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      • 명사 칼럼-우리 몸의 조기경보시스템 '통증'

        황경호,Hwang, Gyeong-Ho 한국건강관리협회 2008 건강소식 Vol.32 No.6

        우리 몸에 상처를 입었거나 상처를 입을 만한 상황에서 느끼는 유쾌하지 않은 감정까지 모두 통증의 범주에 포함된다. 잠재적인 손상을 알리는 통증 즉, 바늘에 찔리거나 불에 데이는 순간에 느끼는 것과 같은 일차적인 통증은 재빠른 회피반사를 일으켜 다가오는 더 큰 조직 손상을 미연에 방지하려는 조기경보시스템이라고 할 수 있다. 반면에 어쩔 수 없이 우리 몸이 손상을 입게 되면 통증은 반사적으로 근육 수축을 일으켜 신체를 움직이지 않게 한다. 골절상을 입었을 때의 통증처럼 움직이면 통증을 더 느끼게 되고, 움직이지 않아야 아프지 않고 뼈가 아물게 되는것이다. 이처럼 통증은 신체의 이상을 신속히 알리고 경고하는 중요한 방어기전 중의 하나이다.

      • SCOPUSKCI등재

        H2-Receptor Blocker 가 Vecuronium 의 길항에 미치는 영향

        황경호,김성열,이성근 대한마취과학회 1988 Korean Journal of Anesthesiology Vol.21 No.3

        Recently, several studies have shown that the H_2-receptor blockers can cause inhibition of cholinestrase, and neuromuscular blockade which suggest involvement of ion-chennel block in relatively large experiemtnal dose. We investigated the effect of three H_2-receptor blockers cimetidine, ranitidine, and famotidine on antagonoism of vecuronium neuromuscular blockade. Forty ASA class 1 or 2 adult patients were studied. All patients were premedicated with hydroxyzine 1.5 mg/kg and glycopyrrolate 0.2mg IM, 1 hour before induction. Anesthesia was induced with thiopental sodium 5∼6mg/kg, succinylcholine 1 mg/kg and was maintained with 02-N20(50%)-enflurane. Intraoperative muscle relaxation was maintained below 5% of control twitch height on TOF stimulation by combined bolus IV(0208mg/kg) and continuous infusion(0.08mg/kg/hour) of vecuronium. Patients were divided into four groups according to use of H_2-receptor blocker just after stop of vecuronium infusion as follows; Control group(n=10) : no use of H_2receptor blocker Cimetidine group(n=10) : cimetidine 200 mg IV Ranitidine group(n=10) : rantidine 50 mg IV Famotidine group(n=10) : famotidine 50 mg IV Reversal of neuromuscular blockade with neostigmine(0.04mg/kg) was performed at 10% recovery of first twitch height(T_1) in all cases. The recovery of T_1 and T_4 ratio after reversal was measured at 1 min. interval for 20 min. The results were as follows; 1) The recovery of twitch height after administration of neostigmine was prolonged in all three H_2-receptor blocker groups as compared to control group, but statistical significance was noted only in Famotidine group(p<0.05). 2) The changes of heart rate and mean arterial pressure after administration of neostigmine were similar in all groups.

      • SCOPUSKCI등재

        각 비탈분극성 근이완제에 의한 Train-four Fade 의 비교

        황경호,한찬수,김성열,박욱 대한마취과학회 1990 Korean Journal of Anesthesiology Vol.23 No.3

        Train-of-four (TOF) fade is a characteristic of the nondepolarizing neuromuscular blocking agents, but the degree of TOF fade has been shown to vary for different nondeplarizing relaxants. In the present study we measured the degree of fade of four nondepolarizing muscle relaxantsatracurium, vecuronium, pancuronium, and d-tubocurarine-during spontaneous recovery of neuromuscular blockade. Forty ASA class 1 or 2 adult patients were studied. All patients were premedicated with glycopyrrolate 0.2 mg and nalbuphine 10 mg IM, 1 hour before induction. After induction with pentothal sodium 5-6 mg/kg IV, neuromuscular monitoring was carried out by stimulaton of the ulnar nerve at the wrist with supramaximal stimuli at a frequency of 2 Hz repeated every 20 seconds using an ABM (Anesthesia and Brain activity Monitor, Datex Co.). The electromyographic response of hypothenar muscles was recorded. Following stabilization of control twitch height, the nondepolarizing relaxant was injected as a bolus dose, and tracheal intubation was performed when the first twich height of the train (T(1)) was 5% of the control. Anesthesia was maintained with O₂-N₂O (50%) -enflurane. Patients were divided into four groups according to use of relaxant: atracurium 0.4 mg/kg (n=10: group A), vecuronium 0.08 mg/kg (n=10; group V), pancuronium 0.08 mg/kg (n=10; group T), and d-tubocurarine 0.4 mg/kg (n= 10: group T). T(4) ratios at T(1) of 25, 50 and 75% recovery of T(1) and recovery index in each group were measured. The results were as follows: 1) The T(4) ratio was decreased significantly in P and T groups, as compared to A and V group. There were no significant differences between P and T groups, and between A and V groups (except 25% recovery of T(1)). 2) The recovery index was 14.8±2.36 min in A group, 16.4±1.85 min in V group, 51.2±4.17 min in P group, and 93.4±7.31 min in T group.

      • SCOPUSKCI등재

        항 Cholinesterase 가 혈장 Cholinesterase 및 Train-of-four 반응에 미치는 영향

        황경호,김선종,김성열 대한마취과학회 1991 Korean Journal of Anesthesiology Vol.24 No.1

        Effects of the anticholinesterase drugs on plasma cholinesterase activity, plasma albumin level and train-of-four response were investigated in 38 ASA class 1 or 2 adult patients undergoing elective surgery. Anesthesia was induced with thiopental sodium 5~6 mg/kg followed by succinylcholine 1 mg/kg to facilitated tracheal intubation, and was maintained with O2-N2O(50%)-enflurane (1~2%). For maintenance of adequate muscle relaxation, initial bolus (0.08 mg/kg) and small incremental doses (0.02~0.04 mg/kg) of vecuronium were administered. At the end of surgery, neuromuscular blockade was reversed with neostigmine 0.04 mg/kg as a single bolus dose (neostigmine group, n=10), divide dose of neostigmine (20%:80%, neostigmine-divide group, n=10), pyridostigmine 0.2mg/kg (pyridostigmine group, n=10), or edrophonium 0.5mg/kg (edrophonium group, n=8) respectively. Reversal was attempt at 10% spontaneous recovery of first twitch height (T₁), which was measured using train-of-four (TOF) stimulation of ulnar nerve repeated every 20 seconds (EMG, Datex co.). The results obtained were as follows: 1) Neostigmine, neostigmine-divide and pyridostigmine groups all produced markedly inhibition of plasma cholinesterase activity which was maximum at 5 minutes after injection, and was persisted significantly for 60 miuntes in both neostigmine and neostigmine-divide groups, and for 120 minutes in pyridostigmine group. The inhibition of plasma cholinesteraae was correlated significantly with TOF recovery in all groups except in edrophonium group. There was no inhibition of enzymatic activity up to 30 minutes in edrophonium group. 2) The changes in plasma albumin level after administration of anticholinesterase drugs were insignificant in all groups. 3) Both T₁ and the ratio of the 4th twitch height to T₁ (T₄ ratio) were recovered above 75% of control within 30 minutes after injection of each anticholinesterase drugs in all groups, but there was significant slow progressing in edrophonium group. Comparing with same height of T₁ the T₄ ratio was not greater in edrophonium than in neostigmine or pyridostigmine. 4) The simultaneous administration of anticholinesterase drug and atropine (0.02 mg/kg) resulted the minimal changes in mean arterial pressure (±7% compared with prior to injection) or heart rate (±10% compared with prior to injection) from 5 minutes to 60 minutes after injection in all groups. In conclusion, although it was not thought that enzyme inhibition may be the sole factor, it should be considered to use succinylcholine or ester type of local anesthetics in patients who had recently received anticholinesterase drugs for reversal of nondepolarizing neuromuscular blockade, or for treatment of myasthenia gravis and glaucoma.

      • SCOPUSKCI등재

        근이완 상태를 평가하기 위한 Isolation Arm Test : 근이완제의 정주 부위에 따르는 재검토 Reevaluation of Injection Site Influencing to the Twitch Responses

        황경호,김선종,김성열,김천숙,박욱,안기량 대한마취과학회 1992 Korean Journal of Anesthesiology Vol.25 No.4

        The isolation arm test at upper limb for the study of muscle relaxants sensitivity of human muscle is described. In the healthy adults, succinylcholine 100 ug/kg or vecuronium 5~6 ug/kg combined with 20 ml saline is given intravenously at various sites of injection while the circulation to the arm is occluded with upper arm pneumatic tournique. After injection of muscle relaxants, neuromuscular transmission is then studied by TOF stimulation to ulnar nerve with EMG monitor(ABM, Datex) and changes of twitch response in evoked muscle action potential amplitude from hypothenar muscle are recorded. In the results, twitch height is depressed weakly and slowly but incompletely after muscle relaxant is injected intravenously at cubital fossa, and declines further depression following recovery after the release of upper arm tourniquet occluded systemic circulation(two stage response). There are not any changes of twitch response while muscle relaxants are given intravenously between upper arm and forearm pneumatic tourniquet. But twitch height is depressed rapidely and completely after muscle relaxants are given intravenously at doris hand under the upper arm or forearm pneumatic tourniquet. Conclusively, twitch response under the isolation arm test is influenced from the site of injection, and in order to obtain the correct assessment of neuromuscular blockade, muscle relaxants will be given intravenously at dorsi hand with forearm pneumatic tourniquet.

      • 국가관광기구(National Tourism Organization)의 SNS 이용, 조직-공중 관계성, 온라인 구전 간의 영향 관계에 관한 연구 : 한국관광공사의 SNS을 중심으로

        황경호,심승하,정남호,구철모 한국경영정보학회 2016 한국경영정보학회 학술대회논문집 Vol.2016 No.11

        본 연구는 잠재적 관광객의 국가관광기구(National Tourism Organization) SNS 이용 후 지각된 주관적 평가가 조직-공중관계성 구축에 미치는 영향을 살펴본 후 이러한 과정을 통해 형성된 조직-공중관계성이 온라인 구전에 미치는 인과적 관계를 실증적으로 규명하였다. 이와 함께, 종속변수에 실질적으로 영향을 미칠 수 있는 국가관광기구의 SNS 이용행태를 통제변수로 설정하여 주요 독립변수와 종속변수 간의 인과 관계를 더욱 명확히 검증하였다. 연구결과, 국가관광기구의 SNS 이용자들이 해당 SNS을 이용한 후 지각한 주관적 평가는 조직-공중관계성을 구성하는 신뢰성, 친근성, 일반이미지, 공동체관여와 긍정적인 영향 관계를 갖는 것으로 밝혀졌다. 특히 국가관광기구의 SNS을 이용한 후의 주관적 평가는 조직-공중관계성의 4가지 구성 차원들 중 친근성에 가장 큰 영향을 미쳤으며, 그 다음으로 일반이미지, 공동체관여, 신뢰성의 순으로 영향을 미치는 것으로 나타났다. 또한, 조직-공중관계성의 구성 차원 중 친근성과 일반이미지는 구전 확산과 구전 수용 모두에 긍정적인 영향을 미치는 것으로 나타난 반면, 신뢰성은 구전 확산, 공동체관여는 구전 수용에만 각각 긍정적인 영향을 미치는 것으로 나타났다.

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