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유산균(L.lactis CBT-8)및 발효 추출물의 Helicobacter pylori 억제 능력
진춘조,박형석,이혜운,김성렬,강동구,이준상,이재동,왕준호 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-
Helicobacter pylori infection was the cause of chronic gastritis, duodenal ulcer and gastric MALT lymphoma. The eradication rates of H. pylori using antibiotics are around 80%. Lactobacilli have been demonstrated to have in vivo and in vitro inhibitory effects on H. pylori infection. We aimed to evaluate the inhibitory effect of L. lactis CBT-8 and its extract on H. pylori in human stomach. Thirty-five H. pylori-infected volunteers(30-49 yr)were randomized into two groups which were treated with L. lactis CBT-8 and its extract(Group A n=17) or milk containing L. lactis CBT-8(Group B, n=18). They underwent 13C-urea breath tests before and after treatment. The DOB30 of group A(n=14) was decreased 41.0% after treatment(26.0±4.9 before, 15.3±2.1 after treatment)(p<0.05). the DOB30 of group B(n=13) was decreased 22.3% after treatment(22.0±2.2 before, 17.1±1.7 after treatment)(p<0.05). In conclusion, L. lactis CBT-8 was effective in suppressing H. pylori infection in human stomach.
강기춘,이청희,왕수환,이천일,표형배,정노희 한국공업화학회 2004 응용화학 Vol.8 No.1
Nowadays many products using nano-technology have been released and nano-technology would be more prospected in all kinds of industries especially cosmetic manufacturing and ingredient fields. In cosmetics, the saturated lecithin, one of the main surfactants to make liposome, has been used for its stability but it has been substituting by unsaturated lecithin which has excellent skin affinity and penetration. So we studied to develop nano-liposome below 50㎚ with unsaturated lecithin. To make stable nano-liposome, many factors including solvent like propylene glycol, pH balance, homogenizing pressure and liposome stabilizer like surfactant are important especially stearate series surfactants have positive effect in liposome size and long term stability. But in liposome with saturated lecithin, surfactant has negative effect and appropriate amount of oil should be used to be stable. So we could conclude that unsaturated lecithin is suitable than saturated lecithin to make nano-liposome.
다발성 간종괴의 형태로 나타난 특발성 과호산구 증후군 치험1예
최승오,연규민,이승민,김순제,왕준호,박형석,이재동,진춘조,이창훈,신현준,김정은 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-
Hypereosinophilic syndrome is characterized by persistent blood eosinophilia of 1,500/ul or more in the absence of known causes and multiorgan dysfunction by eosinophil-related tissue damage. In Korea, some cases of hypereosinophilic syndrome with hepatic involvement have been described with prolonged benign clinical courses. Most of them were diffuse or multifocal lesions in imaging studies, and a few case presenting as a single mass has been described. Here we report a case of hypereosinophilic syndrome with hepatic involvement in a 65-year-old man who presented with multifocal mass lesions. By abdominal US and CT scan, multiple, ill-defined nodules were detected in throughout the liver. Liver biopsy revealed severe eosinophilic hepatitis, suggestive of hypereosinophilic syndrome. Hepatic mass lesions improved after steroid administration for several weeks.
A New Cell Counting Method to Evaluate Anti-tumor Compound Activity
Wang, Xue-Jian,Zhang, Xiu-Rong,Zhang, Lei,Li, Qing-Hua,Wang, Lin,Shi, Li-Hong,Fang, Chun-Yan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8
Determining cell quantity is a common problem in cytology research and anti-tumor drug development. A simple and low-cost method was developed to determine monolayer and adherent-growth cell quantities. The cell nucleus is located in the cytoplasm, and is independent. Thus, the nucleus cannot make contact even if the cell density is heavy. This phenomenon is the foundation of accurate cell-nucleus recognition. The cell nucleus is easily recognizable in images after fluorescent staining because it is independent. A one-to-one relationship exists between the nucleus and the cell; therefore, this method can be used to determine the quantity of proliferating cells. Results indicated that the activity of the histone deacetylase inhibitor Z1 was effective after this method was used. The nude-mouse xenograft model also revealed the potent anti-tumor activity of Z1. This research presents a new anti-tumor-drug evaluation method.
Exercise is positively associated with cognitive Function:The role of exercise modalities
Chun-Chih Wang,Chien-HengChu,Chih-HanWu,조유민,Yu-KaiChang 국민체육진흥공단 한국스포츠정책과학원 2017 International Journal of Applied Sports Sciences Vol.29 No.2
An increasing number of studies have explored the relationship between exercise and cognitive function. While the majority of studies have focused on the effects of aerobic exercise, some studies have shifted their attention to other exercise modalities such as resistance exercise and Tai Chi Chuan. The purpose of this brief review is to explore the effects of aerobic exercise, resistance exercise, and Tai Chi Chuan on cognitive function by reviewing previous research on each of those exercise modalities and their relationships to cognition, including the potential mechanisms underlying those relationships. Generally speaking, a positive effect of aerobic training on cognitive function is observed. While the research evidence regarding the effects of resistance exercise and Tai Chi Chuan on cognitive function are only somewhat established, their positive trend indicates that future studies are warranted to investigate them further.
Chun Yan Wang(왕춘연),Chung Ha Lee(이청하),Mi Ra Lee(이미라),Beom Sik Yun(윤범식),Lei Liu(유뢰),Zhen Wang(왕젠),Zhe Ming Fang(방철명),Dong Liang Zhang(장동량),Zheng Li(이정),Chang Keun Sung(성창근) 한국생명과학회 2010 생명과학회지 Vol.20 No.5
본 논문은 선충 포식성 곰팡이에 대한 선충의 영향을 조사한 연구로, 소나무 기생곰팡이인 E. vermicola에 미치는 소나무 선충의 영향을 체계적으로 분석하였다. 선충 대사물과 선충 균질액 모두 E. vermicola의 성장을 빠르게 촉진하였으나, 선충 대사물이 선충 균질액보다 약간 높은 효과를 보였다. 또한 소나무 선충이 생성하는 휘발성 물질이 E. vermicola 성장에 미치는 영향을 분석하는 새로운 실험방법을 개발하였다. 본 연구결과에 따르면, 선충의 휘발성 물질은 E. vermicola에 아무런 영향을 끼치지 않는다는 재현성 있는 결과를 도출하였다. 본 연구는 소나무 선충의 생물학적인 조절인자로서 E. vermicola을 적용할 수 있는 정보를 제공할 수 있을 것이다. The influence of nematodes on nematophagous fungi has seldom been investigated. In the present study, the influence of pinewood nematode on its endoparasitic fungus, Esteya vermicola, was investigated systemically. Although both nematodal metabolite and nematodal homogenate could stimulate and speed up the growth of E. vermicola, the impact of nematodal metabolite was slightly higher than that of nematodal homogenate. In addition, a method was developed to investigate the influence of volatiles, discharged by pinewood nematodes in their metabolic process, on the growth of E. vermicola. Reproductive results were given and confirmed that nematodal volatiles have no influence on the cell growth of E. vermicola. This study may provide information for the application of E. vermicola as biological control agent of pinewood nematode.
The Presence of Borrelia valaisiana-Related Genospecies in Ticks and a Rodent in Taiwan
Chun-Man Huang,Hsi-Chieh Wang,Ying-Chun Lin,Shih-Hui Chiu,Ying-Shun Kao,Pei-Lung Lee,Hsiu-I Wang,Ruei-Chen Hung,Huang-I Chan,Ho-Sheng Wu,Chuen-Sheue Chiang,Jung-Jung Mu 한국미생물학회 2010 The journal of microbiology Vol.48 No.6
A field survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato (s.l.) in six counties of Taiwan. Spirochetes were successfully isolated from one rodent ear sample out of 485 rodent ears and 53live, fed tick (Ixodes granulatus) samples. The spirochetes were confirmed to be B. burgdorferi s.l. by real-time PCR. In addition, 23 of 113 tick samples were tested positive for Borrelia DNA according to real-time PCR. The Borrelia isolate from the rodent and the 23 Borrelia DNA samples from the ticks were identified as B. valaisiana-related genospecies by phylogenetic analysis based on flagellin gene sequences. These findings suggest that the Borrelia valaisiana-related strains are maintained in a zoonotic cycle between tick vectors and reservoir hosts in Taiwan.
Chun-Huy Wang 한양대학교 세라믹연구소 2013 Journal of Ceramic Processing Research Vol.14 No.2
Although PbZrO3-PbTiO3 (PZT)-based ceramics are playing a dominant role in piezoelectric materials, their evaporation of harmful lead oxide during the sintering process causes a crucial environment problem. It is necessary to search for lead-free piezoelectric materials that have such excellent properties as those found in the PZT-based ceramics. Therefore (Na0.5K0.5)NbO3-based solid solutions were studied to improve piezoelectric properties. In the present study, various quantities of Bi2O3 were added into 0.98(Na0.5K0.5)NbO3-0.02Bi(Na0.80K0.20)TiO3 (0.98NKN-0.02BNKT) ceramics. It was found that 0.98NKN-0.02BNKT with the addition of 0 ~ 0.5 wt.% Bi2O3 exhibit relatively good piezoelectric properties. For 0.98NKN0.02BNKT ceramics, the electromechanical coupling coefficients of the planar mode kp and the thickness mode kt reach 0.35 and 0.41, respectively, at the sintering of 1100 o C for 3 hrs. For 0.98NKN-0.02BNKT ceramics with the addition of 0.3 wt.% Bi2O3, the electromechanical coupling coefficients of the planar mode kp and the thickness mode kt reach 0.42 and 0.46, respectively, at the sintering of 1100 o C for 3 hrs. It is obvious that 0.98NKN-0.02BNKT solid solution ceramic by adding low quantities of Bi2O3 is one of the promising lead-free ceramics for electromechanical transducer applications.