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      • KCI등재후보

        Audiologic Results of Ossiculoplasty Using Malleus Footplate Assembly: The Comparison between Autologous Incus and Hydroxyapatite

        Sun O Chang,Sue Jean Mun,Joo Hyun Park,Chang Myeon Song,Kyu-Hee Han,이준호,Seung Ha Oh 대한청각학회 2011 Journal of Audiology & Otology Vol.15 No.3

        Introduction A disruption of the ossicular chain of the middle ear causes conductive hearing loss. Ossicular reconstruction is performed to restore hearings in those patients with congenital ossicular chain anomaly or ossicular chain disruption caused by chronic otitis media or cholesteatoma. A study from Japan with 52 auditory ossicular malformation revealed that 44% of the patients had a fixation of the stapes, 40% had incudostapedial joint defects followed by fixation of the malleus and/or incus and defects in the incudostapedial joint with a fixation of the stapes.1) One of the most common ossicular chain anomalies in Korea was a stapes footplate fixation (54.5%) followed by a mobile stapes footplate with other anomalies (19.7%) including a stapes without suprastructure and an incus long process, stapes without anterior crus and an incus long process.2) One of the most common ossicular chain anomalies is the absence of an incus with or without an intact stapes suprastructure. In incudostapedial deformed ears, ossiculoplasty is mandatory to restore the hearing process. Ossiculoplasty is also needed in cases with incus long process erosion with inflammation. As the most vulnerable ossicles, one report said that incus erosion is found in 80% of the chronic otitis media.3) Austin-Kartush classified ossicular chain disruptions into four categories after 1,151 operation on chronic otitis media. Group A ears with an intact malleus handle and a stapes suprastructure was found in 59.2% followed by group B ears with an intact malleus handle but an eroded stapes suprastructure group.4) In the group of a tympanic membrane and malleus preserved but a stapes suprastructure eroded, ossicular continuity can be restored between the stapes footplate and manubrium of the malleus with the method of malleus footplate assembly (MFA) using either the incus body or if the incus is unavailable, a biocompatible material such as hydroxyapatite (HA).5,6,7) Until now, MFA has proven to be the safe and effective way to restore hearings in such patients.8,9,10,11,12)Though successful results using MFA with either incus body or biocompatible material are reported world widely, there were a few reports on audiologic results after MFA ossiculoplasty in Korea. Authors reviewed our procedure and report hearing results of ossiculoplasty with MFA using either incus or HA. In this paper, a single-surgeon series of 32 MFA operations was analyzed. The cases were limited to autologous interposition grafts performed on Austin-Kartush group B ears in order to provide consistency within the analysis. Subjects and Methods Data collection A retrospective evaluation has been carried out on patients who underwent MFA ossiculoplasty between September 2001 and March 2010 in Seoul National University Hospital. A total of 55 patients with Austin-Kartush type B defect repaired with incus body or HA were identified. Of those, 20 were excluded due to a failure to recover operation records or a lack of no more than 1 year postoperative audiograms. Three patients who had undergone MFA with a homologous incus were excluded in order to provide consistency within the analysis. Finally, 32 cases were enrolled into the study. All procedures were conducted by a single surgeon. All data including previous operations, follow-up duration, age, sex, etiology, materials which were used in the operation, combined mastoidectomy, complications, and revision operations were analyzed. Eustachian tube function was analyzed according to the results of the Eustachian tube test. The status of the middle ear mucosa was described as either 'healthy' or 'inflamed' according to the operation records. Demographic data are presented in Table 1. Analysis of audiologic data Preoperative and postoperative hearing results were evaluated according to the guidelines of the Committee on Hearing and Equilibrium of the American Academy of Otolaryngology-Head Neck Surgery Foundation13) an... Background and Objectives: Absence of incus is one of the most common ossicular anomalies and also frequently found in chronic otitis media or chornic otitis media with cholesteatoma. Ossiculoplasty with malleus footplate assembly (MFA) can be an excellent option in the above situations. We reviewed our procedures and evaluated the hearing results of ossiculoplasty using the MFA. Subjects and Methods: This study retrospectively reviews a series of 32 patients who underwent MFA ossiculoplasty between September 2001 and March 2010 in an academic tertiary referral center. The autologous incus or hydroxyapatite (HA) was used as materials for reconstruction. Results: Thirteen of 32 patients (40.6%) had ossicular chain anomaly, 9 patients (28.1%) had congenital cholesteatoma and 8 patients (25.0%) had chronic otitis media with cholesteatoma and 2 patients (6.3%) had chronic otitis media. The patients with ossicular chain anomaly showed the greatest air-bone gap (ABG) closure. Overall, postoperative ABG was 17.7±11.7 dB at postoperative 6 months and 19.7±14.3 dB at postoperative 1 year, compared with preoperative ABG of 37.9±9.3 dB. There was no statistical difference of ABG at postoperative 12 months, 24 months between MFA using incus (n=17) and HA (n=15)(p=0.300, and p=0.563). There was no meaningful difference of postoperative ABG between the patients with combined mastoidectomy (n=10) and those without mastoidecmoy (n=22)(p=0.555). No extrusions occurred.

      • 벽오동(Firmiana sirmlex W.F.Wight) 가지의 수용성 추출액이 작물발아에 미치는 Allelopathy의 효과

        박현철,박선일,하상영 東亞大學校生命資源科學大學附設 農業資源硏究所 1997 農業生命資援硏究 Vol.6 No.1

        벽오동나무 2년, 3년생 가지를 1월과 4월에 채취하여 수용성 추출액을 희석 농도별 공여작물에 발아 실험하여 Allelopahy의 효과를 조사항목별 결과는 다음과 같다. 발아율은 시료의 년별, 월별에 있어 년별 또 토마토, 벼는 월별 발아억제 효과가 없고 월별은 배추, 갓은 1월에 발아율이 낮았으며, 발아기는 벼가 제일 빨랐으며, 다른 공여작물은 무처리에 비하여 2배 내지 3배 정도의 기간이 더 지연되었으며 발아평균기간은 년수에 관계없이 배추, 갓, 벼는 1월이 지연되었으며, 토마토는 오히려 4월은 지연되었다. 발아양부는 벼를 제외한 공여작물은 4월 채취가 발아양부가 양이었으며, 1월은 불량이 많았다. 농도 30%에서는 중, 불량이었으며, 벼는 년수, 월별, 농도에 관계없이 지수가 양이었다. Two and three years old branches of a Phoenix tree were respectively collected on January and April, and the aqueous extract from the branches was then treated to four tested crops, Chinese cabbage, leaf mustard, tomato and rice, in order to find the allelopathic effects by different concentration of the extracts. Generally, there were allelopathic effects of the aqueous extracts on the tested crops with increment of concentration and regardless of branch ages and/or collecting season. The results were summarized as follows. Germination rate of Chinese cabbage and leaf mustard were lower with treatment of the extracts from the branches which were collected on January. Otherwise, there were no significant effects of the extracts on the germination of tomato and rice. Germination time of rice were greater than other crops which germination time were delayed. Average germination time of Chinese cabbage, leaf mustard and rice were delayed with value of tomato was delayed with treatment of the extracts from the branches collected on April. State of germination of all crops, except rice were high with treatment of the extract on April, and were low on January. In case of rice, it was high without regard to the collection season of branches and concentration of extracts.

      • 균열밀도에 따른 R·C 슬래브 교량의 내하력 평가

        박길현,양승현,황선하,정경덕 朝鮮大學校 建設技術硏究所 2003 建設技術硏究 Vol.23 No.1

        Through the exterior features on reinforced concrete slab, crack density and crack originate deflections ratio crack density, decrease percentage of load carrying capacity, crack originate deflections ration and decrease percentage of load carrying capacity were statistically analyzed. Crack density, crack originate deflections ratio and decrease percentage of load carrying capacity are very closely related each other with 0.724, 0.821 and 0.317 of correlation coefficient within 95% of mind level. However, the correlation between crack originate deflections ratio and decrease percentage of load carrying capacity was low. Through the regression equation curve method in which crack density selected as independent variable, crack originate deflections ratio and decrease percentage of load carrying capacity as dependent variable, regression equations were presumed. Equations exist in mind level range of F(0.05, S-curve showed the highest, conformance with 79.5%, 72.2%. The regression equation between CRD or LCCD and CD was also shown. The overall judgement of load carrying capacity of bridges can be possible through the moreover investigation of crack density, the time needed precision could be valuable data for lower maintenance cost, the degree of deterioration of bridges and safety judgement.

      • KCI등재

        구개부에 발생한 다형선종의 처치

        하주원,백승,송종운,박충열,이용욱,박홍주,오희균,유선열,김옥준 大韓顎顔面成形再建外科學會 2001 Maxillofacial Plastic Reconstructive Surgery Vol.23 No.6

        Pleomorphic adenoma of the palate is the most common of all intraoral salivary tumors. It can occur at any age but it presents most commonly in the 40∼60 age group, and there is no significant sex preponderance. It grows slowly and is usually painless, firm, well-circumscribed nodule. Because of high rate of recurrence, extra-capsular excision including the overlying mucosa and margin of normal tissue is recommended. We report 10 cases of palatal pelomorphic adenoma which have been successfully treated by extra-capsular excision. The surgical defects smaller than 3㎝ in diameter were covered with palatal acrylic splint for the secondary healing. The larger defects were repaired using palatal island flap in 3 cases, rotation flap and buccal fat graft in each 1 case. No patient showed any recurrence or malignant change during the mean follow-up period of 4 years and 9 months. These repair methods seem to be simple, reliable and uncomplicated procedures in the palatal surgical defects.

      • RC교량의 외관상태지수가 내하력에 미치는 영향

        박길현,황선하 朝鮮大學校 建設技術硏究所 2007 建設技術硏究 Vol.27 No.2

        In a regularly intervaled check service, sight checking may not be the best way to check internal problems, but it is a very fit process to examine objectively in a economical point of view. Since sight checking is limited by its quality and quantity, it is necessary to use the small numbers of uncertainties in many different points with our instinct and experiences. Since sight checking is limited by its quality and quantity, it is necessary to use the small numbers of uncertainties in many different points with our instinct and experiences. Because of these certain situations, the condition and the reliability have been evaluated by professional instinct and scientific decisions. Properties of the selected items were standardized with reference to the existing research results and actual data. As for the item that is difficult to represent quantitatively, word variable of the Analytic Hierarchy Process was introduced and standardized so that the objectivity of the subjective valuation was acquired. Results from this study are as followed, It is possible to acquire very reliable appraisal results of the reinforced concrete bridges according to the Analytic Hierarchy Process defined in this study. Result from this study can be applied practically through the application and analysis of the appraisal technique and the procedure with actual data. Verification through the practical uses and improvements are required for the development in this field.

      • 균열밀도에 따른 RC교량의 내하력 평가 및 수명 예측

        박길현,황선화,박종환 朝鮮大學校 建設技術硏究所 2006 建設技術硏究 Vol.26 No.1

        There are several causes, the Percussion from the exterior, the decline of capacity by circumstances, the crack occurred in the interior, the carbonation and soon, that can shorten the span of the concreted construction. And crack density of bridge structures gets higher when they are deteriorated because the concrete crack is the problem of usability. Higher crack density cause the higher bending moment and lower load carrying capacity. In this reason, crack investigation was executed to understand the relation among the degree of degradation caused by the crack occurred on reinforced concrete structures and deflections ratio and load carrying capacity. Deflections ratio and decrease percentage of load carrying capacity of the structures were statistcally analyzed when medium crack which has crack width over O.lmm generated. However, the crack itself, as the primary factor of the life-curtailment of concreted construction, is principal and should bring about the erosion of the reinforcing rod and the span of life.

      • 새로운 세파로스포린 유도체의 합성과 항균력에 관한 연구

        박의석,김하정,최원식,황선암 순천향대학교 기초과학연구소 1996 순천향자연과학연구 논문집 Vol.2 No.1

        New cephalosporin antibiotics, 7-[(3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4-thiazin-3-yl 1-oxide) -acetamido]-3-heterocyclothiomethyl-3-cephem-4-carboxylic acid derivatives (2a-2d) were synthesized. Anti-bacterial activities of these new cephalosporin derivatives and the relationship between their stucture and their activities were examined. Among them, 7-[3,4-dihydro-6-methoxycarbonyl-2,2-dimethyl-2H-1,4- thiazin-3-yl1-oxide)acetamido]-3-[(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl]-3-cephem-4-carboxylic acid exhibited the broad antibacterial activities against Gram(+) and Gram(-) bacteria.

      • KCI등재후보

        아질산 노출이 이스라엘잉어 혈장내 아질산 농도 및 간장 약물대사효소에 미치는 영향

        박관하,최상훈,김영길,김용호,최선남,김종배 한국환경독성학회 2003 환경독성보건학회지 Vol.18 No.2

        Effects of ambient nitrite, N0₂^(-), at 1, 3, 10 and 30 mg/l, on the changes of plasma nitrite/nitrate and on hepatic drug-metabolizing enzyme activity were examined in the juvenile Israeli carp, Cyprinus carpio. When the fish were exposed to 1 and 3 mg/l N0₂^(-), there was an exposure duration-dependent increase in plasma N0₂- over the 96-hr period reaching 6~7 fold excess the ambient concentration, In the fish exposed to 10 mg/l, a plateau concentration of less than 2-fold of the environment was attained in 12 hr. With 30 mg/l, however, the maximal plasma NOf was 41.25 mg/1 at 12 hr followed by a gradual decline. There was a concentration increase in methemoglobin (metHb) level in all N02^(-)-exposed groups and a significant decrease in hematocrit value in 30 mg/l group after 96-hr exposure. Apart from the blunted increase in plasma N0₂^(-) with higher N0₂^(-)(10 and 30 mg/1) exposure, the ratio of plasma N0₃^(-) to N0₂^(-) was significantly higher in these groups compared to 1 and 3 mg/l. The imbalance in the plasma N0₃^(-)/N0₂^(-) at higher N0₂^(-) exposure suggests a possible accelerated conversion of N0₂^(-) to N0₃^(-). Nitrite exposure did not affect the hepatic drug-metabolic activities in juvenile Israeli carp. All these data indicate that disposition of N0₂- differ depending upon exposed concentration and that metHb production may not be the exclusive toxic mechanism in carp

      • 퇴비 및 부산물 비료의 시비량에 따른 잎들깨의 생장특성

        박선일,정대수,하상영 東亞大學校 1999 東亞論叢 Vol.36 No.-

        잎들깨에 유기질 퇴비와 부산물 비료를 시비량의 차이에 따라 재배한 생장의 특성을 조사한 결과를 요약하면 다음과 같다. 초장은 퇴비나 부산물 비료의 종류에 구별없이 시비량이 증가하면 초장이 생장에 기여하며, 엽의 길이에는 인분분박과 구비에서 길이의 신장이 우수하였으며, 엽폭은 명신바이오에서 넓어지는 현상이 있고 4종류의 비료는 비슷하며, 엽의 건물비율은 시비량이 증가하면 건물비율이 증가하는 현상이 있으나 순수동화량의 생산량을 결정하는 환경요인이 관여하는 것으로 판단되고, 엽내의 무기원소의 함량은 분석한 무기원소의 함량은 모두가 비슷하였고, S는 모든 엽에서 함량이 적었다. This study was conducted to elucidate the growth characteristics of perilla by fertilizer level of manure and organic compost. In this study, as the fertilizer level of manure and organic compost increased, height of perilla was increased. Leaf length was the longest in human manure and cattle manure, and leaf width was the widest in Myoungsin-Bio. As the fertilizer level increased, the rate of dried leaf weight was increased, but the real assimilation quantity was decided by environmental factor. There were no difference in the content of inorganic element of the perilla leaf. However, S in the leaf was low.

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