TTV DNA in serum of HD-undergoing patients and healthy controls using the nested polymerase chain reaction. Results: TTV DNA was detected in 15 (20.0%) of 75 HD-undergoing patients and 10 (13.2%) of 76 healthy controls (p$gt;0.05). The prevalence of TTV did not differ according to the duration of HD or transfusion history of the patients. The prevalence of TTV was higher in IgG anti-HBc positive patients than IgG anti-HBc negative patients (27.5% vs. 4.2%, p=0.03). There was no relationship between TTV infection and liver diseases. Conclusions: The prevalence of TTV infection in CRF patients undergoing HD was similar with that of healthy controls. These results suggest that TTV infection may share the route of transmission with HBV infection in adults.

Continuous Transforming Growth Factor β₁Secretion by Cell-Mediated Gene Therapy Maintains Chondrocyte Redifferentiation

Lee, Dug Keun,Choi, Kyoung Baek,Oh, In Suk,Song, Sun U.,Hwang, Sally,Lim, Chae-Lyul,Hyun, Jong-Pil,Lee, Hyeon-Youl,Chi, Guang Fan,Yi, Youngsuk,Yip, Vivian,Kim, Jeannie,Lee, Eun Byul,Noh, Moon Jong,Lee Mary Ann Liebert 2005 Tissue engineering Vol.11 No.1

<P>One of the most important factors in the production of cartilage is transforming growth factor beta1 (TGF-beta1). To obtain sustained release of TGF-beta1, a cell-mediated gene therapy technique was introduced. We infected chondrocytes with a retroviral vector carrying the TGF-beta1 gene. The single clone derivative showed sustained TGF-beta1 secretion. It also showed constitutive type II collagen expression. Whereas the TGF-beta1 protein itself is unable to induce formation of cartilage in vivo, human chondrocytes engineered to express a retroviral vector encoding TGF-beta1 showed cartilage formation in vivo when cells were injected into nude mice intradermally. These data suggest that cell-mediated gene therapy using TGF-beta1 as a transgene would be a promising treatment for osteoarthritis.</P>

THE BIDAS-2007: BIOASSAY DATA ANALYSIS SOFTWARE FOR EVALUATING A RADIONUCLIDE INTAKE AND DOSE

Lee, Jong-Il,Lee, Tae-Young,Kim, Bong-Whan,Kim, Jang-Lyul Korean Nuclear Society 2010 Nuclear Engineering and Technology Vol.42 No.1

Bioassay data analysis software (BiDAS-2007) has been developed by KAERI, which adds several new functions to its previous version. New functions of the BiDAS-2007 computer code enable the user not only to do a simultaneous analysis by using two or more types of bioassay for the best internal dose evaluation, but also to do a continual internal dose evaluation from a change of the internal exposure conditions such as an intake type (acute, chronic), an intake pathway (inhalation, ingestion), an absorption type (Type F, M, S), and a particle size (AMAD, activity median aerodynamic diameter), and also to estimate the intakes in various conditions of an internal exposure at a time. The values calculated by the BiDAS-2007 code are consistent and in good agreement with those values by IMIE-2004 code by Berkovski and IMBA code by Birchall. The BiDAS-2007 computer code is very useful and user-friendly to estimate the radionuclide intakes and committed effective doses of a radiation worker.