원자력 발전소 근로자에서 업무상 질병으로 인정받은 급성 골수성 백혈병 1예

임현술,정해관,김수근,박병찬,이관 약업신문사 1983 의약정보 Vol.9 No.-

腸收縮機能에 미치는 Diazepm의 影響

林良洙,朴海根 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.2

This study was carried out to determine the effect of diazepam on the isolated intestinal smooth muscles. The intestinal mucle strips were prepared from mouse duodenum (about 2cm long) and were arranged isometrically, in vitro. Intestinal motility was recorded on a Physiograph (Four-A, Narco Biosystem) with force transducer (F-60) by means of Magnus method in Lock's solution. Diazepam significantly inhibited (p<0.001) the contractility of isolated smooth muscle in concentration of 0. 02, 0. 04, 0. 05, and 0.08mg/ml by dose dependently, and ceased the contraction in the concentration of 0.08mg/ml, and the effect of diazepam was not affected by presamina(10^-6M) propranolol (10^-4M), hexamethonium (10-5M), and acetylcholine (10-4b1). Diazepam inhibited the K^+-induced contraption by dose dependently and also in Ca^++-free Lock's solution, and effect of diazepam (0.08mg/ml) on muscle contraction was same pattern by the, effect of verapamil (10-7M). Diazepam (0.08mg/ml) decreased ^45Ca^++-uptake by the isolated intestinal muscle strip significantly (p<0.05) but more potent effect was observed by verapamil (10^-7M). These results suggested that diazepam inhibited the contractility by inhibiting the Ca++ movement by means of direct interaction with receptor in the muscle membrane.

원자력 발전소 근로자에서 업무상 질병으로 인정받은 급성 골수성 백혈병 1예

임현술,정해관,김수근,박병찬,이관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.2

저자들은 10여 년 동안 원자력 발전소 협력업체에 종사하면서 저선량의 방사선에 노출된 근로자로 급성 골수성 백혈병으로 진단 받고 사망 후 업무상 질병으로 인정된 증례를 보고하는 바이다. 증례에 대한 의무기록과 혈액검사 및 조직검사, 세포유전학 검사를 검토하였으며 환자의 작업 내역, 방사선 피폭량 및 동료 근로자에 대하여 조사하였다. 환자는 35세 남자로 1997년 11월 20일 경북 포항시 소재 D 대학병원에서 용접공에 대하여 실시하는 기타 중금속 특수건강진단(망간)에서 백혈구 수가 μL당 108.9×10³개, 혈색소는 8.6g/dL로 급성 백혈병을 의심하였다. 11월 24일 대구광역시에 위치한 K 대학병원을 방문하여 급성 골수성 백혈병으로 확진되었다. 골수검사에서 이소성 B 임파구성 표지자를 지닌 AML M2로 진단되었고, 염색체 검사에서 필라델피아 염색체가 발견되었으며, 46 XY t(1:4)(p32:p16)의 소견을 보였다. 항암 화학요법을 시행하였고 주기적인 항암 약물요법과 추적 관찰을 시행하였다. 1999년 5월 30일 급성 골수성 백혈병에 의한 합병증인 폐렴 및 패혈증으로 사망하였다. 본 증례의 방사선 피폭량은 1,853 mRem (18.53 mSv)이었으며, 방사선에 의한 암발생 원인확률은 미국 기준으로 5.4-6.1%이었다. 우리나라는 업무상 질병인정 기준에 방사선 노출에 의한 백혈병이 인정된다고 명시하고 있어 업무상 질병으로 인정되었다. 그러므로 우리나라 실정에 맞는 전리방사선 피폭량에 따른 업무상 질병 인정기준을 설정하여야 하며 방사선 피폭 근로자에 대하여 방사선 질환의 감시체계를 운영하여야 한다. Acute myelogenous leukemia (AML) has been known as an occupational disease induced by irradiation. We report a case of acute myelogenous leukemia with a history of low dose irradiation in a nuclear power plant. The authors reviewed the clinical and hematologic features of the case. We also reviewed the job contents of his workplace. We also interviewed other workers in the same workplace. The amounts of radiation exposure were reviewed. The worker was a 35-year-old male who had worked in a nuclear power plant for 11 years (1987-1997). Total amounts of radiation exposure during the work period was 1,853 mRem. He had been diagnosed as AML on November, 1997 at a routine periodic health examination. He died of refractory leukemia on May, 1999. The AML developed in this patient seems to be related to the exposure to radiation. To prevent irradiation injury, we must modify work procedures, begin comprehensive medical surveillance, educate workers on risks of radiation, and increase workers awareness of safety regulations in the workplace.

유리섬유에 의한 피부질환 및 임상적 진단

임현술,김정란,정해관,김수근 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.2

This study was conducted to evaluate the health hazards and to develop diagnostic methods of glass fiber workers. We examined 40 male glass fiber workers(exposure group) and 57 male non-glass fiber workers (reference group) with a questionnaire, physical examination, chest x-ray and pathological examination in Mar, 1997. Also we examined 65 male glass fiber workers(exposure group) and 42 male non-glass fiber workers(reference group)with the same methods also we did some energy-dispersive x-ray analyses with a scanning electron microscopic examination in Sep, 1997. Most of the clinical symptoms were significantly more frequent among the exposure group than the reference group. Coughing(32.5%), itching of the nose(30.0%), irritation of eyes(27.5%), irritation of the nose(25.0%) and sputum(22.5%) were the major symptoms among the exposure group in Mar, 1997. Only itching of the nose was significantly more frequent in Sep, 1997. No cases of pneumoconiosis were observed among the groups and there were no differences in chest abnormalities between the exposure group with the reference group on both examinations. The prevalence of dermatosis among the exposure group was 20.0% (8cases) and the cumulative prevalence was 72.5%(29 cases) in Mar, 1997. The prevalence of dermatosis among the exposure group was 23.1% (15 cases)and the cumulative prevalence was 58.5%(38 cases) in Sep, 1997. Onset of dermatosis among the exposure group was most frequent within one month after handling. The frequent sites of skin lesions were the hands and arms on both examinations. Glass fiber induced skin lesions can be diagnosed by the scotch tape method or KOH mount and then can be examined under the light, polarizing and phase-contrast microcopies. Glass fibers can be identified by some energy-dispersive x-ray analyses with a scanning electron microscopic examination.

일개 자동차 부품공장 근로자에서 초음파로 측정한 수근관 형태와 수근관증후군 위험도

김덕수,정해관,임현술,권용욱,이종민,조대현,최대섭 大韓産業醫學會 2002 대한직업환경의학회지 Vol.14 No.3

목적 : 일개 사업장의 생산직 근로자를 대상으로 손목 계측치 및 초음파를 이용한 수근관 계측치의 상관성 분석을 통하여 수근관증후군 발생에 관여하는 개인의 감수성 및 위험요인을 파악하여 생산직 근로자들의 수근관증후군 예방에 활용하고자 본 연구를 수행하였다. 방법 : 경주시에 위치한 자동차 방음재를 생산하는 사업장에 생산직 근로자 남자 24명, 여자 11명 등 총 35명을 대상으로 2000녀 4월과 2000년 10월 반드시 각 설문조사, 이학적검사, 전기진단검사를 실시하였으며, 2000년 10월에는 초음파를 이용한 수근관계측도 실시하였다. 결과 : 수근관증후군의 신체계측 요인에 따른 분석에서는 수근관 전치/폭 비가 0.17 미만인 군에 비하여 0.17 이상인 군에서 통계적으로 유의하게 높았다(p<0.05). 총 수근관 면적(두께×폭)은 300 ㎟이상인 군에 비하여 300㎟ 미만인 군에서 통계적으로 유의하게 높았다(p<0.05). 성별을 통제변수로 처리한 신체 계측치간 상간 분석에서는 수근관폭은 전기진단 검사와 음의 상관성을 보였으며, 수근관 두께는 전기진단 검사와 양의 상관성을 보였다. 수근관 두께/폭 비는 전기진단 검사와 양이 상관성을 보였으며, 수근관비 전치/두께 비는 전기진단 검사 결과와 음의 상관성을 보였다. 하부 수근관 면적[폭×(두께-전치)]은 전기진단 검사와 양의 상관성을 보였으며, 상부 수근관 면적(폭×전치)은 전기진단 검사와 음의 상관성을 보였다. 또한 수근관 전치의 상대적 비가 클수록 수근관증후군의 회복이 유의하게 좋았다. 결론 : 수근관증후군은 수근관 폭이 좁을수록, 수근관 두께가 두꺼울수록, 수근관 전치가 작을수록 수근관증후군 위험도가 증가한다. 저자들은 초음파를 이용한 수근관 형태의 측정은 수근관증후군의 발생의 내적 요인에 대한 중요한 정보를 제공하면 수근관증후군 발생 및 회복의 개별적 위험요인을 예측하는데 중요한 근거를 제공하는 것으로 판단하였다. Objectives: This study was conducted to evaluate individual susceptibility to carpal tunnel syndrome (CTS) by ultrasonographic measurement of the carpal tunnel configuration in workers doing repetitive work. Methods: The study subjects consisted of 24 male and 11 female workers in a soundproof material manufacturing company in Gyeongju. We conducted a self-reported questionnaire survey, a physical examination and an electrodiagnostic study (EDS) in April 2000. After the examination, jobs were rearranged for workers with CTS. A follow up physical examination. EDS, and measurement of the carpal tunnel by ultrasonography was done six monsths later. Results: Of those studied. prevalence or CTS was 63.6/100 persons among women and 29.2/100 persons among men. Mean depth and width of wrist was shorter in those with CTS compareal to the controls (p<0.05). The risk of CTS was higher in workers whose carpal tunnel ratio (displacement/width) was 0.17 or higher (OR 7.13, 95% confidence interval 1.18-43.1), and in workers whose carpal tunnel area was less than 300 ㎟ (OR 8.00, 95% confidence interval 1.18-68.5). Carpal tunnel depth and depth/width ratio had a positive correlation with motor latency of the median nerve and median-ulnar sensory latency difference (p<0.05). whereas the carpal tunnel width. displacement/depth ratio, and area (width×displacement) had a negative correlation with median nerve latencies after adjusting for gender. Workers who showed an improvement in the clinical stage of CTS after job rearrangement had a significantly lower carpal tunnel displacement/width ratio and displacement/depth ratio. They also had smaller upper carpal tunnel area (width×displacement) and larger upper carpal tunner\l area [(depth-displacement)×width] than the controls (p<0.05). Conclusions:Ultrasonographic measurement of the carpal tunnel is a good predictor of susceptibility and prognosis of CTS in workers doing repetivive work.

스포츠 외상에 의한 척추·척수손상 분석

김대경,임완기,임정일,김범수,추해광,강은균 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.2

I have researched 46 examples, 43 are spinal column and cord injury and 3 are thoracic vertebrae and cord injury, of J hospital S health caring center. 46 patients were cured by this J hospital medical staffs, and their external injury were caused by sports accidents. I have acquired next four meaningful conclusions. First, the external injury caused by golf sports are 24 cases, and this is the primary cause of injury. Second, high-rank bonn fracture are 78.8 percent in C4, C5, C6 situation. And the bone-fracture, tear-drop fracture, figure in the activity of gold is 45.8 percent, and fracture dislocation is 63.2 percent in other sports activities. Third, there are twenty six cases of paralysis that links frankel C. Four, the sports injuries such as bone fracture are able to prevent by education and effective learning programs.

한국어의 특성을 고려한 용례 검색 시스템

홍금원,임재수,서희철,임해창 고려대학교 컴퓨터과학기술연구소 2001 JOURNAL OF COMPUTER SCIENCE & ENGINEERING TECHNOLO Vol.3 No.-

본 논문에서는 한국어의 특성을 고려한 용례 검색 시스템을 제안한다. 제안된 시스템은 직접 용례 검색과 색인 기반 용례 검색을 제공한다. 직접 용례 검색에서는 원시 말뭉치에서 한글 음절 단위의 검색뿐만 아니라 한글 자소 단위의 검색이 가능하며, 색인 기반 용례 검색에서는 어절, 형태소, 그리고 체계화된 품사정보를 이용한 검색이 가능하다. 검색속도 및 색인된 파일의 크기는 실험을 통하여 최적화 한다. 사용자는 검색된 용례로부터 연산 및 정렬 과정을 거쳐서 보다 정확하게 선별된 용례를 얻을 수 있다. 본 시스템을 통해 얻어진 용례 정보는 사전 편찬 등의 한국어 연구의 기초 자료로 활용할 수 있으며, 말뭉치를 기반으로 한 다양한 분야에서 활용할 수 있을 것이다. In this paper, we propose the concordance system considering the characteristics of Korean. The proposed system provides two kinds of retrieval method: direct access retrieval and index based retrieval. In direct access retrieval method, it is possible to retrieve examples using grapheme-based query as well as syllable based query. In index-based retrieval method, it is possible to retrieve examples using eojeol, morpheme, or part-of-speech. The speed of the system and the size of the indexed file is optimized through several experiments. Users can acquire the exact and selective examples from previously retrieved items by filtering and/or sorting. The linguistic information acquired by the system can be utilized as basic data for Korean Linguistic research such as lexicography and it can be used in various application fields based on corpus.

Physiochemical Characteristics of Lim’s Valley Potatoes in Korea

Hee-Don Choi,Hae-Chang Lee,Sung-Soo Kim,Yun-Sook Kim,Hak-Tae Lim,Gi-Hhyung Ryu 한국원예학회 2008 한국원예학회 기타간행물 Vol.- No.-

Potential hybrids of Miscanthus sinensis x M. sacchariflorus revealed by morphological traits analysis

Soo-Hyun Lim,Hae-Rim Park,Dong-Gil Kim,DoKyoung Lee,Gyoungju Nah,Do-Soon Kim 한국육종학회 2015 한국육종학회 심포지엄 Vol.2015 No.07

More than 300 Miscanthus accessions as a potential bioenergy crop were collected in Korea and their morphological traits were investigated at various growth stages. Among morphological traits, stem growth habit, the presence of awn in spikelet, and autumn new shoot are the most important key traits enabling to cluster Miscanthus accessions into M. sinensis and M. sacchariflorus groups. Miscanthus sinensis has bunch stem growth habit and awn in spikelet, and produces autumn new shoot, while M. sacchariflorus has scattering stem growth habit with no awn in spikelet and does not produce autumn new shoot. Interestingly, we found several Miscanthus accessions showing intermediate morphological traits. 7 M. sinensis accessions showed morphological traits similar to M. sacchariflorus and 17 M. sacchariflorus accessions showed morphological traits similar to M. sinensis. Flow cytometry and chromosome counting finally revealed 5 Miscanthus hybrids, suggesting that they are resulted from natural hybridization between M. sinensis and M. sacchariflorus. Therefore, these Miscanthus hybrids can be used to understand genetic recombination between these two Miscanthus species and our understanding may support future efforts for breeding new Miscanthus variety with high biomass productivity and environmental adaptability.

HCC : Vascular Enhancement Patterns of HCC with Contrast-Enhanced Ultrasound

( Hae Lim Baek ),( Yun Soo Kim ),( Young Kul Jung ),( Oh Sang Kwon ),( Ju Hyun Kim ),( Duck Joo Choi ),( Yeon Suk Kim ),( Yang Suh Ku ),( Seung Jun Jang ),( Seung Kak Shin ),( Hyunhwa Yoon ),( Soo Yon 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1

Background: Classic enhancement pattern of hepatocellular carcinoma(HCC) with dynamic CT or MRI includes hyperenhancement in arterial phase and hypoenhancement during portal and delayed phase. It is known that vascular pattern after SonoVue injection is similar to that observed with CT or MRI. However, atypical enhancement and washout pattern are not unusually encountered with CEUS. We have studied CEUS patterns of HCC in 32 consecutive patients with HCC. Methods: 32 HCCs were analysed(mean age 55.5, 6 females, 26 males). Twenty two were diagnosed with liver biopsy, and in 10 patients diagnosis was made with typical dynamic CT or MRI findings. CEUS using SonoVue(Bracco, Milan, Italy) were performed. Arterial, portal and delayed phases were determined as -30s, 31-120s and 121-360s. Results: HBsAg and anti-HCV were positive in 24 (75%) and 5 (15%) patients, respectively. Mean tumor size was 5.3±4.3 cm (1.1-20.0 cm). Mean serum alpha fetoprotein was 9,174 ng/mL (1.3-200,000 ng/mL). All the HCCs showed arterial enhancement (hyper or iso-). Arterial hyperenhancement was observed in 26 (81%) lesions, and remaining 6 (19%) HCCs showed isoenhancement relative to the adjacent liver parenchyme. Hypoenhancement (wash-out) in portal phase was observed in only 9 (28%) lesions (mean diameter: 5.1±4.2 cm), and remaining 23 lesions (72%) were isodense in portal phase (mean diameter: 5.4±4.5 cm). Hypoenhancement in delayed phase was observed in 28 lesions (88%) (mean diameter: 5.8±4.4 cm). And remaining 4 lesions showed persistent isoenhancement until 6 min, and their mean diameter was 2.2±0.9 cm (P=0.126). Enhancement during arterial phase, isoenhancement during portal and hypoenhancement during delayed phase was observed in 19 (59%) lesions, which was most common enhancement pattern. Conclusions: Arterial hyperenhancement with isodense portal phase and hypoenhancement in delayed phase was most common CEUS finding in HCC. It seems that tumor size affects on the hypoenhancement during delayed phase in CEUS.