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박동연,이유상,조은영,조승희,장용이,전현옥,장수연,윤세창,김종원,홍경수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3
Objectives : The authors recently found a suggestive evidence of linkage of chromosome 8p21-12 to schizophrenia in Korean multiplex families. Neuregutin 1 (NRGI) was identified in this locus as a positional and functional candidate gene for Schizo-phrenia, through several independent studies with European and Chinese populations. The purpose of this study is to determine whether NRGl is associated with schizophrenia in Korean population. Methods : Three SNPs (SNP8NRG221533, SNP8NRG241930, SNP8NRG243177) and two microsatellites markers (478B14-848,420M9-1395) located at the 5' end of NRGI were genotyped for 242 unrelated schizophrenia patients and the same num-ber of normal controls. Genetic association was tested by χ²-test (df=1). Not only for the whole patients group but also for asubgroup of patients with auditory hallucination. This subtype showed stronger linkage with chromosome 8p12 in the prior study of the authors with multiplex families. Results : G allele of SNP8NRG241930 was significantly in excess in the subgroup of patients with auditory hallucination compared to the control group (p=0.03, 0R=1.76). We also found that 3 SNPs haplotype TTC (p=0.04, 0R=0.58) and five markers haplotype TTC53 (p=0.01,0R=0.49) were associated with schziophrenia with a protective effect. Three SNPs haplotype CGT which is a part of the at-risk haplotype of the Icelandic schizophrenia families was found in excess in the patients group but no significant association was observed. Conclusion : NRGI might either play a mle in the predisposition to schizophrenia or be in linkage disequilibrium with a causal locus of this illness.
이준,변유미,조민근,조주연,원경준,김영대,박찬국,김만우,유재근,서홍주,이석기 朝鮮大學校 附設 醫學硏究所 2008 The Medical Journal of Chosun University Vol.33 No.2
구토 후 발생한 토혈을 주소로 내원한 환자에서 좌측 늑막 삼출 동반 시 식도 파열의 가능성을 고려하여 흉수 천자 및 지속적인 흉부 단순 촬영의 추적관찰이 필요하며 식도 파열이 배제된 후 환자의 생체 징후 및 토혈 양을 파악하여 내시경 검사 시기를 신중히 결정하는 것이 좋을 것으로 생각된다. 본 증례는 토혈을 주소로 내원하여 Mallory-Weiss 증후군 의심 하에 내시경을 통한 치료 시행 후 추적 관찰에 의해 진단된 Boerhaave 증후군을 경험하였기에 보고하는 바이다. Boerhaave's syndrome is a spontaneous perforation of the esophagus most commonly resulting from a sudden increase in intraesophageal pressure combined with negative intrathoracic pressure caused by straining or vomiting. Surgery should generally be performed within 24 hours because mortality approached 30 to 50 percent in which surgery was delayed. Therefore, early diagnosis and prompt surgical repair are critical for survival. We have experienced a case of Boerhaave's syndrome in a patient presenting with hematemesis with left pleural effusion without any signs or symptoms of pneumomediastinum or pneumothorax.
이용곤,김형상,홍치유,유연봉 동국대학교 자연과학연구원 2000 자연과학연구 논문집 Vol.5 No.-
The embrittlement of fast neutron-irradiated reactor pressure vessel (RPV) steels was investigated by X-ray diffraction patterns at room temperature and Mo¨ssbauer spectroscopy at room- and liquid nitrogen-temperature. Neutron fluence on the samples were 1012, 1013, 1014, 1015, 1016, 1017, 1018n/cm². The X-ray diffraction patterns at room temperature showed that the structure of neutron unirradiated sample was bcc type, where as but the neutron irradiated samples with the fluence higher than 1017 n/cm² were so severely damaged, that bcc type structure disappeared. The Mo¨ssbauer spectra of all samples showed superposition of two or more sextets. In this paper all Mo¨ssbauer spectra were fitted by three set of sextet. The isomer shift and quadrupole splitting values were found around zero. At liquid nitrogen temperature, magnetic hyperfine field increase rapidly to 480 ∼ 552 kOe at S1 sextet in the samples of 1017∼1018n/cm² neutron fluences. And room temperature, magnetic hyperfine field also increased rapidly to 480 ∼507 kOe at S1 sextet in the samples of 1017∼1018n/cm²neutron fluences. This rapid increase of magnetic hyperfine field was infered to be caused by the change of 56Fe, 55Mn into 57Fe by neutron irradiation.
정신분열병의 인지적 표지자와 Catechol-O-Methyltransferase Val158Met 유전자 다형성의 연합연구
박해정,박동연,조은영,김나라,전현옥,이유상,이동수,홍경수 대한신경정신의학회 2008 신경정신의학 Vol.47 No.2
Objectives : Catechol-O-methyltransferase (COMT) gene has been identified as a positional and functional candidate gene of schizophrenia. Although specific mechanism of increasing schizophrenia susceptibility by this gene has not been well described yet, recent studies suggest that the valine allele of COMT Val158Met polymorphism may contribute to cognitive decline in schizophrenia. The present study investigated the association between this polymorphism of COMT gene and cognitive markers related to schizophrenia in both schizophrenia patients and normal controls. Methods : The subjects were 78 patients with schizophrenia diagnosed by DSM-IV and 97 normal controls. Comprehensive neurocognitive tests for which performance deficits have been reported in schizophrenia were administered. Genotyping for COMT Val158Met polymorphism was done with SNapShot method. Association analyses between genotype and cognitive functions were performed using ANCOVA and MANCOVA. Results : In the comparison of allele frequencies between patient and control groups, no significant association between the polymorphism and schizophrenia was observed. Significant differences of cognitive performance among genotype groups were not identified in control group. This trend was also observed in the patient group. In the combined analysis of both patient and control groups, there was no significant genotype or genotype-by group effect on any cognitive function measure. Conclusion : These findings do not support a major role of COMT gene in the regulation of the cognitive processes of schizophrenia.
Hong, Yeon-Sik,Moon, Su-Jin,Joo, Young-Bin,Jeon, Chan-Hong,Cho, Mi-La,Ju, Ji Hyeon,Oh, Hye-Jwa,Heo, Yu-Jung,Park, Sung-Hwan,Kim, Ho-Youn,Min, Jun-Ki The Korean Academy of Medical Sciences 2011 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.26 No.9
<P>The interleukin-33 (IL-33)/ST2 pathway has emerged as an intercellular signaling system that participates in antigen-allergen response, autoimmunity and fibrosis. It has been suggested that IL-33/ST2 signaling has been involved in the pathogenesis of rheumatoid arthritis (RA), because IL-33 and its receptor have been specifically mapped to RA synovium. The aim of this study was to determine the levels of IL-33 and sST2 in sera and synovial fluids in patients with RA. The serum level of IL-33 was significantly higher in patients with RA (294.9 ± 464.0 pg/mL) than in healthy controls (96.0 ± 236.9 pg/mL, <I>P</I> = 0.002). The synovial fluid level of IL-33 was significantly higher in RA patients than in osteoarthritis patients. The level of serum sST2 was higher in RA patients than in healthy controls (<I>P</I> = 0.042). A significant relationship was found between the levels of IL-33 and IL-1β (<I>r</I> = 0.311, <I>P</I> = 0.005), and IL-33 and IL-6 (<I>r</I> = 0.264, <I>P</I> = 0.017) in 81 RA patients. The levels of IL-33, sST2 and C-reactive protein decreased after conventional disease-modifying antirheumatic drugs treatment in 10 patients with treatment-naïve RA. Conclusively, IL-33 is involved in the pathogenesis of RA and may reflect the degree of inflammation in patients with RA.</P>
Hong-Yeon Yu,Min-Sung Kim,Do-Young Jun,Chan-Hyon Kim,Sung-Hoon Hong 대한전자공학회 2007 ITC-CSCC :International Technical Conference on Ci Vol.2007 No.7
In this paper, we propose an efficient moving object extraction algorithm which is suitable for content based digital video applications. The proposed algorithm combines the background histogram modification and the local watershed techniques. The current background area is estimated by using the histogram modification table which maps the original background image to the current on. Then, the moving object region is extracted by background subtraction. Finally, the local watershed segmentation and hierarchical queue based region merging are applied on the uncertain region of moving object mask instead of whole image region, which can decrease processing time. Also proposed method is robust to both noise and intensity changes in the present input image. Experimental results show the effectiveness and convenience of our method.
Flowing with Jeju heanyeo - Jeju National University High school club Tewak is floating
Hong Ji Hee,Kang Gyeong Ji,Kim Eun Hee,Kim On Yu,Lee Yu Bin,Ko Jun Hyeok,Kang Min Jae,Yang Hyeon Jeong,Yang Yeon Jae,Sim Yu Rim,Kim Min Ji,Geum Na Hyeon,Kim Geum Byeol,Heo Jeong In 제주학회 2016 제주학회 학술발표논문집 Vol.2016 No.2
Crowd Counting 경량화를 위한 Knowledge Distillation 적용 연구
홍연주 ( Yeon-joo Hong ),전혜령 ( Hye-ryung Jeon ),김유연 ( Yu-yeon Kim ),강현우 ( Hyun-woo Kang ),박민균 ( Min-gyun Park ),이경준 ( Kyung-june Lee ) 한국정보처리학회 2023 한국정보처리학회 학술대회논문집 Vol.30 No.2
딥러닝 기술이 발전함에 따라 모델의 복잡성 역시 증가하고 있다. 본 연구에서는 모델 경량화를 위해 Knowledge Distillation 기법을 Crowd Counting Model에 적용했다. M-SFANet을 Teacher 모델로, 파라미터수가 적은 MCNN 모델을 Student 모델로 채택해 Knowledge Distillation을 적용한 결과, 기존의 MCNN 모델보다 성능을 향상했다. 이는 정확도와 메모리 효율성 측면에서 많은 개선을 이루어 컴퓨팅 리소스가 부족한 기기에서도 본 모델을 실행할 수 있어 많은 활용이 가능할 것이다.