Melkersson-Rosenthal Syndrome

김태정,이성근,김일호,황경호,김선종,박 욱,송후빈,김성열 대한통증학회 1989 The Korean Journal of Pain Vol.2 No.1

The Melkersson-Rosenthal (M-R) syndrome consists of a triad of (1) recurrent peripheral facial nerve paralysis which develops alternately on both sides of face, (2) non-inflammatory facial edema, and (3) fissuring of tongue. A 59 years old female patient developed the left facial palsy on September, 1988. Right facial palsy developed continuously 2 months later after the spontaneous remission of left facial palsy. On February, 1989, we have found out M-R syndrome which accompanied with migraine type of intermittent headache, and hypertension in one attack of cerebral stroke several years ago, there were no diabetes mellitus, pulmonary tuberculosis and brain tumor in clinical studies. Although the causes of this syndrome were not noted, we performed the stellate ganglion block and transcutaneous electrical nerve stimulation for treatment of the palsy, but the clinical effectiveness of these were not satisfactory.

한방병원에 입원한 요통 환자의 요추 전만각, 요천각 변화의 심각도에 따른 예후 분석 연구

한수빈 ( Su-bin Han ),김은산 ( Eun-san Kim ),김효준 ( Hyo-jun Kim ),조후인 ( Hoo-in Jo ),김미혜 ( Mi-hye Kim ),이남우 ( Nam-woo Lee ),한정훈 ( Jeong-hun Han ),박병학 ( Byung-hak Park ),손재민 ( Jae-min Son ),강도현 ( Do-hyeon Kang 한방재활의학과학회 2020 한방재활의학과학회지 Vol.30 No.4

Objectives To analyze the prognosis of patients with low back pain according to the severity of abnormal lumbar lordotic angle and Ferguson's angle. Methods Data from electronic medical record of a total of 199 patients hospitalized in Korean medicine hospital were analyzed. With the sagittal view of lumbar spine X-ray, lumbar lordotic angle was defined as the angle between the superior endplate of L1 with the inferior endplate of L5. Ferguson’s angle was defined as the angle between the superior surfaces of the sacral with a horizontal line. ‘Measure Cobb’s Angle Tool’ of ‘INFINITT PACS’ was used to measure both angles. Lumbar lordotic angle and Ferguson's angle were subdivided into five sections. The number of days from onset and the duration of hospitalization were analyzed in each section. Results Severe hypolordotic lumbar lordotic angle group were found to have longer medical history and hospitalization duration than the control group. The ratio of long-term hospitalization (over 15 days) and chronic medical history (over 180 days) of patients with severe hypolordotic Ferguson’s angle were significantly higher than the control group. The ratio of patients with chronic medical history (over 180 days) was significantly higher in severe hyperlordotic Ferguson's angle group than the control group. Conclusions Severe hypolordotic lumbar lordotic angle was related to patient’s prognosis. Both severe hyperlordotic and severe hypolordotic Ferguson’s angle were found to be related to patient’s prognosis. However, a moderate loss of lumbar lordotic angle and Ferguson’s angle was not related to prognosis of low back pain patients. (J Korean Med Rehabil 2020;30(4):143-154)

Effects of different inorganic: organic zinc ratios or combination of low crude protein diet and mixed feed additive in weaned piglet diets

( Han Jin Oh ),( Myung Hoo Kim ),( Ji Hwan Lee ),( Yong Ju Kim ),( Jae Woo An ),( Se Yeon Chang ),( Young Bin Go ),( Dong Cheol Song ),( Hyun Ah Cho ),( Min Seok Jo ),( Dae Young Kim ),( Min Ji Kim ) 한국축산학회 2022 한국축산학회지 Vol.64 No.1

Thirty-six weaned piglets with an initial body weight (BW) of 8.43 ± 0.40 kg (28 days of age, ([Landrace × Yorkshire] × Duroc) were randomly assigned to 6 treatments for a 2-week feeding trial to determine the effects of different inorganic zinc (IZ), organic zinc (OZ) or combination of low crude protein diet (LP) and Mixed feed additive (MFA) on diarrhea score, nutrient digestibility, zinc utilization, blood profiles, organ weight, and fecal microflora in weaned piglet diet. The pigs were individually placed in 45 × 55 × 45 cm stainless steel metabolism cages in an environmentally controlled room (30 ± 1℃). The dietary treatments included a negative control (NC), positive control (PC; zinc oxide, 1,000 mg/kg), T1 (IZ : OZ, 850 : 150), T2 (IZ : OZ 700 : 300), T3 (IZ : OZ, 500 : 500), and T4 (LP + MFA [0.1% Essential oils + 0.08% Protease + 0.02% Xylanase]). The daily feed allowance was adjusted to 2.7 times the maintenance requirement for digestible energy (2.7 × 110 kcal of DE/kg BW^0.75). This allowance was divided into two equal parts, and the piglets were fed at 08 : 30 and 17 : 30 each day. Water was provided ad libitum through a drinking nipple. The diarrhea score was significantly increased (p < 0.05) in NC treatment compared with other treatments. The apparent total tract digestibility (ATTD) of dry matter (DM), nitrogen (N), and gross energy (GE) was significantly increased (p < 0.05) in the T2 treatment compared with the PC and NC treatments in week 1. In week 2, the ATTD of DM, N, and GE was significantly decreased (p < 0.05) in the NC treatment compared with other treatments. The T3 treatment had significantly higher (p < 0.05) ATTD and apparent ileal digestibility of zinc than the PC and T1 treatments. The Escherichia coli count in feces was significantly decreased in the T4 treatment compared with the NC and T2 treatments. The Lactobacillus count in feces was significantly increased in the T4 and T1 treatment compared with the T2 and T3 treatments. In conclusion, IZ : OZ 500 : 500 levels could improve nutrient digestibility and zinc utilization in weaned piglets, Moreover, MFA in LP diets could be used as a zinc alternative.

손목 통증의 수기 치료에 대한 체계적 문헌 고찰과 메타분석

이예지(Ye-Ji Lee),전천후(Cheon-Hoo Jeon),김효빈(Hyo-Bin Kim),전주현(Ju-Hyun Jeon),김은석(Eun-Seok Kim),김진엽(Jin-Youp Kim),최강민(Kang-Min Choi),김영일(Young-Il Kim) 척추신경추나의학회 2020 척추신경추나의학회지 Vol.15 No.1

Objectives : This study aimed to evaluate the effectiveness of manual therapy for wrist pain. Methods : We searched electronic databases (PubMed, Embase, Cochrane, CAJ, KISS, RISS, NDSL, OASIS, and KMBASE) for randomized controlled trials for manual therapy as a treatment for wrist pain. Results : A total of 9 randomized controlled trials were selected and meta-analysis was conducted on 6 studies. Three studies with different design of the intervention/control group were excluded from the meta-analysis. A high risk of bias was observed for both performance bias and detection bias. Conclusions : Our systematic review verified the clinical effect of manual therapy on wrist pain. Based on the results of this study, it is expected that clinical studies on wrist diseases and high-level follow-up studies will be conducted.

수술 및 화학요법으로 치험한 중복암 1예 : 위 선암과 식도 편평상피 세포암 A Case of Concurrent Esophageal and Gastric Double Primary Cancer Treated by Surgery and Chemotherapy

김영수,이진우,박기수,신용운,권계숙,홍성빈,김여주,정원재,장동섭,정석,김선후 대한소화기내시경학회 1995 Clinical Endoscopy Vol.15 No.4

Double primary cancer of the stomach and esophagus has been revealed a very low incidence in the world except Japan and reported only 6 cases in Korea. Furthermore, it is difficult to manage this type of double cancer because esophageal cancer has a biologic tendency to early metastasis. This paper is concerned with a case of double primary cancer, which we have synchroniously confi~rmed esophageal squamous cell carcinoma and gastric adenocarcinoma with gastrofiberscopic biopsy, and then treated them by radical resec tion and systemic chemotherapy.

근이완제 Vecuronium 이 안압에 미치는 영향

김일호,황경호,송후빈,김성렬,김용익 대한마취과학회 1987 Korean Journal of Anesthesiology Vol.20 No.2

Thirty healthy patients were studied to evaluate the effect of muscle relaxants on intra-ocular pressure (IOP) during anesthesia. The patients were divided intro three groups-succinrlcholine group(Img/kg,n=10) , pancu-ronium group(0.08mg/kg,n=10), and vecuronium group(0, Img/kg,n=10) according to the muscle relaxants used. All patients were premedicated with robinul 0.2mg and lorazepam 4mg one hour before surgery. Tracheal intubation was fellowed by thiopental sodium 5mg/ kg and muscle relaxant. Anesthesia was maintained with O2-N2O-enflurane and respiration and was controlled by anesthetic ventilator (Dameca). The 1OP was measured hy Schotz tonometer, before induction of anesthesia, at 75∼100% depression of twitch height on train-of-four after injection of muscle relaxant, and at 1,3, 5, 10, minutes after intubation respectively. Heart rate, mean arterial pressure, and end-tidal CO_2 tensions were also measured simultaneously. The results were as follows ; 1) At 75∼100% depression of twitch height, 1OP w elevated significantly in succinylc-holine group but reduced significantly in both pancuronium and vecuronium groups as Compared With pre-induction value. 2) 1OP was elevated in all groups after 1 minute of intubation, there were no statistical significance in pancuronium or vecuronium group as compared with pre·induction value. After 3 minutes of intubation, 1OP was reduced in all groups in proportion to the depth of anesthesia. 3) Cardiovascular changes in vecuronium group were less than those in succinrlcholine or pancuronium group. In conclusion vecuronium, with less cardiovascular changes, may be indicated for anest-hesia of open eye injury compare other muscle relaxants.

Involvement of Pin1 induction in epithelial-mesenchymal transition of tamoxifen-resistant breast cancer cells

Kim, Mi Ra,Choi, Hoo-Kyun,Cho, Kyoung Bin,Kim, Hyung Sik,Kang, Keon Wook Wiley (Blackwell Publishing) 2009 CANCER SCIENCE Vol.100 No.10

<P>Acquisition of resistance to tamoxifen is a critical therapeutic problem in breast cancer patients. Epithelial-mesenchymal transition (EMT), where cells undergo a developmental switch from a polarized epithelial phenotype to a highly motile mesenchymal phenotype, is associated with invasion and motility of cancer cells. Here, we found that tamoxifen-resistant (TAMR)-MCF-7 cells had undergone EMT, as evidenced by mesenchymal-like cell shape, downregulation of basal E-cadherin expression, and overexpression of N-cadherin and vimentin, as well as increased Snail transcriptional activity and protein expression. Given the roles of glycogen synthase kinase (GSK)-3beta and nuclear factor (NF)-kappaB in Snail-mediated E-cadherin deregulation during EMT, we examined the role of these signaling pathways in the EMT of TAMR-MCF-7 cells. Both Ser9-phosphorylated GSK-3beta (inactive form) and NF-kappaB reporter activity were increased in TAMR-MCF-7 cells, as was activation of the phosphatase and tensin homolog depleted on chromosome ten (PTEN)-phosphoinositide 3 (PI3)-kinase-Akt pathway. Pin1, a peptidyl-prolyl isomerase, was overexpressed in TAMR-MCF-7 cells, and Snail transcription and the expression of EMT markers could be decreased by Pin1 siRNA treatment. These results imply that Pin1 overexpression in TAMR-MCF-7 cells is involved in the EMT process via PTEN-PI3-kinase-Akt-GSK-3beta and/or GSK-3beta-NF-kappaB-dependent Snail activation, and suggest the potential involvement of Pin1 in EMT during breast cancer development.</P>

삼차 신경절 액조내 글리세를 주입에 의한 삼차신경통 치험 : 12예 보고

김용익,김일호,황경호,박 욱,송후빈,김성열 대한통증학회 1988 The Korean Journal of Pain Vol.1 No.2

In 1983, Sten Hakanson^(4)) first reported the clinical safety and efficacy of retrogasserian glycerol injection as a treatment of typical trigeminal neuralgia in 96 of l00 patients during a follow-up period of 1-6 years. Since September 1987, we have injected sterile pure glycerol into the trigeminal cistern using an anterior percutaneous approach via the foramen ovale (Harte! Route^(5))) for treatment of tic douloureux in 12 patients who were suffering from attacks pain of following discontinuation of carbamazepine. The results were as follows; 1) Eight patients were completely free from pain attacks with a single dose of glycerol (0.4 ml). The remaining four patients needed a second dose (0.4 ml) several days later following the single dose. The degree of patient's subjective satisfaction by those injections was very good in 11 and fair in one. 2) During the follow-up period (1-13 months), persistent sensory deficit as determined by the pin prick test, appeared to be mild in 10 and moderate in one patient. There was no sensory deficit in one patient. further attacks of pain from those injections were still noted. 3) As a transient complication, there was headache in all patient, facial hematoma in 4, nausea and vomiting in two each, and vertigo and herpes simplex in one each. In conclusion, we confirmed that the above glycerol injections into the trigeminal cistern were clinically very effective as a treatment of tic douloureux even though the follow-up period was short.

디지털 I-PD 제어기에 의한 태양광 발전 시스템의 정출력 제어

박지호,김영빈,신동률,문백영,우정인 東亞大學校 大學院 2000 大學院論文集 Vol.25 No.-

In this paper, constant output control of solar power generation system with instantaneous variable output is proposed. In order to get constant DC and AC voltage source, we construct Buck-Boost chopper equip with the digital I-PD type controller first. Consequently, we are able to get constant DC boltage. Next, we obtain AC source through construction PWM single phase inverter that has the constant frequency output. And we design LC filter to reduce THD(Total Harmonic Distortion). The validity of proposed control strategy is verified from results of simulation.

High Dosage Sildenafil Induces Hearing Impairment in Mice

Hong, Bin Na,Yi, Tae Hoo,Kim, Sun Yeou,Kang, Tong Ho Pharmaceutical Society of Japan 2008 Biological & pharmaceutical bulletin Vol.31 No.10

<P>Sildenafil is widely administered for the treatment of erectile dysfunction. Recently, sensorineural hearing loss following the ingestion of sildenafil was reported in one male patient. We examined hearing in mice that were administered high doses of sildenafil for up to 105 d. To assess hearing impairment, we evaluated auditory brainstem responses, auditory middle latency responses, and otoacoustic emissions. At high doses, sildenafil increased the hearing threshold shift of auditory brainstem responses. High-dose sildenafil treatment also resulted in delayed latency of both auditory brainstem responses and auditory middle responses. Otoacoustic emissions differed between control and high-dose sildenafil groups with long-term treatment. Collectively, these data demonstrate that high-dose and long-term sildenafil administration can induce hearing impairment in mice.</P>