Two Poems by Shin Dong-jip

Shin Dong-jip,Ko Ch’ang-su(번역자) The Academy of Korean Studies 1966 Korea Journal Vol.6 No.10

혈관질환 정보관리 시스템

김동익,김덕경,허세호,이병붕,김용신,김은숙,문지영,도영수,신성욱,김동수,김만태,진재욱,김용신 대한혈관외과학회 2002 Vascular Specialist International Vol.18 No.1

As medical technology progresses rapidly, there is a rise in the average age along with the Korean dietary lifestyle becoming more westernized, which leads to an increase in the number of vascular disease patients in Korea. Thus, we need to manage the medical information of a disease systematically in order to diagnose and treat constructively. However, since there has been no standardized method of man agement to date, a great deal of information could not be properly utilized nor studied. Therefore, the departments of Cardiology, Radiology and Neurology of Samsung Seoul Hospital recently got together to develop an information management system called the Vascular Data System. This program was developed to be run on win98 O/S, upper Pentium Ⅲ, and upper 128 MB Memory, and its source code is Dephi 4.0. It was configured for the user to set the configurations as well as do a variety of search and analysis. If this program were to be updated continuously, it may be used extensively as well as in various parts of clinical research activities.

시멘트 제품군의 전과정평가

신동희,정재수,이건모 한국전과정평가학회 2002 한국전과정평가학회지 Vol.4 No.1

국내산업계에서 범용적으로 생산되는 시멘트 제품군에 대하여 원료채취부터 제품제조까지에 대한 전과정평가를 수행하였다. 대상제품군은 국내 산업현황을 바탕으로 1종 포틀랜드 시멘트, 2종 포틀랜드 시멘트, 3종 포틀랜드 시멘트, 5종 포틀랜드 시멘트 및 고로슬래그 시멘트를 선정하였다. 각 대상 제품군별 국내 생산량이 큰 기업을 선정하여 전과정 목록분석을 수행하였다. 데이터는 현장 데이터를 적용하였으며, 현장 데이터 취득이 어려운 경우 데이터베이스를 사용하였다. 영향평가는 분류화, 특성화, 정규화 및 가중치부여 단계로 수행하였다. 환경영향평가지수는 1종 포틀랜드 시멘트, 2종 포틀랜드 시멘트, 3종 포틀랜드 시멘트, 5종 포틀랜드 시멘트 및 고로슬래그 시멘트공정이 각각 6.53E-05, 4.81E-05, 4.39E-05, 4.84E-05 및 3.84E-05로 나타났다. CO2에 의한 지구온난화가 전체 환경영향의 대부분을 차지하였다. A life cycle assessment has been conducted from raw material acquisition to manufacturing for cement products in korea. The product category included portland cement - Type Ⅰ, Type Ⅱ, Type Ⅲ and Type Ⅴ - and Blast furnace cement. The major manufacturing companies were chosen for each product category and conducted life cycle inventory analysis. Generally, Site-specific Data was applied. If it's not impossible, database was used. Impact assessment was carried out consecutively as classification, characterization, normalization and weighting. The eco-indicators of portland cement - Type Ⅰ, Type Ⅱ, Type Ⅲ and Type Ⅴ - and Blast furnace cement were 6.53E-05, 4.81E-05, 4.39E-05, 4.84E-05 and 3.84E-05, respectively. Global warming from CO2 was major contributor of product category.

자동 문턱치 방법을 이용한 밀리미터파 영상의 은닉된 물체 영역 검출

이동수,염석원,손정영,김신환 대구대학교 정보통신연구소 2010 情報通信硏究 Vol.7 No.1

본 논문은 수동형 밀리미터파 영상 시스템을 이용하여 은닉된 물체의 영역을 검출에 관한 연구이다. 밀리미터파 영상은 악천후에도 영상 촬영이 가능하고 플라스틱, 종이, 나무, 옷, 머리카락 같은 특유한 물질들을 투과한다. 그리고 밀리미터파는 금속과 특수한 인공 구조물에 대한 반사율이 높기 때문에 은닉된 물체를 쉽게 검출할 수 있다. 본 논문에서는 밀리미터파 영상에서 은닉된 물체 검출의 영상 분할을 자동 문턱치 방법으로 나타낸다. 본 논문에서는 8㎜ 파장을 수평과 수직 편광 방향으로 수신하는 두 채널에서 획득된 밀리미터파 영상을 Gonzalez와 Otsu 방법으로 영역 분할을 한다. 실험 결과는 Gonzalez과 Otsu 방법 모두 은닉된 물체 영역의 형태를 잘 분리하지만 Otsu 방법이 노이즈와 몸체 영역의 경계 부분이 안정적으로 영역 분할됨을 보인다. We address an image segmentation method to detect concealed objects captured by passive millimeter wave (MMW) imaging. Passive MMW imaging can create interpretable imagery on the objects concealed under clothing. Due to the penetrating property of the MMW imaging, the MMW imaging system is often employed for the security and defense system. In this paper, we develop automatic thresholding methods for the segmentation of concealed objects detected by PMMW imaging. The automatic thresholding method is useful for the image with bimodal distributions. We compare several thresholding methods for two MMW channel images which have 8 mm-horizontal and 8 mm-vertical polarization, respectively. The experimental results show that concealed weapon area is well segmented from the background body by the presented methods.

유한요소법을 이용한 밸브 스프링 리테이너의 형상설계

신혁수, 김동범, 박진근, 이인환, 조해용 충북대학교 산업과학기술연구소 2013 산업과학기술연구 논문집 Vol.27 No.2

A valve spring retainer is a small disc and located at intake and exhaust valve stem of engine. The retainer supports a valve spring and transmits spring force to a valve. Force is applied to the retainer repeatedly by a rocker arm. Durability of the retainer is an important factor of performance. Weight of retainer affect dynamic performance of engine. Therefore, optimal strength and weight of the retainer design are needed. In this study, stress distribution and fracture load of retainer were analyzed by using FEM to design optimal strength and weight. Static load test was simulated by using commercial FEM code DEFORM-3D. Shapes of the retainer to reduce weight were designed and analyzed to verify validity of it. Simulated results and experimental ones were compared

最小流動化速度에 關한 實驗的 考察

申東秀 啓明大學校 産業技術硏究所 1990 産業技術硏究所 論文報告集 Vol.13 No.1

The minimum fludization velocities and maximum pressure drops of 0.241 - 0.588 ㎜ glass beads, 0.293 - 0.433 ㎜ sand, 0.174-0.180 ㎜ alumina particles, and 0.054-0.149 ㎜ iron powder were measured in an air fluidized bed of 0.0667 m inside diameter. The observed minimum fluidization velocities and maximum pressure drops were compared with corresponding equations proposed by different investigators. The observed minimum fluidization velocities were in agreement with Wen and Yu equation within 20%, Leva equation within 23%, and Baerg equation within 15%. The observed maximum pressure drops were in good agreement with Parent equation and Ergun equation.

北韓 「合營法」의 綜合的 批判

申東秀 단국대학교 교육대학원 1985 敎育論叢 Vol.1 No.-

The real objects of the NK's joint venture law are to supplement the present economic system so that the hireditary succession of Kim Ilsung to his son might be easily achieved, to approach the way to narrow th economic gab between the south and the north Korea, to search for an alternative to get more of economic aids than it gets from the communist countries, and to go with the current international desire for peace on the Korean peninsula. Despite such opening gesture of north Korea, it is doubtful if the law could attract many Western countries because NK holds far more foreign debts than it can pay and the market of the NK is much smaller than that of the PRC. Though the relations between the south and the north Korea seem to change after the law is put into practice, the prospects for better cmprovements of the relations between the two sides are not bright because the relations can only be improved when a co-existential order is established and the present political system is admitted by both sides, the homogeneousness of the people is realized through gradual and bilateral intercourse in every field. It should be noticed that NK's joint venture law was announced on the stage of its political transition to a hireditary succession of Kim Jungil, son of Kim Ilsung, and, therefore, it may take a considerably long time for the law to be put into practice throughout the peninsula.

호중구 감소성 발열환자에게 경험적으로 투여한 Teicoplanin의 효과

이동건,임동석,최수미,박선희,유진홍,최정현,민우성,신완식,김춘추 대한감염학회 2004 감염과 화학요법 Vol.36 No.2

목적 : 호중구감소성 발열 환자에게 경험적으로 teicoplanin을 투여할 때의 효과를 알아보고자 전향적 연구를 시행하였다. 방법 : 2003년 7월부터 12월까지 가톨릭조혈모세포이식센터에 입원하여 항암치료 혹은 조혈모세포이식을 시행하고 호중구감소성 발열이 있는 환자 중 초기 항균요법에 반응이 없어 경험적 teicoplanin 투여가 필요한 49명을 대상으로 A, B 제조회사에서 제공한 teicoplanin을 무작위로 어느 한 쪽 치료군에 배정하여 투여하였다. 용량은 첫날 400㎎ 부하용량을 정맥내 bolus로 투여하고 매 24시간마다 200㎎ 유지용량을 투여하였다. 결과 : A군 27명, B군 22명이 연구에 참여하였고 대부분의 환자가 신독성이 있는 약제를 병용하고 있었다. A군 8명, B군 7명에서 그람양성균이 동정되었고, teicoplanin에 대한 내성률은 A군 22.2%, B군 28.6%로 유의한 차이는 없었다(P=1.00; 0.61<95%CI<1.95). 미생물학적 확인 감염이 있었던 환자 중 평균 53.3%에서 완치 혹은 개선의 반응이 있었고 양 군간 유의한 차이는 없었다(A군 4명 [50.0%], B군 4명 [57.1%], P=1.00; 0.29<95%CI<2.60). 미생물학적 제거율은 평균 62.5% (A군 55.6%, B군 71.4%)이었고 그 외 미생물학적 효과는 A군에서 제거 후 재발 2명(22.2%), 내성 2명(22.2%)이었고 B군에서 각각 0명(0.0%), 2명(28.6%)이었으며 양 군간 유의한 차이는 없었다(P=0.28). 발열기간(P=0.89), teicoplanin 사용기간(P=0.47) 및 전체적인 사망률(P=1.00; 0.78<95%CI<1.24)도 양 군간 유의한 차이는 없었다. 이상반응 중 신독성은 16.3% (A군 18.5%, B군 13.6%)에서 나타났고 양 군에 차이는 없었으며(P=0.72; 0.39<95%CI<3.51), 신기능 이상과 관련있는 약제를 적어도 2개 이상 병용하고 있었다. 피부발진은 A군에서 1명, B군에서 3명 발생하였다(P=0.31; 0.93<95%CI<1.34). 결론 : 호중구감소성 발열환자에게 teicoplanin을 투여하였을 때 임상적 반응률은 평균 53.3%(A군 50.5%, B군 57.1%), 미생물학적 제거율은 평균 62.5%(A군 55.6%, B군 71.4%)이었고 두 제조회사간 차이가 없었고 이상반응도 양 군간 차이가 없었다. 앞으로 국내 호중구감소증 환자에서의 teicoplanin의 적정 용량, 용법 등을 알기 위한 집단 약동학 등의 연구를 시행할 예정이다. Background : This study was done to elucidate the efficacy of teicoplanin as the empirical treatment for febrile neutropenia. Methods : Patients were randomized to two groups according to pharmaceutical company (company A or B). Total of 49 patients (A, 27; B, 22) with neutropenic fever were studied prospectively for 6 months (Jul. 2003-Dec. 2003). Patients received 400 mg i.v. once, then 200 mg i.v. once daily. Results : Groups were matched for all demographic variables. Most of the patients were concurrently receiving nephrotoxic drugs. Gram positive microorganisms were isolated in 8 patients for A and 7 patients for B. Resistance rate against teicoplanin was 22.2% in A and 28.6% in B (P=1.0; 0.61 < 95% confidence interval [Cl] < 1.95). Among the patients with microbiologically documented infection, clinical cure or improvement was seen in 4 (50%) of 8 patients for A and 4 (57.1%) of 7 patients for B (P=1.00; 0.29 <95%CI <2.60). Bacteriologic efficacy was assessed as follows; elimination in 5 (55.6%), elimination with relapse in 2 (22.2%), resistance in 2 (22.2%) out of 9 gram-positive bacteria for A and 5 (51.4%), 0 (0.0%), 2 (28.6%) out of 7 bacteria for B, respectively (P=Q.28). There were no significant differences in duration of fever, duration of use of teicoplanin, and overall mortality. The incidence of nephrotoxicity and ototoxicity was not significant. Conclusion : For using teicoplanin as the empirical therapy for febrile neutropenia, the rate of clinical, microbiological response, and nephrotoxicity was 53.3%, 62.5%, and 16.3% respectively with no significant differences between the 2 preparations of teicoplanin. Supplementary evaluation on the adequate dose and duration of teicoplanin may be required.

Tetracyclic Isoquinoline유도체의 합성

조수동,정윤성,김정주,안철진,신동수 Institute of Genetic Engineering Changwon National 1998 Gene and Protein Vol.2 No.1

To develop new pharmacological charactization of isoquinoline derivatives, we have synthesized 3-benzyl-9,10-dimethoxy-6,7,11b,12-tetrahydropyridazino [4',5': 5,6] [1,4] -oxazino [3,4-а]isoqinolin-4(3H) -one. We have developed a convenient cyclization of novel isoquinoline derivatives starting from 3,4-dimethoxy phenethylamine using boron trifluoride diethyl etherate.

시상하부-뇌하수체 질환에서 종합적 뇌하수체전엽 기능검사의 진단적 의의

김수동,김신우,김정국,하승우,김보완 慶北大學校 醫科大學 1993 慶北醫大誌 Vol.34 No.4

시상하부-뇌하수체질환의 기저질환에 따른 종합적 뇌하수체전엽 자극검사의 진단적 가치를 알아보고자 81례의 뇌하수체 기능부전증환자를 대상으로 시상하부질환군과 Sheehan증후군, 말단비대증과 프로랙틴종, 그리고 뇌하수체선종에서 시야장애가 동반된 군과 장애가 없는 군으로 나누고 기능검사의 결과를 비교하였다. 1. Sheehan증후군 15례 가운데 GH 및 cortisol결핍이 전례(각각 100%)에서 FSH, LH 및 TSH결핍이 11∼12례(73∼80%)에서 관찰되었고 13례(86%)에서는 TRH에 대한 PRL분비증가가 저하 또는 소실되었다. 두개인두종 10례를 포함한 시상하부질환 14례 가운데 12례(86%)는 PRL의 기저지가 비정상직으로 증가되어 있었으며 TRH자극에 대해 PRL분비 증가가 11례(79%)에서 둔화되어 있었다. GH분비능도 11례(79%)에서 저하되었으며 그 밖의 cortisol, LH, TSH, FSH의 순으로 분비능이 저하되어 있었으나 그 빈도는 Sheehan증후군에 비해 전반적으로 낮았다. 2. 말단비대증 18례 가운데 14례(78%)에서 GH기저치가 비정상적으로 증가되어 있었고 13례(72%)는 저혈당자극에 대해 정상적인 GH의 증가를 보였으며 8례(44%)에서 고프로랙틴 혈증이 동반되었다. 프로랙틴종 18례 가운데 전례(100%)에서 PRL기저치가 증가되었고 13례(72%)에서 TRH에 대한 PRL의 증가반응이 둔화되었다. LH, FSH, cortisol 및 TSH분비능의 장애는 말단비대증군에서 프로랙틴종에 비해 다소 높은 빈도를 보이는 경향이었다. 3. 뇌하수체선종 가운데 시야장애가 동반된 21례에서 시야장애가 없는 23례에 비해 GH, cortisol및 LH의 분비반응이 저하된 빈도가 다소 높은 경향이었다. 이상의 결과로 보아 종합적 뇌하수체전엽 기능검사는 시상하부-뇌하수체질환의 기저질환을 진단하는데 중요한 정보를 제공할 수 있다고 생각한다. The combined stimulation test using TRH, LHRH and insulin has allowed investigation of the reserve of all pituitary tropic hormones under physiological and pathological conditions. To evaluate the diagnostic efficacy of this test for differentiating the underlying causes of hypopituitarism, we analyzed retrospectively the results of these tests done in 81 patients with proven hypothalamo-pituitary disorders. 1. In 15 patients with Sheehan's syndrome as a typical type of primary hypopituitarism, responses of both GH and cortisol to insulin-induced hypoglycemia were decreased in 15 cases all (100% in both) and of FSH, LH and TSH in 11 to 12 cases(73-80%). Incremental response of prolactin(PRL) to TRH was diminished or absent in 13 cases(86%). In 14 patients with hypothalamic diseases, including 10 cases of craniopharyn-gioma, as a representative secondary hypopituitarism, the basal PRL levels were abnormally elevated in 12 cases (86%) and both responses of PRL to TRH and of GH to hypoglycemia were blunted in 11 cases (79% in both). The frequency of impaired cortisol secretion was 50%, followed by LH, TSH and FSH secretion : overall frequency much lower than in Sheehan's syndrome. 2. In 18 acromegalics with pituitary adenoma, basal GH levels were abnormally elevated in 14 cases(78%) and incremental responses of GH to hypoglycemia were found in 13(72%). Hyperprolactinemia was accompanied in 8 (44%). In 18 patients with prolactinoma, basal PRL levels were moderately to markedly elevated in all of them(100%) and responses of PRL to TRH were blunted in 13(72%). The frequency of impaired secretion of LH, FSH, cortisol and TSH was slightly higher in acromegalics than in patients with prolactinoma. 3. The frequency of impaired secretion of GH, cortisol and LH tended to be slightly higher in patients with pituitary adenoma associated with visual field defect than those without visual field defect. These results suggest that the combined pituitary stimulation test will give us some of reliable information for evaluating the underlying causes of hypopituitarism.