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엄용대,신민교,이영미,김형민,신태용,정종길,송호준 대한본초학회 2000 大韓本草學會誌 Vol.15 No.1
We investigated the effects of methanol extract of Fructus Chebula (MEFC) on local and systemic anaphylaxis. Passive cutaneous anaphylaxis inhibited to 61.42 12.8 % by oral administration of MEFC(I.0 glkg). MEFC inhibited compound 48/80-induced anaphylactic shock 100% with doses of 0.05-1.0 glkg . Administrations of MEFC (1.0 glkg) 60 min before, 5 min after, and 10 min after the compound 48/80 treatment were shown the mortality rates as 0%. MEFC (0.01-1.0 glkg) inhibited the histamine release significantly from the rat peritoneal mast cells by compound 48/80. These results indicate that MEFC inhibits mast cell mediated anaphylactic reactions by inhibition of mast cell degranulation in vivo and in vitro.
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嚴龍大,全吉煥,辛民敎,宋昊埈 대한본초학회 1997 大韓本草學會誌 Vol.12 No.1
For the purpose of developing Korean Herbalogy with the plants of ulmaceae which grow wild and is planted in Korea, the thesa and weitings on herbalogy, from literature of successive generations, haye been thoroughly investigative and the results obtained were as follows: 1. There were totaled td 5 genera and 33 species in Korea and among them medicinal plants are 4 genera, 30 species, some 91% in total, but the number of species may be added because of the similiar. 2. According to the oriental names which can be used for medical purpose, the medicinal plants belonging to the ulnaceae family wear classified as Cortex22, Folium15, Lignum15, Fruit2, Floral. Thus it was noticed that the cortex was main kind. 3. According to sum of 33 species in Ulmaceae family, they wear classified into Aphamanthe genera 1, celtis genera 15, Ulmus genera 13, Zelkowa genera 3,hemiptelia genera lect. Thus it noticed that Celtis genera was the main kind, some 45% in total. 4. According to nature and flavour of medicinal plants, they were calssifed into cold and cool, 6, balance 6, warmth and teat; 1, and unidentified 4. Thus it was noticed that cold, cool and balanceis the main in nature and flavour of medicinal plants. 5. In vicw of their efficacy and allouing for duplicate nomenclature, they can be classified into 5 heat - clearing and detoxifying harbs, 10 promote diuresis to reduce edema herbs, 3 drugs for red-ucing sputum and cough, 6 drugs for safeting embryo fetus and 2 in secticdes heabs. 6. Surveying to whold medicinal plant 30 kinds, toxic drugs include none. from this result, It was revealed that the plants for medical purpose in ulmaceae was 91% kinds of the whold, incortex was abundunt, toxic plants were so none that it will be used for clinical treatments more easily. It is considered that clinical experiments and approaches should be continued to use ulmaceae plants widely.
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卞宗鎬,嚴龍大,柳泓善,辛民敎 한국전통의학연구소 1999 한국전통의학지 Vol.9 No.2
We studied biblographically on the origin of Zitanxiang which is commonly used at Oriental Traditional and Herbal Drugs Clinic. Results are as follows. We can find out that ; 1. In China, Pterocarpus indicus Wild. and Pterocapus santalinus L. which are duramen of woody parts of the plants of Leguminosae are used as Zitanxiang medicinal stuff. 2. In Korea, Sabina chinensis(L) Antoin (= Juniperus chinensis L.) which is the woody parts of Chinese cypress which is evergreen arbor and one of the plants of Cupressaceae is used as Zitanxiang medicinal stuff. Therefor, it is thought that comparison research have to be studied on these different Zitanxiang medicinal stuffs on the basis of efficacy.
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류명환,엄용대,변종호,조훈,양은영,강길웅,신민교,백승화,Ryu, Myeng-Hwan,Aeam, Yong-Dea,Byun, Jong-Ho,Cho, Hoon,Yang, Eun-Yeong,Kang, Kil-Ung,Shin, Min-Kyo,Baek, Seung-Hwa 한국생약학회 2000 생약학회지 Vol.31 No.1
This study was carried out to evaluate cytotoxic effects of Ajuga multiflora Bunge extracts on murine leukemia tumor $(P388D_1)$ cell lines. Disruptions in cell organelles were determined by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay. The comparison of $IC_{50}$ values of Ajuga multiflora Bunge extracts in L1210 and $P388D_1$ cell lines showed that their susceptibility to these extracts decreased in the following order: Adriamycin>methanol extract>chloroform extract>ethyl acetate extract>hexane extract>water extract by the MTT assay. In order to develop an antimicrobial agent, dried Ajuga multiflora Bunge was extracted with several solvents, and then antimicrobial activity was investigated. The minimal inhibitory concentration (MIC) of the extract against microorganisms were also examined. Antimicrobial activities of amocla and ketoconazole as references were compared to those of extracts of $H_2O$, n-hexane, chloroform, ethyl acetate and methanol. The antimicrobial activity of all extracts from the sample had growth inhibition activity against gram-negative bacteria, gram-positive bacteria and fungi $(MIC>200\;{\mu}g/ml)$. These results suggest that the methanol soluble extract of Ajuga multiflora Bunge may be a valuable choice for the studies on the treatment of murine leukemia tumor cell lines.
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