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Urological Problems in Patients with Menkes Disease
Kim, Mi Young,Kim, Ji Hyun,Cho, Myung Hyun,Choi, Young Hun,Kim, Seong Heon,Im, Young Jae,Park, Kwanjin,Kang, Hee Gyung,Chae, Jong-Hee,Cheong, Hae Il The Korean Academy of Medical Sciences 2019 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.34 No.1
<P><B>Background</B></P><P>Menkes disease (MD) is a rare X-linked hereditary multisystemic disorder that is caused by dysfunction of copper metabolism. Patients with MD typically present with progressive neurodegeneration, some connective tissue abnormalities, and characteristic “kinky” hair. In addition, various types of urological complications are frequent in MD because of underlying connective tissue abnormalities. In this study, we studied the clinical features and outcomes of MD, focusing on urological complications.</P><P><B>Methods</B></P><P>A total of 14 unrelated Korean pediatric patients (13 boys and 1 girl) with MD were recruited, and their phenotypes and genotypes were analyzed by retrospective review of their medical records.</P><P><B>Results</B></P><P>All the patients had early-onset neurological deficit, including developmental delay, seizures, and hypotonia. The girl patient showed normal serum copper and ceruloplasmin levels as well as milder symptoms. Mutational analysis of the <I>ATP7A</I> gene revealed 11 different mutations in 12 patients. Bladder diverticula was the most frequent urological complication: 8 (57.1%) in the 14 patients or 8 (72.7%) in the 11 patients who underwent urological evaluation. Urological imaging studies were performed essentially for the evaluation of accompanying urinary tract infections. Four patients had stage II chronic kidney disease at the last follow-up.</P><P><B>Conclusion</B></P><P>Urologic problems occurred frequently in MD, with bladder diverticula being the most common. Therefore, urological imaging studies and appropriate management of urological complications, which may prevent or reduce the development of urinary tract infections and renal parenchymal damage, are required in all patients with MD.</P>
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김현경(Kim Hyun-Gyung),임상임(Im Sang-Im) 한복문화학회 2002 韓服文化 Vol.5 No.1
This study looks at the documents and actual practices concerning the ceremonial costumes of the Soowoon sect to find out what characteristics they have In terms of the names. structures, designs, and colors, and see what religious ideas they convey, and I reached the following conclusions.<br/> 1. Most Soowoon sects have ceremonial costumes, and they are called CeremonY-Robe, Religion-Robe, Zen-Robe. The headpieces are called Jungja-gwan (shaped like the headpiece of a Chosun nobleman). You-gun (shaped like the headpiece of a Confucian scholar), Sun-gwan ("Zen-headpiece"), Yunhwa-gwan (shaped like a lotus flower). and Samchung-gwan ("three-tiered headpiece"). Soowoon is the only sect that allows women to wear a headpiece.<br/> 2. The basic outfit for most sects is hanbok. I. e. the traditonal Korean costume. Men add a robe and a headpiece to this, but it is the only costume for most women.<br/> 3. The hanbok worn by men and women in Soowoon sect Is the basic traditional type, and men wear a vest. a robe with a side slit. or a robe without a slit with wide sleeves. straight lapel. or a robe with narrow sleeves. straight lapel. or a robe with a slit down the back. an additional layer of fabric In the back over it. whereas only two sects allow women to wear a robe with narrow sleeves and round lapel or a robe with wide sleeves, a slit. and a straight lapel) over hanbok. Men wear various headpieces inlcudlng Yunhwa-gwan (shaped like a lotus flower). Jungja-gwan (shaped like the headpiece of a Chosun nobleman). You-gun (shaped like the headpiece of a Confucian scholar). in the order of frequency. Soowoon Is the only sect where women wear Yunhwa-gwan (shaped like a lotus flower).<br/> 4. The color of most Soowoon costumes is yellow for men. white for women. but the colors of yin and yang and the Five Elements and various compound colors are also used.<br/> 5. The main Ideas reflected in the physical characteristics of the ceremonial costumes of Soowoon sects include the oneness of the Confucianism. Buddhism, and Zen Buddhism, the Chundo Idea that identifies men and the supreme being. and yin and yang and the Five Elements.<br/>
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김경임 ( Gyung-im Kim ),한창민 ( Chang-min Han ),양수영 ( Su-yeoung Yang ),박정선 ( Jeong-seon Park ),정희택 ( Hee-taek Ceong ) 한국정보처리학회 2012 한국정보처리학회 학술대회논문집 Vol.19 No.1
일반적인 환경모니터링시스템은 다양한 환경 상태 데이터를 수집하여 사용자들에게 다양한 정보를 제공한다. 측정된 정보를 원격 CDMA의 단말기를 이용하여 사용자가 쉽게 관찰할 수 있도록 구성되어 있으나 이동성의 제한 및 SMS 요금이 발생하는 단점을 지닌다. 본 연구에서는 스마트폰을 기반으로 모바일 애플리케이션의 장점을 활용할 수 있는 안드로이드 기반의 환경정보 모니터링 시스템을 제안한다. 제안된 시스템에서는 푸시기반 알림 기능을 제공함으로써 사용자는 이동성을 확보함과 동시에 기존의 SMS 방식에서 발생한 비용의 문제를 해결할 수 있는 장점이 있다.
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사람골수줄기세포가 연골조직으로 분화되는 과정에 나타나는 세포표지자의 표현
김상경 ( Sang Gyung Kim ),최정윤 ( Jung Yoon Choe ),김채기 ( Chae Gi Kim ),정승혜 ( Seung Hie Chung ),신임희 ( Im Hee Shin ),서헌석 ( Hun Suk Suh ) 대한류마티스학회 2005 대한류마티스학회지 Vol.12 No.1
Objective: Multipotent bone marrow stromal cells have the ability to differentiate toward a variety of connective tissue lineages including cartilage. The future use of adult mesenchymal stem cells (MSCs) for human therapies depends on the establishment of preclinical studies. Therefore, in this preclinical study we demonstrated the expression of MSC surface markers CD29, CD105, and CD44 on human bone marrow derived stromal cells during chondrogenic differentiation. Methods: Adult human bone marrow was collected from the iliac crest of 7 donors following informed consent. Mononuclear cells were isolated, incubated in monolayers, and embedded in alginate beads for three-dimensional cultures. Cellualr viability was assessed by MTT assay. Flow cytometry of alginate bead cultures was performed on days 0, 7, 14, 21, and 28 using monoclonal antibody against surface molecules, CD105, CD29, CD44, CD34 and CD45. Total contents of collagen and glycosaminoglycan (GAG) of the alginate beads was measured. SPSS 11.0 was used for data analysis. Results: After 7 days of culture, 89% of the cells expressed the human integrin beta 1 antibody, CD29. The CD29-positive cells remained elevated at 83% on days 28. However, while only 18% expressed the type II TGF-beta receptor endoglin, CD105 on day 7, the CD105-positive cells increased abruptly 65% on day 14 remaining elevated up to day 28. The expression of CD44 was maximal in the first passage cell (63%). High concentration of TGF-beta 3 (10 ng/mL) was more favorable for sustaining cell viability than a low concentration (0.5 ng/mL)(n=4, p=0.002, day 21). The total contents of collagen and GAG in the MSC-alginate beads increased during the three-dimensional culture (n=4, p=0.02, p=0.006) suggesting its differentiation into a chondrogenic lineage. Conclusion: CD29 was expressed earlier than CD105 during chondrogenic differentiation of human bone marrow MSC. CD44 expression was highest in the first passage cells and gradually decreased afterwards.
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임상임(Sang Im Im),김현경(Hyun Gyung Kim) 한국복식학회 1998 服飾 Vol.39 No.-
This study researchs forms of Egyptian religious dress for studying formation-process of religious dress and its ornament. The study goes abreast literature and the very spot`s materials also divides god`s dress, priest`s. Ancient an egyptian worshiped mainly animals, step by step animal`s humanization. So gods were expressed animal`s face and human`s body. Egypt god`s costume is 1st, to take off upper hament and wear loin cloth on trousers 2nd only to wear short sheath skirt. 3rd to wear shout sheath skirt and to wear loin cloth on there 4th to cover whole body and to open hand like mummy. Eqypt goddess` costume is largely to wear long sheath skirt up to the ankle and we can see selkit goddess`s figure that wearing kalasiris after new dynesty. Priest had been a bald head and worn loin cloth and surrounded leopard`s skin on there, but after the period of empire, worn a wig and worn less stoically. Also god had hung the lion`s tail at symbol of the dignity and priest had put on sandals for a ceremony.
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( Min Kyoung Kim ),( Jin Hee Ahn ),( Sung Bae Kim ),( Young Suk Im ),( Soon Im Lee ),( Sei Hyun Ahn ),( Byung Ho Son ),( Gyung Yub Gong ),( Hak Hee Kim ),( Woo Kun Kim ) 대한내과학회 2007 The Korean Journal of Internal Medicine Vol.22 No.4
Background: The objectives of this study were to determine the incidence, outcome and risk factors for HBV reactivation in HBsAg positive breast cancer patients while on anthracycline-based adjuvant chemotherapy. Methods: We retrospectively reviewed the records of 2,431 patients with early breast cancer who received adjuvant chemotherapy from March 2001 to December 2005. Among these patients, 111 HBsAg positive women were enrolled in this study. Results: Thirty-seven patients (33.3%) developed acute hepatitis, of which 23 (20.7%) were related to HBV reactivation. Univariate analysis showed that an age ≥47 years (p=0.034) and abnormal sonographic findings such as a fatty liver or cirrhotic changes (p=0.034) were associated with HBV reactivation. However, an HBeAg positive status and the use of corticosteroids were not. Multivariate analysis found that no clinical factors could predict HBV reactivation during chemotherapy. All 23 patients who developed HBV reactivation received lamivudine as a therapeutic measure at the time of HBV reactivation. Despite the use of lamivudine, disruption in the chemotherapy protocol occurred in 18 patients (78.3%) and 14 of these patients had premature termination of their chemotherapy. Conclusions: HBV reactivation occurred in a significant proportion of HBsAg positive patients during adjuvant anthracycline-based chemotherapy. Once hepatitis developed, most patients could not finish the chemotherapy as planned despite lamivudine treatment. Until the risk factors for reactivation are clearly identified, HbsAg-positive patients should begin prophylactic antiviral treatment before initiating chemotherapy.
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김현경(Hyun Gyung Kim),임상임(Sang Im Im) 한국가정과학회 2002 한국가정과학회지 Vol.5 No.1
The purpose of this study is to identify the ritual dress used by the 12 religious bodies of Dankun followers to help understand the teachings of these currently operating religious groups in Korea. The findings from the survey and related literatures are used to analyze the characteristics of these ritual dresses in terms of their items, construction, form, and color. The results of the study are as follows: first, most of the religious groups of Dankun followers have established the code for ritual dresses and they are named as `chaebok`(제복, sacrificial robes), `yebok`(예복, ceremonial dress), `chungbok`(정복, formal attire), `pubbok`(법복. Buddhist formal dress), or `tobok`(도복, Taoist garments). The official headgear is usually named as chaemo`(제모), `soogun`(수건), `moja`(모자), or `yoogun`(유건, 儒巾). Though, there are some groups which do not use any specific names for headgear. Second, the ritual dresses of most groups are composed of the `hanbok`(한복,韓服) or usual Western-style dress, a traditional outer wear, `po`(포,袍), and a headgear, as a basic attire. Third, the traditional `hanbok` is worn as a base garment and an outer wear is worn above. The different types of outer wear are used; mostly `chaksu jueui jikyoun po`(착수주의직령포, 窄袖周衣直領袍) for men and `kwangsu jikyoung po`(광수직령포, 廣袖直領袍) and other various styles for women. The headgear from the ancient times are worn by both men and women. Fourth, the most frequently-used color for ritual dress is white for both men and women`s dress. The colors from the Yin and Yang ideology are also used in the ritual dresses. Finally, the kinds of materials are not considered as an important element for the ritual dresses.
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