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Association of Chronic Hepatitis C Virus Infection and Diabetes Mellitus in Korean Patients
(Ji Kon Ryu),(Sang Bae Lee),(Sa Joon Hong),(Seo Kin Lee) 대한내과학회 2001 The Korean Journal of Internal Medicine Vol.16 No.1
N/A Background : It has been suggested that chronic hepatitis C virus (HCV) infection is associated with diabetes. The aim of this study was to establish a potential relationship between chronic HCV infection and diabetes mellitus in Korean patients. Methods : We performed a prospective analysis of 404 patients with chronic viral hepatitis or liver cirrhosis who visited our hospital and analyzed whether age, sex, body mass index, alcohol consumption, hepatitis B virus (HBV) infection, HCV infection and cirrhosis were associated with diabetes. We also enrolled 627 diabetic patients and the seroprevalence of HBV surface antigen (HBsAg) and anti-HCV was determined. Results : Diabetes was observed more frequently in individuals with HCV infected chronic liver disease (24.0%) than in those with HBV infected (10.4%) (p<0.05). Univariate analyses revealed that age, alcohol consumption and HCV infection were significant independent predictors for diabetes. The mean age of the patients with HCV infected chronic liver disease was higher than that of HBV infected (56±16 vs 44±13, p<0.05). The prevalence of diabetes in HCV infected group was higher than that in HBV infected group in the age of 41~60 (p<0.05). In diabetic group, the seroprevalence of HBsAg positivity was 4.5% and that of anti-HCV was 2.1%. Conclusion : Our study demonstrates an association between diabetes and chronic HCV infection in Korean patients. The prevalence of diabetes in patients with HCV infected chronic liver disease is higher than that in those with HBV infected. Age and alcohol consumption are another risk factor for diabetes in patients with chronic viral liver disease.
Review of 67 Patients With Autoimmune Pancreatitis in Korea: A Multicenter Nationwide Study
Ryu, Ji Kon,Chung, Jae Bock,Park, Seung Woo,Lee, Jong Kyun,Lee, Kyu Tack,Lee, Woo Jin,Moon, Jong Ho,Cho, Kwang Bum,Kang, Dae Whan,Hwang, Jin-Hyeok,Yoo, Kyo-Sang,Yoo, Byung Moo,Lee, Don Hang,Kim, Hae K Lippincott Williams Wilkins, Inc. 2008 Pancreas Vol.37 No.4
OBJECTIVES:: The ideal diagnostic criteria of autoimmune pancreatitis (AIP) are still challenging. Therefore, we investigated the clinical features of AIP in Korea and assessed the clinical use of new Korean diagnostic criteria. METHODS:: We reviewed 67 patients with AIP enrolled in 16 hospitals via a multicenter study. The diagnosis was confirmed according to the Korean diagnostic criteria that included pancreatic imaging, laboratory findings, histopathology, and response to steroid. RESULTS:: Mean age of the patients was 56 years, and 73% were men. Obstructive jaundice (52%) was the most common symptom, and 14 patients (21%) had other organ involvement. Fifty-four patients (81%) revealed diffuse swelling of the pancreas. Either immunoglobulin (Ig)G or IgG4 was elevated in 76%. According to the Korean criteria, 65 patients had definite diagnostic criteria, and 2 patients had probable criteria. Fifteen patients were fulfilled with image, serological, and histopathologic criteria, and 4 patients could be diagnosed with image and steroid responsiveness. Ten patients experienced recurrent attacks of AIP during the mean 20-month follow-up. CONCLUSIONS:: Among 67 cases of AIP, either IgG or IgG4 was elevated in 76% of patients, and 14 patients (21%) had other organ involvement. New Korean diagnostic criteria are useful for diagnosis of AIP.
K-ras 변이가 있는 췌장암세포주에서 Mitogen Activated Protein Kinase와 PI 3-kinase가 세포증식에 미치는 역할
류지곤(Ji Kon Ryu),김진(Jin Kim),장유현(Yoo Hyun Chang),이우진(Woo Jin Lee),김용태(Yong Tae Kim),윤용범(Yong Bum Yoon),김정룡(Chung Yong Kim) 대한소화기학회 2000 대한소화기학회지 Vol.36 No.3
Background/Aims: K-ras mutation is considered to be important for the development and proliferation of pancreatic cancer. After activation of Ras protein, several cytoplasmic protein kinases, such as the mitogen activated protein kinase (MAPK) signaling cascade and PI 3-kinase, are sequentially stimulated. The aim of this study was to examine the role of MAPK and PI 3-kinase on cellular proliferation of pancreatic cancer cell lines with K-ras mutation. Methods: MiaPaCa-2 and Panc-1 cell lines were cultured and stimulated with growth factors such as fetal bovine serum (FBS) and epidermal growth factor (EGF). The cell proliferation was measured by 3H thymidine incorporation assay. MAPK/extracellular signal regulated kinase (ERK) activating kinase (MEK) inhibitor (PD098059) or PI 3- kinase inhibitor (wortmannin) was added in media and their effects on proliferation were examined. The activity of ERK was measured by immunoblotting assay. Results: FBS stimulated cell proliferation dose-dependently in both cell lines but EGF did not. PD098059 blocked dose-dependently the cell proliferation but wortmannin did not. The activities of ERK were increased by both FBS and EGF and blocked only by PD098059. Conclusions: MAPK kinase signal transduction pathway from MEK to ERK plays an important role in the stimulation of proliferation in pancreatic cancer cell lines with K-ras mutation. (Kor J Gastroenterol 2000;36:372 - 382)
류지곤 ( Ji Kon Ryu ) 대한내과학회 2010 대한내과학회지 Vol.79 No.6
A hilar cholangiocarcinoma is a cholangiocarcinoma occurring at the confluence of the right and left hepatic bile ducts which is called as Klatskin tumor. Because hilar cholangiocarcinoma is the most common form of extrahepatic bile duct cancer (EBDC), the epidemiology and risk factors of hilar cholangiocarcinoma are similar to those of EBDC. In Korea, overall incidence of EBDC is 5.1/100,000 individuals without a significant change during past 10 years. Most of cases occur in patients over the age of 50 and the incidence is 1.78 times higher in men than women. The etiology of EBDC has not been clearly defined. A number of pathologic conditions, however, resulting in either acute or chronic biliary tract epithelial injury may predispose to malignant change. Chronic biliary tract parasitic infection, such as Clonorchis sinensis and Opisthorchis viverrini, has been identified as a risk factor of EBDC and hilar cholangiocarcinoma. Other clear risk factors of EBDC are primary sclerosing cholangitis and choledochal cyst. However, there are no enough evidences whether primary sclerosing cholangitis and choledochal cyst are the definite risk factors of hilar cholangiocarcinoma or not. (Korean J Med 79:593-596, 2010)
류지곤 ( Ji Kon Ryu ) 대한내과학회 2013 대한내과학회지 Vol.85 No.1
Pancreatic cancer remains one of the most deadly diseases, despite significant advances in medicine over the past decade. Patients with chronic pancreatitis are known to have an increased risk of pancreatic cancer compared with the general population. There are few studies about the clinical features of pancreatic cancer associated with chronic pancreatitis. A recent retrospective study by Choi et al. showed that pancreatic cancer with chronic pancreatitis patients were younger at the time of the diagnosis and computed tomography findings showed only pancreatic duct dilatation without a mass in some cases. However, there were no differences between the two groups regarding resectability and the preoperative stage. Recent data indicate that imaging tests can detect asymptomatic precursor benign lesions in individuals with an inherited predisposition or strong family history. However, there are no consensus data about screening program in patient with chronic pancreatitis. (Korean J Med 2013;85:38-40)