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      • 하수처리장에서의 악취 배출특성 및 영향 평가

        전의찬,사재환,김천두,김조천 동신대학교 환경연구소 2002 환경연구 Vol.7 No.1

        본 연구에서는 하수처리장에서 발생되는 악취물질 중의 하나인 암모니아를 대상으로 플럭스와 발생량을 산정하였으며, 대기확산모델을 이용한 하수처리장의 악취 영향 평가를 예측하였다. 열린챔버를 이용한 새료채취에 있어서, 채취시간은 설치 후 60분에 실시하는 것이 가장 적절한 것으로 조사되었다. 하수처리장에서 발생되는 암모니아의 단위시간당 단위면적당 플럭스는 각각 531.7㎍/㎡ㆍsec, 4,925.7 ㎍/㎡ㆍsec로 평가되었으며, 단위시간당 발생량은 각각 평균 17.7 ㎍/sec, 6.3 ㎍/sec으로서 침사지에서 다소 높은 발생속도로 배출되고 있는 것으로 평가되었다. 또한, 배출계수는 평균 114.0 mg/activity-ton, 1,055.6 mg/activity-ton으로 평가되었다. 암모니아에 의한 주변의 영향 평가는 1시간 최대 영향 예측의 결과 부지경계선상에서 악취도 '1.0' 수준으로, 인근마을에는 악취도 '0'에 가까운 수준으로 예측되어 인근 주변에 미치는 영향은 거의 없는 것으로 평가되었다. This study is to estimate the flux and the emission of ammonia, one of regulative odor emitted from the sewage treatment plant, and it is to assess impact of odor on the area near the plant using the atmospheric dispersion model. The flux of ammonia in a grit chamber and SBR reactor of the sewage treatment plant was measured as 17.7㎍/㎡ㆍsec and 6.3㎍/㎡ ㆍsec, respectively. The emission velocity of ammonia from a grit chamber and SBR reactor was investigated as 531.7㎍/sec and 187.9㎍/sec. The emission coefficient was also estimated as average 114.0mg/activity-ton for a grit chamber and 1,056.6 mg/activity-ton for SBR reactor. For the assessment of impact of ammonia on the vicinity of the plant, the odor strength was estimated to '1' or below on the boundary of the plant based on the one-hour maximum odor impact according to the result of simulation of odor dispersion model. As a result of modeling, it was reveled that the impact of odor from the sewage treatment plant was negligible.

      • SCIESCOPUSKCI등재
      • SCIESCOPUSKCI등재
      • KCI등재후보

        국내 대학병원에서 정주용 Ciprofloxacin 사용의 적정성 평가

        김신우,박효정,오원섭,김연숙,장현하,정숙인,정두련,이혁,염준섭,기현균,손준성,백경란,우건조,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

        목적 : 국내 병원에서의 정주 ciprofloxacin 사용의 적정성을 평가하고자 하였다. 재료 및 방법 : 2003년 9월 25일부터 8개의 대학병원에서 정주 ciprofloxacin을 받았던 290명의 연속적으로 모집한 성인환자를 대상으로 약제사용 평가(DUE)를 전향적으로 수행하였다. 이 연구에 사용된 DUE 기준은 미국병원약사회의 기준을 국내 실정에 맡게 수정하여 사용하였으며 1) 사용의 정당성에 관한 항목, 2) 사용 시 준수되거나 시행되어야 할 사항에 대한 항목, 3) 부작용에 대한 항목, 4) 치료 효과에 대한 항목으로 나누어 조사하였다. 결과 : 환자의 평균 나이는 54세였다. 33예(26.9%)에서만 약제 사용의 적정성 측면에서 기준을 만족하였고 91예(73.1%)에서는 사용이 적절하지 않았다. 정주 cipro-floxacin의 부적절한 사용의 흔한 원인은 수술 전후의 예방약 사용, 비뇨기계 처치 전의 예방적 사용, 열성 질환에 대한 경험적 사용 등의 순이었다. 사용 시 준수사항 의 측면에서는 사용 전 배양검사(73.8%)와 사용 중 배양검사(68.6%)가 낮은 수행 정도를 보였으나 그 외는 비교적 높은 적정성(82.4-100%)을 보여주었다. 정주 ciprofloxacin사용의 합병증은 드물었다. 치료 효과의 면에서 치료반응은 93.3%였다. 결론 : 약제 사용의 정당성 기준에 따른 정주 cipro-floxacin의 부적절한 사용은 연구에 포함된 대학병원에서 매우 흔하였다(73.1%). 그러므로 적절한 항생제 사용에 대한 교육과 제도적 장치가 매우 필요한 것으로 판단되었다. Background : To evaluate the appropriateness of intravenous (IV) ciprofloxacin usage in university hospitals in Korea. Materials and Methods : We prospectively evaluated the appropriateness of drug usage in 290 consecutive adult patients who received IV ciprofloxacin in eight teaching hospitals during the period from September 25, 2003 to November 15, 2003. Drug use evaluation (DUE) in this study was based on the modified standard by the American Society of Hospital Pharmacy with regard to the justification of drug use, critical and process indications, complications, and outcome measures. Results : Average age of the patients was 54 years. The use of IV ciprofloxacin was appropriate only in 33 cases (26.9%). Common reasons for inappropriate use of IV ciprofloxacin include perioperative uses or prophylactic injection before urologic procedures, and empirical therapy for febrile episodes. Most of the "critical indications" and "process indications" showed high rate of appropriateness (82.4-100%). However, the rate of taking culture and sensitivity test before (73.8%) and during ciprofloxacin use (68.6%) were low. Complications with ciprofloxacin use were rare. In 93.3% of cases, ciprofloxacin treatment was clinically effective. Conclusion : Use of intravenous ciprofloxacin is frequently inappropriate in tertiary care hospitals in Korea. Implementation of education program and antibiotic control system is critical in improving the appropriateness of antimicrobial use.

      • KCI등재후보

        관동맥연축에서 서방형 칼슘길항제인 Diltiazem 과 Verapamil 의 치료효과 : Ergonovine Echocardiography 를 이용한 무작위 비교 연구

        송재관(Jae Kwan Song),박성욱(Seong Wook Park),제수정(Soo Jung Je),김재중(Jae Joong Kim),두영철(Young Cheoul Doo),김원호(Won Ho Kim),진재용(Jae Yong Chin),김형호(Hyeong Ho Kim),정상식(Sang Sig Cheong),박승정(Seung Jung Park),이종구(Jo 대한내과학회 1994 대한내과학회지 Vol.46 No.3

        N/A Background: Detection of left ventricular regional wall motion abnormality with two dimensional echocardiography during ergonovine injection (Ergonovine Echocardiography: Erg Echo) is a useful noninvasive diagnostic method of coronary vasospasm, and as it can be used repeatedly, comparison of the therapeutic efficacy of the prescribed drugs for the patients with variant angina may be possible with this method. The purpose of this study were to compare the antispasmotic action of short-term medication of two currently available sustained-releasing (SR) calcium antagonists (Diltiazem vs Verapamil) with Erg Echo, to investigate the factors determining the drug efficacy and to determine if the results of repeated tests of Erg Echo after shortterm medication correlate with the clinical response. Methods: Forty patients with angiographicallyproven coronary vasospam and positive Erg Echo without medication were randomly assigned into group I and II. Diltiazem SR 90mg b.i,d. was prescribed in the patients of group l and Verapamil SR 120 mg b.i.d. in group II. Isosorbide-5-mononitrate (ISMN, Elantan 20 mg b.i.d.) was commonly given in both groups. After medication of 4 days Erg Echo was repeated, and if follow up results were positive doubling of the dosage of prescribed calcium channel antagonists (i.e. Diltiazem SR 180 mg or Verapamil SR 240 mg b.i.d.) was done and the second follow up test of Erg Echo was performed after another 4 days. Clinical follow-up was done with the dosage of negative Erg Echo, and during 9 (±3) month follow-up period one patient of group I and two of group II were lost and final analysis was done with total 37 patients (19 in group I and 18 in group II). Results: Among 37 patients with variant angina, 32 were male and the mean age was 53 (±8). Sex ratio, mean age, body weight, clinical activity of variant angina assessed by the frquency of chest pain attack, number of spasm-documented coronary vessels, dosage of ergonovine for positive response in baseline Erg Echo and number of the patients with concomitant fixed coronary stenosis were not significantly different between both groups. After 4 day medication coronary vasospasm was not provoked with ergonovine injection in 13 patients of group I, and the positive rate of Erg Echo after medication was 32% (6/19) in group I, which was not significantly different from that (50%, 9/18) of group II (p=0.66). In 15 patients coronary vasospasm was provoked with ergonovine injection despite the medication, and ergonovine dose for positive response rose from 146±84 microgram (mcg) to 218±75 mcg with medication. Patients with 'mixed disease' (coronary vasospasm and concomitant fixed disease) showed higher positive result of Erg Echo after medication than the patients with pure spasm (p=0.001). During open label follow-up of 9±3 months, there was neither case of acute myocardial infarction nor that of sudden cardiac death. Recurrent chest pain with medication was observed in 6 patients of group I and 7 of group II (p=0.90), and recurrent chest pain during follow-up was more frequently observed in patients with positive Erg Echo after 4 day medication than those with negative test (p=0.01). In group II medication was modified to control the high activity of variant angina (chest pain attacks more than 5 per week) in 3 patients and verapamil SR was withdrawned in 4 patients due to side effects (2 cases of impotence, each case of constipation and peripheral edema), while there was no case of drug modification or withdrawl of diltiazem SR (p<0.05) in group I. Conclusion: Although there was no significant difference of short term medication on prevention of coronary vasospasm provoked by ergonovine injection, during long term follow-up of variant angina, diltizem SR with ISMN was superior to verapamil SR with ISMN in control of chest pain and absence of side effects. Erg Echo after short term medication was useful in comparison of drug efficacy, investication of the fact

      • A study on the removal of sulfate and nitrate from the wet scrubber wastewater using electrocoagulation

        Jo, Eun-young,Park, Seung-Min,Yeo, In-seol,Cha, Jae-doo,Lee, Ju Yeol,Kim, Young-Hee,Lee, Tae-Kwon,Park, Chan-gyu Informa UK (Taylor Francis) 2016 Desalination and Water Treatment Vol.57 No.17

        <P>Wet scrubber is widely used to remove pollutants from a furnace flue gas or from other gas streams. However, high cost for the treatment or exchange of contaminated washed water is one of the problems. Electrocoagulation (EC) is an electrochemical method for treating polluted water, whereby sacrificial anodes dissolve to produce active coagulant precursors in the solution. This technology can be used for the removal of color, anionic contaminants, and colloidal particles. The goal of the present study was evaluation of EC process for treatment of wet scrubber wastewater and optimization of the process. In this study, the influence of electrode material and electrode distance on removal efficiency (%) of nitrate, sulfate, and total suspended solids (TSS) was investigated with synthetic wastewater. Using an Al electrode, 60.6% of nitrate, 50.0% of sulfate, and 96.8% of TSS were removed by EC treatment within 30 min. In case of Fe electrode, 69.7% of nitrate, 75.0% of sulfate, and 98.8% of TSS were removed. The treatment efficiency for real wet scrubber wastewater was evaluated with Fe electrode. After 180 min of EC treatment, 50% of color, 40% of nitrate, 40% of sulfate, and 95% of TSS were removed, respectively. All these results give clear evidence that EC process can effectively reduce the TSS, nitrate, and sulfate ions from wet scrubber wastewater.</P>

      • Tidy-Up Tasks Using Trajectory-based Imitation Learning

        Doo-Jun Kim,HyunJun Jo,Jae-Bok Song 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10

        When performing reinforcement learning using a robot arm in the real environment, it is important to perform reinforcement learning safely and quickly. This is because unexpected behaviors during reinforcement learning and long-term learning can damage the robot arm or surrounding objects. In this study, trajectory-based imitation learning that suppresses unexpected situations and quickly learns the policies suitable for the robots is proposed by limiting the workspace to be explored through one human demonstration. Trajectory-based imitation learning consists of two stages. First, a reference trajectory is generated considering the position of a target object and the expert trajectory from the human demonstration. Second, the target task is trained by performing reinforcement learning based on the generated reference trajectory. Experiments were conducted in simulation and real environments to verify the proposed imitation learning algorithm. In the simulation, a laptop folding task was performed with a success rate of 97% to verify the performance of the algorithm. In addition, it was shown that safe and fast learning is possible with only one demonstration video on the drawer arrangement in a real environment.

      • SCIESCOPUSKCI등재

        High-yield Production of Functional Human Lactoferrin in Transgenic Cell Cultures of Siberian Ginseng(Acanthopanax senticosus)

        Jo, Seung-Hyun,Kwon, Suk-Yoon,Park, Doo-Sang,Yang, Kyoung-Sil,Kim, Jae-Whune,Lee, Ki-Teak,Kwak, Sang-Soo,Lee, Haeng-Soon The Korean Society for Biotechnology and Bioengine 2006 Biotechnology and Bioprocess Engineering Vol.11 No.5

        Human lactoferrin (hLf) is an iron-binding glycoprotein that has been considered to play many biological roles in the human, including the stimulation of the immune system, antimicrobial and anti-inflammatory effects, and regulation of iron absorption. We generated transgenic Siberian ginseng (Acanthopanax senticosus) cell cultures producing a functional hLf protein using the signal peptide sequence from the endoplasmic reticulum and driven by an oxidative stress-inducible SWPA2 promoter which is highly expressed in plant cell cultures. The production of hLf increased proportionally to cell growth and showed a maximal level (up to 3.6% of total soluble protein) at the stationary phase in suspension cultures. Full-length hLf protein was identified by immunoblot analysis in transgenic cell cultures of Siberian ginseng. Recombinant hLf (rhLf) was purified from suspension cells of Siberian ginseng by ammonium sulfate precipitation, cation-exchange and gel filtration chromatography. N-terminal sequences of rhLf were identical to native hLf (nhLf). The overall monosaccharide composition of rhLf showed the presence of plant specific xylose while sialic acid is absent. Antibacterial activity of purified rhLf was higher than that of nhLf. Taken together, we anticipate that medicinal Siberian ginseng cultured cells, as demonstrated by this study, will be a biotechnologically useful source for commercial production of functional hLf not requiring further purification.

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