세포질내 정자주입법(ICSI)에 있어서 정자흡입 및 난자내 주입방법에 관한 연구

이택후,김항진,송건호,김대근,전상식,박윤규,서태광,전병균,류은경,이은숙,문진수,김광철 경북대학교 의학연구소 2000 경북대학교병원의학연구소논문집 Vol.4 No.1

Study on Method of Sperm Aspiration and Injection into an Oocyte in Intracytoplasmic Sperm Injection(ICSI) Immobilization of spermatozoa prior to intracytoplasmic sperm iniection(ICSI) sometimes results in crooked tail and this makes it difficult to aspirate sperm into an injection pipette tail first. Head-first sperm aspiration into an injection pipette avoid this problem due to the bigger size of the sperm head. The effect of head or tail-first sperm injection into an oocyte on fertilization cleavage, percentage of grade I embryos and development to blastocyst stage in ICSI program has been studied. A single living immobilized spermatozoa from oligoasthenozoospermic patient was injected into an oocyte head-first or tail-first according to the treatment. Eighteen hours after microinjection, oocytes ware inspected for survival and fertilization Fertilized oocytes with two pronuclei were cultured in 30μl drop of mHTF supplemented with 10% heat-inactivated follicular fluid(FF) at 37℃. On day 2. embryo transfer was performed with cleaved embryos. The remaining 2-8 cell stage embryos were co-cultured with BRL cells in mHTF + 10% FF for 72 hours and the developmental stage was observed. The data were analyzed by Analysis of Variance. A total of 164 oocytes from 36 cycles were assigned to earth treatment and ICSI was performed(88 head-first, tail-first). The rates of normal fertilization were 81.8% and 76.3% for head-first and tail-first, respectively. Of the fertilized oocytes, the percentage of cleaved embryos and the percentage of grade 1 embryo among cleaved embryos were 88.9% and 68.8%, 93.1% and 74.1% for head-first and tail-first, respectively. Of the 2-8 cell embryos cultured, 44.4%(16/36) and 50.0%(10/20) for head first and tail first, respectively developed to blastocyst stage. There were no differences in fertilization, cleavage, rates of grade 1 embryos, and development to blastocyst stage. In conclusion, head-first or tail-first sperm injection into an oocyte in ICSI program does not affect fertilization and subsequent embryo development to blastocyst stage in vitro.

확대된 여가제약 척도의 최적범주

이창진(Lee, Chang-Jin),김응준(Kim, Eung-Joon) 한국웰니스학회 2017 한국웰니스학회지 Vol.12 No.1

본 연구는 김응준(2012)이 Rasch 모형을 적용하여 선행연구에서 개발된 확대된 여가 제약 척도의 심리측정학적 특성 결과를 바탕으로 최적범주를 탐색하는데 목적이 있었다. 이 목적을 달성하기 위해 대학교 410명의 학생들을 대상으로 조사를 실시하고 통계분석하였다. 사용된 척도는 Crawford와 Godbey(1987)에 의해 제시된 여가제약 척도를 지현진과 이철원(2003)이 수정 보완하고, 김응준(2006)에 의하여 타당화 시킨 확대된 여가 제약 척도를 조사도구로 사용하였다. 수거된 자료 중 410명의 자료를 SPSS 23.0프로그램을 이용하여 빈도분석, 기술통계분석을 실시하였다. 최적범주를 탐색하고자 WINSTEPS 3.92 (Linacre, 2016)을 사용하여, 척도수의 적절성, 문항적합도와 문항난이도 등을 산출하였다. 연구목적에 따른 연구결론으로는 첫째, 문항의 반응범주는 문제가 있는 것으로 확인되어 기존 5점 범주 대신 4점 범주로 수정되는 것이 타당하였다. 둘째, 문항적합도를 분석한 결과 22문항은 적합하였다. 셋째, 척도의 응답자 신뢰도가 낮게 확인되어 문항난이도를 고려한 문항순서의 변경이 필요하였다. 넷째, 개인 능력점수와 난이도를 교차하여 비교한 결과, 개인 능력점수 분포와 문항난이도 분포는 적절하였다. The purpose of this study was to investigate the extended leisure constraint questionnaire’s optimal categorization in undergraduate students. To accomplish study purpose, complete enumeration survey and statistical analysis were conducted for 410 students enrolled university. A research tool used in this study was an extended leisure constraint scale developed by Eung-Joon KIM (2012), which was originally from Crawford & Godbey(1987). Total 22 questions were used with 5 point Likert scale and high point stands for higher the leisure constraint. Frequency analysis was conducted with SPSS 23. An assumption to test Rasch Model, which is satisfaction of unidimensionality, is regarded through theoretical aspects, and WINSTEPS 3.92(Linacre, 2016) program is used to test the goodness-of-fit of items. Statistical analysis showed results as follows. First, 4-point rating scale was appropriate for the extended leisure constraint scale. Second, 22 items of the extended leisure constraint scale were suitable in item fitness and item difficulty to undergraduate students. Third, the extended leisure constraint scale was somewhat suitable in person reliability of item separation. Fourth, the person ability score of the extended leisure constraint scale was distributed appropriately.

Landsat TM Data를 이용한 해안 환경림 조사

박용진,김응남 강릉대학교 동해안지역연구소 2000 국제 심포지움 Vol.2000 No.1

흔치않은 대상포진 치험 2예 : 비전형적 부위와 다른 부위로 재발한 예 Unusal Dermatome and Recurs Other Dermatome

김정미,조은경,조정선,최용석,한영수,한정호,김두응,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Herpes zoster is well known as an acute, self-limited disease of unilateral sensory dermatome caused by varicella-zoster virus and characterized by grouped vesicular skin eruption and pain over several dermatomes as well as single. This virus usually affects the thoracic dermatome and there are a few reports that this virus involves lower lumbar or sacral area, and recurrent cases. We experienced 2 cases that zoster virus involved L4 or S2 dermatome and left typical skin lesions, of which one was a recurrent case involving different dermatome at an interval of 8 years and the other was a rare case involving sacral dermatome.

직장암 수술 후 국소재발과 예후

김태윤,백무준,김성용,신응진,박내경,이문수,김창호,송옥평 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Locally recurrent rectal cancer is a difficult clinical problem. Local recurrence following treatment for rectal cancer is a major cause of morbidity and mortality. The reported range of local recurrence rates following surgical treatment for rectal cancer has varied from 4% to 50%. We retrospectively reviewed the charts of 142 rectal cancer patients from January 1991 to December 1999. Analysis of patients factors included age, gender, type of surgery, and adjuvant therapy. Tumors were assessed for level, stage, and grade. Local recurrence and distant metastases were also documented. Variables influencing local recurrence in this group were identified and disease-free survival is determined. Of the 142 patients(74 males, 68 females; mean age 62.6 years), 137 consecutive patients operated on for rectal cancer and followed up to December 2000 (range 23-118months) were analyzed. Local recurrence rate was 18.3%. Age and sex of patients, type of surgery, location of tumor in the rectum, size, morphology and grading of the tumor were all unrelated to the event under investigation. At Cox regression, the Dukes stage and the postoperative radiotherapy were the only independent prognostic factors for local recurrence, and Dukes stage (Hazard ratio=2.89, p<0.001) and local recurrence (Hazard ratio=3.31, p<0.01) were the only independent factors associated with improved survival.

데빅병 치료에 사용한 Interferon β-1b의 부작용 1예

김정미,조은경,조정선,최용석,한영수,한정호,김두응,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

A 63 year-old woman who had diagnosis of multiple sclerosis complaining left hemiparesis and fluctuating decreased visual acuity in her right eye and abnormal findings in pattern shift visual evoked potentials(PSVEPs) and on T2 weighted MR scanning. We treated her subcutaneously with 250μg interferon (3-lb(ITFß -lb) every other day. There were detected pancytopenia, skin rash, and abnormal liver function test seven days after the therapy. In spite of reducing the dose of interferon injection, abnormal laboratory findings were not returned to normal. Dose adjustment of interferon-I3 for body weight or race, may be helpful to reduce the side effects.

논리적 디스크 개념을 이용한 적응적 디스크 재배치 방법

김진응,장태무 동국대학교 산업기술환경대학원 1996 산업기술논총 Vol.3 No.-

During the last decade, the performance of microprocessors and memory systems has been improved dynamically. But the disk system performance has been improved sightly, and it became a dominant factor of overall computer system performance. To improve the performance of disk systems, there have been studies on adaptive disk rearrangement techniques, which dynamically change the disk layout to reduce the seek distance. In this paper, a more efficient and flexible method of performing adaptive disk rearrangement and a new rearrangement policy called organ pipe arrangement variant' are proposed. Logical disk concept is introduced to provide efficiency and flexibility in the adaptive rearrangement system. Logical disk, implemented in the disk controller together with non-volatile memory and modified logical disk interface primitives, is suggested. A trace-driven simulation methods shows that the methods in the present paper can reduce the average seek distance by about 35%.

"人類의 共同遺産" 槪念의 法的 意味

김효진,엄응용 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(B)

After the world war Ⅱ, an international society has been concerned about the outside region of national jurisdiction(Deep seabed, Outer Space, Moon, South Pole etc), and the development and conservation of its resources. As a result, Antarctic Treaty(1959), Outer Space Treaty(1967), the Moon Treaty(1979), and UNCLOS(1982) were concluded. Above all, through the treaties common Heritage of Mankind(CHM) was induced expressly or analogically as a new approach for the development and conservation of International Common Spaces. However, the question at issue is that the concept, character , extent, and regulations of CHM which was induced by the treaties have been interpreted and applied according to each treaty or standpoint of each nation. This lead to denunciation on the status of the CHM in international law. By the way, the core cause of this denunciation could be that there's no right legal definition on the terms of the CHM. It means that a prior question on the status of the CHM from the point of the international law is to analyze and examine closely the terms of this concept and define the legal implication. Therefore, I am willing to describe the appearance and development of the concept of CHM, analyze the legal significance on each term of the concept and evaluate generally the legal position of it through this study.

Osteogenic Sarcoma에 관한 연구

김영일,김영진,박응천,최원재 大韓口腔顎顔面 放射線學會 1993 Imaging Science in Dentistry Vol.23 No.1

The author observed a case of osteogenic sarcoma in a 11-year-old female with complaint of painful swelling on face in fight side. The observed results were as follows: 1. Large hematoma was observed, and patient complanited painful swelling on c/c site. 2. Predisposing factor of osteogenic sarcoma was not clear, but patient had history of extraction before patient visiting infirmary of our dental collage. 3. Serologic findings were not specific, and serum alkaline level was normal. 4. Radiographic findings were as follows: ① Diffuse faint radiopacity in the lesion ② Bony destruction and increased radiopaciy in right antrum ③ Displacement of multiple teeth on involved area(i. e #12, 15, 55, 16, 17, 18) ④ Increased periodontal space in single tooth(#13) ⑤ Destruction of bony crypt on involved teeth(#13, 14, 15, 17, 18) ⑥ Loss of lamina dura of three teeth in involved area(#11, 12, 16) 5. Computed tomographic findings were as follows: ① Large calcific and hetergenous component mass in the Rt. maxillary sinus, and this mass extending to Rt. maxilla, alveolar bone, ethmoid sinus. ②Soft tissue bulging into Rt. side nasal cavity and oral cavity. ③ Bone destruction of maxillary sinus wall and Rt. alveloar bone.

慢性 精神病棟 入院患者의 藥物服用狀態에 對한 調査

金哲應,孫鎭旭 서울대학교 의과대학 정신과학교실 1983 精神醫學報 Vol.7 No.8