Genetic Variations of the Apolipoprotein B Gene in Korean People and Its Association with Hypercholesterolemia

Sung Han Kim,Un Kyung Kim,Jae Jin Chae,Jeong In Baek,Soo Young Choi,Jae Woong Bae,Sang Hyun Kim,Hyo Soo Kim 한국유전학회 2008 Genes & Genomics Vol.30 No.5

Genetic polymorphisms at the apolipoprotein B have been associated with elevated plasma concentrations of LDL, atherosclerosis and increased risk of coronary artery disease. 106 individuals composed of 46 hypercholesterolemic patients and 60 controls were analyzed with Ins/Del length polymorphism, four RFLPs (HincII, PvuII, AluI, EcoRI) and 3`-VNTR to clarify the characteristics of the apolipoprotein B gene and to determine their influence on the lipid profile of hypercholesterolemic patients and controls in Korea. A total of 212 apolipoprotein B alleles from six markers were identified in this study. Heterozygosityranges from zero to 0.32, and the genotyope frequencies in the case of 3`-VNTR are significantly different between two groups. Analysis of linkage disequilibrium revealed paired nonrandom associations between four pairs of polymorphic sites of the apolipoprotein B gene (p<0.05). Moreover, addition of all 4 polymorphic sites provided the highest PIC value. This study also investigated the association of these polymorphisms with the patients and with variation in lipid levels. A significant association between 3`-VNTR genotypes and Lp(a) was observed in hypercholesterolemic patients (p<0.05). The results suggest that genotypes of six polymorphic markers were not significantly associated with TC, TG or LDL-chol level between the patients and controls in the Koreans.

농촌지역 보건시설의 기능설정에 관한 연구

韓仁雄,蔡熙在 三陟大學校 2000 論文集 Vol.33 No.2

우리나라와 외국의 비교한 결과는 수도권 5개 신도시의 개발 밀도가 일본의 센리 뉴타운 및 지바 뉴 타원의 2배에서 크게는 4배정도 높게 나타났으며, 미국과 영국의 경우보다는 크게는 9배 이상의 차이를 보이고 있다. 이를 요약하면 첫째로 짧은 기간에 많은 수의 주택을 확보하기 위해 토지이용의 제약성을 보이고 있다. 둘째로 우리나라의 신도시 건설을 위한 법의 적용은 영국이나 프랑스, 일본처럼 신도시 개발법을 제정하여 신도시 건설을 추진하는 것이 아니라 기존의 법률이나 한시적인 특별법을 적용함으로서 각 부처에서 소관하고 있는 법률들의 적용을 받기 때문에 신도시 건설을 추진함으로써 복잡하고 일관성이 부족한 단점을 가지고 있어, 신도시 건설을 위한 법의 제정이 요구된다. 셋째로 영국의 경우 각 신도시 별로 개발공사와 같은 특별기구를 설치하여 신도시를 건설하는데 비해 우리 나라의 경우는 신도시를 개발하는 개발주체는 기존의 공공기관에 의하여 주도되어 신도시 개발사업의 획일성을 보이고 있다. This study is to provide the basic data for the function of public healthcare facility in rural areas. Health center offers the public health care and offers the medical service of the poor in the district. Recently the change of social environment has the living of human for the complexity and the variety. And so the relation of architecture and function required the mixed-use space. The government tried to complex the service for healthcare and social welfare by the exhibition model for district health and welfare center. So this provides the basic data of planning for public health center in rural areas. In sum, the useful data were collected, analyzed, and synthesized through this study and could be used in the relevant research in the future as reference informations.

대학 건축공학과의 실습학기제에 관한 연구

이승준,한인웅,정구용,조방현,한기원,박재호,김진원 三陟大學校 2000 論文集 Vol.33 No.2

In order to solidify the architectural education in university, we should enlarge the opportunity of field training and develop the field training course system as a part of industry-scholastic cooperation. And we should develop new educational process to bring up potent engineers adaptable to the training affairs, faithful to the educational object of the industrial university.

S-208 In-Stent Restenosis-prone Lesion Characteristics

( Duck-jun Seo ),( Yong-kyun Kim ),( Ki-hong Kim ),( Taek-geun Kwon ),( In-geol Song ),( Dong-ju Yang ),( Wan-ho Kim ),( Yo-han Park ),( Hwan-hyi Cho ),( Young-hoon Seo ),( Hyun-woong Park ),( Jang-ho 대한내과학회 2016 대한내과학회 추계학술발표논문집 Vol.2016 No.1

Objective: Instent restenosis (ISR) remains still an important issue even in drug-eluting stents era. We hypothesized that higher inflammatory reaction, which is known as an important atherosclerotic process, at the culprit lesion may have higher restenosis. We sought to evaluate the baseline coronary plaque composition in patients with ISR. Methods: Study population consisted of 241 patients with coronary artery disease, who underwent percutaneous coronary intervention with virtual histology- intravascular ultrasound (VH-IVUS) and 9 months follow up coronary angiography. We compared coronary plaque composition between patients with ISR and those without ISR. Results: Patients with ISR (n=27, 11.2%) were likely to be older (66.2±9.5 years vs. 58.7±11.7 years, p=0.002), increased high sensitivity C-reactive protein (hs-CRP, 1.60±3.59 mg/dl vs. 0.31±0.76 mg/dl, p<0.001) than those without ISR (n=214, 88.8%). Baseline angiographic, procedural findings and gray scale IVUS findings showed no significant differences between 2 groups. VH-IVUS examination showed necrotic core volume (22.1±19.9 mm3 vs.14.2±12.7 mm3, p=0.045) and percent necrotic core volume (14.3±8.7% vs. 19.5±9.1%, p=0.005) were higher in those without ISR than those with ISR, whereas percent fibrofatty volume was higher (16.6±9.7% vs. 12.4±8.4%, p=0.018) in those with ISR than those without ISR. The independent predictors for ISR were hs-CRP (Odd ratio=3.334, 95% confidence interval (CI); 1.158~9.596, p=0.026), and age (Odd ratio=3.557, 95% CI; 1.242~10.192, p=0.018). Conclusions: This study suggests that ISR was not associated with baseline coronary plaque composition but old age and an increased inflammatory marker such as hs-CRP. Keywords: Intravascular Ultrasound, Instent Restenosis, Inflammation and restenosis after percutaneous coronary intervention

액상정액을 이용한 인공수정시 품종, 계절, 인공수정 횟수 및 정자농도가 번식성적에 미치는 영향

김인철,박창식,이규승,서길웅,한성욱 충남대학교 농업과학연구소 2001 농업과학연구 Vol.28 No.2

돼지에서 액상정액을 이용한 인공수정이 번식성적에 미치는 영향을 구명하기 위하여 축산기술연구소 종축개량부 (충남, 성환) 돼지 인공수정센터에서 사육중인 인공수정용 종모돈을 이용하여 1995년부터 2000년까지 액상정액을 이용한 인공수정시 종모돈의 품종, 인공수정횟수, 계절 및 정자농도가 번식성적에 미치는 영향을 조사하여 돼지 인공수정시 번식성적 향상과 실용화에 기여하고자 본 연구를 실시하였다. 액상정액 인공수정시 정액을 생산한 종모돈의 품종 (Landrace, Yorkshire, Duroc)간 번식성적은 유의차가 인정되지 않았다. 발정당 2회 또는 3회 인공수정 시에도 번식성적에 차이가 없었다. 인공수정을 실시한 계절별로 번식성적을 조사하였으나 계절간 차이점은 발견할 수 없었다. 액상정액 인공수정시 1회 주입정자의 최저농도를 구명코자 활력 70% 이상인 정자수를 기준으로 80 ml 병당 정자농도를 3.0, 2.5, 2.0 및 1.5×10^(9)로 조절하여 인공수정한 결과 수태율, 분만율, 총산자수 및 생존산자수에서 통계적인 유의차가 인정되지 않아 1회 주입정자농도는 운동성 정자 기준으로 1.5×10^(9)/80 ml 이상으로 조절하면 인공수정에 실용적으로 사용 할 수 있음을 보였다. This study was carried out to investigate the effects of liquid boar semen on reproductive performance in swine artificial insemination Many factors, which were breeds, time of insemination, breeding season, sperm per dose etc. have been tried to improve reproductive efficiency. Boars were raised at Swine Artificial Insemination Center in National Livestock Research Institute. Sunghwan, Chungnam, Korea. This experiment was carried out from 1995 to 2000. There were no differences in the fertility results compared with 3 breeds (Landrace, Yorkshire and Duroc), frequencies of artificial insemination (double and triple) per estrus cycle and different seasons by using liquid boar semen. There were no significant differences in conception rate, farrowing rate and litter size using 4 trials of 3.0, 2.5, 20 and 1.5×10^(9)/80㎖ in liquid boar semen with 70% of motile sperm cells. We confirmed that the sperm number per dose of 1.5×10^(9)/80㎖ could be used for commercial artificial insemination.

산업대학 건축공학과 교육과정 개발에 관한 연구

임응찬,한인웅,이승준,박재호,조방현,서형수,정구용,한기원,김진원,임상규,이재윤 三陟大學校 1996 論文集 Vol.29 No.2

By impproving the educational program of the Department of Architectural Engineering and studying the theory of learning and the applied method necessary for the development of nation and society, we should develop a satisfying course of education to meet the demand and skill in the industralized society for the purpose of cultivating men of baility with great personalities and creative minds. Therefore, this study focused on classifying several kinds of occupations in the prart of architectured related to what graduates from the department of Architectural Engineering go with into the society. Accordingly after choosing some works adequate to each occupation by the proposed curricula, we tried to establish the scope of education and courses corresponding to the jobs and thus and develop a satisfying curriculum.

산업대학 건축공학과 교육과정 개발에 관한 연구

김진원,한인웅,이승준,박재호,조방현,정구용,한기원 三陟大學校 1999 論文集 Vol.32 No.2

Education of technology should renew itself according to the demand of the change of times. Especially college of industrial technology is encouraged to develop diverse educational methods and continual educational process for the purpose of offering life-time educational opportunities, bringing up professional technicians, and re-educating the work-forces in the industry sector. Therefore, to make the education of architectural engineering substantial, the department of architectural engineering is working to develop a practical educational process by taking the following several things into consideration: job analysis of industrial society, development of educational process in the line of special necessities of college of industrial technology, actualization of subject course, industrial-academic cooperation secure of training equipment, readjustment of educational period.

National survey of Korean hepatobiliary-pancreatic surgeons on attitudes about the enhanced recovery after surgery protocol

Sang Hyun Shin,Woo-hyoung Kang,In Woong Han,Yunghun You,Huisong Lee,Hongbeom Kim,Woohyun Jung,Yong Chan Shin,Jin Seok Heo 한국간담췌외과학회 2020 Annals of hepato-biliary-pancreatic surgery Vol.24 No.4

Backgrounds/Aims: The purpose of this study was to investigate attitudes regarding the Enhanced Recovery After Surgery (ERAS) protocol of hepato-biliary-pancreatic (HBP) surgeons in Korea and the extent to which they use the protocol for perioperative management. Methods: An online survey was conducted among members of the Korean Association of Hepato-Biliary-Pancreatic Surgery (KAHBPS) for eight weeks beginning on August 2019. The questionnaire, which was written in Korean, was based on the latest ERAS guidelines. Total responses were collected from 127 surgeons. Results: Of the 127 total respondents, the largest proportion (44.9%) were working in Seoul. In terms of established in-hospital clinical pathways (CP), 19.7% of the participating surgeons had and followed a CP in pancreaticoduodenectomy (PD) and 21.3% in hepatectomy. Regarding the ERAS protocol for each surgery, four items (18.2%) regarding PD and seven items (35.0%) related to hepatectomy were followed by more than 50% of respondents. Conclusions: ERAS guidelines are one of the consensuses for better recovery in perioperative management of patients undergoing major surgeries and encompass the overall process of patient recovery including patient education, pain control, physiologic balance, and perioperative nutrition. A novel project is needed to successfully implement an evidence-based enhanced recovery strategy.

Liver‐Specific and Echogenic Hyaluronic Acid Nanoparticles Facilitating Liver Cancer Discrimination

Min, Hyun Su,Son, Sejin,Lee, Tae Woong,Koo, Heebeom,Yoon, Hong Yeol,Na, Jin Hee,Choi, Yongseok,Park, Jae Hyung,Lee, Jaeyoung,Han, Moon Hee,Park, Rang‐,Woon,Kim, In‐,San,Jeong, Seo Young,Rh WILEY‐VCH Verlag 2013 Advanced Functional Materials Vol.23 No.44

<P><B>Abstract</B></P><P>With the increasing demand for instant real‐time ultrasound (US) imaging of a specific organ, target‐specific and long‐circulating ultrasound contrast agents are of special interest. A new species of echogenic hyaluronic acid nanoparticles is presented as an ultralong‐acting, liver‐specific, US contrast agent that is distinct from conventional gas‐filled microbubbles. Using an oil‐in‐water (O/W) emulsification method, bioinert and hydrophobic perfluoropentane (PFP) is encapsulated as an ultrasound gas precursor into hyaluronic acid nanoparticles (HANPs) using hydrophobic interactions. HANPs are formulated by self‐assembly, with amphiphilic hyaluronic acid‐5β‐cholanic acid (HA‐CA) conjugating in aqueous conditions. The resulting echogenic PFP‐encapsulated HANPs (Echo‐NPs) show solid nanostructures, differentiated from core‐empty conventional microbubbles, and exhibiting outstanding physical properties as an ultrasound contrast agent. They are more stable and robust echogenic solid bodies with an in vivo favorable hydrodynamic size and because PFPs vaporize gradually, their expansion process is very slow in body conditions. After several systemic circulations, echo‐NPs generated intense and ultralong echo signals for US imaging at the target site. The echogenic properties of Echo‐NPs show a significantly increased half‐life and echo persistence, compared with conventional microbubbles. The results clearly show that echo‐NPs outperform conventional microbubbles in terms of both physical and echogenic in vitro and in vivo properties.</P>

하시모토 병과 동반된 악성 빈혈 1 예

한 호,안명주,최정혜,이창범,이영열,최일영,김인순,이웅수 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Pernicious anemia is the most common cause of vitamin B12 deficiency and is caused by autoimmune destruction of parietal cell containing gastric mucosa region. This disease is significantly associated with autoimmune endocrinopathies and anti-receptor autoimmune disease. We report here a case of 26-year old man who was diagnosed pernicious anemia with high level of autoantibody titer (antithyroglobulin antibody 1:25,600 and antimicromosomal antibody 1:6,400) indicating subclinical Hashimoto's thyroiditis. Since other autoimmune diseases are frequently associated with pernicious anemia even without evidence of clinical symptoms, screening test for the presence of autoimmune disease should be evaluated in these patients.