Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Shin, Tae-Kyeong,Kang, Mi-Sun,Lee, Ho-Youn,Seo, Moo-Sang,Kim, Si-Geun,Kim, Chi-Dae,Lee, Won-Suk The Korean Society of Pharmacology 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1 ${\alpha}$ (HIF-1 ${\alpha}$) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1 ${\alpha}$ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

Fluoxetine and Sertraline Attenuate Postischemic Brain Injury in Mice

Tae Kyeong Shin,Mi Sun Kang,Ho Youn Lee,Moo Sang Seo,Si Geun Kim,Chi Dae Kim,Won Suk Lee 대한생리학회-대한약리학회 2009 The Korean Journal of Physiology & Pharmacology Vol.13 No.3

This study aimed to investigate whether selective serotonin reuptake inhibitors (SSRIs) attenuate brain injury and facilitate recovery following photothrombotic cortical ischemia in mice. Male ICR mice were anesthetized and systemically administered Rose Bengal. Permanent focal ischemia was induced in the medial frontal and somatosensory cortices by irradiating the skull with cold light laser. The animals were treated with fluoxetine or sertraline once a day for 14 d starting 1 h after ischemic insult. Treatment with fluoxetine and sertraline significantly reduced the infarct size. The Evans blue extravasation indices of the fluoxetine- and sertraline-treated groups were significantly lower than that of the vehicle group. Treatment with fluoxetine and sertraline shifted the lower limit of the mean arterial blood pressure for cerebral blood flow autoregulation toward normal, and significantly increased the expression of heme oxygenase-1 (HO-1) and hypoxia-inducible factor-1Ձ (HIF-1Ձ) proteins in the ischemic region. These results suggest that SSRIs, such as fluoxetine and sertraline, facilitate recovery following photothrombotic cortical ischemia via enhancement of HO-1 and HIF-1Ձ proteins expression, thereby providing a benefit in therapy of cerebral ischemia.

Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions

Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8

Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.

수생식물을 이용한 수질정화 SYSTEM 개발에 관한 연구

신대윤,홍완해,왕승호 조선대학교 환경공해연구소 1999 環境公害硏究 Vol.15 No.2

This study focused on the removal of COD, SS, T-N and T-P of home wastewater in batch and continuous culture reactors using parsley. And the amounts of nitrogen and phosphorus in the tissues of parsley were also detected. The results are as follow ; 1. Parsley has achieved 42% COD removal rate, 55% SS, 10% T-P and 41% T-N for 48 hours retention time. Residual concentration was COD 6.1㎎/ℓ, SS ll㎎/ℓ, T-P 1.112㎎/ℓ and T-N 4.9㎎/ℓ respectively. 2. Nitrogen and phosphorous content, accumulated in the tissues of parsley are 40.4% and 9.2% respectively in batch reactor with 48 hours SRT. They are presenting increasing rate 37.6% of nitrogen and 9% of phosphorous, compared with their influent sample, contending 2.8% of nitrogen and 0.19% of phosphorous. 3. Continuous reactor has achieved 42% COD removal rate, 62% SS, 10% T-N, and 46% T-P, Effluent COD concentration was 5.8㎎/ℓ, SS 8.13㎎/ℓ, T-P 0.84㎎/ℓ and T-N 4.09㎎/ℓ.

건식경량벽체의 내충격성능 평가방법에 관한 연구 (Ⅰ) : 인간이 벽체에 가하는 충격하중의 분석을 위한 실험 및 고찰 An Experiment to Analyze the Human Impact Load Applied to Framed Walls

신윤호,안정업,김대희,최수경 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

The purpose of this study is to establish an evaluation method of fracture of light-weight framed walls by human impact load. In this paper, part (I), we analyzed human impact load applied to framed walls. At first, we made original measuring equipment of impact load, and carried out the experiment on human impact load in various action. After the experiment, we extracted the essential characteristics. And grasped the property of human impact load systematically based on the relation between maximum load and load velocity.

일과성 전 기억상실증으로 나타난 크로이츠펠트 : 야콥병 1례

신대수,이승희,이한샘,박성욱,박현영,장혁,장성조,김요식,조광호 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.1

운동실조를 동반하지 않은 급성외안근마비 1례

신대수,이승회,이한샘,박성욱,박현영,장혁,김요식,조광호 圓光大學校 醫科學硏究所 2004 圓光醫科學 Vol.19 No.2

강재 슬릿형 댐퍼를 부착한 철근콘크리트조 골조의 거동

신종익,이정한,송한범,강대언,오상훈,차승렬,이용재,김상대,이원호 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

This study investigates the performance of the reinforced concrete frame with the steel plate slit damper. The test was carried out to investigate the structural behavior between the reinforced concrete bare frame and the reinforced concrete frame with the steel plate slit damper. The test results showed that the energy absorption capacity of the damped-frame was several times larger than that of the bare frame. For the damage by the input energy is concentrated on the steel plate slit damper, the ductilities of the former structure were increased and the damaged frame can be reused after exchange the steel plate slit damper.

韓國産 錦葵科 植物에 관한 本草學的 硏究

金大漢,辛民敎,宋昊埈 한국전통의학연구소 1998 한국전통의학지 Vol.8 No.1

이 논문은 아욱과 Malvaceae에 속한 植物에 對하여 本草學的으로 文獻을 조사하여 硏究한 것으로 다음과 같이 要約되었다. 1. 아욱과 植物 總 36種 中 갯아욱屬 Hibiscus 植物이 14種,어저귀屬 Abutilon 植物이 6種,목화屬 Gossypium 植物과 아욱屬 Malva 植物이 各名 5種,황촉규屬 Abelmoschus 植物이 3種,촉규화屬 Althaea 植物이 2種,그外 현렁화屬 Malvaviscus 植物이 1種으로 調査되어 갯아욱屬 Hibiscus 植物이 가장 많이 나타났다. 2. 아욱과 植物은 總 7屬 36種으로 調査되었으며 그 가운데 藥用植物은 경麻, 蜀葵, 棉花, 木槿, 冬葵 等의 7屬 26種으로서 約 72%를 차지하고 있었다. 3. 아욱과 植物 中 藥用植物을 藥用 部位別로 分類해보면 根類 20種, 花類 18種, 種子類 14種, 葉類 12種, 全草類와 皮類가 名各 8種, 外果皮와 脂訪油가 名各 5種, 그외 果實類 2種의 順으로 調査되어 根類 藥物이 가장 많이 나타났다. 4. 藥性에 있어서 藥用部位에 따라 重複되는 것을 包含하여 寒凉性 藥物이 45種, 平性 藥物이 20種,溫熱性 藥物이 6種 等으로 나타나 寒凉性 藥物이 가장 많이 나타났다. 5. 效能에 있어서는 淸熱 解毒 藥物이 19種, 利水消腫 藥物이 17種, 化痰止咳 藥物이 10種 等으로 調査되어 淸熱解毒 藥物이 가징 많이 나타났다. 6. 有毒 藥物로는 棉花子와 棉子油 2種만 나타났다. 以上의 結果로 아욱과 植物中 藥用植物이 72%를 차지하였고 이 가운데 根類 植物이 가장 많았으며 아울러 毒性 約物도 거의 없기 때문에 臨床에 容易하게 使用될 수 있을 것으로 생각된다. 앞으로 아욱과 藥用植物 가운데 起源 植物이 複雜한 것은 實驗的인 硏究가 持續되어져야 할 것으로 思料된다. For the purpose of developing Korean Herbalogy with the plants of Malvaceae which grow wild and is planted in Korea, the these and writings on herbalogy, from literature of successive generations, have been thoroughly investigative and the results obtained were as follows: 1) There were totaled 7 genera and 36 species in Korea and among them medecinal plants are 7 genera, 26 species, some 72% in total but the number of species may be added because of similar plants. 2) According to the oriental name which can be used for medical purpose, the medicinal plants beloning to the Malvaceae were classified as Radix 20, Aora 18, Semen 14, Folium 12, Herba 7, Cortex 7, Exocarpium and Oil 5, Fructus 2 eet. Thus it was noticed that radix was the main kind. 3) According to sum of 36 species in Malvaceae they were classified into Hibiscus genera 14, Abutilon genera 6, Gossypium and Malva genera 5, Abelmoschus genera 3, Althaea 2, Malvaviscus genera 1. Thus it was noticed that Hibiscus genera was the main kind. 4) According to nature and flavour of medidnal plants, they were dassified into cold and cool; 45, balance 20, wormth and heat; 6. Thus it was noticed that cold and cool is the main in nature and flavour of medicinal plants. 5) According to the Properties and Prindpal Curative action, they were dassified into, dearing up heat and toxin 19, drugs for inducing diuresis to allevitae edema 17, drugs for releving cough and reducing sputum 10. 6) Comparing to whole medicinal plants 53 kinds, toxic durgs were 2 kinds. Thus toxic durgs were rare. From this result, It was revealed that the plants for medical purpose in Malvaceae was 72% kinds of the whole, in which radix was mostly abundunt, toxic plants were so rare that it will be used for dinical treatments more easily. It is considered that many clinical experiments and approaches must be continued to use widely.

가자의 즉각형 알레르기 반응 억제 효과

엄용대,신민교,이영미,김형민,신태용,정종길,송호준 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1

We investigated the effects of methanol extract of Fructus Chebula (MEFC) on local and systemic anaphylaxis. Passive cutaneous anaphylaxis inhibited to 61.42 12.8 % by oral administration of MEFC(I.0 glkg). MEFC inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.05-1.0 glkg . Administrations of MEFC (1.0 glkg) 60 min before, 5 min after, and 10 min after the compound 48/80 treatment were shown the mortality rates as 0%. MEFC (0.01-1.0 glkg) inhibited the histamine release significantly from the rat peritoneal mast cells by compound 48/80. These results indicate that MEFC inhibits mast cell mediated anaphylactic reactions by inhibition of mast cell degranulation in vivo and in vitro.