어지러움증 환자의 임상 및 검사소견에 관한 연구

이향운,박기덕,최경규 대한신경과학회 1997 대한신경과학회지 Vol.15 No.1

여성 간질 환자에서 항경련제 복용에 따른 대사 및 생리주기의 변화

김지영,이진화,김숙희,이향운 이화여자대학교 의과대학 2005 EMJ (Ewha medical journal) Vol.28 No.2

Background & Objectives : Women with epilepsy(WWE) are at risk for reproductive and metabolic disorders. This study was performed to investifate whether WWE are more likely to have menstual or metabolic abnormalities, and whether some antiepileptic drugs(AEDs) more likely provoke those problems. Methods : WWW aged 15-50 years old, taking one or more AEDs for at least 6 months, were recruited. Subjucts checked their oral temperature each morning. Body mass index(BMI : kg/㎡) and waist to hip (W/H) ratio were calculated as obesity markers. Hirsutism index, as a marker of polycystic ovary syndrome, was calculated by Ferriman-Gallwey score(hirsutism if score>8). Serum tests ofr gonadotrophins, steroid hormones, sex hormone binding globulins (SHBG), lipid profiles, insulin were performed on menstrual cycle days 3 to 5. Results : Among 54 patients, 18 women were diagnosed as primary generalized epilepsy(PGE) and the other 36 were localoization-related epilepsy(LRE). Also, 21 women(38.9%) were treated with carbamazepine(CBZ), 14 women(25.9%) with valproate(VPA), and 19(35.2%) with lamotrigine(LTG) or topiramate(TPM). Menstrual disturbance was found in 60.0% of PGE versus 30.6% of LRE patients(p=0.050), while 64.3% of VPA and 28.6% of CBZ-treated patients(p=0.036). The W/H ratio and BMI were higher in VPA, than in CBZ-treated patients(p=0.048 and 0.018). The total and HDL-cholesterols decreased in the VPA group compared to the CBZ group(p=0.025 and 0.009). Conclusion : WWE are more likely to experience menstrual and metabolic alterations. WWE with VPA tend to have abdominal obesity and alterations in lipid metabolism.

상악골 침범 소견을 동반한 선천성 침윤 지방종

허경회,이향옥,이서영,최형길,하병각,문제운,이삼선 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.37 No.2

Infiltrating lipoma is a rare mesenchymal neoplasm that, in spite of benign nature, characteristically infiltrates adjacent tissues and tends to recur after surgery. It has a predilection for the extremities and the trunk and is extremely rare in the head and neck region. We present a case of congenital infiltrating lipoma of the face, describing the intrabony invasion and osseous dystrophy as well as the soft tissue changes seen on plain radiographs and magnetic resonance imaging.

척수 경막외 혈관 기형에 의한 재발성 척수병증

오동호,김희태,박운규,이영주,김승현,김주한,김명호,박문향 대한신경과학회 1998 대한신경과학회지 Vol.16 No.5

Early Seizure Detection by Applying Frequency-Based Algorithm Derived from the Principal Component Analysis

Lee, Jiseon,Park, Junhee,Yang, Sejung,Kim, Hani,Choi, Yun Seo,Kim, Hyeon Jin,Lee, Hyang Woon,Lee, Byung-Uk Frontiers Media S.A. 2017 Frontiers in neuroinformatics Vol.11 No.-

<P>The use of automatic electrical stimulation in response to early seizure detection has been introduced as a new treatment for intractable epilepsy. For the effective application of this method as a successful treatment, improving the accuracy of the early seizure detection is crucial. In this paper, we proposed the application of a frequency-based algorithm derived from principal component analysis (PCA), and demonstrated improved efficacy for early seizure detection in a pilocarpine-induced epilepsy rat model. A total of 100 ictal electroencephalographs (EEG) during spontaneous recurrent seizures from 11 epileptic rats were finally included for the analysis. PCA was applied to the covariance matrix of a conventional EEG frequency band signal. Two PCA results were compared: one from the initial segment of seizures (5 sec of seizure onset) and the other from the whole segment of seizures. In order to compare the accuracy, we obtained the specific threshold satisfying the target performance from the training set, and compared the False Positive (FP), False Negative (FN), and Latency (Lat) of the PCA based feature derived from the initial segment of seizures to the other six features in the testing set. The PCA based feature derived from the initial segment of seizures performed significantly better than other features with a 1.40% FP, zero FN, and 0.14 s Lat. These results demonstrated that the proposed frequency-based feature from PCA that captures the characteristics of the initial phase of seizure was effective for early detection of seizures. Experiments with rat ictal EEGs showed an improved early seizure detection rate with PCA applied to the covariance of the initial 5 s segment of visual seizure onset instead of using the whole seizure segment or other conventional frequency bands.</P>

Altered functional connectivity in seizure onset zones revealed by fMRI intrinsic connectivity

Lee, Hyang Woon,Arora, Jagriti,Papademetris, Xenophon,Tokoglu, Fuyuze,Negishi, Michiro,Scheinost, Dustin,Farooque, Pue,Blumenfeld, Hal,Spencer, Dennis D.,Constable, R. Todd Lippincott WilliamsWilkins 2014 Neurology Vol.83 No.24

<P><B>Objective:</B></P><P>The purpose of this study was to investigate functional connectivity (FC) changes in epileptogenic networks in intractable partial epilepsy obtained from resting-state fMRI by using intrinsic connectivity contrast (ICC), a voxel-based network measure of degree that reflects the number of connections to each voxel.</P><P><B>Methods:</B></P><P>We measured differences between intrahemispheric- and interhemispheric-ICC (ICC<SUB><I>intra−inter</I></SUB>) that could reveal localized connectivity abnormalities in epileptogenic zones while more global network changes would be eliminated when subtracting these values. The ICC<SUB><I>intra−inter</I></SUB> map was compared with the seizure onset zone (SOZ) based on intracranial EEG (icEEG) recordings in 29 patients with at least 1 year of postsurgical follow-up. Two independent reviewers blindly interpreted the icEEG and fMRI data, and the concordance rates were compared for various clinical factors.</P><P><B>Results:</B></P><P>Concordance between the icEEG SOZ and ICC<SUB><I>intra−inter</I></SUB> map was observed in 72.4% (21/29) of the patients, which was higher in patients with good surgical outcome, especially in those patients with temporal lobe epilepsy (TLE) or lateral temporal seizure localization. Concordance was also better in the extratemporal lobe epilepsy than the TLE group. In 85.7% (18/21) of the cases, the ICC<SUB><I>intra−inter</I></SUB> values were negative in the SOZ, indicating decreased FC within the epileptic hemisphere relative to between hemispheres.</P><P><B>Conclusions:</B></P><P>Assessing alterations in FC using fMRI-ICC map can help localize the SOZ, which has potential as a noninvasive presurgical diagnostic tool to improve surgical outcome. In addition, the method reveals that, in focal epilepsy, both intrahemispheric- and interhemispheric-FC may be altered, in the presence of both regional as well as global network abnormalities.</P>

A comparison of ankle function between adults with and without Down syndrome

Yoon, Hyang-Woon,Yu, Tae-Ho,Seo, U-Hyeok,Lee, Jee-Won,Kim, So-Yeon,Chung, Soo-Jin,Chun, Hye-Lim,Lee, Byoung-Hee korean Academy of Physical Therapy Rehabilitation 2017 Physical therapy rehabilitation science Vol.6 No.4

Objective: The purpose of this study was to compare ankle function between adults with and without Down syndrome (DS). Design: Cross-sectional study. Methods: Ten adults with DS and 18 without participated in this study and underwent manual muscle test (MMT), range of motion (ROM) assessment, star excursion balance test (SEBT), and functional movement screen (FMS). The tests were demonstrated to increase their accuracy and the actual measurements were assessed after one or two demonstrations. To minimize the standby time and fatigue, the travelled distance and measuring order were adjusted. To remove the influence of shoes on the measurements, the shoes were taken off and only socks were worn. Results: Dorsal and plantar flexion MMTs of both ankles were significantly weaker and plantar flexion ROM of both ankles were significantly lower in adults with DS compared with those without (p<0.05). However, dorsal flexion ROM of both ankles were not significantly different between them. There were significant differences in distances measured in all the directions (anterior, anterolateral, lateral, posterolateral, posterior, posteromedial, medial, and anteromedial directions) of SEBT (p<0.05). Significant differences were also demonstrated in the scores of hurdle step, inline lunge, shoulder mobility, and rotary stability among the seven items of FMS (p<0.05). Conclusions: To enhance the dynamic stability of adults with DS, it is necessary to improve ankle stability by strengthening the ankle dorsal and plantar flexors.

보행 중 입각기 시 정상 성인과 편마비 환자의 환측과 건측의 족저압 분포 비교

윤향운 ( Hyang Woon Yoon ),이상열 ( Sang Yeol Lee ),이현민 ( Hyun Min Lee ) 대한물리의학회 2009 대한물리의학회지 Vol.4 No.2

Objects:The purpose of this study is to investigate the values of foot pressure of the stance phase during a gait cycle in hemiplegic gait. Method:42 patients who had a stroke and 42 healthy adults were evaluated by the RSscan system to analyze the stance phase of hemiplegic gait. The stance phase was evaluated as plantar foor pressure. Results:1) Foot plantar pressure of toe area, affected side and less affected side showed low distribution of the plantar foot pressure which is lower than plantar foot pressure of normal adults(p<0.05). 2) Foot plantar pressure of metatarsal area, showed significantly differences among hemiplesic patient`s affected side and less affected side and distribution of plantar foot pressure of normal adults(p<0.05). 3) Foot plantar pressure of heel area, hemiplesic patients` affected side and less affected side showed lower distribution of the plantar foot pressure than plantar foot pressure of normal adults(p<0.05). Conclusion:The results of this study suggest that not only affected side but also less affected side in hemiplegic patients showed significantly differences in distribution of the plantar foot pressure of normal adults.

Characterization of Monoclonal Antibodies against Human Leukocyte Common Antigen (CD45)

Shin, Hyang-Mi,Cho, Woon-Dong,Lee, Geon-Kook,Lee, Seon-Hwa,Lee, Kyung-Mee,Ji, Gil-Yong,Yoon, Sang-Soon,Koo, Ji-Hae,Lee, Ho-Chang,Lee, Ki-Hyeong,Song, Hyung-Geun The Korean Association of Immunobiologists 2011 Immune Network Vol.11 No.2

Background: The leukocyte common antigen (CD45) is a transmembrane-type protein tyrosine phosphatase that has five isoforms. Methods: We generated seven murine mAbs against human CD45 by injecting cells from different origins, such as human thymocytes, PBMCs, and leukemic cell lines. By using various immunological methods including flow cytometry, immunohistochemistry, and immunoprecipitation, we evaluated the reactivity of those mAbs to CD45 of thymus as well as tonsil lysates. Furthermore, we transiently transfected COS-7 cells with each of gene constructs that express five human CD45 isoforms respectively, and examined the specificities of the mAbs against the transfected isoforms. Results: In case of thymocytes, lymphocytes, and monocytes, all the seven mAbs demonstrated positive reactivities whereas none was reactive to erythrocytes and platelets. The majority of immune cells in formalin-fixed paraffin-embedded thymus and tonsil tissues displayed strong membranous immunoreactivity, and the main antigen was detected near 220 kDa in all cases. Among the mAbs, four mAbs (AP4, DN11, SHL-1, and P6) recognized a region commonly present in all the five isoforms. One mAb, YG27, recognized four isoforms (ABC, AB, BC, and O). Two mAbs, P1 and P14, recognized the isoforms that contain exon A encoded regions (ABC and AB). Conclusion: In this study, we confirmed that AP4, DN11, SHL-1, YG27 and P6, are mAbs reactive with the CD45 antigen whereas P1 and P14 are reactive with the CD45RA antigen.

부분적 간질에서 SPECT Subtraction을 이용한 발작 중 뇌혈류 변화에 대한 연구

이향운(Hyang Woon Lee),홍승봉(Seung Bong Hong),태우석(Woo Suk Tae),김상은(Sang Eun Kim),서대원(Dae Won Seo),정송철(Seung Cheol Jeong),이지영(Ji Young Yi),홍승철(Seung Chyul Hong) 대한핵의학회 2000 핵의학 분자영상 Vol.34 No.3

N/A Purpose: To investigate the various ictal perfusion patterns and find the relationships between clinical factors and different perfusion patterns. Materials and Methods: lnterictal and ictal SPECT and SPECT subtraction were performed in 61 patients with partial epilepsy. Bath positive images showing ictal hypoperfusion and negative images revealing ictal hypoperfusion were obtained by SPECT subtraction. The ictal perfusion patterns of subtracted SPECT were classified into focal hypoperfusion, hypoperfusion-plus, combined hypoperfusion-hypoperfusion, and focal hypoperfusion only. Results: The concordance rates with epileptic focus were 91.8% in combined analysis of ictal hypoperfusion and hypoperfusion images of subtracted SPECT, 85.2% in hypoperfusion images only of subtracted SPECT, and 68.9% in conventional ictal SPECT analysis. Ictal hypoperfusion occurred less frequently in temporal lobe epilepsy (TLE) than extratemporal lobe epilepsy. Mesial temporal hypoperfusion alone was seen only in mesial TLE while lateral temporal hypoperfusion alone was observed only in neocortical TLE. Hippocampal sclerosis had much lower incidence of ictal hypoperfusion than any other pathology. Some patients showed ictal hypoperfusion at epileptic focus with ictal hypoperfusion in the neighboring brain regions where ictal discharges propagated. Conclusion: Hypoperfusion as well as hypoperfusion in ictal SPECT should be considered for localizing epileptic focus. Although the mechanisrn of ictal hypopertusion could be an intra-ictal early exhaustion of seizure focus or a steal phenomenon by the propagation of ictal discharges to adjacent brain areas, further study is needed to elucidate it. (Korean J Nucl Med 2000;34:169-82)