습동면유 겸용 수용성 금속가공유제의 제조 및 특성 연구

윤을용,노정석,김해원,김선덕,진경록,김재권 한국공업화학회 2004 응용화학 Vol.8 No.2

At processing of a metal process, much problems are happening by mixing between slide-way fluid and water-solubility metal-working fluid(MWF). In this study, measure physical & chemical properties and biodegradable properties of base stock and additives that is used to lubricant, and developed water-soluble metal working fluid by slide-way fluid combined use. Biodegradability of developed combined use fluid for 28 days is displayed lower than 10 ppm, and more superior performance than similar fluids in lubrication special quality test.

양극성 장애에서 표피성장인자의 유전적 다형성에 대한 연합연구

김수경,이규영,주은정,강웅구,안용민,김용식 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.6

Objectives : Epidermal growth factor (EGF) is a neurotrophic factor which regulates the intracellular signaling molecules. These molecules are also affected by mood stabilizers such as lithium and valproate. In addition, epidermal growth factor enhances neuronal survival, maturation and differentiation especially in midbrain dopaminergic neurons of which dysfimction may play a role in pathophysiology of bipolar disorders. Bipolar disorder has some genetic commonalities with schizophrenia, and several association studies of EGF have been done with schizophrenia. In this study, we tried to investigate the geneticassociation between EGF A61G polymorphism and bipolar disorder. Methods : Total of 189 patients and 347 nonnal control were included. All patients satisfied the diagnostic criteria of DSM-IV for bipolar disorder type I (BPDI, N= 146) and bipolar disorder type II (BPDII, N=43). Genomic DNA was extracted from the peripheral blood, and genotyping was performed by TaqMan™ method. Genotype and allele frequency of EGF A61G polymorphism between the patients and the control were compared by contingency chi-square test or the Fisher's exact test. Results : No association was found between EGF A61G polymorphism and susceptibility of BPDI, BPDII and bipolar disorder (all patients). Female patients with BPDII showed overexpression of AG genotype compared to that ofcontrol group (p=0.03). However, this association was not significant after correction of multiple testing. Conclusion : In conclusion, EGF A61G polymorphism has no association with susceptibility of bipolar disorder. However, the disease modifying role of EGF gene polymorphism for bipolar disorder remains to be elucidated in respect to factors such as gender difference or diagnostic subtype.

외과계 집중치료실에서 입원한 환자에서 APACHE II score의 의의

이영재,이영준,박순태,하우송,정민화,권수인,조영현,권진용,최상경,손신 대한외상학회 1997 大韓外傷學會誌 Vol.10 No.1

This study attempts to evaluate the prognostic value of the APACHE II scoring system in patients of surgical intensive care unit(SICU) and to examine its usefullness in stratifying these patients according to their surgical risk and as a potential aid in making rational and objective treatment decision. The records of 161 patients admitted to the Department of Surgery, Gyeong-Sang National University Hospital between Jan. 1991 and Dec. l995 were reviewed. 1) Of a total of 161 patients, 87 were male, 74 were female, and male to female ratio was 1.71: 1. 2) This group was seen most commonly in the age group of 55-64 which occupied 30.3% of entire group. 3) The distribution of patients according to the etiology were 74 patients(46%) in trauma, 61 patients(37%) iin postop-complication, 26 patients(9%) in others. 4) The distribution of patients according to the APACHE II scores was 9 to 29 point in adm. Day and the most patients was located between 10 and 14 of 62 patient(39%). 5) The length of hospitalization was 9 days in survived patients and 8 days in non-survived patients. The length of hospitalization of 77% of patients in this study was below 10 days. 6) The death rate was 45.45%(73 patient), this patients according to APACHE II scores was 13 to 29, median 19.2 in adm. Day, the most patients was located 20 to 24(20%). Non of the survived patients had the APACHE II score of above 20 points, but all recovered patients were below 13 points. 7) The median APACHE II score in survived patients was 10.52 point at adm. Day and 6.55 point at 5 days after admission. And non-survived patients was 20.25 point at adm. Day and 30.48 point 5 days after admission(p$lt;0.001). 8) Among the patients with low APACHE II score (below 14 points), there was no mortality. But, there was mortality with APACHE II score of above l5 points. We conclude that APACHE II scoring system is useful in measuring the severity of acute disease and predicting the outcome.

Open versus laparoscopic surgery for mid-rectal or low-rectal cancer after neoadjuvant chemoradiotherapy (COREAN trial): survival outcomes of an open-label, non-inferiority, randomised controlled trial

Jeong, Seung-Yong,Park, Ji Won,Nam, Byung Ho,Kim, Sohee,Kang, Sung-Bum,Lim, Seok-Byung,Choi, Hyo Seong,Kim, Duck-Woo,Chang, Hee Jin,Kim, Dae Yong,Jung, Kyung Hae,Kim, Tae-You,Kang, Gyeong Hoon,Chie, E Elsevier 2014 LANCET ONCOLOGY Vol.15 No.7

<P><B>Summary</B></P> <P><B>Background</B></P> <P>Compared with open resection, laparoscopic resection of rectal cancers is associated with improved short-term outcomes, but high-level evidence showing similar long-term outcomes is scarce. We aimed to compare survival outcomes of laparoscopic surgery with open surgery for patients with mid-rectal or low-rectal cancer.</P> <P><B>Methods</B></P> <P>The Comparison of Open versus laparoscopic surgery for mid or low REctal cancer After Neoadjuvant chemoradiotherapy (COREAN) trial was an open-label, non-inferiority, randomised controlled trial done between April 4, 2006, and Aug 26, 2009, at three centres in Korea. Patients (aged 18–80 years) with cT3N0–2M0 mid-rectal or low-rectal cancer who had received preoperative chemoradiotherapy were randomly assigned (1:1) to receive either open or laparoscopic surgery. Randomisation was stratified by sex and preoperative chemotherapy regimen. Investigators were masked to the randomisation sequence; patients and clinicians were not masked to the treatment assignments. The primary endpoint was 3 year disease-free survival, with a non-inferiority margin of 15%. Analysis was by intention to treat. This trial is registered with ClinicalTrials.gov, number NCT00470951.</P> <P><B>Findings</B></P> <P>We randomly assigned 340 patients to receive either open surgery (n=170) or laparoscopic surgery (n=170). 3 year disease-free survival was 72·5% (95% CI 65·0–78·6) for the open surgery group and 79·2% (72·3–84·6) for the laparoscopic surgery group, with a difference that was lower than the prespecified non-inferiority margin (–6·7%, 95% CI −15·8 to 2·4; p<0·0001). 25 (15%) patients died in the open group and 20 (12%) died in the laparoscopic group. No deaths were treatment related.</P> <P><B>Interpretation</B></P> <P>Our results show that laparoscopic resection for locally advanced rectal cancer after preoperative chemoradiotherapy provides similar outcomes for disease-free survival as open resection, thus justifying its use.</P> <P><B>Funding</B></P> <P>National Cancer Center, South Korea.</P>

Anti-oxidative and Anti-microbial Activities of fermented extract of Guajava Leaves (Psidium guajava)

Gyeong-Hee Kang,Seong-Yong Jeong,Woo-bin Jeong,Hyo-Jeong Seo,Sun-Woo Jin,Jong-Kwon Seo 한국식품영양과학회 2011 한국식품영양과학회 학술대회발표집 Vol.2011 No.10

Effect of Korean Medicine Combined with Electric Moxibustion in Patients with Traffic Accident-Induced Lumbago

Jeong, Hui-Gyeong,Kwon, Oh-Hoon,Park, Ju-Hun,Kim, Sang-Gyun,Kim, Yong-Hyeon,Lee, Ju-Young,Kim, Eun-Ji,Kim, Tae-Ju,Jeong, Sang-Jun Korean AcupunctureMoxibustion Medicine Society 2018 Korean Journal of Acupuncture Vol.35 No.4

Background: The purpose of this study was to investigate electric moxibustion on patients with back pain caused by road traffic accidents. Methods: This was a retrospective study (n = 112) comparing treatment with Korean medicine combined with electric moxibustion (n = 56), and Korean medicine alone (n = 56). Patient gender, age, Numeric Rating Scale (NRS), Oswestry Disability Index (ODI) and EuroQol-5 Dimension (EQ-5D) was recorded for each group at the time of hospital admission. Mean NRS measured weekly, mean ODI and EQ-5D scores were measured 2 weeks post-treatment, and evaluated by paired sample t test. using the Statistical Program for Social Science v. 25.0 for Windows. An independent, two-sample t test was used to test for a significant difference in the decrement of NRS, ODI and increment EQ-5D scores between groups. Results: NRS scores decreased in both groups after 1 week of treatment (electric moxibustion, from $5.13{\pm}0.79$ to $3.86{\pm}0.67$; Korean medicine alone, from $5.18{\pm}0.92$ to $4.30{\pm}0.94$; both p < 0.001). There was a significantly greater reduction in NRS score in the electric moxibustion group ($1.27{\pm}0.59$) than in the Korean medicine alone group ($0.88{\pm}0.61$; p = 0.001). After 2 weeks of treatment, EQ-5D scores increased significantly in the moxibustion group ($0.19{\pm}0.12$) compared with the Korean medicine alone group ($0.13{\pm}0.20$; p = 0.043). After 2 weeks of treatment, NRS and ODI scores decreased in both groups. EQ-5D increased in both groups. Conclusion: We suggest that electric moxibustion treatment may be effective for reducing early-stage back pain in patients with road traffic accident injuries.

Properties of Doenjang (Soybean Paste) Fermented with Multiple Starters

Min Jeong Cho,Jae Yong Lee,Kang Wook Lee,Kye Man Cho,Chang Kwon Lee,Gyeong Min Kim,Jeong Hee Shin,Jong Sang Kim,Hyun-Jin Kim,Jeong Hwan Kim 경상대학교 농업생명과학연구원 2014 농업생명과학연구 Vol.48 No.6

Multiple starters consisting of two Bacillus amyloliquefaciens strains (MJ1-4 and EMD17), Pichiafarinosa SY80, and Rhizopus oryzae were used for Doenjang making. Bacillus strains were selected based on their abilities to inhibit toxinogenic fungi and Bacillus cereus, fibrinolytic activity, and their ability to confer good flavor to Cheonggukjang. P. farinosa SY80 and R. oryzae, previously isolated from soy sauce, were selected because they were not inhibited by two bacilli. Doenjang was prepared by inoculation of multiple starters (A1 Doenjang). Control Doenjang was prepared by inoculation of B. subtilis KACC 16750 (Natto strain) and Aspergillus oryzae KCCM 60166 (A2 Doenjang). Another control (A3 Doenjang) was prepared by inoculation of microorganisms present in rice straw. Doenjang samples were fermented for 70 days at 20℃. pH of 3 samples decreased from the initial value of 6.4 to 5.8~6.0 and titratable acidity (TA) increased from 0.6 to 1.1~1.3. The amount of amino-type nitrogen increased during fermentation. There were slight differences in moisture, crude-protein, and crude-fat contents after 70 days. Contamination of fungi was observed only in A3 Doenjang and B. cereus was not detected from all 3 samples. A1 Doenjang showed the highest fibrinolytic activity and A2 Doenjang the second. These results indicate that Doenjang made with carefully selected starters was functionally improved and microbially more safe.

소동물 Iodine-125 SPECT 개발을 위한 컴퓨터 시뮬레이션

정진호 ( Jeong Jin Ho ),최용 ( Choe Yong ),송태용 ( Song Tae Yong ),정용현 ( Jeong Yong Hyeon ),정명환 ( Jeong Myeong Hwan ),홍기조 ( Hong Gi Jo ),민병준 ( Min Byeong Jun ),최연성 ( Choe Yeon Seong ),이경한 ( Lee Gyeong Han ) 대한핵의학회 2004 핵의학 분자영상 Vol.38 No.1

목적: I-125는 저에너지(27-35 keV) 방사선을 방출하기 때문에 두께가 얇은 섬광결정과 조준기를 사용할 수 있어 고분해능, 고민감도 영상획득에 유리한 물리적 특성을 가지고 있다. 이 연구의 목적은 새로운 시뮬레이션 도구인 GATE (Geant4 Application for Tomographic Emission)를 사용하여 최적의 I-125 SPECT 시스템 파라미터를 도출하는 것이다. 대상 및 방법: 시뮬레이션 방법의 신뢰성을 검증하기 위해, Weisenberger 등이 개발한 감사카메라 시스템을 모사하였다. 섬광채로 평판형 Mal(Tl)을 사용하였으며, 두께는 검출효율을 계산해서 결정하였다. 평행구멍조준기와 바늘구멍조준기의 여러 파라미터가 공간분해능과 민감도에 미치는 영향을 평가하였다. 그리고 최적화된 조준기를 결합한 I-125 SPECT의 성능을 평가하였다. 결과: 시뮬레이션에 대한 신뢰성 검증연구 결과, 측정과 시뮬레이션에서 공간분해능(4%)과 민감도(3%)가 유사함을 확인하였다. Nal(Tl) 두깨는 I-125 감마선을 98% 검출할 수 있도록 1 mm로 결정하였다. 시뮬레이션 결과 고분해능 평행구멍조준기로 구멍크기가 0.2 mm이고 길이가 5 mm인 사각구멍조준기를 선택하였고, 범용 평행구멍조준기로 구멍크기가 0.5 mm이고, 길이가 10 mm인 육각구멍조준기를 선택하였다. 바늘구멍주준기는 구멍지름이 0.25 mm이고 채널높이가 0.1 mm이며, 허용각도가 90도인 조준기를 선택하였다. 최적화된 고분해능 평행구멍조준기, 범용 평행구멍조준기, 바늘구멍조준기를 결합한 I-125 SPECT의 재구성 영상 공간분해능은 각각 1.2mm, 1.7 mm, 0.8 mm이였으며, 민감도는 39.7 cps/MBq, 71.9 cps/MBq, 5.5 cps/MBq이었다. 결론: GATE 시뮬레이션으로 I-125 영상에 적합한 섬광결정 파라미터 및 조준기 파라미터를 도출하였다. 이 연구결과는 I-125 SPECT로 탁월한 고분해능, 고민감도 영상을 얻을 수 있음을 보여준다. Purpose: Since 1-125 emits low energy (27-35 keV) radiation, thinner crystal and collimator could be employed and, hence, it is favorable to obtain high quality images. The purpose of this study was to derive the optimized parameters of 1-125 SPECT using a new simulation tool, GATE (Geant4 Application for Tomographic Emission). Materials and Methods: To validate the simulation methods, gamma camera developed by Weisenberger et al. was modeled. Nal(Tl) plate crystal was used and its thickness was determined by calculating detection efficiency. Spatial resolution and sensitivity curves were estimated by changing variable parameters for parallel-hold and pinhole collimator. Performances of 1-125 SPECT equipped with the optimal colimator were also estimated. Results: In the validation study, simulations were found to agree well with experimental measurements in spatial resolution (4%) and sensitivity (3%). In order to acquire 98% gamma ray detection efficiency, Nal(Tl) thickness was determined to be 1 mm. Hole diameter (mm), length (mm) and shape were chosen to be 0.2:5:square and 0.5:10:hexagonal for high resolution (HR) and general purpose (GP) parallel-hole collimator, respectively. Hole diameter, channel height and acceptance angle of pinhole (PH) collimator were determined to be 0.25 mm, 0.1 mm and 90 degree. The spatial resolutions of reconstructed image of the 1-125 SPECT employing HR:GP:PH were 1.2:1.7:0.8 mm. The sensitivities of HR:GP:PH were 39.7:71.9:5.5 첸/MBq. Conclusion: The optimal crystal and collimator parameters for 1-125 imaging were derived by simulation using GATE. The results indicate that excellent resolution and sensitivity imaging is feasible using 1-125 SPECT.

자동화유방초음파 검사시 부위별 gel pad 부착 전후의 통증 평가

김정단(Jeong-dan kim),박용성(Yong-sung Park),차경민(Gyeong-min Cha),최현정(Hyeon-jeong Choi),양정아(Jeong-a Yang),홍완식(Wan-sik Hong),조민연(Min-yeon Cho),김성헌(Seong-heon Kim) 대한초음파의료영상학회 2015 대한초음파의료영상학회지 Vol.6 No.1

목적 : 자동화 유방초음파 검사시 기존 검사에 비해 환자의 통증을 경감시키고자 검사를 시행하고 평가하였다. 대상 및 방법 : 2013년 6월부터 2013년 8월까지 유방외과에 조직검사를 위해 내원했던 환자들 중 유방의 병변부가 피부 가까이에 만져지거나, 유두하인 경우의 환자(115명, 47.7세)를 대상으로 AWUS를 동의서 작성 후 시행했다. 검사는 Anterior-posterior, Lateral, Medial 3방향에서 시행하고, 이후 Gel pad를 부착하여 병변부위만 한번 더 시행하여 검사의 영상을 평가하고, 환자통증을 수치화 하여 통증경감과 검사시 불편했던 사항을 환자와 검사자에게 조사하였다. 결과 : 환자의 통증경감을 나이대별, 유방실질별, 병리학적 검사결과별, 불편했던 부위별, 검사시 자세잡기 어려웠던 해부학적 인자별로 조사하였다. 환자의 객관적 인자로 인한 부착전후 통증경감은 나이대별(40미만, 40이상 50미만, 50이상)에서 P-value 0.001미만, 유방실질별(지방형 유방, 치밀 유방)에서 P-value 0.001미만, 병리학적 검사결과별(고위험, 중위험, 저위험)에서 P-value 0.001이하로 분석되었다. 환자․검사자 주관적 인자로 인한 부착 전후 통증경감은 불편했던 부위별(유두․유륜, 병변, 흉골, 유방전체, 늑골, 어깨)에서 어깨부위를 제외한 P-value 0.02이하, 검사시 자세잡기 어려웠던 해부학적 인자별(크기가 큰 흉곽, 크기가 작은 흉곽, 피부탄력도가 낮은 피부, 피부탄력도가 높은 피부, 마른 체구, 뚱뚱한 체구)에서 P-value 0.05이하로 분석되었다. 전체적인 Gel pad 부착전 평균검사통증 수치는 5.10, 부착후 평균검사통증 수치는 2.73으로 46.5% 경감되어 P-value가 0.001미만이었다. 결론 : 부위별 어깨부위를 제외한 나머지 통계에서 Gel pad를 이용한 검사는 비교적 통증경감에 유의하다. 하지만 병변의 정보 평가가 필요하며, 검사자의 숙련성이 요구되고, 통증경감에 따른 기대효과와 손익적인 측면이 고려되어야 할 것으로 사료된다. Purpose: This examination was conducted and evaluated in order to reduce pain in patients during the automated whole breast ultrasound compared to other existing examination methods. Materials and Methods: After the subjects filled out the consent forms, AWUS was conducted with subjects (115 patients, Mean age: 47.7) who visited the breast center for biopsy between June and August 2013 and who had palpable lesions near the skins of their breasts or subareolar lesions. The examination was conducted in 3 directions (Anterior-posterior, Lateral, Medial) after which the examination was repeated for only the lesion with gel pad applied. By evaluating the images from the examination and quantifying the pain experienced by the patients, pain relief and any inconvenience or discomfort during the examination were studied from the patients and technologist. Results: The pain relief in patients was investigated according to age, breast density, pathological examination results, region of discomfort and anatomical factors regarding difficult body positions during the examination. The P-values for the pain relief after gel pad application in consideration of the objective factors of the patients were analyzed to be as follows: below 0.001 for age group (below 40 y.o., 40 y.o. or older, below 50 y.o., 50 y.o. or older), below 0.001 for breast parenchyma types (fatty breast, dense breast), and 0.001 or below for pathological examination results (high risk, mid-risk, low risk). The P-values for the pain relief after gel pad application in consideration of the subjective factors of the patients and technologist were analyzed to be as follows: 0.02 or below for regions of discomfort (nipple/areola, lesion, sternum, whole breast, ribs, shoulder) except in case of shoulder region, and 0.05 or below for the anatomical factors regarding difficult body positions during the examination (large thorax, small thorax, skin with low elasticity, skin with high elasticity, thin physique, fat physique). In general, the average pain from examination was 5.10 before gel pad application, which decreased by 4.65% to 2.73 after application. The resulting P-value was below 0.001. Conclusion: The examination using gel pad is relatively significant in pain relief according to the statistics except in case of the shoulder region. However, it is considered that the evaluation of the information on the lesion would be needed, trained skills of the technologist are required, and profit/loss aspect and expected effects from pain relief must be reviewed.

기술논문 : 하천합류부에서 갈대매트를 이용한 하천식생대 조성에 대한 기초적 연구

정경진 ( Jeong Gyeong Jin ),김미경 ( Kim Mi Gyeong ),안원용 ( An Won Yong ) 한국환경복원녹화기술학회 2003 한국환경복원기술학회지 Vol.6 No.4