고장성 식염수를 이용한 실험적 근육통에서의 통증 양상

손민균,김태민,서정수,김봉옥,윤승호 大韓再活醫學會 2000 Annals of Rehabilitation Medicine Vol.24 No.3

조혈모세포이식 환자의 삶의 질에 대한 연구 : 화학요법 환자 및 정상인과의 비교

김병수,서재홍,최철원,김열홍,김준석,김정아,손상균,김재석,이경희,이제중,정익주,곽재용,안진석,이정애,박영석 대한조혈모세포이식학회 1999 대한조혈모세포이식학회지 Vol.4 No.1

연구배경: 조혈모세포이식후 신체 및 정신적 장애의 정도가 얼마나 환자의 '삶의 질(QOL)'에 영향을 미치는지에 대하여 외국에서는 연구들이 활발히 진행되고 있다. 그러나 우리나라에서는 조혈모세포이식이 비교적 활발히 시술되고 있음에도 불구하고 이에 대한 연구가 미미한 실정이었다. 연구자 등은 우리 나라에서 조혈모세포이식을 받은 환자들의 QOL은 어떤지를 알아보고자 하는 목적으로 본 연구를 시행하였다. 방법: 본 연구에 참여한 각 기관에서 조혈모세포이식을 받고 주된 치료가 끝난 후 1999년 2월 시점에서 최소 3개월이 지나고 관해상태에서 일상생활을 영위하고 있는 재생불량성 빈혈과 급성 및 만성 백혈병 환자들을 각각 자가 및 동종 조혈모세포이식을 시행받은 조혈모세포이식군(1군)과 항림프구 글로불린, 공고요법 등으로 치료를 끝낸 화학요법군(2군)으로 분류하고 연구자 병원에 내원한 건강한 환자 보호자들로 이루어진 정상대조군(3군)을 선정하여 각각의 QOL을 비교, 분석하였다. QOL의 측정은 EORTC QLQ-C30 문항을 우리나라의 실정에 맞게 번역하여 사용하였다. 결과: 조혈모세포이식군(1군)은 53명, 화학요법군(2군)은 57명, 정상대조군(3군)은 55명 이었고, 성별, 나이, 질환별 분포, 검사시점 등에서의 유의한 차이는 없었다. 각 군간의 QLQ-C30 평균 점수를 비교한 결과, 전반적인 삶의 질에서는 1군이 73.5, 2군이 51.7, 3군이 79.3으로 2군이 1.3군보다 낮았고 역할 및 사회기능은 각각 1군이 64.3/68.9, 2군이 57.6/70.3, 3군이 85.2/85.5로 1,2군이 3군에 비하여 낮았다.(P<0.01). 또한, 오심/구토가 1군은 8.7, 2군은 4.5, 3군은 3.2로 1군이 2, 3군보다 높았으며 통증은 1군은 17.0, 2군은 19.2, 3군은 9.6으로 1,2군이 3군에 비하여 높았다(p〈0.01). 기타 신체, 감정, 인식기능 및 피로에서는 각군간에 유의한 차이를 발견할 수 없었다. 결론: 본 연구에 참여한 조혈모세포이식환자들의 전반적인 삶의 질은 화학요법을 받은 환자들보다 우월하면서 정상인들과 유사하였으나 역할기능 및 사회기증, 통증에서는 화학요법 환자들처럼 정상인들에 비하여 열악하였고 오심/구토는 화학요법 환자들 및 정상인에 비하여 심한 양상을 보였다. 그러므로 본 연구를 바탕으로 하여 국내 실정에 맞는 QOL 측정 방법을 개발하고 조혈모세포이식을 시행받는 환자들의 삶의 질에 관한 연구들이 향후 계속 진행되어야 하리라고 생각된다. Background: It is very important to endow patient with satisactory quality of life (QOL). However, little is known about QOL after hematopoietic stem cell transplantation (HSCT) in Korea. In this study we tried to measure QOL in the patients treated with HSCT and compare QOL scores with those of patients treated with usual chemotherapy and normal populations. Methods: The QOL evaluation was performed with EORTC QLQ-C30 questionnaires interpreted to Korean language. The study populations were consisted with 53 patients treated with HSCT (Group 1), 55 patients treated with usual chemotherapy (Group 2), and 55 normal populations (Group 3). The QLQ-30 scores of each group were evaluated and compaired with x² test. Results: Global quality of in group 1, 3 (score: 73.5, 79.3, respectively) were higher than that (score: 51.7) of group 2. Role and social function were lower in group 1, 2 (score: 64.3/68.9, 57.6/70.3, respectively) than those (score: 85.2/85.5) of group 3. The degree of nausea and vomiting was more severe in group 1 (score: 8.7) than those of group 2, 3 (score: 4.5, 3.2 respectively). Pain scores of group 1, 2 (score: 17.0, 19.2, respectively) were more higher than that of group 3 (score: 9.6) In other parameters of QLQ-C30, there was no significant difference between each groups. Conclusion: Our perliminary result may suggest that HSCT is not necessarily associated with deterioration of QOL. This underlines the necessity of undertaking perospective studies using reliable and well-validate methods for measuring QOL

장기간 항갑상선제 투여 후 임의 중단 뒤 재복용시 발생한 무과립구증 1 예

김승만;김태영;박수영;배영환;서영경 정은주;김태균;권민정;박정현;이순희 인제대학교 2011 仁濟醫學 Vol.32 No.-

Agranulocytosis, one of the major side effects of antithyroid a gents, probably occurs in less than 0.25% of cases treated with antithyroid agents. It usually occurs within the first several weeks or months after the initiation of therapy, when drug dosage is higher. Most reported cases of agranulocytosis have occurred during the first 3 months of therapy. We describe here a rare case that did not experience the side effect for 6 years of antithyroid agent treatment but presented with agranulocytosis in one month after re-exposure. It suggests that the major side effect such as agranulocytosis can occur in patients who had undergone prior uneventful antithyroid drug therapy.

Free Paper Session : Biliary Diseases ; Risk Factors And Management Of Biliary Complications In Adult Living Donor Liver Transplantation Patients

( Jeong Kyun Seo ),( Nam Joon Yi ),( Sang Hyub Lee ),( Hea Won Lee ),( Ji Kon Ryu ),( Joo Kyung Park ),( Sang Myung Woo ),( Ki Young Yang ),( Yong Tae Kim ),( Yong Bum Yoon ),( Kyung Suk Suh ) 대한소화기학회 2007 SIDDS Vol.9 No.-

Background/Aims: The major morbidity after adult living donor liver transplantation (ALDLT) is due to biliary complications. The aim of the present study is to evaluate 1) the kinds of biliary complications and their incidence, 2) the risk factors of biliary stricture and 3) the clinical outcomes of management. Methods: Between January 2000 and December 2006, 259 adult patients underwent ALDLT at Seoul National University Hospital. Among 259 recipients, 20 patients died during the postoperative period. We retrospectively analyzed the remaining 239 patients. Results: The mean follow-up period was 40 months (range, 7-90 months), and the graft failure rate was 3%. The 1-year survival rate was 91%. The main causes of death were hepatocellular careinoma recurrence (65%), acute or chronic rejection (10%), sepsis (10%) and HCV reactivation (5%). The overall incidence of biliary complications was 28.9% for biliary stricture, 6.2% for bile leakage, 1.6% for bile duct stone and 0.8% for biliary cast. On multivariate analysis, the risk factors of biliary stricture were multiple bile duct anastomosis (OR 3.25, CI 1.2-8.7, p=0.02), bile leakage (OR 28.1, CI 3.3-238.1, p-0.02) and hepatic artery stenosis (OR 9.7, CI 2.3-41.4, p=0.002). All strictures were initially treated nonsurgically (endoscopic cholangioplasty, n=27; percutaneous cholangioplasty, n=41; and observation, n=1). However, 6 patients ultimately required biliary reconstruction. The patients with bile leakage were treated with endoscopic nasobiliary drainage (n=3), percutancous transbiliary drainage (n=11) or biliary reconstruction (n=1). Biliary casts and stones that developed after ALDLT were cured with endoscopic or percutaneous removal. Conclusions: The most common biliary complication after ALDLT was biliary stricture. Hepatic artery stenosis, multiple bile duct anastomosis and bile leakage were significantly associated with biliary stricture. Biliary complications can be successfully managed with nonsurgical methods.

Assessment of OKT-3 induced cytokine release syndrome in hPBMC-humanized mouse model

Seo Yule Jeong,Myeongjin Choi,Chang Hoon Choi,Jihye Son,Dong Ho Woo,Yu Bin Lee,Mi-lang Kyun,Hyun-A Oh,Ye-Ji Kim,Inhye Kim,Yu Yeong Jeong,Hyewon Jung,Kyoung-Sik Moon 한국실험동물학회 2022 한국실험동물학회 학술발표대회 논문집 Vol.2022 No.7

Appropriate diagnosis of biliary cystic tumors: comparison with atypical hepatic simple cysts

Seo, Jeong Kyun,Kim, Su Hyun,Lee, Sang Hyub,Park, Joo Kyung,Woo, Sang Myung,Jeong, Ji Bong,Hwang, Jin-Hyeok,Ryu, Ji Kon,Kim, Jin-Wook,Jeong, Sook-Hyang,Kim, Yong-Tae,Yoon, Yong Bum,Lee, Kuhn Uk,Kim, S Lippincott Williams Wilkins, Inc. 2010 European journal of gastroenterology & hepatology Vol.22 No.8

BACKGROUND: Biliary cystadenoma (BCA) and biliary cystadenocarcinoma (BCAC) are often confused with other intrahepatic cystic diseases. AIMS: The aims of this study were to investigate predictive factors of biliary cystic tumor (BCT) and clinical characteristic of BCAC. METHODS: We retrospectively reviewed preoperative diagnoses, overall characteristics and postoperative outcome of 20 BCTs and 19 cystadenoma-mimicking simple cysts that were pathologically confirmed. RESULTS: Comparing with atypical simple cysts, symptoms, left-lobe cyst, thick wall, septation, mural nodule, bile duct dilatation and an increase of serum alkaline phosphatase were associated with BCTs. However, on multivariate analysis, mural nodule, left-lobe cyst, and an increase of serum alkaline phosphatase were significantly frequent in BCTs with odds ratios of 75.5, 13.8, and 33.0, respectively. Among the 20 BCTs, seven BCACs were diagnosed. The characteristics of BCACs were mural nodule (P<0.01), intrahepatic cyst debris (P<0.01), and bile duct dilation (P=0.04). Cystic fluid analysis provided no significant differences between BCT and simple cyst. After fine needle aspiration cytology of BCTs, all except one BCAC with atypical cell showed nonspecific findings. After complete surgical excision (97.4% of patients), only one patient with BCAC had recurrence during 29 months of follow-up period. CONCLUSION: In hepatic cysts with mural nodule, left-lobe cyst or increment of serum alkaline phosphatase seem to be indicative of BCTs in the diagnosis of suspicious hepatic cyst. Intracystic debris, bile duct dilation, and mural nodule may be suggestive clinical features of malignancy in BCTs.

HVAC USING BIOMIMICRY AND GEOTHERMAL ENERGY

Jeong Kyun Seo 한국신재생에너지학회 2014 AFORE Vol.2014 No.-

요거트아이스크림의 냉각에 따른 오버런 특성실험

서정균(Jeong Kyun Seo),임병주(Byung-Ju Lim),함영복(Young-Bog Ham),김형재(Hyung-Jae Kim),정광수(kwang-su Cung) 대한기계학회 2010 대한기계학회 춘추학술대회 Vol.2010 No.11

Overrun in ice cream, it is the % increase in volume of ice cream greater than the amount of mix used to produce that ice cream, because injection of air bubbles during freezing due to ice formation and the spread of defined volume. 40-50% of the case is a suitable overrun for frozen yogurt. The organization is determined by the size of ice particles, the size of bubble and its distribution and the size of the particles not frozen in the frozen yogurt. The experimental results of characteristics of the overrun were summarized by changes in environmental factors in the process of producing frozen yogurt, such as temperatures and mixing rate of producing materials and air.

건축용 목재 및 목질재료의 난연 성능 향상 연구

서현정(Seo Hyun Jeong),김남균(Kim Nam Kyun),조정민(Jo Jeong Min),이민철(Lee Min Chul) 한국방재학회 2018 한국방재학회논문집 Vol.18 No.1

본 연구에서는 국내 유용 수종 중 소나무 원목과 집성재의 연소특성 및 난연성 화학종(Fire retardant chemical composites; FRCs) 처리에 따른 난연 성능 향상에 대해 콘 칼로리미터 시험을 통해 분석을 진행하였다. FRCs 처리 원목 시험편의 경우 무처리에 최대 열방출률 및 총 방출열량이 90% 정도 감소되며, 착화가 발생하지 않았다. 집성재는 FRCs를 처리한 결과 50% 이상의 최대 열방출률 감소, 약 60% 정도의 총 방출열량 감소 효과를 나타내었다. 또한 연기방출률은 FRCs 처리 시집성재 시험편이 증가하는 경향을 보였으나, 다른 목질재료에 비해 낮은 값으로 확인되었다. 본 연구는 목재 및 목질재료용 난연제와 그 처리 방법을 개발 및 상용화하여 국산 목재의 활용도를 높이고 화재 안전성을 확보하는 데 그 목적이 있다. In this study, the improvement of fire retardant performance for wood and glue-laminated woods (GLWs) by treating fire retardant chemical composites (FRCs) were analyzed by cone calorimeter test method. In the case of FRCs treated wood, the maximum heat release rate and the total heat release amount were reduced by 90% as compared to untreated wood, and no ignition occurred. GLWs treated with FRCs exhibited a maximum heat release rate reduction of more than 50% and a total heat release reduction of about 60% compared to untreated GLWs. Also, the smoke production rate of specimens tended to increase with FRCs, but that was lower than other wood-based materials. The purpose of this study is to develop and commercialize fire retardants for wood and wood-based materials, and their treatment methods to enhance utilization of domestic wood and ensure fire safety.

비 안전등급 케이블의 연소생성물 및 인체유해성 평가 연구 필요성

서현정(Seo Hyun Jeong),김남균(Kim Nam Kyun),조정민(Jo Jeong Min),이민철(Lee Min Chul),이상규(Lee Sang Kyu),문영섭(Moon Young Seob) 한국방재학회 2018 한국방재학회논문집 Vol.18 No.2

The present study has been conducted to investigated the gas toxicity of two kinds of non class 1E cable jackets and insulations (produced by A company and B company) according to Naval Engineering Standard (NES) 713. From the NES 713 standard, CO2, CO, NOX, HCHO, HCl, HBr, and HCN were detected for both types of cable jacket and insulation materials, and the toxicity index was calculated according to the standard code of US Department of Defense (MIL-DTL). The toxicity factors were obtained as 5.08 for the cable jacket of A company, 4.78 for cable insulation of A company, 4.85 for the cable jacket of B company, and 4.01 for the cable insulation of B company. These results can be used as basic data to increase the necessity of establishment of the regulation standards to evaluate the human hazardousness of non class 1E cables. 본 연구에서는 비안전등급 케이블의 피복재 및 절연재의 연소가스 유해성을 영국 해군 규격인 Naval Engineering Standard(NES) 713 규격에 의거하여 분석하였다. 또한 독성지수의 구체적인 분석을 위해 미국국방성 규격(MIL-DTL)을 적용하여 세분화하여 유해성을 평가하였다. 케이블은 A사와 B사 등 국산 케이블 2종을 적용하였고, 각 케이블의 피복재 및 절연재에서는 이산화탄소, 일산화탄소, 질산화물, 염화수소, 브롬화수소가 공통적으로 방출되었다. 독성 지수는 A사 케이블 피복재 5.08, 절연재가 4.78, B사 케이블 피복재가 4.85, 절연재가 4.01로 산출되었다. 해당 데이터는 비 안전등급 케이블의 인체유해성을 평가하는 규격의 필요성을 재고하기 위한 기초 데이터로 활용될 예정이다.